39results about How to "Broad-spectrum high-efficiency antibacterial effect" patented technology

The present invention relates to a strain for food preservation and its antibacterial product, belonging to the field of food bio-technology. The antibacterial product produced by Bacillus subtilis strain fmbJ has obvious depressing effect for main pathogenic bacteria and putrefactive bacteria in the food, including 7 Gram-negative bacteria, 3 Gram-positive bacteria and 4 moulds. Its production process includes the steps: slope, shave-flask seed, seed tank, fermentation tank, separation extraction and antibacterial metabolic product.

The invention discloses a Yangtze alligator antimicrobial peptide Alligatorin 6 as well as an amino acid sequence thereof and an application of the Yangtze alligator antimicrobial peptide Alligatorin 6 in antibiosis. The antimicrobial peptide Alligatorin 6 is a mature peptide sequence of the antimicrobial peptide which is obtained by searching a Yangtze alligator gene database by virtue of screening and analyzing, wherein an amino acid sequence of the mature peptide sequence is as shown in a sequence table SEQ ID NO.1. By virtue of analysis and comparison, the Yangtze alligator antimicrobial peptide Alligatorin 6 has obvious difference from the amino acid sequences of all of the existing known antimicrobial peptides, and belongs to a novel antimicrobial peptide. According to an antimicrobial test, the Yangtze alligator antimicrobial peptide Alligatorin 6 has very strong antimicrobial activity on gram positive bacteria and gram negative bacteria, is broad-spectrum and efficient in antimicrobial action. Besides, the Yangtze alligator antimicrobial peptide Alligatorin 6 has the characteristics of low hemolytic activity, good salt tolerance, good heat tolerance and good heat stability, and can be applied to the fields of medicines, cosmetics, food fresh keeping and breeding industry.

Belonging to the technical field of biomedicine, the invention in particular relates to a natural antibacterial peptide QHA and application thereof. The natural antibacterial peptide QHA is composed of 30 amino acid residues, is straight chain polypeptide, and has a molecular weight of 3628.5Da and isoelectric point of 12.61. The antibacterial peptide QHA provided by the invention has the beneficial characteristics of small molecular weight, simple chemical synthesis method, efficient, broad-spectrum and efficient antibacterial action, and good stability, etc., thus having broad application prospects. In addition, the invention also relates to a coding gene of antibacterial peptide QHA and application thereof.

The invention relates to a streptomyces antibacteria product and a method for manufacturing the same, belonging to the biotechnology field. GB-2 seeds of the streptomyces are proliferated and cultivated, then inoculated to undergo submerged ferment under 28 DEG C for 144-168 hours, then the fermentation liquor is filtrated, n-hexane and ethyl acetate is used for twice extractions to eliminate thelipid fat-soluble impurities, and then an ultrafiltration membrane is used to intercept the biological molecules with the molecular weight below 1,000, the filter liquor is made pass through a 1-2nm nanometer filtration membrane to obtain the antibacterial metabolic product. As proved by test, the antibacterial substance has the broad-spectrum antibacterial activity against bacteria and epiphyte,aswell as the significant antibacterial activity against multiple pathogenic organisms and spoilage organisms. The antibacterial product provided by the invention has significant inhibitive effect onmu ltiple pathogenic bacterium and moulds, thereby manifesting the efficient and broad-spectrum activity, simple method and low cost, with high applicable value and great prospect in the market in therespect of antiseptics, forage additives and medicine.

The invention relates to application of natural host defense peptide Alligatorin5 to preparation of aquatic pathogenic bacterium resisting medicine. The invention also discloses application of the natural host defense peptide Alligatorin5 to preparation of an aquaculture animal immune activating agent. The invention further discloses application of the natural host defense peptide Alligatorin5 to preparation of aquaculture animal feed. The results of study using hairy crabs as experimental animals show that the Alligatorin5 can enhance the immune function of the hairy crabs; the immunity of the hairy crabs on bacterial infection is improved; the survival rate of the hairy crabs is improved. The Alligatorin5 has wide application prospects in the field of aquaculture.

The invention discloses migration-free antibacterial cellulose-based foam. The migration-free antibacterial cellulose-based foam is prepared from the following raw materials in parts by weight: 95 to 99 parts of water, 1 to 5 parts of cellulose, 0.1 to 0.3 part of a wet strengthening agent, 0.1 to 0.5 part of a surfactant, 0.01 to 0.2 part of a cross-linking agent and 0.03 to 0.2 part of an antibacterial agent. A migration-free antibacterial cellulose-based foam product is prepared through the following steps: mixing the weighed cellulose and water and defibering; (2) adding the wet strengthening agent, the surfactant, the cross-linking agent and the antibacterial agent, which are weighed in step (1), into a substance obtained by defibering; mixing and stirring, and filtering; drying for 8h to 48h at temperature in a range from room temperature to 60 DEG C. A preparation process of the migration-free antibacterial cellulose-based foam is simple and environmentally friendly; extra equipment is not needed and the product can be produced by a standard papermaking basic facility, so that the preparation process is suitable for industrial production.

The invention relates to application of natural host defense peptides Alligatorin4 to preparing aquatic pathogenic bacterium resistant medicines, aquaculture animal immunity activators and aquaculture animal feed. The application has the advantages that as shown by results of research on Chinese mitten crab which is an experimental animal, immunity functions of the Chinese mitten crab can be enhanced by the natural host defense peptides Alligatorin4, the bacterial infection resistance of the Chinese mitten crab can be improved, and the survival rate of the Chinese mitten crab can be increased; the natural host defense peptides Alligatorin4 have broad application prospects in the field of aquaculture.

The invention discloses a nanometer polymer antibacterial agent and a preparation method thereof. The invention utilizes the organic nanotechnology of emulsion polymerization to directly obtain the nanometer macromolecule product with antibacterial function through a one-step process. The particle size of the obtained product is in the range of 40-90nm, with large specific surface area and high utilization rate. At the same time, the surface of the antibacterial agent is positively charged, which can firmly capture and absorb harmful microorganisms and interfere with their physiological processes; The puncture damage will cause its death, realize the broad-spectrum and high-efficiency antibacterial effect, and have the characteristics of contact sterilization. In addition, the product of the invention has a stable structure, is not easy to migrate, is easy to disperse, has good compatibility with polymer materials, has a wide range of applications, and is low in cost.