The invention discloses a
rare cell filter and application thereof. The filter comprises a filter
pipe, wherein an opening is formed at one end of the filter
pipe; an elastic sealing head sliding along the inner wall of the filter
pipe is arranged inside the filter pipe; a
syringe sliding along the inner wall of the filter pipe is arranged above the elastic sealing head in a matching manner; the
syringe comprises a
bobbin with openings at two ends; a
barrel cover is arranged above one end of the
bobbin; a filter support ring is arranged at the opening of the
bobbin below the
barrel cover; a micro-hole array filter membrane with covered opening is arranged on the filter support ring; the bobbin, the elastic sealing head and the filter support ring form a
recovery pool; the filter membrane is formed by a conical micro-hole and dual
layers of micro-hole arrays with different calibers; a sample tube is arranged inside the
recovery pool; one end of the sample tube passes through the filter support ring and extends into a filter cavity; the other end of the sample tube passes through the elastic sealing head and extends into a sealed cavity. By adopting the
rare cell filter, the problems of poor selectivity and sensitivity for capturing rare cells are solved, and the
rare cell filter is applicable to efficient capture, cultivation and analysis of circulating
tumor cells and fetal circulation cells in human
peripheral blood.