49results about How to "Efficient activation" patented technology

The invention provides a method for extracting lithium by leaching spodumene. The method comprises the following steps: roasting a mixture of spodumene concentrate and a roasting aid to obtain roasted clinker; and under the condition that an external field is applied, acid leaching is conducted on the roasted clinker, solid-liquid separation is conducted, and lithium leaching liquid and spodumene smelting slag are obtained. According to the method, roasting transformation is optimized through a process route of combining one-step additive roasting transformation with external field enhanced leaching lithium extraction, the process flow is shortened, meanwhile, external field synergistic enhanced leaching is adopted, and efficient leaching of the lithium element in spodumene and selective leaching of the lithium element are achieved.

The invention relates to application of iron-doped carbon nitride rich in nitrogen vacancies, in particular to application of the iron-doped carbon nitride rich in the nitrogen vacancies in degradation of active pharmaceutical compounds based on a degradation system of UV-LED / NaClO and / or UV-LED / NH2Cl. The removal rates of the UV-LED / NaClO / Fe-g-C3N4-Nv degradation system and the UV-LED / NH2Cl / Fe-g-C3N4-Nv degradation system on carbamazepine are as high as 98.3% and 67.2% respectively, the oxidation capacity of g-C3N4 is enhanced through iron doping, a new intermediate energy level is formed through introduction of nitrogen vacancy, the effect of an electron capturer is achieved, a new electron transmission channel is formed under the combined action of iron doping and nitrogen vacancy, and the degradation efficiency of carbamazepine is improved. The migration rate of electrons and the separation efficiency of photon-generated carriers are obviously improved; meanwhile, the Fe-g-C3N4-Nv achieves efficient activation of NaClO and NH2Cl through O2.-and hvb + under UV-LED irradiation, the yield of HO., RCS and RNS in a degradation system is increased, the adaptability to water quality fluctuation is high, and stable degradation of pharmaceutical active compounds can be achieved.

The invention discloses multi-walled carbon nanotube functionalized sludge biochar as well as a preparation method and application thereof. The method comprises the following steps: firstly, mixing sludge biochar prepared by anaerobic pyrolysis with a multi-walled carbon nanotube, and carrying out ball milling treatment, so as to prepare the sludge biochar functionalized by the multi-walled carbon nanotube; the multi-walled carbon nanotube functionalized sludge biochar prepared by the invention can efficiently activate peroxymonosulfate to degrade trace antibiotics in a water body, and the removal rate of sulfamethoxazole can reach 96% when the reaction is carried out for 60 minutes. According to the method, harmless treatment and resource utilization of the sludge can be realized, and meanwhile, efficient removal of antibiotics in the water body is also realized.

According to the nickel-based catalyst and the preparation method and application thereof, through Ga modification, the methane cracking depth can be reduced, and then carbon deposition is effectively inhibited; ceO2 oxygen vacancies can effectively activate CO2, the generated intermediate oxygen species O further reacts with deposited carbon so as to achieve the purpose of carbon cleaning, the GaxNi / CeO2 catalyst is prepared by adopting a urea homogeneous precipitation method, 1000-hour long-term stable catalytic conversion of the nickel-based catalyst in a carbon dioxide methane dry reforming reaction is achieved, and the catalyst has the advantages of simple process, low cost and high efficiency. The nickel-based catalyst prepared by the method can keep good catalytic stability.

The present invention relates to the fields of tumor therapy and molecular immunology, and provides an anti-CTLA4 monoclonal antibody or an antigen-binding fragment thereof, a pharmaceutical composition thereof, and its use. The monoclonal antibody of the present invention can block the binding of CTLA4 to β7, alleviate the immunosuppression in the body caused by CTLA4, and activate T lymphocytes.

This invention discloses a carbon-based composite catalytic material, its preparation method, and its applications. The invention employs a one-step carbonization process involving molten salt confinement, a non-urea nitrogen source, and no ball milling: a dinuclear iron precursor, nitrogen-containing organic matter (as both a non-urea nitrogen source and a carbon source), ZnCl2, and a molten salt system are mixed. After high-temperature pyrolysis under an inert atmosphere, the mixture is sequentially washed with hot water to dissolve the molten salt, followed by washing with HCl solution and drying. The entire process eliminates the need for complex mechanical treatments such as ball milling, simplifying the steps and providing milder conditions, making it more suitable for scale-up preparation and engineering applications. The above-mentioned carbon-based composite catalytic material is applied to the degradation of chlorinated organic pollutants in soil, particularly in conjunction with persulfate oxidants to construct an advanced oxidation system. The highly coordinated dinuclear M2N6 reaction center efficiently activates persulfate, generating sulfate radicals, hydroxyl radicals, and / or non-radical active species, achieving rapid degradation of recalcitrant chlorinated organic pollutants.

The invention discloses a hansenula polymorpha efficient gene editing system based on CRISPR (clustered regularly interspaced short palindromic repeats) / Cpf1 and application of the hansenula polymorpha efficient gene editing system. The hansenula polymorpha gene editing system comprises: (1) a Cpf1 integration plasmid, wherein the Cpf1 integration plasmid is expressed by an endogenous constitutive promoter, and the Cpf1 is integrated into a hansenula polymorpha genome; (2) a crRNA expression plasmid, wherein the crRNA expression plasmid comprises a crRNA expression cassette; wherein the crRNA expression cassette is composed of an RNA pol III type promoter and a terminator.

This invention provides a method for the artificial breeding of bullfrogs, including bullfrog selection, pairing, breeding, artificial spawning induction, artificial insemination, fertilized egg hatching, and tadpole rearing. This invention uses precise control of water temperature and quality in the breeding water to stimulate the gonadal development of the bullfrogs. It utilizes artificial spawning induction, insemination, fertilized egg hatching, and seedling rearing techniques to solve the problems of existing bullfrog germplasm degradation and difficulties in artificial breeding. By adding *Lactobacillus rhamnosus* to the feed, the mortality rate of bullfrogs is effectively reduced, the hatching rate of fertilized eggs is high, and the seedling growth rate is fast. This allows for a stable and continuous supply of high-quality bullfrog stock, meeting the effective demand for bullfrog seedlings throughout the year, and providing a technical foundation for the artificial breeding of bullfrogs.

Provided is a multi-domain fusion protein molecule close to a native state. The fusion protein is composed of an antibody single-chain molecule without an immune effect and a polypeptide receptor molecule, which specifically binds to pMHC epitope, or component part thereof or fragment thereof. These protein domains close to the natural state can be mixed to form a fusion protein complex molecule having a biological function, and can avoid the risk of immunogenicity caused by introducing artificial flexible peptide chains to link each domain into a single polypeptide chain molecule.

The invention relates to the technical field of preparation of methanol through hydrogenation, in particular to a preparation method and application of a hydrophobic supported catalyst, and the preparation method comprises the following steps: S1, preparing a mesoporous gamma-Al2O3 carrier by adopting an evaporation-induced self-assembly method; s2, carrying out hydrophobic modification on the gamma-Al2O3 carrier by adopting a method of heating in a water bath kettle at a constant temperature and a low temperature and adopting silane reagents such as dimethyl diethoxy silane, propyl trimethoxy silane, octyl trimethoxy silane and the like; s3, loading Cu and ZnO by adopting a wet impregnation method or an easy impregnation-capture method; the surface property of the gamma-Al2O3 material is improved through hydrophobic modification of a methyl group, and the catalyst prepared by the method has higher hydrophobicity and has higher methanol selectivity and reaction stability compared with an unmodified catalyst in the reaction of synthesizing methanol through co-hydrogenation of carbon monoxide and carbon dioxide.

The invention discloses a mouse 4T1 breast cancer therapeutic tumor neoantigen mRNA vaccine and a preparation method and application thereof.The breast cancer therapeutic tumor neoantigen mRNA vaccine comprises an antigen epitope composition, the antigen epitope composition comprises at least one of seven polypeptide fragments combined with MHC class I molecules and three polypeptide fragments combined with MHC class II molecules, and the antigen epitope composition comprises at least one of three polypeptide fragments combined with MHC class II molecules; the amino acid sequences of the seven polypeptide fragments combined with the MHC class I molecules are respectively shown as SEQ ID NO.1-SEQ ID NO.7, and the amino acid sequences of the three polypeptide fragments combined with the MHC class II molecules are respectively shown as SEQ ID NO.8-SEQ ID NO.10. The invention further discloses a preparation method of the polypeptide fragments combined with the MHC class I molecules. The vaccine has an obvious inhibition effect on tumor growth.

The present invention discloses a method for removing antibiotics by using a persulfate system activated by light response of edible dyes, comprising the following steps: mixing edible dyes and antibiotics to obtain a mixed solution; adding persulfate to the mixed solution to obtain a reaction system; and performing light response activation on the reaction system under simulated sunlight to achieve synergistic removal of edible dyes and antibiotics. The present invention reduces the cost of a traditional PMS light activation system, increases the benefits, improves the pollutant removal efficiency of a persulfate activation system, and achieves the goal of treating waste with waste, while avoiding the risk of secondary pollution caused by the introduction of exogenous catalysts.

The invention relates to the technical field of medical instruments, in particular to a photo-initiation medicine balloon catheter which comprises a catheter body, a balloon fixedly arranged at the far end of the catheter body, a catheter base fixedly arranged at the near end of the catheter body and a plurality of micro spraying pipes fixedly arranged on the outer surface of the balloon. Wherein the catheter main body comprises a first catheter, and a second catheter which is fixedly arranged outside the first catheter in a sleeving manner; wherein a first pipe cavity is formed between the inner wall of the second guide pipe and the outer wall of the first guide pipe, and a plurality of second pipe cavities are arranged between the outer wall of the second guide pipe and the inner wall of the second guide pipe in an annular array mode with the axis of the second guide pipe as the reference; through local administration, the photosensitizer is efficiently activated, the side effects of the whole body are reduced, the treatment effect on diseases such as bile duct cancer is improved, the medical cost is reduced, and the living quality of a patient is also improved.

This invention discloses a method for preparing and applying chitosan-encapsulated CoCe layered double hydroxide CoCe-LDH. This material can achieve rapid and efficient degradation of roxarsone and removal of the resulting inorganic arsenic. In this material, LDH is encapsulated by chitosan, resulting in a sheet-like material. Chitosan can disperse active sites and adsorb and enrich PMS, while LDH can transfer PMS ions into the anion layer through anion exchange, thereby increasing the active sites. After coupling with the material, PMS is specifically converted to... 1 O2 accelerates the degradation rate.

The application relates to the technical field of water pollution treatment, in particular to a preparation method and application of porous structure CuFe2O4. The preparation method of the porous structure CuFe2O4 comprises the following steps: stirring and mixing copper salt, iron salt and a pore-forming agent, grinding into a gelatinous product, calcining the gelatinous product for 1.5-3 hours, naturally cooling to below 100 DEG C and taking out, and finally fully grinding and sieving to obtain the porous structure CuFe2O4; wherein the molar ratio of the copper salt to the iron salt is 1:2-2.1; and the molar ratio of the copper salt to the pore-forming agent is 1:1.5-1.55. The preparation method of the porous structure CuFe2O4 and the application of the porous structure CuFe2O4 in activated sulfite degradation of organic pollutants have the advantages of high efficiency, environmental protection, economy and the like, and have important significance for the field of water treatment.

Provided are a bispecific antibody and a use thereof. The bispecific antibody includes an IL-21 molecule and a CD16a antibody. The CD16a antibody includes a CD16a single-chain antibody and FC. The N-terminus of the FC is linked to the C-terminus of the single-chain antibody. The CD16a single-chain antibody includes a heavy chain variable region and a light chain variable region. The C-terminus of the FC is linked to the N-terminus of the IL21 molecule. The prepared bispecific antibody can simultaneously target CD16 and IL-21 receptors and can also activate NK cells. It has a long half-life period, exhibiting stronger anti-tumor and antiviral capabilities than single-target antibodies. It has the application potential of promoting NK cell proliferation and can be used for in-vitro culture and expansion of NK cells, and the expanded NK cells have good cytotoxicity.

The invention discloses a multi-field control pyrolysis reactor which comprises a lifting pipe at least provided with a preheating section and a rapid pyrolysis section, a reaction channel is formed in the lifting pipe, a carrier gas inlet is formed in the lower end of the preheating section, a material inlet is formed in the preheating section, and a material outlet is formed in the rapid pyrolysis section; the carrier gas inlet and the material inlet are respectively communicated with the reaction channel; the guide pipe penetrates through the lifting pipe and is positioned in the reaction channel, and a plurality of guide pipe gas outlets with different gas outlet directions are formed in the guide pipe. The multi-field control pyrolysis reactor provided by the invention can realize regulation and control of a temperature field, a velocity field and a reaction atmosphere in a reaction process, optimizes a pyrolysis process, and improves product yield and quality.

The invention relates to a polyoxometallate cluster, a preparation method and application of the polyoxometallate cluster in a CO2 hydro-conversion process, and belongs to the field of catalytic materials. The invention provides an Anderson type PtMo6O24 cluster which is positioned in a stable metal organic framework, has a clear molecular structure and has a catalytic effect on low-temperature CO2 hydrogenation. After the performance of the cluster is operated for a long time, the activity or methanol selectivity of the cluster does not show an attenuation sign, and the one-way yield of the cluster also exceeds that of the most advanced heterogeneous catalyst. In combination with in-situ spectrum and DFT (Discrete Fourier Transform) calculation, the formation of CH3OH is mainly dominated by reverse water-gas shift and a subsequent CO hydrogenation path, and an HCOO path possibly serves as an auxiliary path. The cluster structure with a clear structure is used for CO2 hydrogenation, and has the characteristics of high activity and low-temperature catalysis.

Provided are a universal T cell (CNK-UT) and an application thereof. The CNK-UT has the broad-spectrum ability to recognize and kill tumor cells and virus-infected cells.

Disclosed is an antigen targeting, anti-CD16A, and immune effector cell activating trifunctional fusion protein, comprising: a CD16A binding region that specifically binds to CD16A, a tumor-associated antigen (TAA) binding region that specifically binds to a TAA, an IL-15 / IL-15Rα complex formed by combining IL-15 and IL-15Ra, and an Fc domain. A designed tumor-targeting innate immune cell activation molecule, i.e., an anti-TAA, anti-CD 16A, and cytokine IL 15 trifunctional fusion protein targets NK cells to a tumor by simultaneously binding to a TAA on tumor cells and CD16A on NK cells, so that the NK cells release perforin and granzymes to induce apoptosis and cause tumor cell death. The cytokine IL15 expands and maintains the function of the NK cells, stimulates immune cell proliferation, and changes the immune microenviroment of the tumor.

This invention relates to a method for controlling surface defects and phase states of indium oxide (IoA) using cold plasma. The production method primarily involves placing the IoA precursor, indium hydroxide, in a dielectric barrier discharge plasma reactor. Subsequently, a gas is introduced, and a high-voltage electric discharge is applied to break down the gas, generating plasma. The high-energy electrons in the plasma cause the indium hydroxide to decompose, forming IoA of different phase states, while simultaneously allowing oxygen atoms in the IoA lattice to escape, thus creating oxygen defects on the IoA surface. This method is simple to operate, operates under mild conditions, is quick, consumes little energy, and is environmentally friendly, showing promising application prospects in the field of materials science.

The invention discloses a molten metal methane cracking hydrogen production method based on refractory particulate matter reinforcement, and belongs to the technical field of methane cracking hydrogen production. The molten metal methane cracking hydrogen production method provided by the invention comprises the following steps: adding refractory particles into a molten metal phase and uniformly dispersing to form a solid-liquid mixed reaction system; the refractory particles are selected from at least one of carbon black, activated carbon and tungsten particles; and introducing methane into the solid-liquid mixed reaction system, and carrying out cracking reaction to generate hydrogen and a solid carbon product. According to the method, the refractory particles selected from carbon black, activated carbon and tungsten particles are uniformly dispersed and added into the molten metal phase, so that the conversion per pass of methane and the selectivity of hydrogen are greatly improved, meanwhile, the morphology of the generated solid carbon product is regulated and controlled, and a carbon material which is more ordered in structure and higher in additional value can be obtained.

The invention discloses a ball-milled red mud photocatalyst and a preparation method and application thereof, and belongs to the technical field of solid waste resource utilization, the ball-milled red mud is subjected to ball milling to obtain a red mud aqueous solution, a saturated Na2CO3 solution is added into the red mud aqueous solution, heating reaction is performed to obtain a red mud mixed solution, the red mud mixed solution is washed to be neutral, and the red mud photocatalyst is obtained. And centrifuging the neutral red mud mixed solution, and drying the obtained red mud precipitate to prepare the ball-milled red mud photocatalyst. Rich metal oxides in the red mud are activated after ball milling, active sites are enhanced, the effect of purifying the antibiotic wastewater is achieved, meanwhile, pollution of the red mud to the environment can be reduced, the environment treatment cost is reduced, and resource utilization of the red mud is achieved.

The invention discloses a preparation method and application of a two-dimensional bismuth-based surface molecular imprinting photocatalyst. Template molecule venlafaxine and functional monomer 2-acrylamide-2-methylpropanesulfonic acid are dissolved in an ethanol solvent containing a carrier BiOCl, prepolymerization is performed at 20-40 DEG C for 2-8 h, and the two-dimensional bismuth-based surface molecular imprinting photocatalyst is obtained. Adding ethylene glycol dimethacrylate serving as a cross-linking agent and azodiisobutyronitrile serving as an initiator, performing thermal polymerization for 20-30 hours at the temperature of 50-70 DEG C after ultrasonic and nitrogen charging protection, and performing elution and drying to obtain the two-dimensional bismuth-based surface molecular imprinting photocatalyst. The imprinted photocatalyst prepared by the invention has strong capability of selectively adsorbing a target object venlafaxine in an aqueous solution, the venlafaxine is preferentially and rapidly degraded under an illumination condition, and the imprinted photocatalyst can be used for selective photocatalytic removal of the venlafaxine in an actual water sample.

The invention relates to the technical field of fuel cells, and provides a PEM fuel cell stack rapid activation method and system, and the method comprises the following steps: S1, connecting a to-be-activated fuel cell stack to a load, introducing air into a cathode of a fuel cell, introducing hydrogen into an anode of the fuel cell, and loading to a rated current or a rated voltage of the fuel cell for self-humidification; s2, changing the load to a first single-chip voltage, and recording a first current corresponding to the first single-chip voltage; s3, greatly reducing the air supply of the cathode of the fuel cell, and adjusting the load to adjust the current to a second current after the voltage of the single sheet is reduced to be lower than the second voltage of the single sheet, so that the membrane electrode of the fuel cell is subjected to hydrogen pump reaction; s4, recovering the air supply amount of the cathode of the fuel cell, recovering the current to the first current, and recording a third monolithic voltage; s5, repeating the steps S3 and S4 until the voltage of the third single chip is stable; and S6, loading the rated current or the rated voltage of the fuel cell to carry out self-humidification. The method has the advantages of accelerating activation of the fuel cell stack and reducing the hydrogen consumption.

The invention provides a tire pressure sensor activation method and device, activation equipment and a program product. The method comprises the steps that a target tire pressure sensor and preset signal strength corresponding to the target tire pressure sensor are determined; an activation signal is sent to the target tire pressure sensor according to the preset signal intensity, and the target tire pressure sensor is activated; if the target tire pressure sensor is not activated successfully, the preset signal intensity is adjusted according to a preset rule, an activation signal is sent to the target tire pressure sensor according to the adjusted preset signal intensity, and the target tire pressure sensor is activated again until the preset signal intensity exceeds the preset signal intensity threshold value. According to the method, when the target tire pressure sensor is not successfully activated by using the activation signal with the preset signal intensity, the preset signal intensity is adjusted according to the preset rule, and the activation attempt is performed by using the activation signals with various preset signal intensities, so that the target tire pressure sensor can be effectively activated. Therefore, the method can improve the success rate of activating the tire pressure sensor.

This invention relates to an activation method for a proton exchange membrane fuel cell stack based on an AC impedance meter. The steps include: checking the airtightness of the stack; heating the stack and purging the anode and cathode with nitrogen gas; introducing hydrogen gas into the anode and nitrogen gas into the cathode, with the anode pressure greater than the cathode pressure; switching the nitrogen gas at the cathode to air; performing oxygen-deficient activation; performing constant current discharge activation and recording polarization curve 1; repeating oxygen-deficient activation and constant current discharge activation to obtain multiple polarization curves; determining whether the impedance deviation of a single cell between the new polarization curve and the previous polarization curve is less than 0.2 mΩ; if so, further determining whether the voltage deviation between the new polarization curve and the previous polarization curve is less than 10 mV, thus completing the stack activation. This invention rapidly reduces oxides on the catalyst surface, improving catalyst activity and utilization, fully wetting the proton exchange membrane, establishing good ion channels, accelerating stack activation, and reducing hydrogen consumption.

The present invention discloses an antigen delivery carrier that targets dendritic cells, promotes antigen lysosomal escape, and activates the immune system, and its preparation method and application. The present invention provides a carrier for delivering antigens into the body, which is a metal skeleton complex obtained by functionally modifying a metal skeleton material with polyethyleneimine and mannose. The antigen delivery carrier provided by the present invention has uniform particle size, good dispersibility, high biosafety, and a large antigen loading capacity. It exhibits high targeting to dendritic cells, increases the uptake of antigens by dendritic cells, promotes the maturation of dendritic cells, and promotes the cross-presentation of antigens in dendritic cells, and can efficiently activate CD4 + and CD8 + T cells, causing a strong immune response and killing cancer cells. This carrier has a wide range of applications and can be used to encapsulate single or multiple antigens, and has the ability to kill common tumors.

The purpose of the present invention is to provide a novel method for increasing the number of newly generated neurons in the adult brain, and to provide a polynucleotide, a vector, and a pharmaceutical composition for use in the method. The present invention provides: a polynucleotide characterized by including (A) the nucleic acid sequence of the Plagl2 gene, (B) an miR-shRNA (microRNA adapted short hairpin RNA) nucleic acid sequence for the Dyrk1a gene, and (C) a promoter sequence operatively connected to the nucleic acid sequences; a vector including the polynucleotide; and a pharmaceutical composition including the polynucleotide and the vector.