33 results about "Naphthalene Compound" patented technology

The invention provides a method for modifying polyurethane acrylate with a triazine naphthalene compound, a polyurethane acrylate polymer and application of the polyurethane acrylate polymer. The method comprises the following steps: (1) adding isocyanate and polyol in a molar ratio of (1.8-2.2): 1 into a reaction kettle, then adding an organic solvent of which the mass is the same as the total mass of the isocyanate and the polyol, and uniformly mixing to obtain an initial solution; the isocyanate is prepared from a triazine naphthalene compound with an isocyanate group and diisocyanate; the polyhydric alcohol comprises a triazine naphthalene compound with a hydroxyl group and dihydric alcohol; (2) under protective gas, dropwise adding a catalyst into the initial solution, and carrying out heating reaction to obtain a reaction solution; (3) keeping the temperature unchanged, and continuously adding hydroxyl acrylate and a polymerization inhibitor into the reaction solution for blocking until the content of isocyanate functional groups is lower than 0.1%; and cooling, neutralizing to be neutral, carrying out reduced pressure distillation to remove the solvent, carrying out immersion cleaning with deionized water, filtering and drying to obtain the polyurethane acrylate polymer.

The application discloses a 2-phenyl-4-pinacol boron-based-2,1-boronazanaphthalene, a 2-phenyl-4-pyrimidyl-2,1-boronazanaphthalene compound and a preparation method thereof, and belongs to the technical field of organic synthesis chemistry. The method is based on a copper-catalyzed selective dehydrogenation boronation reaction strategy, 2-phenyl-2,1-boronazanaphthalene and pinacol diboron ester are used as raw materials, CuCl is used as a catalyst, 4,5-bis(diphenylphosphino)-9,9-dimethyloxyanthracene is used as a ligand, 2-adamantanone is used as an additive, p-xylene is used as a solvent, and 2-phenyl-4-pinacol boron-based-2,1-boronazanaphthalene is efficiently obtained. The 2-phenyl-4-pinacol boron-based-2,1-boronazanaphthalene compound synthesized by the application can be used as a key intermediate, is efficiently converted through a C-B bond, and is convenient for synthesizing a 2-phenyl-4-pyrimidyl-2,1-boronazanaphthalene compound, thereby providing a new way for functional modification of boronazacyclic compounds.

The present invention relates to oligomeric binaphtyl compounds of the formula (I) that are suitable as monomers for preparing thermoplastic resins, such as polycarbonate resins, which have beneficial optical and mechanical properties and can be used for producing optical devices. where X1 and X2 are independently selected from hydrogen, -Alk1-OH, -CH2-A2-CH2-OH, -Alk2-C(O)ORX, -CH2-A2-C(O)ORX and -C(O)-A2-C(O)ORX, where Rx is selected from the group consisting of hydrogen, phenyl, benzyl and C1-C4-alkyl; Y1 and Y2 are independently selected from -CH2-, -CHArY- and -CH(CH2ArY)-; A1 is e. g. a single bond, -CH2-, -CHArA -CH(CH2ArA)-, -C(CH2ArA)2-, a moiety of the formula (A), mono- or polycyclic arylene having from 6 to 26 carbon atoms as ring members or mono- or polycyclic hetarylene having a total of 5 to 26 atoms, which are ring members, alternatively, the moiety -Y1-A1-Y2- in formula (I) may be -CH2- or -CHArY-, n is 1, 2 or 3; m, p, q and r are independently 0, 1 or 2; R1, R2, R3 and R4 are independently selected from the group consisting of halogen, C2- C3-alkynyl, CN, R, OR, CHsR'3-s, NR2, C(O)R and CH=CHR", it being possible that R1, R2, R3 or R4 is identical or different if more than 1 of R1, R2, R3 or R4 is present, where s on each occurrence is 0, 1 or 2.

The present invention provides: high-purity 2-naphthylacetonitrile which contains less impurities and is useful as a starting material or intermediate for the synthesis of various pharmaceutical products, agrochemicals, and chemical products; and a production method thereof. The high-purity 2-naphthylacetonitrile has an HPLC purity of 95% by area or more, and the content of naphthalene compounds represented by formulae (a) to (j) is equal to or less than a specified area percentage. The production method of the high-purity 2-naphthylacetonitrile is characterized by comprising the following steps: step 1 and step 2. Step 1 is a step for obtaining 2-naphthylacetic acid by hydrolyzing an amide compound obtained by subjecting 2 '-acetophenone to a Willgerodt reaction, if necessary, in the presence of an additive. Step 2 is a step of obtaining 2-naphthylacetonitrile by reacting the 2-naphthylacetic acid obtained in Step 1, a halogenating agent and sulfonamide in the presence of a catalyst if necessary in an organic solvent.

The invention relates to the technical field of titanium tetrachloride, and provides a vanadium removal reagent for removing vanadium impurities in titanium tetrachloride and a use method of the vanadium removal reagent, the vanadium removal reagent is prepared from the following components in percentage by mass: 20-60% of anthracene compounds, 1-10% of phenanthrene compounds, 5-20% of pyrene compounds, 10-30% of thiophene compounds and 10-30% of naphthalene compounds, the sum of the mass percentages of all the components is 100%, and the vanadium removal reagent is used for reacting with vanadium oxychloride in titanium tetrachloride to remove vanadium impurities. According to the scheme, the defects that the vanadium removal efficiency is low, the speed is low, dangerous reagents are used and secondary carbon pollution is introduced in a traditional process are overcome, and the purity of the obtained titanium tetrachloride product completely meets the strict application requirements in the high-end field.

The invention provides mixed side-chain alkyl naphthalene base oil and a preparation method thereof, and the preparation method comprises the following steps: in the presence of an ionic liquid catalyst, adding more than two olefins into naphthalene, and carrying out an alkylation reaction on the naphthalene to obtain a mixed side-chain alkyl naphthalene compound, wherein the difference between the olefin with the maximum carbon number and the olefin with the minimum carbon number in the olefins is at least two carbon numbers. The mixed side chain alkyl naphthalene base oil synthesized by the invention has more side chain structures, so that the mixed side chain alkyl naphthalene base oil has higher viscosity index and flash point.

The present invention relates to binaphthyl compounds of the formula {I) that are suitable as monomers for preparing thermoplastic resins, such as polycarbonate resins, which have beneficial optical and mechanical properties and can be used for producing optical devices, where X1 and X2 are independently selected from —CH2OH and —C(O)ORX, where Rx is selected from the group consisting of hydrogen, phenyl, benzyl and C1-C4-alkyl: A1 and A2 are independently e.g. mono- or polycyclic arylene having from 6 to 26 carbon atoms as ring members or mono- or polycyclic hetarylene having a total of 5 to 26 atoms, which are ring members: R1 and R2 are independently selected from the group consisting of halogen, C2-C3-alkynyl, CN, R, OR, CHsR′3-s, NR2, C(O)R and CH═CHR″, it being possible that R1 and R2 are identical or different if p+q>1, where s on each occurrence is 0, 1 or 2; p and q are independently 0, 1 or 2.

The invention provides a method for photocatalytic asymmetric intermolecular dearomatization cycloaddition reaction based on naphthalene derivatives, and belongs to the technical field of chemical synthesis. The olefin compound and the 2-pyrazole amide naphthalene derivative are used as reaction raw materials, [2 + 2]-cycloaddition or [4 + 2]-cycloaddition reaction is realized under specific reaction conditions, and the obtained product has high yield and high enantioselectivity. The substrate provided by the invention is good in universality, is especially suitable for raw materials containing naphthalene, overcomes the problem that naphthalene-containing compounds are not easy to react in the prior art, and has a good application prospect.

This invention discloses a binaphthyl compound, its preparation method, and its applications. The structural formula of the binaphthyl compound is shown in any one of formulas A1-A5. In the technical solution of this invention, an organic phosphorescent molecule is developed by rationally designing its molecular structure, maintaining an appropriate energy level difference between the singlet and triplet excited states, enabling effective intersystem crossing (ISC) from the singlet to the triplet excited state; and by creating a rigid environment, the non-radiative deactivation of the triplet excited state of the organic phosphorescent molecule is suppressed, thereby obtaining efficient, stable, and long-lived phosphorescence.

The present invention relates to the use of the compound of the formula (I) where the variables are as defined in the claims and the description, or of a mixture thereof, as a monomer for producing a thermoplastic resin selected from polyesters, polycarbonates and polyestercarbonates. The invention relates moreover to compounds (I), except for compounds where A1 and A2 are both unsubstituted 1,4-phenylene, p and q are both 0, and X1 and X2 are both —CH2OH or —C(O)OH, and except for the compound where A1 and A2 are both unsubstituted 2,3-quinolinylene, p and q are both 0, and X1 and X2 are both —CH2OH.

The present application relates to the field of lithium battery detection, in particular to a boron naphthalene compound, a preparation method and application thereof.The boron naphthalene compound has a structure as shown in general formula (1).The boron naphthalene compound can realize specific characterization of lithium fluoride in the SEI film without using high-cost experimental equipment, and the experimental condition threshold is low.

The invention relates to the technical field of organic chemical synthesis, in particular to a method for synthesizing a 1, 3-diboron ester naphthalene compound through aromatization driving, which comprises the following steps: mixing a benzo cyclohexanone derivative with an enol leaving group, bis (pinacol) borate and organic alkali (bis (trimethylsilyl) sodium amide) in a solvent (trifluorotoluene and cyclohexane); the preparation method comprises the following steps: firstly, stirring at room temperature for pre-complexing, then heating to 30-70 DEG C (preferably 40 DEG C), and carrying out double boronation and aromatization reaction to generate the 1, 3-diboron ester naphthalene compound. The preparation method is simple, does not need a transition metal catalyst, avoids the problems of heavy metal residues and biotoxicity, realizes efficient and regioselective double boronation reaction, and solves the problems that a traditional method depends on a metal catalyst and the regioselectivity is poor.

The invention provides a synthetic method of a deuterated naphthalene borate compound, which comprises the steps of converting a brominated naphthalene compound into a chlorinated naphthalene compound and then carrying out deuteration, so that the generation of an isomeride is avoided, the yield of the deuteration step reaches more than 85%, the yield is improved, the deuteration cost can be effectively reduced, and the product purity reaches more than 99%. The method is suitable for industrial production.

The present invention provides a novel naphthalene compound, a method for synthesizing said naphthalene compound, and a resin composition containing said naphthalene compound. The resin composition according to the present invention can be applied to a coating material, an ink, an adhesive, a tackifier, a gas barrier film, a color filter, a prism, a diffraction grating, an optical mirror, an optical film, an optical lens, or the like. The present invention relates to a naphthalene compound represented by chemical formula (I), a method for synthesizing the same, a resin composition containing said compound, and a cured product thereof. (In the formula, Y represents a group selected from formulas (1) to (7). n represents an integer of 1 to 10.) (In formulas (1) to (7), m1 represents an integer of 1 to 3. m2 represents an integer of 1 to 2. The m3 are the same and represent an integer of 1 to 3. m4 represents an integer of 1 to 3.)

The invention discloses an enamel color painting and a preparation method thereof, and relates to the technical field of enamel color paintings. A specific amount of the naphthalene compound and the oily brightening agent are added into the oily ice flower paint, the temperature and the relative humidity of the environment during the reaction are controlled to be within a specific range, and the reaction is carried out under a windy condition, so that an ice crack effect can be formed on various substrates such as glass, stainless steel, copper, ceramic and rock materials; meanwhile, the ice crack road is high in color saturation, more uniform, more regular and better in texture, and the adhesive force between the coating and a substrate is higher.

The present invention provides octahydro fused azadecalin compounds having glucocorticoid receptor binding affinity and modulatory activity for pharmaceutical use Also provided are pharmaceutical compositions containing an effective amount of the fused azedecalin compounds and methods of using the compositions for the-treatment of a glucocorticoid receptor mediated disorder in a subject.

The present invention relates to a use of a compound of the formula (I) or a mixture thereof, which are suitable as additives in resin compositions. The compounds are suitable as additives in particular, for thermoplastic resin compositions for producing optical devices such as optical lenses. The present invention also relates to resin compositions containing such binaphthyl compounds and a resin(s). In formula (I), A1 and A2 are identical or different and independently selected from C1- C6-alkylene which are unsubstituted or substituted by 1, 2, 3 or 4 identical or different 0 radicals R'"; X1 and X2 are identical or different and independently selected from the group consisting of O, C(=O), O-C(=O), S and SO2. In formula (I), Ar1, Ar2, R1, R2, L1, L2, k, l, p and q are as defined in the present description.

The invention discloses a synthesis method of (1R, 4aR, 6S, 8aS)-6-(benzyloxy)-5, 5, 8a-trimethyl-2-methylene decahydronaphthalene-1-methanol, and belongs to the technical field of organic synthesis. The method comprises the following steps: carrying out [2, 3]-Wittig rearrangement reaction on a (4aR, 6S, 8aR)-6-(benzyloxy)-2-[[(tributyltin alkyl) methoxyl] methyl]-5, 5, 8a-trimethyl-3, 4, 4a, 5, 6, 7, 8, 8a-octahydronaphthalene compound in a reactor in an inert atmosphere under the action of n-butyllithium, and carrying out subsequent separation and purification after the reaction is finished, so as to obtain the (1R, 4aR, 6S, 8aS)-6-(benzyloxy)-5, 5, 6, 7, 8, 8a-octahydronaphthalene compound. The method comprises the following steps: adding 2, 3, 5, 8, 8a-trimethyl-2-methylene decahydronaphthalene-1-methanol into a The method provided by the invention has the advantages of simple steps, safe operation, non-toxic and easily available raw materials, simple and easy process and small pollution, and accords with the idea of green chemistry.

A method for analyzing naphthalene-based compounds in a fraction using a multidimensional gas chromatography system, comprising: injecting a measurement sample into a first column through a sample inlet of the multidimensional gas chromatography system, separating the naphthalene-based compounds from other hydrocarbon compounds, and then, under the control of a center-cleavage module, injecting the naphthalene-based compounds into a second column and then into a first detector for analysis to obtain a sample detection spectrum; qualitative and quantitative analysis. The method of the present invention can simultaneously obtain the contents of 15 types of naphthalene-based compound monomers in a fraction through a single direct sample injection, and can particularly separate dimethylnaphthalene-based compounds. The method is simple, reliable, and highly reproducible.

The present disclosures are directed to chlorinated tetralin compounds and pharmaceutical compositions.

The present invention relates to oligomeric binaphthalene compounds of formula (I) which are suitable as monomers for the preparation of thermoplastic resins, such as polycarbonate resins, which have beneficial optical and mechanical properties and which can be used in the manufacture of optical devices. In formula (I), X1, X2, Y1, Y2, E1, E2, Ar, R1, R2, R3, R4, m, n, p and q are as defined in the specification.

A method for analyzing naphthalene-based compounds in a fraction using a multidimensional gas chromatography system, comprising: injecting a measurement sample into a first column through a sample inlet of the multidimensional gas chromatography system, separating the naphthalene-based compounds from other hydrocarbon compounds, and then, under the control of a center-cleavage module, injecting the naphthalene-based compounds into a second column and then into a first detector for analysis to obtain a sample detection spectrum; qualitative and quantitative analysis. The method of the present invention can simultaneously obtain the contents of 15 types of naphthalene-based compound monomers in a fraction through a single direct sample injection, and can particularly separate dimethylnaphthalene-based compounds. The method is simple, reliable, and highly reproducible.

The invention discloses a method for synthesizing an axially chiral isoquinoline naphthalene compound based on nickel / light concerted catalysis, and belongs to the field of organic chemical synthesis. According to the present invention, the racemic isoquinoline naphthalene derivative is subjected to kinetic resolution, such that the target axial chiral isoquinoline naphthalene compound is synthesized with high yield and high enantioselectivity; according to the method, an isoquinoline naphthalene derivative and carboxylic acid are taken as raw materials and react under the action of a nickel catalyst, a chiral oxazoline ligand, a photosensitizer and alkali through visible light irradiation, so that efficient synthesis of a target product and efficient recovery of the raw materials are realized. Further, the axially chiral compound can be converted into a corresponding N-oxide catalyst through an oxidation reaction. The catalyst shows excellent catalytic activity and stereoselectivity in an asymmetric allylation reaction. The method has the advantages of mild reaction conditions, simplicity and convenience in operation, wide substrate applicability, high enantioselectivity, good atom economy and the like, and has an important industrial application prospect.

The invention discloses preparation of a polymethacrylate / alkyl naphthalene compound anticoagulant and application of the polymethacrylate / alkyl naphthalene compound anticoagulant in synthetic ester insulating oil, and relates to the technical field of synthetic ester insulating oil. The preparation method comprises the following steps: mixing beta-naphthol with straight-chain alpha-olefin, carrying out alkylation reaction to obtain beta-(C10-C14 alkyl) naphthalene, and compounding polymethacrylate with the beta-(C10-C14 alkyl) naphthalene to obtain the polymethacrylate / alkyl naphthalene compound anticoagulant for the insulating oil. The Mn of the polymethacrylate is 8000-12000g / mol, and the PDI is less than or equal to 1.2; and the straight chain alpha-olefin is one or more of C10-C14 straight chain alpha-olefin. Through synergistic compounding design of narrow-distribution polymethacrylate and beta-alkyl naphthalene, the comprehensive performance of the synthetic ester insulating oil is remarkably improved, and the technical problem that an existing anticoagulant is difficult to consider low-temperature fluidity, oxidation stability and insulating performance at the same time is solved.

The applicant discloses a method and composition for treating patients suffering from amyotrophic lateral sclerosis (ALS), comprising the administration of a heteroarylketone condensed azadecalin compound. In embodiments, the heteroarylketone condensed azadecalin compound is dazcholilant:(R)-(1-(4-fluorophenyl)-6-((4-(trifluoromethyl)phenyl)sulfonyl)-4,4a,5,6,7,8-hexahydro-1-H-pyrazolo[3,4-g]isoquinoline-4a-yl)(pyridine-2-yl)methanone, which has the following chemical structure. Appropriate dosages include daily administration of 150 mg and 300 mg of dazcholant. Appropriate dosages also include daily administration of dazcholant with food, water, or food and water. Daily administration of dazcholant for seven days or more is effective in increasing exposure to dazcholant by approximately twofold. Administration of such heteroarylketone condensed azadecalin compounds may include oral administration, enteral administration, or other methods. Pharmaceutical compositions containing dazcholant are useful in the treatment of patients with ALS. Suitable pharmaceutical compositions containing dazcholant include, for example, pharmaceutical compositions for oral administration and pharmaceutical compositions for enteral administration. [Formula 1] JPEG2026509959000013.jpg4766

The invention belongs to the technical field of organic synthesis, and particularly relates to a synthesis method of an active marine natural product gorgoniaene (+)-Erogoniaene. According to the present invention, the cheap and easily available brominated naphthalene compound is adopted as the starting material for the first time, the palladium catalyst is adopted to catalyze to achieve the bifunctionalization of the hydronaphthalene, the homemade TADDOL type chiral ligand is adopted to achieve the expected asymmetric catalysis, and the green chemical synthesis technology such as the photoreaction is adopted to achieve the side chain installation and the functional group modification; and finally, the synthesis of the (+)-Erogongiaene is completed by nine steps. According to the synthesis method, other complex fragments do not need to be prepared in advance, related reagents are simple and easy to obtain, reaction conditions are mild, the reaction conversion rate is good, the overall route is simple and efficient, and the synthesis method is suitable for industrial kilogram-level preparation and production of the (+)-Erogongiaene.

Applicant discloses methods and compositions for treating a patient suffering from amyotrophic lateral sclerosis (ALS) comprising administration of a heteroaryl ketone fused azadecalin compound. In embodiments, the heteroaryl ketone fused azadecalin compound is dazucorilant: (R)-(1-(4-fluorophenyl)-6-((4-(trifluoromethyl)phenyl)sulfonyl)-4,4a,5,6,7,8-hexahydro-1-H-pyrazolo[3,4-g]isoquinolin-4a-yl)(pyridin-2-yl)methanone, having the chemical structure illustrated asSuitable doses include daily administration of 150 milligrams and 300 milligrams of dazucorilant. Suitable doses include daily administration of dazucorilant with food, or with water, or with food and water. Daily administration of dazucorilant is effective to increase dazucorilant exposure up to about 2-fold when continued for seven days or more. Administration of such a heteroaryl ketone fused azadecalin compound may comprise oral administration, enteral administration, or other administration. Pharmaceutical compositions comprising dazucorilant are useful in the treatment of patients suffering from ALS. Suitable pharmaceutical compositions comprising dazucorilant include, e.g., pharmaceutical compositions for oral administration and pharmaceutical compositions for enteral administration.

The invention discloses a 2-alkyl boronic acid pinacol ester-2, 1-boron azanaphthalene compound and a preparation method thereof, and belongs to the field of organic synthesis and chemical synthesis. The structural formula of the 2-alkyl boronic acid pinacol ester-2, 1-boron aza-naphthalene compound is as follows: R1 can be placed at any one of 3-8 sites, R1 is selected from any one of hydrogen, unsubstituted or substituted alkyl, unsubstituted or substituted aryl, unsubstituted or substituted alkoxy and halogen, and R2 is selected from any one of hydrogen, unsubstituted or substituted alkyl, unsubstituted or substituted aryl, unsubstituted or substituted alkoxy and halogen. R2 is selected from any one of hydrogen, unsubstituted or substituted alkyl, unsubstituted or substituted halogenated alkyl and halogen, and the core of the compound is to efficiently construct a series of 2, 1-boron aza-naphthalene compounds with novel structures on the basis of a boronizing bifunctionalization strategy catalyzed by a cheap metal copper base.

The invention relates to a neutral ortho-diboronaphthalene compound as well as a synthesis method and application thereof, the compound is synthesized by a method for removing hydrogen bromide and stabilizing coordination through N-heterocyclic carbene under a mild condition, and the compound is simple and efficient. The o-diboronaphthalene compound disclosed by the invention is of a neutral structure, is high in stability and good in reactivity, and has a good application prospect. The neutral ortho-diboronaphthalene compound disclosed by the invention has a wide application prospect in the fields of organic synthesis, functional materials, life science and medical science.