41 results about "Annulation" patented technology

The invention discloses a method for synthesizing a pyrrole compound. The method comprises the following steps: mixing a beta-nitrostyrene compound, an alpha-fluoro-beta-ketone ester compound, cesium carbonate and ethanol, carrying out an addition reaction at 40-60 DEG C, cooling to room temperature after the reaction is finished, adding acetic acid and zinc particles, and carrying out a cyclization reaction at 60-100 DEG C to obtain the pyrrole compound. The method does not need to add a noble metal catalyst and a large number of redox agents, the reaction is carried out under normal pressure, operation is easy and convenient, raw materials are cheap and easy to obtain, and the method is suitable for large-scale production.

The application discloses application of a divinyl tetrazine in cyclization of a linear polypeptide, and a structure formula of the divinyl tetrazine is; the linear polypeptide has at least two free mercapto groups, and the vinyl groups of the divinyl tetrazine are subjected to Michael addition reaction with corresponding mercapto groups to form a ring. The application provides a new use of the divinyl tetrazine, the divinyl tetrazine can be subjected to high-efficiency Michael addition reaction with two natural cysteine mercapto groups on the linear polypeptide through the vinyl groups, so that double-mercapto peg cyclization of the linear polypeptide is realized, and the purpose of limiting the conformation of the linear polypeptide and improving the stability of the linear polypeptide is achieved. Moreover, the divinyl tetrazine can be subjected to a reverse electron demand Diels-Alder reaction with trans-cyclooctene (TCO) after the two vinyl groups are subjected to reaction with mercapto groups, so that functional polypeptides can be modularly constructed by coupling with functional molecules modified with TCO, and related applications are realized.

The application relates to the field of polypeptide medicine preparation, and particularly discloses a preparation method of bumenol peptide, which adopts a solid-liquid combination mode, liquid-phase synthesis of a tripeptide fragment Fmoc-Lys(Ac-Nle-Asp)-OMe, subsequent solid-phase synthesis of a cyclic heptapeptide methyl ester, cleavage, cyclization, deprotection and hydrolysis to obtain crude bumenol peptide. The cyclization site is alpha-COOH of Trp and alpha-NH2 of Lys, the reaction yield is high, and the cyclization problem between Lys and Asp in most current patents is solved. The process operation is simple, the deprotection reagent is conducive to environmental protection requirements. The crude product is easy to purify, the finished product has high yield and purity, and is suitable for industrial large-scale production.

This invention discloses a method for preparing nitrogen-containing conjugated macrocyclic molecules and their composite catalysts, as well as their applications. The method involves adding small-molecule conjugated amines and conjugated anhydride ligands to a polar solvent to obtain a solution containing the ligands and the polar solvent. The precursor solution is then transferred to a reaction apparatus consisting of a flask and a condenser, where the ligands are fully dissolved by magnetic stirring. A highly conductive support and a metal source are then added to the precursor solution, and the precursor is heated to undergo a solvothermal reaction. Simultaneously, an acid is added as a catalyst to initiate a cyclization reaction. After the reaction, a preliminary product is obtained by filtration and vacuum drying. This preliminary product is then redispersed in a polar solvent and subjected to multiple centrifugal washings to remove unreacted small-molecule conjugated amines and conjugated anhydride ligands. After further filtration and vacuum drying, the nitrogen-containing conjugated macrocyclic molecule composite catalyst is obtained. This invention, through the rational design of nitrogen-containing conjugated macrocyclic molecules composed of small-molecule conjugated amines and conjugated anhydride ligands, and their combination with highly conductive supports and metal sources, significantly enhances the conductivity and interfacial charge transport capacity of catalysts, reduces overpotential and reaction energy barriers during catalytic reactions, and expands their application range in electrocatalytic and photocatalytic reactions. It can be used for oxygen reduction reactions, oxygen evolution reactions, hydrogen evolution reactions, carbon dioxide reduction reactions, nitrogen reduction reactions, nitrate reduction reactions, urea synthesis reactions, and oxidation or reduction reactions of small organic molecules.

The invention discloses a high-yield synthesis method of elxalidone, and relates to the technical field of drug synthesis. 1-chloro-2-(trifluoromethyl) benzene and 4-(methylsulfonyl) aniline are used as initial raw materials; according to the present invention, the isaprorenone is obtained through the Grignard reaction, the addition reaction, the bromination reaction, the condensation reaction, the substitution reaction, the cyclization reaction, the reduction reaction, the substitution reaction and the chiral resolution, and the synthesis method has advantages of low raw material cost, short route, high yield and the like, and can be used for the quantitative production of the isaprorenone.

The patent application discloses a kind of polyquinoline acridinedione macrocyclic derivatives and its preparation method and application.The application is by methylene bridging, multiple single-molecule fragments of quinoline acridinedione is gathered into macrocycle, the difference between the electron-withdrawing and electron-donating properties of carbonyl and nitrogen atom is synthesized into a variety of quinoline acridinedione macrocyclic derivatives containing the relative distribution structure of carbonyl and nitrogen atom, the interaction of carbonyl and nitrogen atom heterocycle is conducive to realize high color purity molecular luminescence.Because the free rotation of benzene ring and intramolecular vibration caused by single fragment molecule itself is not fixed, energy is attenuated in the form of non-radiative transition, and the benzene ring after being polymerized into ring can efficiently emit light due to the limited rotation, and improve the color purity of luminescence.

The invention relates to a preparation method of a baloxvir intermediate, and belongs to the technical field of medicine synthesis. The preparation method comprises the following steps: reacting a compound 02 with 2-fluorobenzaldehyde in the presence of an alkaline reagent, and carrying out post-treatment to obtain a compound 03. And carrying out cyclization reaction on the compound 03 in the presence of acid to obtain a compound 04. The preparation method provided by the invention is short in reaction time, mild in reaction, easy in reagent obtaining, safe to operate, high in product yield, high in product purity, capable of reducing the cost and beneficial to industrial implementation.

The invention provides a preparation method of capicotib, which comprises the following steps: carrying out aromatic nucleophilic substitution (SNAr) on 4-aminopiperidine-4-carboxylic acid and 4-chloro-7-toluenesulfonyl-7H-pyrrole [2, 3-d] pyrimidine to obtain a compound as shown in a formula II, then esterifying under the action of trifluoroacetic anhydride to form a ring to form a compound as shown in a formula III, and carrying out cyclization on the compound as shown in the formula III to obtain the capicotib. The preparation method comprises the following steps: carrying out ring-opening reaction with (S)-3-amino-3-(4-chlorphenyl) propan-1-alcohol without separation under an alkali condition to obtain a compound as shown in a formula IV, and finally removing a toluenesulfonyl protecting group to obtain the carpatinib. The preparation method has the advantages of few reaction steps, mild conditions and short SNAr reaction time, the obtained intermediate compound is easy to purify, the purity and the total yield of the cappitatide can be improved, and the preparation method is suitable for industrial large-scale production.

The application discloses a preparation method of a diazabicyclooctene compound. Specifically, the method comprises the following steps: performing ring formation reaction of compound 3 and triphosgene in a solvent under the action of a base, as shown in the following formula, and the solvent is a halogenated alkane solvent, and the base is triethylamine. The preparation method has a short synthesis route, reduces consumption of raw materials, and improves overall yield.

The application provides a preparation method of an electrocatalytic SCF-substituted dihydrofuran compound, and belongs to the technical field of compound preparation. The application uses diazonium and ethylene compounds as substrates, uses an SCF source as a sulfur-containing and fluorine-containing fragment donor, realizes a one-pot cascade reaction of ring formation through electrolysis, and thus constructs the SCF-substituted dihydrofuran compound. The raw material of the application has a wide source, uses electric current as a reaction driving force, avoids or reduces the use of additional photosensitizers and chemical oxidation-reduction reagents, and has the one-pot cascade characteristics of ring C-N bond breaking, C-O bond construction, trifluoromethylation and ring formation and the like, so that the step economy can be improved.

The present invention relates to a synthetic gene cluster of an enfumafungin antibiotic and a synthetic method therefor. Specifically, in the present invention, key functional genes in the linking of a β-D-glucopyranose at position C3 of a fernane-type framework, the oxidation at position C2 into α-OH, the oxidative cleavage of ring E at C19-C20, and the acetylation of hydroxyl at position C2 during the biosynthesis of an enfumafungin antibiotic, i.e. fuscoatroside, are isolated, wherein the genes are named fsoA, fsoD, fsoE and fsoF, respectively. The present invention also provides encoding polypeptides thereof. Provided in the present invention are an artificial fusion enzyme gene, i.e. efuA(TC)fsoA(GT); and on the basis of the artificial fusion enzyme gene, the heterologous expression of four genes, i.e. efuA(TC)fsoA(GT), fsoD, fsoE and fsoF, can synthesize an enfumafungin precursor (13). The present invention clarifies an FsoE-mediated C-C bond breaking function of a P450 enzyme, and provides a key catalytically active residue of FsoE. The present invention reports the biosynthetic pathway of such compound for the first time, and establishes an important foundation for the green and efficient synthesis of the compound.

The application discloses a kind of modified carboxylate macrocyclic molecules and preparation method and application thereof, it is related to organic material and electroluminescent device technical field;Macrocyclic molecules include molecular structure formula I and molecular structure formula II, and the macrocycle of it respectively contains 8 and 10 1,4-para phenylene, R in structure can be selected variously;Its synthesis method includes the steps of gradually connecting carboxylate monomer, using template to guide ring formation, intramolecular ring closure reaction and palladium catalysis reaction;Device based on this molecule has electronic device, hole device and OLED device, all contain functional film layer, and preparation method is various;The molecule and device of the application have outstanding photoelectric performance, can reduce intermolecular force, reduce π-π stacking, improve solubility, reduce device start-up voltage, control luminescent color;Through application in different devices, provide a new solution for related field, with wide application prospect.

The invention relates to the field of metal organic chemistry, and discloses a rare earth metal complex as well as a preparation method and application thereof, the structural formula of the rare earth metal complex is as shown in Cat-1 or Cat-2: # imgabs0 #, RE is rare earth metal, Het is an aromatic heterocyclic substituent containing at least one heteroatom, X is a heteroatom in Het, X is an aromatic heterocyclic substituent containing at least one heteroatom, X is an aromatic heterocyclic substituent containing at least one heteroatom, X is an aromatic heterocyclic substituent containing at least one heteroatom, X is an aromatic heterocyclic substituent containing at least one heteroatom, and X is an aromatic heterocyclic substituent containing at least one heteroatom. R is alkyl, aryl or amido without or with a substituent group, R1 and R2 are respectively and independently C1-C15 linear alkyl or aryl, or R1 and R2 form a ring. The rare earth metal complex disclosed by the invention has good yield, and when the rare earth metal complex is used as a catalyst, the cycloaddition reaction of CO2 and epoxide has the characteristics of high activity, high conversion rate, high product selectivity and low reaction pressure.

The invention relates to a piperidine functionalized ring-containing polyfluorene ether ketone anion exchange membrane and a preparation method thereof. The preparation method comprises the following steps: reacting tetramethyl bisphenol fluorene with excessive 4, 4 '-difluorobenzophenone to generate an ABA type compound containing four methyl groups, performing cyclization reaction on the ABA type compound and tetramethyl dimethoxy bisphenol fluorene in a dilute solution to obtain a dimethoxy group-containing cyclic compound, reacting the dimethoxy group-containing cyclic compound with boron tribromide to prepare a cyclic monomer containing two phenolic hydroxyl groups, and reacting the cyclic monomer with 4, 4'-difluorobenzophenone to obtain a dimethoxy group-containing cyclic monomer. The preparation method comprises the following steps: carrying out polycondensation on 4, 4 '-difluorobenzophenone and bisphenol fluorene at a high temperature to prepare a ring-containing polyfluorene ether ketone compound, brominating methyl in the ring-containing polyfluorene ether ketone compound by utilizing bromination reaction, reacting with N-methylpiperidine to prepare a piperidine functionalized ring-containing polyfluorene ether ketone compound, and carrying out solution casting to obtain the anion exchange membrane. The obtained anion exchange membrane has the advantages of high ion conductivity, low vanadium ion permeability, high mechanical strength and the like.

The application discloses a preparation method of 4-[2-[(2-methoxyethoxy)methoxy]ethyl]morpholine, which comprises two steps of reactions: in the first step, triethanolamine is used as a starting material, and intramolecular dehydration and ring formation reaction occur under the action of a catalyst iron trichloride, so that an intermediate N-hydroxyethyl morpholine is obtained after rectification; in the second step, nucleophilic substitution reaction occurs between the intermediate and 2-methoxyethoxymethyl chloride in an organic solvent under the action of an acid binding agent, so that 4-[2-[(2-methoxyethoxy)methoxy]ethyl]morpholine crude product is obtained after extraction, water removal and solvent rotary evaporation, and the crude product is purified to obtain 4-[2-[(2-methoxyethoxy)methoxy]ethyl]morpholine product; the use amount of the catalyst iron trichloride in the first step is 2% to 4% of the mass of the triethanolamine; and the mass ratio of the intermediate to the 2-methoxyethoxymethyl chloride is 1:1.2 to 1.4; the product prepared by the method has a purity meeting the demand of electronic chemicals, provides a raw material basis for subsequent research in the photoresist field, and has high industrial popularization value.

The application discloses a preparation method of an intermediate of Axitinib and an intermediate of Axitinib as shown in formula VI. The application provides a preparation method of a compound as shown in formula VII, which comprises the following steps: performing ring formation reaction on a compound of formula VI in the presence of a base and a solvent to obtain the compound of formula VII. The Axitinib synthesis route provided by the application has the advantages of less steps, low cost, high purity of a synthesis product and no introduction of toxic substances.

A compound represented by formula (1) (wherein either one of R16 and R18 is an unsubstituted aryl group having 6-18 ring-forming carbon atoms or an unsubstituted monovalent heterocyclic group having 5-18 ring-forming atoms, and has at least one deuterium atom in the molecule).

The invention provides a preparation method of a selenium-containing or sulfur-containing pyrimidine heterocyclic compound, and belongs to the field of organic synthesis. The invention provides a preparation method of a 2, 4-disubstituted-5-(sulfur / selenium group) pyrimidine compound, which comprises the following steps: mixing an enaminone compound, an amidine compound and an analogue thereof, a sulfuration / selenylation reagent and a polar organic solvent, and carrying out olefin addition and subsequent cyclization reaction to obtain the 2, 4-disubstituted-5-(sulfur / selenium group) pyrimidine compound. The preparation method disclosed by the invention has the advantages of no need of transition metal and other external oxidants, wide substrate range, good functional group tolerance, high regioselectivity, simplicity and convenience in operation, mild conditions and the like, and the prepared 2, 4-disubstituted-5-(thio / seleno) pyrimidine compound has relatively high purity which is 98.5-99.9%.

The invention relates to the technical field of organic photoelectric materials, in particular to an organic metal compound and an organic light-emitting layer material. The organic metal compound has a La ligand with a structure as shown in a formula I, R1, R2, R3, R4, Ra, Rb, Rc and Rd are respectively and independently selected from any one of hydrogen, deuterium, tritium, halogen, cyano, trifluoromethyl, methyl, deuterated methyl, substituted or unsubstituted C2-C15 alkyl, substituted or unsubstituted C3-C20 cycloalkyl, substituted or unsubstituted C6-C30 aryl and substituted or unsubstituted C6-C30 heteroaryl, p, q, r, r, r, r, r, r, r, r, r, r, r, r, r, r, r, r, r, r, r, r, r, r, r, r, r, r, r, r, r, r, r, r, r, r, r, r, r, r, r, r, r, m and n are respectively and independently selected from 1 to the permissible maximum substitution on the ring; two adjacent substituents can be connected with each other to form a ring; x1 and X2 are respectively and independently selected from C and N. After the compound is applied to the organic light-emitting device, the organic light-emitting device has the characteristics of long service life, high efficiency and low driving voltage.

The synthesis method comprises the following steps: by taking 3, 5-dimethoxyacetophenone as shown in a formula I as a raw material, carrying out Wittig reaction to obtain mixed-configuration trisubstituted olefin as shown in a formula b, carrying out asymmetric hydroboration reaction by taking pinacolborane as a boron source and a chiral CoCl2-TIP complex as a catalyst under the action of a reducing agent, and carrying out recrystallization to obtain the actinomycete ketone key intermediate. The preparation method comprises the following steps: preparing a chiral alkyl boron compound as shown in a formula c, deprotecting an aldehyde acetal group of the chiral alkyl boron compound as shown in the formula c to form an aldehyde group, carrying out intramolecular electrophilic addition reaction to form a ring, carrying out dehydration elimination to prepare a dihydronaphthalene compound as shown in a formula d, and oxidizing to prepare a key intermediate compound of actinomycete ketone as shown in a formula II. The method has the advantages of mild reaction conditions, simple operation, good reaction conversion rate, total yield of 67.2%, and high enantiomer selectivity of 92%. According to the invention, the reaction steps are shortened, the reaction yield is increased by more than 10 times, and good enantioselectivity is still maintained.

The present invention relates to the technical field of fine chemical product preparation, and is directed to a method for producing methylpyrrolidone. The method comprises the following steps: (1) subjecting butyrolactone to a ring-opening reaction with methylamine to obtain a stream 1; and (2) subjecting the stream 1, hydrogen, and optionally water to a ring-forming reaction in the presence of a catalyst; wherein, in the ring-opening reaction of step (1), the conversion rate of butyrolactone is not less than 80%. The method provided by the present invention has the advantages of short reaction time, low energy consumption, and high synthesis efficiency.

The application belongs to the technical field of organic synthesis, and particularly relates to an asymmetric total synthesis method of catharanthine. Commercially available oxazolidinone 1 is used as a starting material, and is condensed with bromoacrylic acid to obtain compound 2. Then, asymmetric DA reaction of compound 2 and compound 3 occurs under the catalysis of scandium triflate to obtain compound 4. Compound 4 is hydrolyzed into a carboxylic acid under the condition of lithium hydroxide and hydrogen peroxide, and is treated by trimethylsilane diazomethane to obtain compound 6. Compound 6 is selectively reacted with sodium methoxide, and after the protective group is removed by treatment of iodo-trimethylsilane, compound 6 is condensed with an acid to obtain compound 9. Compound 9 is subjected to radical annulation under the catalysis of a photocatalyst Ir(ppy)3 to obtain compound 10. Finally, selective reduction of the amide obtains natural product (+) - catharanthine. The asymmetric total synthesis route of the application has a total step of 8 or 9, and a total yield of 17.8% - 23.5%, which is shorter than that of the prior art, and the total yield is significantly improved.

The invention discloses a preparation method of an optical pure amino acid herbicide. The preparation method comprises a preparation method of a refined glufosinate-ammonium intermediate. The method comprises the following steps: carrying out cyclization reaction on a compound as shown in a formula (III) and a compound as shown in a formula (IV) in the presence of a solvent and organic alkali to obtain a compound as shown in a formula (V), and then carrying out intramolecular Arbuzov rearrangement reaction under the action of a halogenation catalyst to obtain the refined glufosinate-ammonium intermediate. The preparation method is simple in process, the synthesis route is reduced, complex and tedious separation and purification processes are avoided in the synthesis steps, particularly, waste salt, waste acid and toxic waste gas are not generated in the aspect of three-waste control, and the product quality is high. In addition, the reaction conditions are mild, the operation is simple, the continuity among the working sections is strong, the raw material cost and the industrial investment are effectively reduced, and the trend of green chemical industry is met.

The invention belongs to the technical field of organic synthesis, and relates to a synthetic method of chroman-5-amine. The molecular structural formula of the chroman-5-amine is shown as a formula 1. The synthesis method of the chroman-5-amine comprises the following steps: by taking methyl 4-bromo-3-hydroxybenzoate as a raw material, carrying out six-step reaction of substitution, cyclization, elimination, hydrolysis, amination and Boc group removal to synthesize the compound chroman-5-amine. The synthesis method is mild in condition, simple and efficient.

The invention provides synthesis and application of a boron-nitrogen-doped dark red / near-infrared narrow-band luminescent material, and solves the problems that existing boron-nitrogen-doped polycyclic aromatic hydrocarbon is difficult to cover near-infrared requirements, the synthesis route is complex and the half-peak width is relatively wide. The material comprises a boron-nitrogen coordination center; the boron-nitrogen coordination center is composed of a boron atom and three nitrogen atoms; the boron atom and one nitrogen atom form a boron-nitrogen coordination bond, the nitrogen atom participates in ring formation to form a substituted or unsubstituted ring A, and the ring A is selected from pyridine or pyridine derivatives; the boron atom and the other two nitrogen atoms form two boron-nitrogen covalent bonds, and the two nitrogen atoms are two secondary nitrogen atoms of indolocarbazole respectively; a ring A is connected with a benzene ring between the two indolocarbazoles, and the para-position of the ring A is substituted by an R group; r groups independently exist or form a ring C with similar nitrogen atoms.

The invention relates to a preparation method of an aromatic cyclic carboxylic acid intermediate compound I. The preparation method comprises the following steps: S1, reacting with a ketal reagent under the catalysis of acid to prepare a compound as shown in a formula II; s2, reacting under an alkaline condition, and treating with acid to obtain a compound I; wherein X is an optionally substituted aromatic ring, and the aromatic ring is selected from a benzene ring, a thiophene ring and a naphthalene ring; the substituent group of the aromatic ring is selected from methyl, ethyl, propyl, butyl, amyl and isopropyl, preferably methyl; aromatic rings are selected from R1 and are independently selected from carbonyl protecting groups; or in the formula II, R1-R1 and atoms connected with the R1-R1 form a ring, and-R1-R1-is selected from carbonyl protecting groups; r1 is independently selected from a methyl group, an ethyl group, a benzyl group, a propyl group, a butyl group, a amyl group, an isopropyl group and a methylthio group; or R1-R1 cyclizes together with the atom to which they are attached, selected from the group consisting of R1-R1

The application discloses a preparation method of a heterocyclic alkyl compound, an intermediate thereof and application of the intermediate. The application provides a preparation method of a compound shown in a formula IN-06, which comprises the following steps: performing ring formation reaction and deprotection reaction on a compound shown in a formula IN-05 in an organic solvent in the presence of an acid-binding agent to obtain the compound shown in the formula IN-06, and the acid-binding agent is NaOH, NaH or potassium carbonate; wherein R is halogen. The preparation method has one or more advantages of higher chiral purity and being beneficial to industrial production.

The invention discloses an internal electron donor regulator, a solid catalyst component and a preparation method and application thereof. The internal electron donor regulator comprises at least one of compounds with a structure as shown in the following formula (I), r1 and R1'are the same or different, and are respectively and independently one of hydrogen, halogen, hydroxyl, C1-C30 straight-chain alkyl containing or not containing a substituent group, C3-C30 branched-chain alkyl containing or not containing a substituent group, C2-C30 alkenyl containing or not containing a substituent group, C2-C30 ester group containing or not containing a substituent group, C6-C30 aryl containing or not containing a substituent group, and C3-C30 cycloalkyl or heterocyclic radical containing or not containing a substituent group; r1 and R1'can form a ring at will; r < 2 >, R < 3 >, R < 4 >, R < 5 >, R < 2 '>, R < 3' >, R < 4 '> and R < 5' > are the same or different and are respectively and independently one of hydrogen, halogen, hydroxyl, nitryl, amino, C1-C30 linear alkyl containing or not containing substituent groups, C3-C30 branched alkyl containing or not containing substituent groups, C2-C30 alkenyl containing or not containing substituent groups, C6-C30 aryl containing or not containing substituent groups, and C3-C30 cycloalkyl or heterocyclic radical containing or not containing substituent groups; any two of R2, R3, R4, R5, R2 ', R3', R4 'and R5' can form a ring at will; a is selected from one of alkylene, arylene, heteroarylene, alkyl arylene and aryl alkylene which contain or do not contain substituent groups. When the compound with the structure as shown in the formula (I) and the existing internal electron donor compound are used together, the performance of the internal electron donor can be effectively improved, and the obtained catalyst has higher catalytic activity and orientation capability, and can adjust the molecular weight distribution of a polymer to obtain a polyolefin product with moderate molecular weight distribution.

A compound having at least one group represented by the following general formula (11) and containing only one benzo[de]anthracene derivative skeleton represented by the following general formula (1000) in a molecule. Ar1 is a substituted or unsubstituted aryl group having 4 or more rings, R 10 ~R 19 At least one of the groups represented by the above general formula (11), L1 is a substituted or unsubstituted aromatic group having 6 to 15 ring-forming carbon atoms or a substituted or unsubstituted divalent heterocyclic group having 5 to 15 ring-forming atoms, and mx is 1, 2 or 3.

The invention relates to the technical field of organic synthesis, and particularly discloses a synthesis method of 2, 3, 3 ', 4'-diphenyl ether tetracarboxylic dianhydride. The invention relates to a synthetic method of 2, 3, 3 ', 4'-diphenyl ether tetracarboxylic dianhydride, which comprises the following steps: firstly carrying out nucleophilic reaction on methyl 3-hydroxybenzoate and 3-nitro-N-methylphthalimide in a base catalyst, then hydrolyzing under an alkaline condition, and finally carrying out cyclization reaction with paraformaldehyde under an acidic condition to obtain 6-(2, 3-dicarboxyl phenoxy) phthalide, the preparation method comprises the following steps: oxidizing 6-(2, 3-dicarboxyphenoxy) phthalide into acid, and then forming anhydride, thereby obtaining the 2, 3, 3 ', 4'-diphenyl ether tetracarboxylic dianhydride. According to the synthesis method, the low-toxicity methyl 3-hydroxybenzoate is adopted as the raw material to synthesize the target product, so that the synthesis cost of the 2, 3, 3 ', 4'-diphenyl ether tetracarboxylic dianhydride is effectively reduced.