Patents
Literature
Hiro is an intelligent assistant for R&D personnel, combined with Patent DNA, to facilitate innovative research.
361results about How to "High specificity" patented technology
Efficacy Topic
Property
Owner
Technical Advancement
Application Domain
Technology Topic
Technology Field Word
Patent Country/Region
Patent Type
Patent Status
Application Year
Inventor
Applications of the stimulation of neural tissue using light
InactiveUS20060155348A1Increase electrical field sizeHigh specificityLight therapyLIGHT STIMULATIONLight source
The present invention comprises systems and methods for stimulating target tissue comprising a light source; an implantable light conducting lead coupled to said light source; and an implantable light-emitter. The light source, lead and emitter are used to provide a light stimulation to a target tissue
Owner:DECHARMS RICHARD CHRISTOPHER
Infrared frequency comb methods, arrangements and applications
ActiveUS20110058248A1High performanceHigh specificityLaser detailsLight demodulationMid infraredResonator
Certain embodiments relate to and involve producing broadband phase-locked frequency combs in the near-infrared and mid-infrared spectral ranges. One such embodiment is directed to a system, with a pump laser and an optical parametric oscillator (OPO) resonator, that is configured to produce broad-bandwidth frequency combs in the near-infrared and mid-infrared frequency ranges. The pump laser is configured to produce femtosecond pulses of light having a pulse repetition rate. The optical parametric oscillator (OPO) resonator that is coupled to the pump laser for facilitating synchronous OPO pumping by matching a roundtrip time of the pulses of light within the OPO resonator with the pulse repetition rate of the pump laser. Among other more specific aspects, the OPO resonator can include a nonlinear optical gain element to provide broad-bandwidth parametric amplification, and optical elements to direct the pulses of light from the femtosecond laser to the nonlinear gain element and to direct subharmonic frequencies of the light out of the optical cavity.
Owner:THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV
Fusion protein in Cpf1 and p300 core structural domain, corresponding DNA target activation system and application
The invention discloses a fusion protein in a Cpf1 and p300 core structural domain, a corresponding DNA target activation system and application. CRISPR / Cpf1 with enzyme cutting activity is mutated to be free of enzyme cutting activity and of target gene identification characteristic, is fused with p300 protein transcriptional activation, reaches the purpose of target gene activation inside mammalian cells, and has the characteristics of being simple, efficient and high in specificity. The fusion protein has the advantages of low off-target rate, cost saving and the like. The system can be mutually complementary with an existing target gene activation method based on CRISPR / Cas9, the gene editing range of the CRISPR / Cas9 system is expanded, and the system has a good application prospect.
Owner:SOUTHERN MEDICAL UNIVERSITY
Methods of detecting gene expression in normal and cancerous cells
InactiveUS20060210979A1High specificityStrong specificitySugar derivativesMicrobiological testing/measurementMolecular beaconGene expression
The present invention provides methods for detecting gene expression in normal and cancerous cells. Specifically, provided are methods utilizing molecular beacons (MB) technology combined with fluorescence imaging techniques for detecting, identifying or quantitating the presence of, or alterations in gene expression of, various tumor markers in a sample of cells.
Owner:EMORY UNIVERSITY
Detection composition for guiding hypertension medication, applications of detection composition, kit and detection method
ActiveCN106367479AHigh specificityReduce operating errorsMicrobiological testing/measurementDNA/RNA fragmentationGenotypeCYP2C9*3
Owner:HANGZHOU KMB BIOTECH
Primer for detecting pathogenic microorganism and multiple PCR using the same
InactiveCN101113475AHigh specificityBroad application prospectsMicrobiological testing/measurementFermentationPathogenic microorganismListeria monocytogenes
The invention relates to a primer used for detection of pathogenic microorganism so as to detect pathogenic microorganism such as vibrio cholerae, pathogenic escherichia coli, campylobacter jejuni, Yersinia enterocolitica, parahemolytic vibrio, salmonella, shigella and Listeria monocytogenes, etc. The invention also relates to a method by using the primer to do multiple amplification detection and further relates to applications of the primer for detection of pathogenic microorganism in preparation of detection agent and further relates to kits containing the primer for the detection of pathogenic microorganism.
Owner:ICDC CHINA CDC
Method for detecting trace ochratoxin A (OTA) by adopting electrochemical aptamer sensor
InactiveCN103424448AHigh specificityNon-deterministicMaterial analysis by electric/magnetic meansOchratoxin AStandard curve
The invention relates to a method for detecting trace ochratoxin A by adopting an electrochemical aptamer sensor, and belongs to the technical field of electrochemical sensors. The method comprises the following steps: firstly, the DNA modification is performed on a gold electrode; then an aptamer is assembled through the complementary base pairing effect so as to capture labeled DNA of gold nanoparticles; the DNA rich in G is assembled on the surfaces of the gold nanoparticles so as to capture a great quantity of methylene blue (MB) to build a signal amplification strategy; finally, a series of OTA standard solutions is detected by taking differential pulse voltammetry scanning as the detection means so as to obtain the response relation between the reductive peak current of MB and the concentration of OTA, and a standard curve is drawn. The invention aims to provide a preparation method of an aptamer sensor, which is simple in operation, high in sensitivity and strong in specificity and is used for sensitivity detection of trace OTA.
Owner:JIANGSU UNIV
Compositions and Methods for Maintenance of Fluid Conducting and Containment Systems
InactiveUS20110027803A1Easily and conveniently monitorHigh specificityAnalysis by subjecting material to chemical reactionBiological testingMedicineSmall molecule
Latently detectable small molecules, or ‘labels’, used for monitoring of treatment substances in fluid conducting and containment systems. A composition comprising the treatment substance and the label, a method of manufacturing the composition, a method and kit for use in monitoring the treatment substances in a fluid conducting and containment system, and a method for treating such a system using the composition are also disclosed.
Owner:LUX INNOVATE
Fast detection method of PCR amplification products of food pathogenic bacteria
InactiveCN105543368AHigh specificityGood stabilityMicrobiological testing/measurementHeminForward primer
Owner:NINGBO UNIV
Method for manufacturing aptamer biosensor used for quickly detecting antibiotic and heart disease markers
InactiveCN101738425AHigh specificityGood stabilityMaterial electrochemical variablesGlassy carbon electrodeRapid detection
Owner:TIANJIN UNIVERSITY OF SCIENCE AND TECHNOLOGY
Testing kit and testing method for early screening or assisting diagnosis of urinary system diseases as well as applications of testing kit and testing method
The invention relates to a testing kit and a testing method for early screening or assisting diagnosis of urinary system diseases. The testing kit contains at least one testing reagent and a capturing reagent and can be used for specifically recognizing and correctly quantifying any one or combination of more proteins of COL6A1, GC, RBP4, DNASE1, GAA, SERPING1, CTSD, KNG1, UMOD, PIGR, AHSG, A1BG, AMBP, AZGP1, PTGDS, HPX, CD14 and ORM1 which are stably expressed in the urine of healthy people. The testing method can test whether the content of any of the eighteen proteins in the urine of a person to be tested is abnormal so as to prompt the generation of the urinary system diseases and achieve the purpose of early screening or assisting the diagnosis of the urinary system diseases.
Owner:THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
Anti-human Tim-3 monoclonal antibody 8E11 and preparation method thereof
InactiveCN106632675AHigh specificityHigh potencyImmunoglobulins against cell receptors/antigens/surface-determinantsBiological testingHeavy chainAmino acid
The invention relates to the technical field of biology, and particularly relates to an anti-human Tim-3 monoclonal antibody 8E11 and a preparation method thereof. The antibody contains a light chain variable region and a heavy chain variable region, wherein the light chain variable region contains an amino acid sequence shown in SEQ ID NO:1, and the heavy chain variable region contains an amino acid sequence shown in SEQ ID NO:2. The monoclonal antibody has high specificity and high potency, thereby providing a brand-new means for Tim-3 detection.
Owner:常州格露康生物医药科技有限公司
Toxoplasma gondii detection kit and application thereof
InactiveCN102002531AHigh specificityHigh sensitivityMicrobiological testing/measurementDNA/RNA fragmentationGenomeToxoplasma gondii
The invention discloses a toxoplasma gondii detection kit and application thereof. The kit provided in the invention comprises three pairs of primers, i.e. an inside primer pair, an outside primer pair and an annular primer pair which are combined with Gen Bank Accession Number AF146527 genes in a toxoplasma gondii genome. The toxoplasma gondii detection kit has high detection sensitivity, can beused for detecting 10 copied target DNAs at minimum, is simple and convenient for operation, and is especially suitable for regular checkup, base clinical medicine detection works and site immediate detection of a hoggery.
Owner:CHINA AGRI UNIV
Joint detection method of cardio-cerebral-vascular disease (CCVD) biomarkers and diagnostic kit
The invention discloses a joint detection method of cardio-cerebral-vascular disease (CCVD) biomarkers and a diagnostic kit. The joint parallel detection method is characterized in that a plurality of the biomarkers in the same sample can be detected at one time, namely, a tetrad complex of 'detection antibodies for signal marks-the CCVD biomarkers-capture antibodies-beads' is formed by preparing a liquid chip, and then existence and content of various different CCVD biomarkers in the sample to be detected are determined by detecting mark signals of different beads in the tetrad complex. The invention further discloses composition and application of the diagnostic kit. The method and the kit have the outstanding advantages of high throughput, high sensitivity, high specificity, rapid and accurate detection and the like, and can be used for qualitatively and quantitatively detecting the plurality of the CCVD biomarkers at the same time.
Owner:邵棠
KRAS gene mutation detection kit and detection method
InactiveCN102888466AReduced wild-type backgroundHigh specificityMicrobiological testing/measurementMutation detectionKRAS Gene Mutation
The invention belongs to the field of biotechnology and medical science, and provides a KRAS gene mutation detection kit. The kit comprises a polymerase chain reaction (PCR) buffer solution, 7 pairs of specificity primers, one pair of quality control primers, a specificity probe, a locked nucleic acid probe, an interior label system, an enzyme solution and a reference dye. The invention also provides a human KRAS gene seven-mutation detection method. The detection kit has the advantages that the sensitivity is high, the specificity is strong, the pollution is reduced, the result is genuine and believable, and the operation is simple and rapid.
Owner:WUHAN YZY BIOPHARMA CO LTD
Kit and method for detecting beta-lactam antibiotics
ActiveCN102455361AHigh sensitivityHigh specificityMaterial analysisPolyclonal antibodiesAntibiotics beta lactam
The invention discloses a kit and a method for detecting beta-lactam antibiotics. The kit comprises a micropore reagent and a piece of test paper, colloidal gold labeled cephalosporin medicament specific antibodies are freeze-dried in the micropore reagent, and the cephalosporin medicament specific antibodies can be cephalosporin medicament monoclonal antibodies or cephalosporin medicament polyclonal antibodies; the test paper consists of a sample absorption pad, a reaction film, a water absorption pad, a protective film and a bottom plate which are sequentially connected; the reaction film comprises a detection area and a quality control area; the detection area is coated with a cephalosporin medicament-carrier protein conjugate; and the quality control area is coated with anti-antibodies. The method for detecting the beta-lactam antibiotics by using the kit is simple, convenient, fast, intuitive, accurate, wide in application range, low in cost and easy to popularize and use.
Owner:BEIJING KWINBON BIOTECH
Primer combination for synchronously detecting 14 animal-derived components in meat or meat products, and applications thereof
ActiveCN108330168AHigh specificityCheck result is accurateMicrobiological testing/measurementDNA/RNA fragmentationBiologyRapid identification
The invention relates to the technical field of food detection, and discloses a primer combination, a method and a kit for synchronously detecting 14 animal-derived components in meat or meat products. According to the present invention, whether meat or meat products contain the components derived from 14 animals such as pigs, cows, sheep, goats, chickens, ducks, dogs, foxes, raccoon dogs, cats, rats, donkeys, deer and horses is identified by using 10 pairs of specific primers based on two 5-plex PCR reactions and a microchip electrophoresis technology, and the sequences of the 10 pairs of thespecific primers are represented by SEQ ID NO.1-20; and the method has advantages of accurate detection, high sensitivity, strong specificity, simpleness, rapidness and high efficiency, can meet therequirements in the large-batch and rapid identification of the presence of the components derived from 14 animals such as pigs, cows, sheep, goats, chickens, ducks, dogs, foxes, raccoon dogs, cats, rats, donkeys, deer and horses in meat or meat products, can effectively resist the adulteration of meat products and effectively protect the interests of consumers, and has good social benefits.
Owner:CHINA MEAT RES CENT
Preparation and application of gene chip capable of detecting seven diarrhea viruses
InactiveCN104946791AHigh specificityAccurate screeningNucleotide librariesMicrobiological testing/measurementEpidemiologic surveyEnterovirus
The invention relates to preparation and application of a gene chip capable of detecting seven diarrhea viruses. The preparation method comprises the following steps: preparing specific primers and probes for seven diarrhea viruses, preparing an oligonucleotide chip, establishing a multiplex PCR (polymerase chain reaction) system, and establishing a hybridization system. The gene chip provided by the invention can simultaneously detect seven important enteroviruses, including Group A rotavirus, Group B rotavirus, Type I norovirus, Type II norovirus, astrovirus, Sapovirus and enteric adenovirus. The gene chip has the advantages of high speed, high accuracy, high flux and high specificity, and can provide a new detection means for clinical diagnosis and epidemiological survey of diarrhea virus infection.
Owner:INST OF RADIATION MEDICINE ACAD OF MILITARY MEDICAL SCI OF THE PLA
One-tube method with multiplex detection for human Influenza A and B and new Influenza A H1N1 virus and kit
ActiveCN101942525AHigh specificityHigh sensitivityMicrobiological testing/measurementDNA/RNA fragmentationH1N1 influenzaFluorescein
The invention provides a one-tube method with multiplex fluorescent PCR detection for human Influenza A and B and new Influenza A H1N1 virus. The method adopts the primers of which the sequence is shown in SEQ ID NO: 1-6, and also adopts the probes of which the sequence is shown in SEQ ID NO: 7-9. The invention also provides a kit for one-tube method with complex fluorescent PCR detection for human Influenza A and B and new Influenza A H1N1 virus. The kit comprises the primers and the probes. The invention adopts InfA / InfB / A (H1N1) specific primers and Taqman probes, and uses FAM / JOE / TAMRA multiplex fluorescein labels to realize the multiplex detection for the human Influenza A and B and new Influenza A H1N1 virus. The invention has the advantages of high specificity, high sensitivity, high speed, simple and convenient operation, low cost and the like, can be used as a multiple-detection reagent for scientific research and clinical application.
Owner:广东省南山医学发展基金会
Method for detecting new coronavirus SARS-CoV-2 N protein by adopting nucleic acid aptamer
PendingCN111693712AStrong affinityHigh specificityBiological material analysisBiological testingPathogenChemical structure
The invention discloses a method for detecting a new coronavirus SARS-CoV-2 N protein by adopting a nucleic acid aptamer. The aptamer is N Aptamer 1, N Aptamer 2 or N Aptamer 3, can be specifically combined with SARS-CoV-2 virus N protein, and can also be used for specifically detecting N protein diluted in human serum and N protein in a protein electrophoresis sample. By means of the mode, nucleic acid extraction or antibody detection is not needed, meanwhile, the method has the advantages of being high in affinity with target molecules, high in specificity, easy to prepare, low in immunogenicity and toxicity, stable in chemical structure and the like, and conditions are created for early detection of 2019 SARS-CoV-2 pathogens.
Owner:SUZHOU UNIV +1
Application of septin1 gene to detection of nosema bombycis
ActiveCN104017891AHigh specificityStrong specificityMicrobiological testing/measurementMicroorganism based processesNosema bombycisDeoxyribose
The invention belongs to the technical field of molecular biotechnologies and particularly discloses an application of a septin1 gene to detection of nosema bombycis. Researches prove that the transcriptional expression of the septin1 gene is related to the cell division of the nosema bombycis and the development of a host. A specific primer is designed by taking the septin1 gene as a target gene, whether silkworm eggs are infected by the nosema bombycis is detected through PCR (Polymerase Chain Reaction) amplification, and the detected result proves that if the septin1gene is used as the detecting target gene, the interference effects of inhibiting substances in silkworm egg extracts to the effective PCR amplification of pathogenic gene DNA (Deoxyribose Nucleic Acid) are very low, the detected result is more accurate and sensitive, and more importantly, whether the silkworm eggs are infected by the nosema bombycis can be rapidly detected at the early stage that the silkworm eggs are infected. The guarantee is provided for the detection and safe egg production of poisonous silkworm eggs in silkworm egg production.
Owner:SOUTH CHINA AGRI UNIV
Al-18F mark fusion peptide and application thereof
InactiveCN103613671AHigh specificityIncreased probe concentrationPeptide preparation methodsHybrid peptidesChemistryFusion peptide
The invention discloses an Al-18F mark fusion peptide and an application thereof. The Al-18F mark fusion peptide comprises glioma specific targeted polypeptides cRGDyK and A7R connected together. The preparation method comprises the following steps: (1) preparing NOTA-PEG-RGDyK-Lys-Ac-A7R; (3) preparing 18F physiological saline liquor; (3) preparing [Al18F]NOTA-PEG-RGDyK-Lys-Ac-A7R; and (4) purifying the prepared [Al18F]NOTA-PEG-RGDyK-Lys-Ac-A7R to obtain the Al-18F mark fusion peptide. The Al-18F mark fusion peptide disclosed by the invention comprises glioma specific targeted polypeptides cRGDyK and A7R connected together, and the specificity of the fusion peptide on glioma is further improved by means of different targeted biological characteristics.
Owner:THE FIRST AFFILIATED HOSPITAL OF XIAMEN UNIV
Remote health monitoring system
ActiveUS20120265029A1High specificityLow resolutionElectrotherapyTransmission systemsDetailed dataData collector
A data collection system collects and stores physiological data from an ambulatory patient at a high resolution and / or a high data rate (“more detailed data”) and sends a low-resolution and / or downsampled version of the data (“less detailed data”) to a remote server via a wireless network. The server automatically analyzes the less detailed data to detect an anomaly, such as an arrhythmia. A two-tiered analysis scheme is used, where the first tier is more sensitive and less specific than the second tier. If the more sensitive analysis detects or suspects the anomaly, the server signals the data collector to send more detailed data that corresponds to a time period associated with the anomaly. The more specific second tier analyses the more detailed data to verify the anomaly. The server may also store the received data and make it available to a user, such as via a graphical or tabular display.
Owner:INFOBIONIC
Chlorpromazine hapten, artificial antigen, antibody as well as preparation method and application thereof
The invention provides a chlorpromazine hapten, an artificial antigen and an antibody as well as a preparation method and application thereof. The chlorpromazine artificial hapten has a molecular structure (I); the chlorpromazine artificial antigen has molecular structures (II) or (III); the antiserum obtained by the invention has the titer of 1:3*105, the lowest detection limit of 3ng / mL and the half-inhibition concentration of 29ng / mL; and the generated antibody has high specificity, sensitivity and accuracy. The antigen and the antibody have wide application prospect in the detection of residual chlorpromazine in the food.
Owner:SOUTH CHINA AGRI UNIV
Protein amino acid sequence de novo sequencing method based on unequal stable isotope labeling at two ends of polypeptide
ActiveCN105301119AHigh reaction efficiency and selectivityHigh specificityComponent separationChemistrySide chain
The invention relates to a protein amino acid sequence de novo sequencing method based on unequal stable isotope labeling at two ends of polypeptide. The method comprises the following steps: conducting enzyme digestion on protein subjected to denatured reduced alkylation by intracellular protease lysine-C to form peptide fragments containing N-terminal alpha-amino and C-terminal lysine side chain epsilon-amino; after the sample is divided into two parts, conducting selective derivatization on the N-terminal alpha-amino of the polypeptide by using a labeling reagent containing different isotopes; then conducting derivatization on C-terminal lysine side chain epsilon-amino of the polypeptide by using the labeling reagent containing different isotopes, or in cell culture, labeling lysine in the protein by using a culture solution containing isotope labeling lysine; finally mixing the sample, and conducting separation and identification by using high performance liquid chromatography- mass spectrometry. According to the method, paired polypeptide fragment ions are formed through labeling for resolution, the influence of interference signals is reduced, the selective specificity of the fragment ions and the accuracy of polypeptide sequencing are improved, and the speed of de novo sequencing is improved.
Owner:DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
Ratio-type nano silicon quantum dot fluorescence probe and preparation method and application thereof
ActiveCN105802611ASynthetic method is simpleHigh specificityOrganic chemistryFluorescence/phosphorescenceWater solubleBiocompatibility Testing
The invention belongs to the technical field of nano material science and molecular biology, and particularly relates to a ratio-type nano silicon quantum dot fluorescence probe and a preparation method and application thereof. The preparation method comprises the steps that a one-pot method is adopted, triaminopropyl-triethoxysilane is reduced with sodium ascorbate at room temperature, and water-soluble silicon quantum dots are obtained; the water-soluble silicon quantum dots and chlorin e6 (Ce6) are mixed and subjected to standing at the room temperature under the lucifugal condition, and a silicon quantum dot and chlorin e6 composite material is obtained. The composite material emits fluorescence with the wavelength of 430 nm-580 nm and the wavelength of 640 nm-680 nm under the fluorescence excitation of 410 nm, and active oxygen radicals can specifically quench fluorescence of silicon quanta and basically have no influence on fluorescence of Ce6. Therefore, the composite material can serve as a ratio-type nano silicon quantum dot fluorescence probe to be used for detecting the content of hydroxyl radicals (-OH), rapidness and high efficiency are achieved, the specificity is high, the sensitivity is high, the probe is used for in-vivo cell imaging, the biocompatibility is good, and the visual degree is high.
Owner:FUDAN UNIV
Gene immunity preparation method for human I-type deoxythymidine kinase monoclonal antibody
InactiveCN101186922AHigh affinityHigh specificityTissue cultureChemical recyclingProtein proteinEukaryotic cell
The invention relates to a novel process for preparing monoclonal antibody of human I-type thymidine kinase by immuno gene. The concrete method is that RNA is extracted in the cell of Hela which is conducted by aminopterin first, TK1 cDNA is amplified through reverse transcription of PCR, TA is conducted to be DNA sequencing to confirm right gene sequence of TK1 after being cloned and is constructed by subcloning pSecTag2 / Hygro B into the point (pSecTag / TK1) between HindIII and XhlI. Protein which is inserted by expression of segments can be secreted to extracellular receptor from eukaryotic cells. Immunized mice with plasmid DNA is directly recombined by pSecTag / TK1, hybridoma is prepared by fusion of myeloma cells and spleen cells, and the hybridoma of monoclonal antibody with anti-TK1 is screened. Pluralities of TK1 monoclonal antibodies are prepared via mouse ascites. At last, the collected mouse ascites is frozen and centrifugated in high speed, the clear liquid on the mouse ascites is extracted by the method of noctanoic acid-ammonium sulphate and purified by the method of protein G column affinity chromatography, and TK1 monoclonal antibody which can be used to detect TK1 markers in clinical sample.
Owner:丁克祥
Preparation method of immune nanometer gold test paper strip for fast detecting furazolidone
InactiveCN1793926AHigh specificityShorten detection timeMaterial analysis by observing effect on chemical indicatorPolyclonal antibodiesAntibody Affinity Chromatography
A method for preparing immune nanogold test paper used to quickly detect furazolidone includes synthesizing coupled matter of flurazolidone ¿C cattle seralbumin and coupled matter of flurazolidone ¿C catalase ; using coupled matter of flurazolidone ¿C cattle seralbumin as immune total antigen; making immune experiment on rabbit to obtain multiple clone antibody of rabbit resistance furazolidone; preparing nanogold reagent being used to label said antibody; fixing IgG antibody and coupled matter of furazolidone ¿C catalase on nitrocellulose film; sealing unreacted active group; using above ¿C prepared film, antibody and paper as well as sample pad to form said test paper.
Owner:SHANGHAI JIAO TONG UNIV
Method for measuring cystatin c in human body fluid
ActiveCN102227639AHigh specificityLow costBiological material analysisBiological testingPolyclonal antibodiesIsrapafant
Disclosed is a particle-enhanced immunoassay method for cystatin C in a human body fluid, which has higher specificity, is more inexpensive, and can be automated more readily compared with conventional assay methods in which polyclonal antibodies having low specificity or monoclonal antibodies having high specificity but having poor aggregability have been used in large quantities. The particle-enhanced immunoassay method utilizes a combination of an antibody-sensitized particle comprising an insoluble carrier particle and an anti-human cystatin C monoclonal antibody having higher affinity and bound to the particle and an antibody-sensitized particle comprising the insoluble carrier particle and an anti-human cystatin C monoclonal antibody having a different recognition site from that of the aforementioned monoclonal antibody and having a relatively lower affinity, wherein the quantity of each of the human cystatin C monoclonal antibodies bound to the insoluble carrier particle is less than 5 wt% relative to the weight of the antibody-sensitized particle.
Owner:SEKISUI MEDICAL CO LTD
Gelation measuring apparatus and sample cell
InactiveUS20100178206A1High sensitivityHigh specificityAnalysis using chemical indicatorsMaterial analysis by observing effect on chemical indicatorPhysicsAmount of substance
It is intended to allow the concentration of a substance such as an endotoxin or β-D glucan measured via gelation reactions to be measured in a short time and at a high sensitivity and a high specificity. In a measuring apparatus for measuring a target substance in a sample cell via a gelation reaction, a sample cell 13 for housing a specimen containing the substance to be measured and a solution containing a gelating reagent is irradiated with a laser beam from a semiconductor laser 11. The solution in the sample cell is stirred by a stir bar 25 to generate minute and uniform gel particles, which are caused to pass through the laser beam. Scattered light from the gel particles generated in the sample cell 13 is detected by a photodiode array 18, and a scattered-light intensity of the generated gel particles or the diameter and the number thereof is measured on time series by a computer 21 on the basis of a scattered-light detection output of the photodiode array.
Owner:KOWA CO LTD +1
Who we serve
- R&D Engineer
- R&D Manager
- IP Professional
Why Eureka
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Social media
Try Eureka
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap