The invention discloses an activation method and system of a payment account. The activation method of the payment account comprises the steps that based on operation information of a user, terminal equipment submits a binding request to a cloud server; wherein the binding request carries identification information, the payment account and authentication information of the user, bank account and codes corresponding to the payment account, and identification data of the terminal equipment; after the binding request is received, the cloud server calls a binding interface, and the binding request is submitted to a payment server; the payment server conducts authentication on the binding request, after the authentication is passed, binding relations between the payment account and the bank account, and between the identification data of the terminal equipment are built, and a binding result is returned to the cloud server; and the cloud server returns the binding result to the terminal equipment so as to complete activation of the payment account. The activation method can ensure that the payment account can be rapidly, conveniently and safety activated.