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148results about How to "Strong antibacterial activity" patented technology

Silver-loaded low-molecular-weight chitosan composite microsphere antibacterial agent and preparation method thereof

The invention provides a silver-loaded low-molecular-weight chitosan composite microsphere antibacterial agent and a preparation method thereof. Low-molecular-weight chitosan is used as a raw material, and a low-molecular-weight chitosan acetic acid solution, a silver nitrate solution and a vanillic aldehyde ethanol solution are mixed to form composite sol; then paraffin is used as a continuous phase, sorbitan monooleate and alkylphenol ethoxylates are used as a compound emulsifier, a silver/low-molecular-weight chitosan sol is used as a monomer, and sodium tripolyphosphate is used as a cross-linking agent for preparing an emulsion system for emulsification crosslinking, and finally washing and drying are performed, so that the silver-loaded low-molecular-weight chitosan composite microsphere antibacterial agent is obtained. Due to the fact that the low-molecular-weight chitosan is used as the raw material, nanometer silver particles can enter microspheres, and the antibacterial activity of the composite antibacterial agent is obviously improved. The obtained antibacterial agent has the broad-spectrum bactericidal activity, and has the efficient fatality rate for both escherichia coli and staphylococcus aureus.
Owner:HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY

Method of cutting propagation of peony immature stem

The invention belongs to the field of plant tissue cultivation, and particularly relates to a method of cutting propagation of a peony immature stem. The method includes the steps of material selection, cutting cultivation, indoor management, oversummer maintenance, overwinter management and strong seedling cultivation. By using low-frequency ultrasonic waves to conduct processing, rooting can be promoted, plant cell division can be remarkably accelerated and induced, the cell growth is stimulated, protein synthesis of protoplast can be accelerated, and the adventitious bud reproducibility can be improved. Due to the fact that intermittent irradiation is adopted, no drastic cavitation effect can be produced, and partial damage to cells caused by the ultrasonic waves can be avoided. Due to the fact that cultivation and rooting are conducted in the dark cultivation process, growth inhibitor is greatly reduced, and rooting is facilitated. The complete and specific method including the steps of oversummer maintenance, auxiliary bud inducing, overwinter management and strong seedling cultication is provided, and therefore application of the peony rapid cutting propagation technology in actual production is promoted, and the method has significance in large-scale production of peony seedlings.
Owner:HENAN UNIV OF SCI & TECH

Preparation method of nano silver chloride/chitosan fiber anti-bacterial dressing

The invention discloses a preparation method of a nano silver chloride/chitosan fiber anti-bacterial dressing. The method includes following steps: (1) pretreatment of a surface of a chitosan fiber nonwoven cloth: spraying an acid solution onto the surface of the chitosan fiber to enable the acid solution to infiltrate into the surface of the nonwoven cloth, treating the nonwoven cloth for 1-5 min and then washing the nonwoven cloth with deionized water; (2) soaking the pre-treated nonwoven cloth in a silver nitrate solution with a concentration of 0.0048-0.036 mmol/mL with a normal-temperature shaking operation for 30 min; (3) draining the nonwoven cloth and air-drying the nonwoven cloth until the water content is 30-40%; (4) uniformly spraying a 0.036-0.27 mmol/mL sodium chloride solution having an equal saturate water absorption amount onto the surface of the nonwoven cloth, wherein molar number of the sodium chloride is 1.2-1.5 times than that of adsorbed silver, and carrying out a reaction for 5-10 min; and (5) spraying deionized water and quickly washing the nonwoven cloth, draining the nonwoven cloth and vacuum-drying the nonwoven cloth at 50-60 DEG C. The preparation method is high in silver recycle ratio. A nano silver chloride anti-bacterial material is stable in physical and chemical performances, is excellent in anti-bacterial performance or bacteria-inhibiting peroformance, is good in fixation performance of silver chloride particles to the chitosan fiber, and can be used as a medical wound dressing.
Owner:FUZHOU UNIV

Beta-lactam twin antibiotic compound, preparation method thereof and use thereof

The invention relates to the technical field of medicines, in particular to a twin antibiotic compound formed by bonding each two parent nucleuses with the same structure of a beta-lactam antibiotic compound or of a derivative of the beta-lactam antibiotic compound with a dicarboxylic acid by two amido bonds, preparation method thereof and use thereof. The chemical structural general formula of the twin antibiotic compound is represented by a formula III. In the formula, R3 is a parent nucleus structure of a molecule of a penicillin compound or a derivative of the penicillin compound or a molecule of a cephalosporin compound or a derivative of the cephalosporin compound; and R may be alkyl and aryl or heteroaryl or substituted alkyl and substituted aryl or heteroaryl. In-vitro antibacterial experiments show that the beta-lactam twin antibiotic compound of the invention has remarkable antibacterial activity and is a novel antibacterial compound. The beta-lactam twin antibiotic compound of the invention can be used in the preparation of bacteriostats or bacteriacides as well as anti-infection medicaments. According to the general knowledge of pharmacy, the compound of the invention can be made into pharmaceutically acceptable salts or hydrates.
Owner:刘超美

Streptomycete antimicrobial production and method of preparing the same

The invention relates to a streptomyces antibacteria product and a method for manufacturing the same, belonging to the biotechnology field. GB-2 seeds of the streptomyces are proliferated and cultivated, then inoculated to undergo submerged ferment under 28 DEG C for 144-168 hours, then the fermentation liquor is filtrated, n-hexane and ethyl acetate is used for twice extractions to eliminate the lipid fat-soluble impurities, and then an ultrafiltration membrane is used to intercept the biological molecules with the molecular weight below 1,000, the filter liquor is made pass through a 1-2nm nanometer filtration membrane to obtain the antibacterial metabolic product. As proved by test, the antibacterial substance has the broad-spectrum antibacterial activity against bacteria and epiphyte, as well as the significant antibacterial activity against multiple pathogenic organisms and spoilage organisms. The antibacterial product provided by the invention has significant inhibitive effect on multiple pathogenic bacterium and moulds, thereby manifesting the efficient and broad-spectrum activity, simple method and low cost, with high applicable value and great prospect in the market in the respect of antiseptics, forage additives and medicine.
Owner:NANJING AGRICULTURAL UNIVERSITY

Self-assembled modified polylactic acid material of lysozyme and mushroom polysaccharide sulfate and preparation method thereof

InactiveCN102675674AGood biocompatibilityImprove surface biological propertiesProsthesisEscherichia coliStaphylococcus aureus
The invention belongs to the technical field of self assembling of the biomedical material and the biomacromolecule, and particularly relates to a self-assembled modified polylactic acid material of lysozyme and mushroom polysaccharide sulfate and a preparation method thereof. The self-assembled modified polylactic acid material of the lysozyme and the mushroom polysaccharide sulfate comprises base material and a modification layer, wherein the base material comprises surface amination polylactic acid material; the modification layer is obtained by carrying out surface modification on the surface of the base material by the layer-by-layer self-assemble technology; and the modification layer contains the lysozyme and the mushroom polysaccharide sulfate which are self-assembled alternately layer by layer on the surface of the base material. The surface of the polylactic acid material prepared by the method has good antibacterial activity for inhibiting staphylococcus aureus and escherichia coli, and the blood compatibility of the surface of the material is improved. Meanwhile, the preparation method for the material has the advantages of simple technology, moderate preparation condition and low cost and is easy to control.
Owner:WUHAN UNIV OF TECH

Preparation method of anti-bacteria cotton fabric containing AgO/TiO2 composite

The invention discloses a preparation method of an anti-bacteria cotton fabric containing an AgO/TiO2 composite. The preparation method comprises the following steps of: mixing AgO powders and TiO2 powders, and then performing ball milling on the mixed powders in a ball mill to obtain AgO/TiO2 composite anti-bacteria powders; then weighing a surface active agent which is then put into a reactor, adding deionized water in the reactor, then heating the mixed liquid, stirring the mixed liquid to dissolve the surface active agent, then adding the ultrafine AgO/TiO2 composite anti-bacteria powders in the mixed liquid, stirring the liquid continuously, finally adding an adhesive into the liquid, and stirring the liquid to obtain AgO/TiO2 composite anti-bacteria finishing agent suspending liquid; and soaking, washing and drying a cotton fabric, heating and stirring the AgO/TiO2 composite anti-bacteria finishing agent suspending liquid, soaking the cotton fabric into the AgO/TiO2 composite anti-bacteria finishing agent suspending liquid, then washing the cotton fabric by tap water under a room temperature, and drying the cotton fabric to obtain the anti-bacteria fabric containing the AgO/TiO2 composite. The preparation method solves the problems that the conventional preparation method of anti-bacteria fabrics is complex, the sterilizing speed of the fabrics is slow, and the anti-bacteria capability of the fabrics is weak.
Owner:XIAN UNIV OF TECH

Method for preparing shell-loaded nano-silver composite antibacterial material with assistance of microwaves

The invention discloses a method for preparing a shell-loaded nano-silver composite antibacterial material with the assistance of microwaves. The method comprises the steps that shell powder is pretreated; the shell powder is added to a silver nitrate solution, an additive is added to prepare a mixed solution, the mixed solution reacts in the microwave synthesis instrument, after the reaction is completed, deionized water washing is conducted, suction filtration and drying are conducted, and then the shell-loaded nano-silver composite antibacterial material can be obtained. By the adoption of the method for preparing the shell-loaded nano-silver composite antibacterial material with the assistance of the microwaves, shells are pretreated through an ultrasonic technique, impurities in a porous structure of the shells are removed, and the surfaces of the shells are activated. The method for preparing the shell-loaded nano-silver composite antibacterial material with the assistance of the microwaves has the advantages of shortening reaction time, improving productivity, preparing the material which is small in particle size, narrow and even in particle size distribution and high in purity, improving the physical-chemical properties of the material and the like; the reaction temperature is lowered, the reaction time is shortened, and the defect that by the adoption of a traditional method, a synthesized material is large in particle and prone to clustering is overcome; the antibacterial performance of the composite material is improved; the technology is simple, resource utilization of the wasted shells is achieved, waste materials are recycled, and cost is reduced.
Owner:THIRD INST OF OCEANOGRAPHY STATE OCEANIC ADMINISTATION

A broadspectrum efficient antimicrobial peptide Pb-CATH-OH1, a gene thereof, a preparing method of the peptide and applications of the peptide

A broadspectrum efficient antimicrobial peptide Pb-CATH-OH1, a gene thereof, a preparing method of the peptide and applications of the peptide are disclosed. The antimicrobial peptide Pb-CATH-OH1 is a straight-chain polypeptide. The sequence of the antimicrobial peptide Pb-CATH-OH1 is as follows: lysine-arginine-phenylalanine-lysine-lysine-phenylalanine-phenylalanine-arginine-lysine-isoleucine-lysine-lysine-glycine-phenylalanine-arginine-lysine-isoleucine-phenylalanine-lysine-lysine-threonine-lysine-isoleucine-phenylalanine-isoleucine-glycine-glycine-threonine-isoleucine-proline-isoleucine. A precursor gene comprises 528 nucleotides, and nucleotides from the number 433 site to the number 525 site code the antimicrobial peptide. The antimicrobial peptide is rich in basic amino acids, low in molecular weight, simple in structure, extremely high in broadspectrum antimicrobial activity, low in hemolysis and not liable to generate drug resistance and has activity for gram-positive bacteria, gram-negative bacteria and fungi. The antimicrobial peptide can be used as an additive for preparation of medicines, cosmetics, foods, feed, and the like which are resistant to pathogenic microorganism infection.
Owner:DALIAN UNIV OF TECH

Preparation method of quaternary ammonium salt polyvinyl alcohol-cellulose-graphene oxide composite membrane

The invention relates to a preparation method of a quaternary ammonium salt polyvinyl alcohol-cellulose-graphene oxide composite membrane. The preparation method comprises the following steps: dispersing cellulose nanocrystals (CNC) and graphene oxide (GO) into deionized water, and carrying out uniform ultrasonic dispersion to obtain composite dispersion liquid (CNC/GO) of the CNC and the GO; dissolving polyvinyl alcohol (PVA) into deionized water at the temperature of 90 DEG C by stirring, adding the CNC/GO dispersion liquid, evenly stirring and then pouring into a glass mould to form a membrane; immersing the PVA/CNC/GO composite membrane into an ethanol/aqueous solution which contains quaternary ammonium salt (DMAEMA-OB), a photocrosslinking agent (ethylene glycol dimethyl acrylate (EGDMA)) and a photoinitiator 2959 for 3h, and enabling the quaternary ammonium salt to be subjected to cross-linking reaction under the radiation of ultraviolet light for fixing the quaternary ammonium salt into a PVA matrix so as to obtain the quaternary ammonium salt polyvinyl alcohol/cellulose/graphene oxide composite membrane. The composite membrane has excellent water resistance, mechanical properties and thermal stability, thus being possibly applied to the field of active package.
Owner:JIANGNAN UNIV

Silver-iodide-doped bioactive glass as well as preparation method and application of silver-iodide-doped bioactive glass

The invention discloses silver-iodide-doped bioactive glass as well as a preparation method and an application of the silver-iodide-doped bioactive glass. The weight ratio of the silver iodide of silver-iodide-doped bioactive glass to the silver iodide of non-silver-iodide-doped bioactive glass is (90-100) to (1-10). The preparation method comprises the following steps of: weighing silver nitrate, potassium iodide and iodine according to a weight ratio of AgI; adding the non-silver-iodide-doped bioactive glass into absolute ethanol, ultrasonically processing, and fully dispersing; adding silver nitrate at first and then adding potassium iodide and iodine; uniformly ultrasonically stirring, centrifuging, filtering, washing deposits by de-ionized water, carrying out freeze drying, grinding, and sieving to obtain the silver-iodide-doped bioactive glass. The silver-iodide-doped bioactive glass is applied to preparation of drugs for preventing and treating various diseases. The silver-iodide-doped bioactive glass can be used for effectively promoting healing of human hard and soft tissue injury and inhibiting/killing bacteria, contains bioactive glass particles and silver iodide crystals, and is convenient to store, carry and use.
Owner:王林

Antibacterial protective environment-friendly composite polymer material and preparation method and application thereof

The invention discloses an antibacterial protective environment-friendly composite polymer material and a preparation method and application thereof, wherein the composite polymer material comprises the following components by weight: 20 parts to 30 parts of benzyl quaternary ammonium salt, 50 parts to 75 parts of a biocompatible high-molecular polymer, 15 parts to 30 parts of modified nano metaloxide, 10 parts to 20 parts of nano metal particles, 30 parts to 40 parts of modified fiber, 25 parts to 45 parts of trisilanol ethyl ester silsesquioxane, 5 parts to 10 parts of a silane coupling agent, 3 parts to 5 parts of ammonium persulfate, 3 parts to 5 parts of dimethyl carbonate, 8 parts to 15 parts of 3-mercaptopropyl trimethoxy silane, and 2 parts to 3 parts of allyl glycidyl ether. Thematerial is capable of blocking and self-cleaning apatter or air with viruses, bacteria or microorganisms, is antibacterial, capable of killing viruses, capable of being repeatedly used, good in shrinkage resistance, high in elastic property and easy to degrade, and can be used for manufacturing window cloth, air conditioners, air purifiers, screen windows, clothes, trousers and masks.
Owner:上海古太创意服务有限公司
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