7 results about "Cyclooctene" patented technology

The application discloses a preparation method of a composite antioxidant and application thereof, and belongs to the field of high polymer materials. In the application, a ring octene and a silicon-containing cyclic olefin monomer are subjected to metathesis copolymerization under the action of a metathesis catalyst, a silicon-containing polymer is obtained after chemical hydrogenation, and then the composite antioxidant is obtained after hydrolysis and mixing with lignin. The main chain of the composite antioxidant is a saturated hydrocarbon chain, the compatibility with polyethylene is high, the silicon-containing polymer is hydrolyzed to generate active silanol, the active silanol is efficiently bonded with lignin, and the lignin provides natural polyphenol antioxidant function. The application realizes efficient antioxidant of the composite material, high compatibility and long-term durability, and provides a new idea for high-performance environment-friendly high polymer composite materials.

The application discloses application of a divinyl tetrazine in cyclization of a linear polypeptide, and a structure formula of the divinyl tetrazine is; the linear polypeptide has at least two free mercapto groups, and the vinyl groups of the divinyl tetrazine are subjected to Michael addition reaction with corresponding mercapto groups to form a ring. The application provides a new use of the divinyl tetrazine, the divinyl tetrazine can be subjected to high-efficiency Michael addition reaction with two natural cysteine mercapto groups on the linear polypeptide through the vinyl groups, so that double-mercapto peg cyclization of the linear polypeptide is realized, and the purpose of limiting the conformation of the linear polypeptide and improving the stability of the linear polypeptide is achieved. Moreover, the divinyl tetrazine can be subjected to a reverse electron demand Diels-Alder reaction with trans-cyclooctene (TCO) after the two vinyl groups are subjected to reaction with mercapto groups, so that functional polypeptides can be modularly constructed by coupling with functional molecules modified with TCO, and related applications are realized.

This invention provides a system for in-situ cardiac NO generation based on bioorthogonal reactions and its application, belonging to the pharmaceutical field. The system of this invention improves the bioavailability of NO in the heart, thereby significantly improving myocardial ischemia-reperfusion injury. Specifically, microneedles are pre-implanted into the heart, and then a delivery system (prepared by modifying L-arginine with trans-cyclooctene to form an L-arginine prodrug, and then preparing a nano-delivery system by electrostatic adsorption of L-Arg-TCO) is injected into the body via intravenous injection. Only when the nano-delivery system circulates to the heart, and the TCO undergoes a bioorthogonal reaction with (4-(6-methyl-1,2,4,5-tetraazinecyclo-3-yl)phenyl)methylamine in the microneedles, can the L-arginine prodrug be activated, thereby achieving cardiac-targeted delivery of L-arginine, leading to the enrichment, activation, and conversion of L-arginine into NO in the heart.

The application discloses a kind of photoactivation biotin-biological orthogonal prodrug system and its anti-tumor application.The system integrates biotin targeting ligand, photo-caged tetrazine (TZ) group into one molecule through connecting chain, and can release activated TZ under specific wavelength light, then, TZ and trans-cyclooctene (TCO) modified prodrug or probe occur biological orthogonal reaction, realize the accurate release of tumor site.The system has the functions of active targeting, light-controlled rapid release and diagnosis and treatment integration, and has high tumor inhibition rate, which is significantly better than traditional chemotherapy, and has no obvious systemic toxicity, providing a new strategy for precise treatment of malignant tumors.

The application discloses a method for quickly regulating layer spacing of a layered molecular sieve and application thereof. The method is characterized by using tetraethyl silicate condensate, tetrabutyl titanate silane and ferrocene silane as intercalation reagents, making a carrier gas carry vaporized intercalation reagents to flow through a reactor loaded with the layered molecular sieve, making the carrier gas carry vaporized deionized water to flow through the reactor loaded with the layered molecular sieve, and then performing calcination on the layered molecular sieve to obtain a pillared post-molecular sieve with good thermal stability. The application adopts gas phase pillaring, and has the advantages of simple preparation method, mild conditions, small amount of raw materials, simple steps, high yield, easy scale production, and the like. The intercalation reagent improves the high-temperature tolerance of the original layered molecular sieve, and at the same time, a plurality of active sites and places for adsorption of reactants are introduced at one time. The pillared post-molecular sieve is used in a reaction of preparing epoxycyclooctane by oxidizing cyclooctene with hydrogen peroxide, and the reaction has a cyclooctene conversion rate of 43% or more and an epoxycyclooctane selectivity of 65% or more.

A polyacid-based supramolecular complex catalyst for catalyzing olefin epoxidation at normal temperature, a preparation method and application thereof, and a molecular formula thereof is as follows: {[Co(cmbpy)(H2O)4](beta-Mo8O 26 ) 0.5}·H2O, wherein, cmbpy is deprotonated 1-(carboxymethyl)-(4,4'-bipyridine). A cobalt sulfate, 1-(carboxymethyl)-4,4'-bipyridinium hydrochloride and (NH4)6Mo7O 24 ·4H2O are added into an ethanol solution, stirred for 2 hours, the pH value is adjusted to 5.84 by using an inorganic base, transferred to a reaction kettle with a polytetrafluoroethylene liner, sealed, heated to 85 DEG C, reacted under hydrothermal conditions for 4 days, naturally cooled to room temperature after the reaction is completed, washed and separated to obtain the polyacid-based supramolecular complex catalyst. The advantage is that the synthesis method is simple, the synthesis time is short, the synthesis yield is high, and the catalyst can be used for selective oxidation of cyclooctene.