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35 results about "Β d glucan" patented technology

Antifungal agents

ActiveUS20080009504A1BiocideAntimycoticsDiseaseEnfumafungin
The present invention relates to novel enfumafungin derivatives of formula I and pharmaceutically acceptable salts thereof, their synthesis, and their use as inhibitors of (1,3)-β-D-glucan synthase. The present compounds and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions comprising the present compounds and pharmaceutically acceptable salts thereof, are useful for treating or preventing antifungal infections and associated diseases and conditions.
Owner:SCYNEXIS INC

Storage Stable Emulsions From Low Penetration Grade Bituminous Binders

The present invention relates to emulsions comprising a (1→3)-β-D-glucan, a cationic emulsifier and a bituminous binder having a low penetration. The emulsion is storage stable whilst fast breaking, even under unfavourable environmental conditions such as high humidity and low temperature. The emulsions can conveniently be used in chip less surface dressings, trackless tack coating compositions, water-proofing compositions, flooring applications, bonding layers, impregnation layers, dense coated materials and semi-dense coated materials which are cold-cast or storable, slurry seals, micro-surfacing compositions and mortars
Owner:LATEXFALT

Wheat having high levels of beta-glucan

InactiveUS20160251670A1Preventing and reducing severityPreventing and reducing and incidenceOrganic active ingredientsMicrobiological testing/measurementBeta-glucanWater soluble
The present invention provides wheat grain comprising (1,3;1,4)-β-D-glucan (BG). The wheat grain is characterised by one or more of the following features; a BG content of at least 3% (w / w); the BG of the grain has a DP3 / DP4 ratio between about 1.0 and about 2.0 or between about 1.0 and 2.3; and the BG is partially water soluble such that between 8.0% and about 25% or between about 10% and about 25% of the BG of the grain is water soluble. The present invention also provides uses of this grain.
Owner:COMMONWEALTH SCI & IND RES ORG

Antifungal agents

ActiveUS20110224228A1BiocideAntimycoticsEnfumafunginMedicinal chemistry
Novel derivatives of enfumafungin are disclosed herein, along with' their pharmaceutically acceptable salts, hydrates and prodrugs. Also disclosed are compositions comprising such compounds, methods of preparing such compounds and method of using such compounds as antifungal agents and / or inhibitors of (1,3)-β-D-glucan synthase. The disclosed compounds, their pharmaceutically acceptable salts, hydrates and prodrugs, as well as compositions comprising such compounds, salts, hydrates and prodrugs, are useful for treating and / or preventing fungal infections and associated diseases and conditions.
Owner:SCYNEXIS INC

Method of assaying physiologically active substance of biological origin, kit for assaying physiologically active substance of biological origin and apparatus for assaying physiologically active substance of biological origin

Provided is a technique whereby a physiologically active substance of biological origin such as an endotoxin or β-D-glucan can be more conveniently and accurately detected and the concentration thereof can be determined even in the case of using a sample which contains a substance affecting LAL activity. For example, a sample is brought into contact with a substance (2) capable of adsorbing an endotoxin and thus the endotoxin contained in the sample is preliminarily adsorbed. Next, the sample per se is washed away and the adsorbed endotoxin (4) is reacted with LAL. Then the gelation of LAL or the formation of gel particles (5) is detected to thereby detecting the endotoxin and determining the concentration thereof.
Owner:KOWA CO LTD

Method for measurement of physiologically active substance derived from organism and measurement apparatus

Disclosed is a measurement method which can largely reduce the time required for the detection of a physiologically active substance derived from an organism (e.g., an endotoxin, β-D-glucan) or the determination of the concentration of the physiologically active substance by utilizing the reaction between the physiologically active substance and LAL. Also disclosed is a measurement apparatus utilizing the measurement method. An incident light from a light source is focused onto a sample and delivered to the sample to cause the bombardment with coagulin which is a final product of a protease cascade (i.e., a coagulin monomer) and an extremely fine aggregate which is produced by the aggregation of the coagulin monomers (i.e. a coagulin aggregate), thereby generating a scattered light. The scattered light is detected by a light-receiving element. The concentration of the endotoxin can be determined based on the initial rate of increase in the scattered light detected.
Owner:KOWA CO LTD

Method for producing factor G derived from horseshoe crab

The invention provides a virus harboring a DNA encoding a subunit of limulus-derived factor G, the virus being capable of mass-producing a (1→3)-β-D-glucan assay reagent of satisfactory quality, steadily and at low cost, a cell harboring the virus, and a method of producing factor G by use of the cell.
Owner:SEIKAGAKU KOGYO CO LTD

Method of inhibiting angiogenesis and food/beverage composition for angiogenesis inhibition

A method of inhibiting angiogenesis by applying a protein polysaccharide of a (1→6)-β-D-glucan with a glucan:protein ratio of 55:43 [w / w], obtained by extracting with a 5 w % aqueous solution of sodium hydroxide a residue of extraction and removal of water-soluble polysaccharides from the Agaricus blazei Murill (himematsutake) fruiting body, and a food / beverage composition for angiogenesis inhibition containing the protein polysaccharide of (1→6)-β-D-glucan.
Owner:ITOH HIROKO +2

Antifungal agents used in combination

The present invention relates to the use of enfumafungin derivative triterpenoid antifungal compounds in combination with other antifungal agents such azoles, polyenes, lipopeptides, and allylamides to treat fungal diseases. More particularly, the invention relates to antifungal combinations of enfumafungin derivative triterpenoids which are inhibitors of (1,3)-β-D-glucan synthesis, in combination with other antifungal agents such as mold-active agents that have activity against molds, including but not limited to voriconazole, isavuconazole, posaconazole, itraconazole and amphotericin B, for the treatment and / or prevention of infections caused by molds.
Owner:SCYNEXIS INC

Polysaccharide synthases

The present invention relates generally to polysaccharide synthases. More particularly, the present invention relates to (1,3;1,4)-β-D-glucan synthases. The present invention provides, among other things, methods for influencing the level of (1,3;1,4)-β-D-glucan produced by a cell and nucleic acid and amino acid sequences which encode (1,3;1,4)-β-D-glucan synthases.
Owner:ADELAIDE RES & INNOVATION PTY LTD +2

Processes for isolation and purification of enfumafungin

The present disclosure relates to processes useful in the isolation and purification of enfumafungin, which is classified as a triterpene glycoside antifungal compound and acts as a glucan synthase inhibitor. Enfumafungin has application in the treatment of conditions caused by fungal infection and is also useful as an intermediate in the preparation of other compounds useful as antifungal agents and / or inhibitors of (1,3)-β-D-glucan synthesis.
Owner:SCYNEXIS INC

Nucleic acid fragment encoding a horseshoe crab-derived pro-clotting enzyme

Objects of the present invention are to provide a DNA fragment encoding a limulus-derived pro-clotting enzyme, a virus harboring the DNA fragment, a cell harboring the virus, a method of producing the pro-clotting enzyme by use of the cell, and means for assaying an endotoxin or (1→3)-β-D-glucan employing the enzyme, wherein these elements are capable of producing an endotoxin or (1→3)-β-D-glucan assay reagent of satisfactory quality, steadily, at low cost, and on a large scale. In the present invention, for example, a DNA fragment encoding a protein having an amino acid sequence defined by SEQ ID NO: 4 is selected as a nucleic acid fragment encoding a limulus-derived pro-clotting enzyme, and the corresponding recombinant pro-clotting enzyme. Use of the enzyme can provide a high-sensitivity method and kit for detecting (1→3)-β-D-glucan and an endotoxin, utilizing a cascade reaction system in a horseshoe crab lysate.
Owner:SEIKAGAKU KOGYO CO LTD

Antifungal agents

ActiveUS20110172225A1BiocideAntimycoticsEnfumafunginMedicinal chemistry
Novel derivatives of enfumafungin are disclosed herein, along with their, pharmaceutically acceptable salts, hydrates and prodrugs. Also disclosed are compositions comprising such compounds, methods of preparing such compounds and methods of using such compounds as antifungal agents and / or inhibitors of (1,3)-β-D-glucan synthase. The disclosed compounds, their pharmaceutically acceptable salts, hydrates and prodrugs, as well as compositions comprising such compounds, salts, hydrates and prodrugs, are useful for treating and / or preventing fungal infections and associated diseases and conditions.
Owner:SCYNEXIS INC
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