Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Naphthalene compound extracted from lavender, and preparation method and application thereof

A compound, the technology of lavender, is applied in the field of natural product chemistry to achieve good antibacterial activity, safe use and low production cost

Active Publication Date: 2017-09-15
CHINA TOBACCO YUNNAN IND
View PDF3 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention isolates a new naphthalene compound from lavender for the first time. The compound is safe, non-toxic, and has significant antibacterial activity. No related reports have been seen in the prior art.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Naphthalene compound extracted from lavender, and preparation method and application thereof
  • Naphthalene compound extracted from lavender, and preparation method and application thereof
  • Naphthalene compound extracted from lavender, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1 - the preparation of compound

[0032] The lavender samples came from Kunming, Yunnan. Sampling 2.0 kg of lavender crushed to 30 mesh, extracting 5 times with 95% methanol for 24 hours each time, combining the extracts, filtering, and concentrating under reduced pressure to obtain 105 g of extract. After dissolving the extract with 2.0 times the amount of pure methanol by weight, mix the sample with 120g of 100-mesh silica gel, pack 0.6kg of 160-mesh silica gel into a column for silica gel column chromatography, and use a volume ratio of 1:0, 20:1, 9:1, 8:2, 7:3, 6:4, 1:1, 1:2 chloroform-acetone gradient elution, TLC monitoring and merging the same parts to obtain 8 parts, wherein the volume ratio is 8: The chloroform-acetone elution part of 2 was separated by Agilent 1100 semi-preparative high-performance liquid chromatography, with 66% methanol as mobile phase, Zorbax SB-C18 (21.2×250mm, 5 μm) preparative column as stationary phase, and the flow rate was...

Embodiment 2

[0033] Embodiment 2 - the preparation of compound

[0034] The lavender sample comes from Kashgar, Xinjiang. A 3.5kg sample of lavender crushed to 40 meshes was extracted, extracted 4 times with 95% ethanol for 48 hours each time, and the extracts were combined, filtered, and concentrated under reduced pressure to obtain 250 g of the extract. The extract is dissolved in pure methanol with a weight ratio of 2.0 times, and then mixed with 250 g of 80 mesh thick silica gel, and 1.2 kg of 200 mesh silica gel is packed for silica gel column chromatography, and the volume ratio is 1:0, 20:1, 9:1, 8:2, 7:3, 6:4, 1:1, 1:2 chloroform-acetone gradient elution, TLC monitoring and merging the same parts to obtain 8 parts, wherein the volume ratio is 8: The chloroform-acetone elution part of 2 was separated by Agilent 1100 semi-preparative high-performance liquid chromatography, with 66% methanol as mobile phase, Zorbax SB-C18 (21.2×250mm, 5 μm) preparative column as stationary phase, and ...

Embodiment 3

[0035] Embodiment 3 - the preparation of compound

[0036] The lavender sample comes from Xichang, Sichuan. Sampling 5kg of the lavender sample crushed to 50 meshes, extracted 3 times with 75% acetone by ultrasound, 72 hours each time, combined the extracts, filtered, and concentrated under reduced pressure to obtain an extract 380g . The extract is dissolved in pure methanol with a weight ratio of 1.6 times, and then mixed with 400 g of 90 mesh thick silica gel, and 2.4 kg of 180 mesh silica gel is packed into a column for silica gel column chromatography, and the volume ratio is 1:0, 20:1, 9:1, 8:2, 7:3, 6:4, 1:1, 1:2 chloroform-acetone gradient elution, TLC monitoring and merging the same parts to obtain 8 parts, wherein the volume ratio is 8: The chloroform-acetone eluted part of 2 was separated by Agilent 1100 semi-preparative high-performance liquid chromatography, with 66% methanol as mobile phase, Zorbax SB-C18 (21.2×250mm, 5 μm) preparative column as stationary phase...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a naphthalene compound extracted from lavender, and a preparation method and application thereof. The compound is named 5-methoxy-2-methyl-7-(3-methyl-2-oxobut-3-enyl)-1-naphthaldehyde. The preparation method comprises the following steps: carrying out organic solvent extraction on a raw material perfume plant lavender to obtain an extract, carrying out silica gel column chromatography, and carrying out high pressure liquid chromatography separation and purification. The compound is nontoxic for animals and safe to use, and has favorable antibacterial activities, and the antibacterial rates for Escherichia coli, Staphylococcus aureus and the like respectively reach 93.4% or above. When being applied to preservation of tobacco sauce, the compound can effectively inhibit growth of microbes in the liquid and prolong the preservation period of the tobacco sauce.

Description

technical field [0001] The invention belongs to the field of natural product chemistry, in particular to a naphthalene compound extracted from traditional spice plant lavender for the first time. At the same time, the invention also relates to the preparation method of the compound and the application of the compound in inhibiting the deterioration of tobacco material liquid. Background technique [0002] Lavender is a plant of the genus Lavender of the Lamiaceae, widely distributed in the Atlantic Islands and the Mediterranean region to Somalia, Pakistan and India; only two species are cultivated in my country. Plants are semishrubs or small shrubs, rarely herbs. Cultivable varieties are widely cultivated in gardens around the world. Lavender is a spice plant with a long history, which has been used for bathing, incense, insect repelling and decontamination since ancient times. Distilled from the lavender spikes, the essential oil is fragrant and versatile. [0003] The...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07C49/258C07C45/78A24B15/30
CPCA24B15/303C07C45/78C07C49/258
Inventor 李晶向海英曾婉俐李雪梅米其利刘欣张承明孔维松王明峰者为周敏杨光宇胡秋芬李干鹏
Owner CHINA TOBACCO YUNNAN IND
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com