185results about How to "No purification required" patented technology

The invention relates to a preparation method of a nitrogen-doped hollow carbon ball loaded palladium-based catalyst, which comprises the following steps of: dispersing o-phenylenediamine in a solvent for being stirred at a low temperature, adding an initiator for reacting for 12-24h, then extracting and filtering, and drying in vacuum to obtain a poly(o-phenylenediamine) hollow ball; pyrolyzing an o-phenylenediamine polymer at a high temperature for 2-6h under the protection of an inert gas to obtain a nitrogen-doped hollow carbon ball; and dispersing the nitrogen-doped hollow carbon ball into water, adding a chloropalladic acid solution for ultrasonic treatment, adding a reducing agent for ultrasonic treatment, extracting and filtering after the reaction is completed, and drying in vacuum to obtain the nitrogen-doped hollow carbon ball loaded palladium-based catalyst. The nitrogen-doped hollow carbon ball loaded palladium-based catalyst prepared by adopting the preparation method has the nitrogen content of 10.4-22.4wt%, has the advantages of excellent oxidization reaction catalysis property to alcohol, stable performance, low preparation cost and simple preparation process, and is a novel high-performance catalyst for a low-temperature direct alcohol fuel cell anode.

The invention discloses a multifunctional urethane acrylate oligomer as well as a synthesis method and application thereof. The synthesis method comprises the following steps: synthesizing a modified glycidyl ether by adding a diglycidyl ether, a dibasic acid and a catalyst which is the triphenylphosphine into a reactor and subjecting the materials to reaction at 120-150 DEG C for 2.5-3.5 hours; synthesizing a semi-adduct by dropwise adding acrylic hydroxy ester and dibutyltin dilaurate into diisocyanate, and keeping the reaction temperature at 40-50 DEG C until the concentration of the isocyanate group is 48-52% of the initial concentration; and synthesizing a hydroxyl-group containing multifunctional urethane acrylate. In the process of synthesizing, by using the difference of raw materials and controlling the proportion of monomers for reaction, the soft and hard segments are introduced into the molecule structure so that the toughness is increased, and the brittleness of the coating film is improved. The hydroxyl groups are provided in the molecular structure design, which is helpful to the improvement of the adhesion of the coating film on the substrate in the later period.

The invention relates to the field of a flexible energy storage system electrode material, in particular to an electrostatic spinning-carbonization preparation method of foldable flexible pure nanometer carbon fiber. The method comprises the following steps of (1) spinning solution preparation: zinc salt and PAN (polyacrylonitrile) are mixed, and are dissolved in DMF (N,N-Dimethylformamide); after the materials are fully stirred at 0 to 110 DEG C, a uniform spinning solution is obtained, wherein the mass percent of zinc salt in the spinning solution is 1 to 20 percent, and the mass percent of the PAN is 5 to 15 percent; (2) nanofiber preparation: the spinning solution obtained in the first step is spun into a nanofiber membrane by an electrostatic spinning method; (3) flexible nanometer carbon fiber preparation: the nanofiber membrane obtained in the second step is preoxidized for 0.5 to 10h at the temperature of 150 to 280 DEG C; then, carbonization is performed for 1 to 10h at the temperature of 550 to 1600 DEG C under the inert gas protection and the foldable flexible pure nanometer carbon fiber is obtained.

The invention relates to a preparation method of a high-graphitized nanometer carbon material. The method comprises the following steps: (1), uniformly mixing magnetic metal or metal oxide particles with a solid organic carbon precursor material, wherein the magnetic metal or metal oxide particles in the mixture account for 10 to 80 percent of the total weight; and (2) putting the mixture in a microwave oven and processing in microwave for 3 seconds or longer under the microwave power of 300W to 3000W so as to obtain carbon-wrapped magnetic metal nanometer particles or a multi-wall carbon nanometer pipe material. The prepared carbon material has high graphitization degree, controllable grain diameter and thickness, simple technology, low preparation cost, high product purity, wide selective raw material range and easy mass preparation.

The invention provides a synthetic method of plant growth regulator trinexapac-ethyl intermediate 3-carbethoxy-5-oxo-cyclohexane-1-enol cyclopropanecarboxylate. The synthetic method comprises the following steps: (1) carrying out annulation reaction on 2-acetonyl-1,4-diethyl succinate and organic alkaline at the temperature of 20-120 DEG C for 0.5-5 hours in a non-polarity organic solvent to obtain 3,5-cyclohexanedione-1-ethyl formate; and (2) adding organic amine and cyclopropanecarboxylic acid chloride, and carrying out acylation reaction at the temperature of minus 5-50 DEG C, so as to obtain 3-ethoxycarbonyl-5-oxo-cyclohexane-1-enol cyclopropanecarboxylate in the presence of micromolecular alcohol, ether, ketone and nitrile the carbon atoms of which are below C8 and are used as additives. According to the method, special additives are added before acylation so that cyclopropanecarboxylic acid chloride can directly react with intermediate-state 3-ethoxycarbonyl-5-oxo-cyclohexane-1-enol sodium salt to obtain the trinexapac-ethyl precursor 3-ethoxycarbonyl-5-oxo-cyclohexane-1-enol cyclopropanecarboxylate, thereby shortening reaction time, simplifying synthesis process and improving yield; and the product is directly rearranged without purification so as to obtain the final product trinexapac-ethyl.

The invention refers to a synthetic method of insect growth regulator of substituted benzoyl urea and to be specific involves the synthetic method of fluorin bell urea, fluorin insect urea and diflubenzuron. It chooses the 2, 6-difluoro benzonitrile as the starting material and gets the compound of the substituted benzoyl urea after fluorination, hydrolysis, esterification and addition. The method adopts the potasium fluoride with high activity and quaternary ammonium salt as the catalyzer during the fluorination, which shortens the time of the fluorination reaction greatly, chooses the base catalysis during the hydrolysis, which reduces the special requirement to the equipment, uses the phosgene instead of the oxalyl chloride during the esterification to decrease the reaction cost and employs the catalyzer during the addition to increase the yield of the reaction. The invention is featured by the high yield, simple steps and cheap raw material and is more adaptable to the scale of the industrial production. Through the method, the yield of the diflubenzuron is 97%, which of the fluorin bell urea 93% and that of the fluorin insect urea 86%.

The invention discloses an Al-18F mark fusion peptide and an application thereof. The Al-18F mark fusion peptide comprises glioma specific targeted polypeptides cRGDyK and A7R connected together. The preparation method comprises the following steps: (1) preparing NOTA-PEG-RGDyK-Lys-Ac-A7R; (3) preparing 18F physiological saline liquor; (3) preparing [Al18F]NOTA-PEG-RGDyK-Lys-Ac-A7R; and (4) purifying the prepared [Al18F]NOTA-PEG-RGDyK-Lys-Ac-A7R to obtain the Al-18F mark fusion peptide. The Al-18F mark fusion peptide disclosed by the invention comprises glioma specific targeted polypeptides cRGDyK and A7R connected together, and the specificity of the fusion peptide on glioma is further improved by means of different targeted biological characteristics.

The invention discloses a low air-entraining viscosity reducing polycarboxylic water reducer which is formed by free radical polymerization of an alkyl phosphotriester mixture, TPEG and unsaturated carboxylic acid under the action of an initiator and a chain transfer agent. By introducing an alkyl phosphotriester monomer containing two double bonds to a main chain, molecules of the obtained polycarboxylic water reducer are of heterocyclic multibranched structures, so that the thickness of a polycarboxylic water reducer adsorption layer is increased, the plastic viscosity of concrete can be remarkably reduced, and meanwhile, by introducing the phosphotriester structure into the molecules of the polycarboxylic water reducer, the foaming property of the obtained polycarboxylic water reducer can be effectively improved and the air entraining property thereof can be reduced. The low air-entraining viscosity reducing polycarboxylic water reducer prepared by the invention is low in dosage and high in water reducer rate, the air entraining property of the low air-entraining viscosity reducing polycarboxylic water reducer can be reduced, the strength and durability of the concrete are improved while the viscosity of high grade concrete is remarkably reduced, and the raw materials are low in cost, the reaction condition is mild, and the low air-entraining viscosity reducing polycarboxylic water reducer is suitable for being popularized and applied.

The invention relates to a method for preparing asenapine shown in a general formula (11) and an intermediate shown in a general formula (8) and used for preparing asenapine. The general formulas are shown in the specification. The method comprises the following steps: obtaining a compound shown in a general formula (9) through ring-closure reaction of the compound shown in the general formula (8); obtaining a compound shown in a general formula (10) through reduction reaction of the compound shown in the general formula (9); obtaining asenapine shown in the general formula (11) through substitution reaction of the compound shown in the general formula (10), wherein in the general formula (8), R1 represents halogen, preferably chlorine or bromine.

The invention discloses a method for preparing 3-aminopyrrolidine hydrochloride by using a one-pot method. Under an ice-water bathing condition, pyrrole is dissolved in acetonitrile, a catalyst di(triphenyl phosphine) cupric nitrate is added at the same time, nitric acid is added dropwise to conduct a reaction to generate reaction liquid containing 3-nitropyrrole, the reaction liquid is subjectedto extraction by water and ethyl acetate, and an organic phase is obtained after separation is conducted; the obtained organic phase is subjected to reduction by pumping in hydrogen gas under the palladium catalysis condition, and a crude product of 3-aminopyrrolidine is obtained; and a solvent ethyl acetate is added into the crude product of 3-aminopyrrolidine, HCl gas is pumped in to conduct a reaction, and 3-aminopyrrolidine hydrochloride is obtained. The experiment route of the method is simple and short, the raw materials are cheap and easy to get, and the reaction condition is mild.

The invention discloses a compound stevioside substitute and a preparation method thereof, relating to a natural sweetener and providing a compound stevioside substitute with natural and pure sweet taste and low cost and a preparation method thereof. The compound stevioside substitute comprises a stevia extract, a complexing agent, a pH regulating agent, a natural malt extract, the natural sweetener and natural edible essence in percent by weight of 100: (20 to 100): (1 to 3): (1 to 3): (0.1 to 0.6): (0.01 to 0.03). After dry leaves of stevia are extracted by using water, extract liquid is decolored, smell removed and then filtered; the complexing agent and the pH regulating agent are added according to a proportion to react; the natural malt extract, the natural sweetener and the natural edible essence are added and uniformly stirred, and dried by spray by a spray drying method for preparing a powdery product. The obtained novel compound stevioside product still is a natural high-magnification sweetener and the sweetness of the compound stevioside sweetener is 60 to 80 times of cane sugar. The compound stevioside substitute can replace 70% of the cane sugar in practical application.

The invention belongs to the technical field of fuel cells, and particularly relates to a phosphonic acid-grafted polybenzimidazole high-temperature proton exchange membrane and a preparation method thereof. The preparation method of the proton exchange membrane comprises the following steps: (1) dissolving polybenzimidazole into a solvent to obtain a polybenzimidazole solution, adding epoxy-alkoxy silane and then reacting to obtain a siloxane-grafted polybenzimidazole solution; (2) dissolving an organo phosphonic acid into the solvent to obtain an organo phosphonic acid solution, adding the epoxy-alkoxy silane and then reacting to obtain a phosphonic acid-bonded siloxane solution; and (3) slowly dropwise adding the siloxane-grafted polybenzimidazole solution to the phosphonic acid-bonded siloxane solution and then reacting for 6-12 hours to obtain sol, ageing the sol at 40-60 DEG C, baking the sol for 1-2 days, heating the sol to 80-100 DEG C, baking the sol for 8-18 hours, finally baking the sol at 110-130 DEG C for 6-8 hours and cooling and demolding the sol to obtain the phosphonic acid-grafted polybenzimidazole high-temperature proton exchange membrane.

The invention relates to a method for preparing dialkyl phenyl-phosphonite which is a key intermediate of acyl phosphate photoinitiator. The method takes benzene, phosphorus trichloride and alcohol as main materials and synthesizes dialkyl phenyl-phosphonite through a two-step reaction. The method has the improvements that: in the second step of reaction, phenyldichlorophosphine reacts with the alcohol to synthesize the object under the condition of non-catalyst, the reaction temperature is controlled within 10 DEG C below zero to 10 DEG C, and phenyldichlorophosphine is dropwise added; and then the reaction is carried out under the condition of stirring at the temperature of 30 to 50 DEG C for 0.5 to 7 hours. The invention has the advantages of low cost, easy post treatment, high yield, and the like and is suitable for industrial production.

The invention discloses a sulfonated aqueous UV polyurethane modified epoxy acrylate emulsion and its preparation method. The preparation method comprises the following steps of: adding dropwisely acrylic acid hydroxyl ethyl or hydroxypropyl acrylate and dibutyltin dilaurate into diisocyanate under the protection of nitrogen to obtain a diisocyanate semi-adduct after the reaction; performing a ring-opening esterification reaction between an epoxy resin and 5-sulfo-1,2,4-benzenetricarboxylic acid under the action of a catalyst to obtain epoxy 5-sulfo-1,2,4-benzenetricarboxylic acid ester; performing a reaction between the semi-adduct and epoxy 5-sulfo-1,2,4-benzenetricarboxylic acid ester under the action of a catalyst dibutyltin dilaurate at the temperature of 40-50 DEG C until 2274 cm<-1> absorption peak in the infrared spectrum of the mixture completely disappears, and adding triethylamine at room temperature for neutralization, so as to obtain the sulfonated aqueous UV polyurethanemodified epoxy acrylate emulsion. By a properly adjusted formula, the product with required performance can be obtained. The product provided by the invention has good stability and excellent film property, and can be used in aqueous UV curing coating and printing ink fields.

The invention discloses a phosphorus-containing polyurethane acrylate oligomer, and a preparation method and an application thereof. The preparation method comprises the following steps: adding hydroxy acrylate and dibutyltin dilaurate to diisocyanate in a dropwise manner, controlling the reaction temperature, and monitoring the concentration change of -NCO in a system to obtain a semi-adduct of diisocyanate; dissolving polyol in toluene, adding an acylchloriration agent phosphorous oxychloride in a dropwise manner, and reacting to obtain cyclic phosphate B; and heating the cyclic phosphate B, the semi-adduct of diisocyanate and a polymerization inhibitor, adding a catalyst dissolved in acetone in a dropwise manner, and reacting to obtain phosphorus-containing annular structured polyurethane acrylate. The above product can be applied in photoimageable components. Introduction of an annular phosphate group in the design process of a molecular structure increases the adhesion of a dry film photoresistive resist on a metal substrate; and the method has the advantages of simple synthesis route, few side reactions, no pollution, and obtaining of the product with good performances without purification.

The invention relates to a method for preparing asenapine shown in a general formula (9) and an intermediate shown in a general formula (7) and used for preparing asenapine. The general formulas are shown in the specification. The method comprises the step that asenapine shown in the general formula (9) is obtained through ring-closure reaction of a compound shown in a general formula (8).

The invention relates to the field of edible pigment and discloses a method for extracting brown pigment from a plant. The method comprises the following steps: pulverizing the plant containing the brown pigment and extracting brown pigment extracting liquid by using deep-eutectic solvent extracting liquid; adding mixed liquid of petroleum ether and ethyl acetate into the extracting liquid to remove fat, and adding an attapulgite loaded chitosan crosslinked cyclodextrin compound into the defatted extracting liquid to obtain a brown pigment compound precipitate adsorbed on the attapulgite loaded chitosan crosslinked cyclodextrin compound; dissolving the precipitate in an organic solvent to perform desorption and centrifugation to obtain brown pigment supernatant containing the organic solvent; enabling the supernatant to pass through a microporous filtration membrane to obtain a purified brown pigment solution containing the organic solvent; and removing the organic solvent from the brown pigment solution to obtain a target product brown pigment. The deep-eutectic solvent serves as an extracting solvent, so the method is green and environment-friendly, and the extraction rate is high; and the brown pigment is purified and separated by the attapulgite loaded chitosan crosslinked cyclodextrin compound, so the process is simple and the purification and separation efficiency is high.

The invention discloses a method for recycling bivalent manganese in electrolytic manganese leached residues. The method comprises the following steps: using water to carry out counter-current rinsing on the electrolytic manganese leached residues through a filter press to obtain a manganese-containing feed liquid, and detecting the content of the bivalent manganese; adding precipitating agent sodium carbonate to the manganese-containing feed liquid, so as to generate precipitate; carrying out pressure filtration after precipitation to obtain filtrate and filter residue containing manganese carbonate; detecting the content of the manganese carbonate in the filter residue containing the manganese carbonate, directly using the filter residue to prepare a manganese sulphate solution when the Mn(2+) of the manganese carbonate in the filter residue is not less than 80%, and re-precipitating the filter residue when the Mn(2+) of the manganese carbonate in the filter residue is less than 80%. The method has the advantages of being simple to operate, safe, low in production cost, and being suitable for industrial production; and moreover, the Mn(2+) in the electrolytic manganese leached residue is sufficiently recycled, thereby the harm caused due to the fact that the soluble metal Mn (2+) enters the natural environment is reduced and the wastes of a manganese resource is reduced; and besides, the content of Mn(2+) in the recycled manganese carbonate is high and more than 80%, and the recycled manganese carbonate can be directly used for preparing the manganese sulphate solution.

The invention discloses a noncellular synthetic biology based preparation method of 2-phenylethanol and an application. According to the preparation method and the application, three recombinases including ARO8, ARO10 and ADH1 are utilized to constitute a co-reaction system, and a complicated metabolic process of an Ehrlich pathway requiring multi-step continuous reaction and multi-enzyme participation for synthesis of 2-phenylethanol in microorganisms is simplified to be performed in the same reaction system in vitro, so that the environmental pollution is reduced and the reaction process is shortened. Furthermore, the three recombinases are subjected to carrier-free co-immobilization with glutaraldehyde serving as a cross-linking agent, Combi-CLEAs (Combi-Cross-linked Enzyme Aggregates) are prepared, a target product is synthesized in vitro, accordingly, the enzymes are further recycled on the basis of the beneficial effects, and the production cost is reduced; the preparation method fills up the technical blank of multi-enzyme preparation of 2-phenylethanol in vitro, and important reference is provided for biological preparation of 2-phenylethanol.

The invention relates to a high-strength self-healing material and a preparation method thereof. The high-strength self-healing material adopts a structural formula as follows: FORMULA, wherein a lateral group R1 adopts a structural formula of -OCOR1' or -OH, and n is greater than or equal to 5 and smaller than or equal to 500. The high-strength self-healing material is prepared by polymerizing the same polyamide monomer under vacuum or copolymerizing different polyamide monomers under vacuum. The high-strength self-healing material synthesized by the preparation method provided by the invention has a large number of non-covalent bonds and relatively low glass transition temperature, so that the high-strength self-healing material has excellent autonomous healing ability; moreover, the high-strength self-healing material adopts a unique chemical structure, and has a large number of reversible non-covalent bonds and a large number of uniformly distributed nanocrystalline regions, so that the defect of low strength of an autonomous healing material is overcome.

The invention relates to a method for preparing high purity surface active agent used for papermaking industry. By intra-molecular structure design, the content of isooctyl alcohol in succinic acid bi-alkyl SEDSS surface active agent is controlled, thus adjusting the hydrophilicity and penetrability of the surface active agent and surface tension of coatings, meeting the need of papermaking industry and promoting the development of the papermaking industry. The preparing method has the advantages of simple preparation, no need of decompression distillation purification after esterification, no need of taking inert gas as protective gas in sulfonation reaction, no need of adding phase transfer catalyst, no time wasting or labor force wasting and that the production cost of the surface active agent is reduced; the prepared succinic acid bi-alkyl SEDSS has the advantages of high purity, less by-product, no need of purification, cheap and easily obtained materials of reaction, low toxicity and wide application prospect.

The invention embodiment provides a preparation method for graphene oxide, and relates to the technical field of material preparation. The method comprises the following steps: placing a carbon-containing carbon source which is used as an anode and an electric conductive material which is used as a cathode into electrolyte water, electrifying the anode and the cathode with a direct current for three minutes or more to obtain a graphene oxide solution, and performing drying treatment on the graphene oxide solution to obtain the graphene oxide. According to the invention, in the preparation method for the graphene oxide, the water is used as an electrolyte and free of pollution, the graphene oxide has good dispersion in the solution, impurities are less and purification is not needed, and the preparation process is simple.

The invention discloses a method for separating a 5-hydroxymethyl furfural and 2,5-diformylfuran mixture; the method comprises the steps: dissolving the 5-hydroxymethyl furfural and 2,5-diformylfuran mixture in an organic solvent, then adding a deep-eutectic solvent, stirring and mixing evenly at room temperature, and splitting phases; and taking an organic phase, removing the organic solvent under a reduced pressure condition, and thus obtaining 2,5-diformylfuran. The method has the advantages of simple purification process, mild conditions, easy amplification, environmental friendliness, high product purity and the like.

The invention relates to room-temperature molten salt and a preparation method and application thereof and belongs to the technical field of low-temperature electrolytic aluminum. The room-temperature molten salt is composed of a cation portion and an anion portion. The general formula of the cation portion is [AlCl2.nBase] <+>, wherein Base is one of ethylene carbonate or propylene carbonate or butene carbonate or dimethyl carbonate or diethyl carbonate or methyl ethyl carbonate or diphenyl carbonate or di-tert-butyl dicarbonate, and n ranges from 2 to 20. The anion portion is AlCl4-. According to the room-temperature molten salt and the preparation method and application thereof, a low-temperature co-molten system is found and compounded for the first time; all raw materials of the system are converted into products; purification and separation are not needed; and the room-temperature molten salt and the preparation method and application thereof meet atom economy. In addition, the room-temperature molten salt and the preparation method and application thereof have the beneficial effects of being high in electric conductivity, small in viscosity, stable in air, insensitive to water and low in cost.

The invention discloses a preparation method of a 24-epibrassinolide intermediate, and belongs to the field of chemical synthesis, and the preparation method comprises the following steps: 1) taking ergosterol as an initial raw material, carrying out methanesulfonylation under the catalysis of tetrabutylammonium hydrogen sulfate to obtain a first-step product, namely an intermediate 1, filtering afirst-step reaction solution, and directly carrying out a next-step reaction on a filtrate; 2) adding water and potassium bicarbonate into the filtrate obtained in the step 1), carrying out heating reaction, and carrying out split-phase water removal, concentration, cooling and filtration to obtain an intermediate 2; 3) reacting the intermediate 2 with benzyl halide in the presence of an acid-binding agent to generate an etherification product; 4) reacting the etherification product with tetrabutylammonium bromide and tetrabutylammonium hydrogen persulfate to obtain an intermediate 3; compared with a traditional CrO3 / pyridine oxidation method, the method has the advantages that the use of an oxidizing agent containing heavy metal chromium and having serious pollution to the environment isavoided, the reaction conditions are mild, the yield is high, the post-treatment is simple, the next step of reaction can be performed without refining, and the method is suitable for industrial production.

The invention discloses a preparation method of a cuprous oxide nano material and hydrogen evolution performance of the cuprous oxide nano material, and belongs to the technical field of nanometer materials. According to the preparation method, ethylene glycol and diethylene glycol are used as reducing agents, copper hydroxide and basic copper carbonate with specific morphology are used as coppersources, and the copper hydroxide and the basic copper carbonate copper are reduced to form cuprous oxide nano material with maintained morphology under the protection of inert gas through a gas phasereduction method. The reaction steps are simple and are environmentally friendly, the obtained product does not need to be washed, and a pure cuprous oxide product can be obtained. According to the preparation method provided by the invention, the simple and rapid method is adopted for synthesizing the cuprous oxide nano material with the maintained morphology, and the prepared cuprous oxide nanomaterial has the performance of electro-catalytic hydrogen evolution.

The invention relates to a method of manufacturing an onion-like nickel carbon particle containing metal by using de-oiled asphalt, which uses the de-oiled asphalt and metal nickel powder as raw materials, the nickel powder as catalyst, hydrochloride, deionized water as cleaning agent and argon as protective gas. Under the protection of the argon, the de-oiled asphalt powder is sintered in a high temperature furnace where temperature is below 1000 DEG C. The de-oiled asphalt powder and the metal nickel powder are sintered for 60 minutes in a vacuum sintering furnace where the temperature of 2000 DEG C is constantly maintained and retained to obtain onion-like nickel carbon particles containing metal. The particles are black and spheroid-shaped, with the diameter of 10 to 30nm. The thickness of carbon layer coating surface of the particle is 5nm. Inner core of the metal nickel is 5 to 20nm. The cross-section of the particle is provided with distinct onion-like cascading coating structure. The carbon layer and the metal nickel particle are uniform, which have high purity and stable physical and chemical properties. The method has short process flow, the rich source of materials and high productivity that can reach 66 per cent.

The invention discloses a preparation method of 5-nitrofurfural, which comprises the following steps: a. 5-nitrofurfural diethyl ester, lower alcohol, inorganic acid, Lewis acid or a mixture thereof are reacted at 70°C to 90°C 1h to 2h to obtain a reaction solution containing 5-nitrofurfural; b. The reaction solution in step a is concentrated under reduced pressure to remove lower alcohols to obtain a concentrate; the obtained concentrate is dissolved in dichloromethane, washed, dried, and concentrated under reduced pressure , to obtain a crude product; c, the crude product of step b was purified by silica gel column chromatography to obtain 5-nitrofurfural. The method of the present invention has few side reactions, short reaction time, and improves the yield and purity of 5-nitrofurfural; the 5-nitrofurfural prepared by the present invention has few impurities and can be directly used to prepare nifurate without purification treatment Er, simplified the operation steps of preparing nifuratel, further improved the yield and the purity of nifuratel.

The invention discloses a molecularly-imprinted nanoparticle for glycoprotein and a synthesis method thereof, belongs to the field of analytical chemistry, and relates to synthesis of molecularly-imprinted polymers. The synthesis method comprises the following steps: firstly, preparing a solution phase A from template glycoprotein molecules, preparing a solution phase B from a functional monomer and a cross-linking agent, and preparing solution phase C from an initiator; secondly, respectively fixing the solution phase A, the solution phase B and the solution phase C on three micro-fluidic injection pumps with adjustable flow rates, connecting and mixing the solution phase A and the solution phase B through a Y-shaped three-way valve, connecting and mixing the mixed solution and the solution phase C through another Y-shaped three-way valve, and enabling the obtained mixed solution and the solution phase C to flow into a reactor for a polymerization reaction; and finally, collecting a polymerized nanoparticle at the tail end of the reactor, and removing the glycoprotein template molecules to obtain the molecularly-imprinted nanoparticle for glycoprotein. The molecularly-imprinted nanoparticle for glycoprotein is prepared in a microfluidic mode, operation is easy, continuous production can be achieved, and the obtained molecularly-imprinted nanoparticle can be used for specific recognition of target glycoprotein molecules.

The invention discloses a method for large-scale preparation of high-efficiency red / near-infrared emission fluorescent carbon dots. The method comprises the following steps: o-phenylenediamine and aninorganic metal salt are ground into powder with uniform granules, the mixed powder of o-phenylenediamine and inorganic metal salt or a mixture of o-phenylenediamine and dilute hydrochloric acid is transferred to the lining of a reaction kettle, then packaged, and transferred to a drying oven, and the reaction temperature and reaction time are set, the temperature of the drying oven is cooled to room temperature after the reaction is completed, and the reaction kettle is taken out to obtain a product; and the product is washed and dried. Compared with the prior art, the method of the inventionhas the advantages of simple and convenient reaction, no purification, low cost, convenient mass production, good environmental stability, and convenient storage and transportation, and the preparedfluorescent carbon dots have excellent red fluorescence performance and four-photon fluorescence property, and realizes the fluorescence emission of the carbon dot in the near-infrared third window for the first time; and the carbon dot product can meet the fabrication requirements of various optoelectronic devices without complicated modification at the later stage.