The invention discloses a novel organic salt-a
berberine glycyrrhizic acid
enantiomer salt which can be used for
medicine, and a preparation method and usage thereof. The chemical name of the
berberine glycyrrhizic acid
enantiomer salt is 5,6-dihydro-9,10-dimethoxy-benzo (g)-1,3-benzo-
dioxolane[5,6-a]quinolizidine.18a(beta),20beta-carboxy-11-oxo-30-norolean-12-
alkene-3beta-yl-2-O-beta-D-glucopyranuronosyl-a-D-glucopyranosiduronic acid. The preparation method comprises the steps that
berberine hydrochloride is dissolved with water according to the pharmaceutical co-
crystal principle, anion exchange resin is added, then the mixture is stirred for one hour and filtered, the filtrate is put into a water solution of a glycyrrhizic acid
enantiomer and stirred for 30 minutes for
centrifugation, the precipitate is dissolved in
ethanol, and decompression is carried out to remove the
solvent to get the berberine glycyrrhizic acid enantiomer salt. The organic salt with double mother nucleuses has practical significance for human in resisting diabetes,
hyperlipidemia, tumor and chronic inflammatory diseases of
rheumatoid arthritis,
hepatitis, Alzheimer and the like and developing the medical industry.