59 results about "Trichophyton" patented technology

A methane-utilizing microorganism capable of producing L-amino acid, for example, bacteria belonging to type I, type X or type II in the taxonomic categorization methane-utilizing bacteria such as Methylomonas albus, Methylococcus capsulatus and Methylosinus trichosporium, is cultivated in a culture medium in contact with gas containing methane which is the main source of carbon, to allow the L-amino acid to be produced and accumulated in the medium, and the L-amino acid is collected from the medium.

External preparations for athlete's foot treatment capable of enhancing patient's compliance and capable of reducing the symptom of rubefaction, comprising an anti-trichophyton drug mixed with at least one compound selected from among 1-menthol, menthol analogue compounds and bactericidal compounds.

The invention relates to the field of clothing, in particular to a medical textile with an antibacterial function. The medical textile is characterized in that a silver ion antibacterial agent, a soil release finishing agent and a permethrin mosquito prevention finishing agent are adopted to treat the textile, so that the textile has antibacterial, soil release and mosquito prevention functions. The processing steps are as follows: fabric is pretreated, a finishing solution with antibacterial, soil release and mosquito prevention functions is prepared, a working solution is padded, and the fabric is dried, baked, packaged, and made into loungewear. The medical textile has a broad-spectrum and efficient antibacterial action on multiple harmful bacteria such as staphylococcus aureus, pneumobacillus, colibacillus, pseudomonas aeruginosa, candida sporogenes and trichophyton mentagrophytes, the antibacterial rate to the harmful bacteria such as staphylococcus aureus is still above 99% after the medical textile is washed for 100 times, the staying and biting of mosquitoes can be reduced effectively, the medical textile has repellent and contact actions on various mosquitoes such as culex, aedes aegypti, ticks and bugs, and the loungewear made of the fabric has obvious antibacterial, deodorization, relieving itching and mosquito prevention functions.

The invention relates to the field of clothing, in particular to a piece of antibacterial, mosquito-and-insect-repellent functional loungewear. The antibacterial, mosquito-and-insect-repellent functional loungewear is characterized in that silver ion antibacterial agent and permethrin mosquito-and-insect-repellent finishing agent are used for processing a textile, and the processing steps are fabric preprocessing, finishing solution preparation, padding, drying, preshrinking and clothing making. The antibacterial, mosquito-and-insect-repellent functional loungewear has a broad-spectrum, high-effective antibacterial effect on a variety of harmful bacteria, such as staphylococcus aureus, pneumobacillus, colibacillus, pseudomonas aeruginosa, candida albicans and trichophyton mentagrophytes, the bacteria inhibition rate of the antibacterial, mosquito-and-insect-repellent functional loungewear on staphylococcus aureus and other harmful bacteria still reaches more than 99 percent after the antibacterial, mosquito-and-insect-repellent functional loungewear is washed for 100 times, the stay and bite of mosquitoes are effectively reduced, the antibacterial, mosquito-and-insect-repellent functional loungewear has repelling and killing effects on various mosquitoes and insects, such as culex, aedes aegypti, tick and bedbug, and the loungewear made of the fabric has remarkable antibacterial, deodorizing, itch-relieving and mosquito-and-insect-repellent functions.

The emergence of opportunistic and antifungal resistant strains has given rise to an urgent need for a rapid and accurate method for the detection of fungal pathogens. In this application, we demonstrate the detection of medically important fungal pathogens at the species level. The present method, which is based on a nucleotide hybridization assay, consists of a combination of different sets of fluorescent beads covalently bound to species specific capture probes. Upon hybridization, the beads bearing the target amplicons are classified by their spectral addresses with a 635 nm laser. Quantitation of the hybridized biotinylated amplicon is based on the fluorescent detection with a 532 nm laser. Using this technology we designed and tested various multiplex formats, the performance of forty eight species specific and group specific capture probes designed from sequence analysis in the D1 / D2 region of ribosomal DNA, internal transcribed spacer regions (ITS), and intergenic spacer region (IGS). Species-specific biotinylated amplicons (>600 bp) were generated with three sets of primers to yield fragments from the three regions. The developed assay was specific and relatively fast, as it discriminated species differing by one nucleotide and required less than 50 min following amplification to process a 96 well plate with the capability to detect up to 100 species per well. The sensitivity of the assay allowed the detection as low as 102 genome molecules in PCR reactions and 107 to 108 molecules of biotinylated amplification product. This technology provided a rapid means of detection of Trichosporon species and had the flexibility to identify species in a multiplex format by combining different sets of beads. The assay can be expanded to include all known pathogenic fungal species.

A natural preservative composition obtained from plant materials provides antimicrobial activity for use as an antifungal agent. The antifungal agent is effective in inhibiting the growth of Epidermophyton floccosum, Trichophyton mentagrophytes and Microsporum canis. The antimicrobial agent has a MIC as low as 0.03 μl / ml capable of inhibiting and / or killing these organisms. The antimicrobial agent includes selective mixtures of Origanum vulgare L., Thymus vulgaris L., Cinnamomum zeylanicum Nees, Rosmarinus officinalis L., Lavandula officinalis L., Mentha piperita L., Citrus Limon L., Hydrastis canadensis L. and Olea europaea L.

The present invention relates to antifungal composition with two or more active components and its application in medicine, cosmetics and sanitary articles. The externally applied antifungal composition butenafine, butenafine hydrochloride or ketoconazole in 0.1-10 wt%, and mometasone furoate in 0.001-10 wt%, except substrate. Animal test shows that the antifungal composition has obvious synergistic effect in resisting Trichophyton mentagrophytes infection.

The invention relates herba dracocephalum heterophylli volatile oil possessing the bacteriostatic and germicidal action and its application. The method adopts steam distillation to extract the herba dracocephalum heterophylli volatile oil and adopts gas-chromatography / mass spectra to analysis the volatile oil, identifying the 83 components and 89.83% total content. The volatile oil can kill and suppress the staphylococcus, streptococcus, gonococcus, enterobacter, Escherichia, salmonella, shigella, pseudomonas, bacillus, oidiomycin, cryptococcus, aspergillus, penicillium, mucor, epidermophytin, micromonospora, trichophyton and other bacteriums. The herba dracocephalum heterophylli volatile oil is used for foodstuffs, drugs, health products, cosmetic products and other industries.

The invention discloses an oil-in-water compound ketoconazole nano-medicament. The grain diameter of the medicament is 1-100nm. The oil-in-water compound ketoconazole nano medicament comprises the following raw materials in percentage by weight: 0.01-8.0 percent of ketoconazole, 0.01-10 percent of eugenol, 0.001-5.0 percent of clobetasol propionate, 25.0-45.0 percent of surfactant, 0-10.0 percentof cosurfactant, 0.1-25.0 percent of oil and the balance of distilled water. The oil-in-water compound ketoconazole nano-medicament can be used for treating stubborn skin mycotic infection, mycodermatitis, chronic mucocutaneous candidiasis, dermatitis blastomycosis, coccidioidomycosis, histoplasmosis, chromoblastomycosis and paracoccidioidomycosis, and dermatomycosis and tinea versicolor caused by dermatophyte and microzyme as well as trichophyton disease, scytitis and pruritus. The oil-in-water compound ketoconazole nano-medicament has the advantages of strong osmosis, favorable stability, favorable infiltrating property, durable acting time, remarkable effect, low cost, simple preparation method and convenience in popularization and application.

The invention relates to a cinnamomum longepaniculatum leaf volatile oil beta-cyclodextrin clathrate compound serving as a functional biological feed additive and a preparation method thereof. The preparation method comprises the following steps of: adding cinnamomum longepaniculatum leaf volatile oil dissolved in an organic solvent into aqueous solution containing beta-cyclodextrin, and stirring. The cinnamomum longepaniculatum leaf volatile oil beta-cyclodextrin clathrate compound has the characteristics of mild clathrate condition, simplicity of operation, easy control and high clathrate yield. The prepared clathrate compound makes the cinnamomum longepaniculatum leaf volatile oil in the solid state and convenient to mix for livestock and poultry, the medicinal effect of the volatile oil can be protected, and the palatability is improved, so the defects of irritation, volatility and the like due to the direct adoption of the volatile oil are overcome. The clathrate compound has theeffects of resisting bacteria (escherichia coli, salmonella and staphylococcus aureus), resisting fungi (trichophyton mentagrophytes, microsporum canis and microsporum gypseum), killing insect pests,easing pain and resisting inflammation, and is a good biological feed additive which is used for resisting diseases and promoting growth and avoids residue.

The invention relates to the clothing field, particularly to an antibacterial functional medical textile. The textile is characterized in that a silver ion antibacterial agent, a soil-releasing finishing agent and a permethrin mosquito repellent finishing agent are used for processing the textile to enable the textile to acquire antibacterial, soil-releasing and mosquito repellent functions. A processing method includes processing fabric into a semi-product for after-treatment after steps of pretreatment, dyeing or printing and the like; preparing a functional finishing agent which is antibacterial, soil-releasing and mosquito repellent; padding the working solution; drying; baking; packaging; and manufacturing leisure wear. The textile has broad-spectrum high-effect antibacterial functions on a plurality of harmful bacteria such as staphylococcus aureus, pneumobacillus, escherichia coli, pseudomonas aeruginosa, monilia albican and trichophyton mentagrophytes, the bacteriostasis rate of the textile for the harmful bacteria such as staphylococcus aureus after washed for 100 times can still reach above 99%, stay and biting of mosquitoes can be reduced effectively, repellent and contact toxicity functions can be performed on various mosquitoes such as culex, Aedes aegypti, ticks and bugs, and the leisure wear made of the textile is provided with obvious antibacterial, deodorant, itching relieving and mosquito repellent functions.

Provided is an anti-Trichophyton agent having as an active ingredient a compound having a 2-(1H-pyrazol-1-yl)phenol backbone represented by formula (I) or (II), or a salt of the compound.

The pharmaceutical composition is useful for treating epithelial tumors in a subject and contains at least two antigens and a pharmaceutically acceptable carrier, where each of the antigens induces or is capable of inducing a cutaneous delayed type hypersensitivity (DTH) response in the subject. This composition is particularly useful in treating epithelial tumors, such as warts or verrucae, that are induced by or related to papillomavirus. Antigens useful in the present pharmaceutical composition are anergy panel antigens, such as killed mumps virus, candida extract, trichophyton extract or comparable antigenic extracts. An additional pharmaceutical composition, also useful for treating epithelial tumors, contains at least one antigen that induces or is capable of inducing a cutaneous DTH response in a subject, at least one cytokine or colony stimulating factor and a pharmaceutically acceptable carrier. Kits containing these pharmaceutical compositions are useful for this immunotherapy.

The present invention provides an antifungal agent for topical use and remedy for athlete's foot that comprises a new combination of medicines and has a strong antifungal activity against both genus Trichophyton and genus Candida. The antifungal agent for topical use and remedy for athlete's foot contain amorolfine with butenafine or terbinafine.

The invention provides a compound bactericide with bacteriostatic or bactericidal activity. The composition comprises, by weight, 40% to 50% of linalool, 18% to 25% of terpilenol, 8% to 15% of geraniol, 2% to 4% of beta-cyclocitral, 2.5% to 5% of nerol, 1% to 3% of myrcene, 1% to 3% of ocimene, 3% to 6% of ionone and 5% to 8% of 2H-beta-ionone. Antibacterial and bacteriostatic drug sensitivity tests show that the bactericide artificially prepared on the basis of natural essential oil components has a broad-spectrum inhibition effect on bacteria and fungi. The bactericide has bacteriostatic andbactericidal effects on bacteria (escherichia coli, bacillus subtilis, staphylococcus aureus, staphylococcus epidermidis and the like) and fungi (candida albicans, Schlechospora crassa, trichophytonrubrum, saccharomyces cerevisiae and the like), and particularly has an obvious effect on zoonosis. The bactericide can be applied to development of zoonosis infection and other sterilization products.

The invention provides application of an evodiamine derivative in preparation of a medicine for treating superficial fungal infection. The evodiamine derivative disclosed by the invention is prepared by taking a methyl anthranilate compound and tryptamine as initial raw materials through amine-ester exchange and a one-step ring closing reaction catalyzed by Lewis acid. The evodiamine derivative disclosed by the invention can show good antibacterial activity on three fungi, namely trichophyton rubrum, trichophyton mentagrophytes and candida albicans. Moreover, cell walls, cell membranes and organelles of fungal spores are destroyed to a certain extent, the hydrophobicity of fungal biomembranes can be influenced to a certain extent, phenomena of dark red erythema, skin hardening and generation of a large amount of scurf caused by errhysis spots of skin subjected to dermabrasion treatment can be obviously relieved, and phenomena of thickened epidermal layer of skin tissue, small-area epidermal layer necrosis, cuticle small-area parakeratosis and the like are avoided. The evodiamine derivative has low toxicity and low drug resistance and can be applied to preparation of drugs for treating the superficial fungal infection.

The invention discloses a plant fiber and chemical fiber blended yarn. The yarn is formed by blending plant fibers matched with chemical fibers. The plant fibers are sisal fibers, castor-oil plant fibers, or aupoz fibers. The chemical fibers are one or more selected from spandex, acrylic fibers, chinlon, modal, tencel, and viscose. The plant fiber and chemical fiber blended yarn is smooth in material surface, good in air permeability, and is light and thin, and is heat insulating. The yarn can resist attack of Escherichia coli O157, staphylococcus aureus, tinea versicoeor bacteria, red trichophyton, trichophyton mentagrophytes, candida albicans, and other pathogenic bacteria.

An anti-Trichophyton film containing calcium hydrogen carbonate and an anti-Trichophyton forming agent enable easy formation, on a human skin, of an antibacterial film containing calcium hydrogen carbonate while assigning antibacterial effect possessed by a natural material thereto by using scallop shell as a raw material, and form an antibacterial film of calcium hydrogen carbonate with the antibacterial effect of the natural material added thereto through a simple structure, thereby enhancing the curative effect to athlete's foot. The anti-Trichophyton film forming agent is obtained by mixing a powder obtained by calcinating scallop shell mainly composed of calcium carbonate with distilled water. Remedies for dermatophytosis are prepared by grinding and calcinating scallop shells having a crystalline structure due to the calcite structure of calcium carbonate.

The invention provides a preparation method of antibacterial sol for shoemaking and an antibacterial finishing method. The preparation method and the antibacterial finishing method include: using TEOSas the precursor, EtOH as the solvent and HNO3 as the catalyst, adding a certain amount of GPTMS and TH, electrically stirring for 5 hours at hydrolysis temperature of 30 DEG C, and standing at roomtemperature for a certain period of time to obtain the transparent antibacterial sol; using a padding finishing process to perform antibacterial finishing on lining fabric for shoes, soaking the fabric into the transparent antibacterial sol for a certain period of time, using a rolling manner to press the transparent antibacterial sol into the gaps of the fabric, and removing the redundant transparent antibacterial sol at the same time. Compared with the prior art, the antibacterial finishing method has the advantages that the two-dipping two-rolling process with the pick up being 70-80% is used under the conditions that dipping time is 10 seconds, pre-drying temperature is 130 DEG C, pre-drying time is 2.5 minutes, drying temperature is 190 DEG C and drying time is 40 seconds, the processed shoe material is good in antibacterial effect on Candida albicans and Trichophyton rubrum, and the antibacterial rate is larger than 90%.

The invention discloses a shoe sole adhesive. EVA glue is utilized as the shoe sole adhesive, and the EVA glue is prepared from main ingredients of EVA resin, water and n-butyl alcohol which cooperate with hydrolyzed peach gum and modified starch. The prepared adhesive disclosed by the invention has good strength, is convenient to use, avoids volatile toxic matter generation in a producing and use process and achieves safe and environment-friendly effects; when the shoe sole adhesive is applied to the field of shoe sole adhesion, an adhesion strength is not smaller than 3.0KN / m, and the problem that the shoe sole is prone to degumming is avoided; by means of a synergistic effect of adding the hydrolyzed peach gum and the modified starch, the adhesion strength of the adhesive is obviously improved; furthermore, an antibacterial rate of the adhesive is greatly improved, especially an inhibiting effect on trichophyton mentagrophytes is obvious; thus, dermatophytosis generation is avoided, health and safety of feet of a shoe wearer are guaranteed, and comfortableness is obviously improved.

The invention discloses a novel compound II with antifungal activity. The chemical components of Selaginella pulvinata Maxim are subjected to systematic intensive study, and the spectrum and mass spectrometric data analysis proves that the novel compound II is separated from the Selaginella pulvinata Maxim. The in-vitro antifungal activity research proves that the compound II disclosed by the invention has the effects of obviously inhibiting multiple pathogenic fungi such as Candida albicans, aspergillus fumigatus, trichophyton rubrum and alpha fungus, is low in toxicity and safe in clinical administration, and is expected to be developed into a novel antifungal medicament.

The invention relates to an antibacterial peptide and an application thereof in preparation of medicines or cosmetics. The antibacterial peptide has significant inhibitory activity on human pathogenicfungi trichophyton rubrum, and the compound also has the advantage of low toxicity, so that the antibacterial peptide can be used for preparing antifungal drugs and cosmetics.

The invention provides freesia hybrida essential oil with antibacterial activity as well as a preparation method and application of the freesia hybrida essential oil. The freesia hybrida essential oilis obtained by distilling and extracting freesia hybrida flowers in a blooming period by adopting a steam distillation method. The results of antibacterial and bacteriostatic drug sensitivity tests,a minimum inhibitory concentration (MIC) and a minimum bactericidal concentration (MBC) show that the essential oil has an antibacterial effect on bacteria (escherichia coli, bacillus subtilis, staphylococcus aureus, staphylococcus epidermidis and the like) and fungi (candida albicans, Shenkei sporidium, trichophyton rubrum, saccharomyces cerevisiae and the like), and presents a broad-spectrum inhibition effect on bacteria and fungi. Therefore, it is found that the freesia hybrida essential oil can be used for development and application of sterilization products and daily products.

The invention discloses compounds with fungus resistance and antineoplastic activity and a preparation method thereof. The chemical components of selaginella pulvinate are researched systematically and deeply; as shown by spectrum and mass spectrum data analysis, a compound A and a compound B with novel structures are obtained by separating from the selaginella pulvinate. as shown by fungus resistance and antineoplastic activity research in vitro, the compound A and the compound B have obvious inhibiting effects on multiple pathomycetes, comprising candida albicans, smoke-colored aspergillus, red trichophyta, alpha fungus and the like. The compound B has obvious inhibitory activity on leukemia, lung cancer, gastric cancer, nasopharyngeal carcinoma, liver cancer and cervical cancer tumours and the like. The compounds can be conveniently prepared into multiple dosage forms and is convenient to take clinically.

The invention provides a method for preparing a trichophyton scanning electron microscope sample. When a sample is fixed, the sample is sequentially treated by at least two kinds of glutaraldehyde solution with different concentration, and the concentration of the latter glutaraldehyde is higher than that of the former glutaraldehyde. Virulent osmic acid is not used in the method, and the glutaraldehyde with gradient concentration is innovatively used for multiple times of fixing, so the fixing effect is good, the method is safe and convenient, and a new method is provided for preparing the trichophyton scanning electron microscope sample.

Provided is a fibrous structural material having an anti-trichophyton activity against trichophyton which is a kind of fungus, and further having an anti-trichophyton spore activity against the spores of the trichophyton. This anti-trichophyton fibrous structural material contains a silver-loaded acrylonitrile-based fiber obtained by heat-treating the acrylonitrile-based fiber containing a silver-based compound in pH 1-6 range, as an active ingredient. The anti-trichophyton fibrous structural material has an excellent anti-trichophyton activity against the trichophyton, and further anti-trichophyton spore activity against the spores of the trichophyton. Further it has an anti-bacterial property against bacteria, and in addition, a so-called photo-catalytic activity function capable of improving the antibacterial activity by the irradiation of light.

The invention provides a method for preparing a trichophyton sample for a scanning electron microscope. The method is mainly characterized in that when the sample is fixed, ultrasonic wave aided treatment is applied during application of treatment with a glutaraldehyde solution. Instead of application of virulent osmic acid, ultrasonic wave aided treatment with glutaraldehyde is innovatively applied, and the new method is provided for preparing the trichophyton sample for the scanning electron microscope and has the advantages of excellent fixing effects, simplicity and convenience in operation, safety and low toxicity.

The invention provides application of carbonized sanguisorba roots in prevention and treatment of tinea corporis and cruris and tinea manus and pedis, and application in preparation of medicines or daily necessities. Meanwhile, the invention provides application of one or more of gallic acid, pyrogallic acid, methyl gallate, ethyl gallate and protocatechuic aldehyde in prevention and treatment oftinea corporis and cruris and tinea manus and pedis, and application in preparation of medicines or daily necessities. Trichophyton rubrum is a main pathogenic bacterium of tinea corporis and cruris and tinea manus and pedis. The invention shows that the carbonized sanguisorba roots can significantly inhibit the growth of the trichophyton rubrum, and the effect is equivalent to that of common traditional Chinese medicines sophora flavescens and golden larch bark for skin tinea. After the carbonized sanguisorba roots are administrated, the growth of the trichophyton rubrum is remarkably inhibited through ocular lens observation. Clinical curative effect observation shows that after carbonized sanguisorba root gel with the content of 0.5% is used for treating for 4 weeks, the cure rate of patients reaches 96.15%, and half of the patients are cured. Meanwhile, the main components including the gallic acid, the pyrogallic acid, the methyl gallate, the ethyl gallate and the protocatechuic aldehyde in sanguisorba roots all have a remarkable effect of resisting the trichophyton rubrum, and the content is not reported.

The invention relates to an application of an antibacterial peptide to preparation of medicines or cosmetics. The antibacterial peptide has significant inhibitory activity on human pathogenic fungi namely trichophyton rubrum, and the compound also has the advantage of low toxicity, and therefore, the compound can be used for preparing antifungal medicines and cosmetics.

The invention relates to the field of clothing and in particular relates to a processing technology of a medical insect-proof and odor-resisting textile fabric. The processing technology comprises thefollowing processing steps: carrying out steps of pre-treating, dyeing or printing and the like on a fabric to obtain a semi-finished product and waiting for after-finishing treatment; preparing finishing liquid with antibacterial, stain-releasing and anti-mosquito functions; padding a working solution; drying; pre-shrinking and packaging. The medical insect-proof and odor-resisting textile fabric provided by the invention has a broad-spectrum and efficient antibacterial effect on various harmful bacteria including staphylococcus aureus, pneumobacillus, escherichia coli, pseudomonas aeruginosa, candida sporogenes, trichophyton mentagrophytes and the like, is used for effectively reducing staying and biting of mosquitoes and has dispelling and contact killing effects on various mosquitoes,such as culex mosquitoes, aedes aegypti mosquitoes, ticks and bugs; loungewear produced by the fabric has remarkable antibacterial, odor-resisting, itching-relieving and anti-mosquito functions.