21 results about "Trichophyton" patented technology

The invention relates to the technical field of biological medicine, in particular to application of a combination of a Cd1 and Mdr1 double-target inhibitor and an azole drug in preparation of an antifungal drug. Based on the fact that the compound as shown in the formula (I) can be used as a CCd1 and Mdr1 double-target inhibitor, the inhibition effect of the compound on candida albicans, candida auricula, candida glabrata, candida tropicalis, trichophyton rubrum and trichophyton indicus when the compound is combined with azole drugs is further evaluated, and the result shows that the compound as shown in the formula (I) has no obvious antibacterial activity on various fungi, and can be used for preparing a medicine for treating various fungi. The drug resistance of CCd1 and Mdr1 overexpression drug-resistant fungi can be reversed, the activity of Candida albicans, Candida auricula, Candida glabrata, Candida tropicalis, Trichophyton rubrum and Trichophyton indicus can be synergistically inhibited when the drug is combined with azole drugs, the treatment dosage of the azole drugs is effectively reduced, and the drug toxicity is small. Therefore, the compound shown in the formula (I) can improve the antifungal effect of azole drugs and reduce the drug resistance of the azole drugs.

The invention discloses a copper-based multifunctional close-fitting textile and a preparation method thereof. The copper-based multifunctional close-fitting textile comprises a copper conductive fiber layer which is blended and woven with any other fibers; the natural fiber layer is selected from any natural fiber and is blended with the copper conductive fiber layer, the product integrates antifungal, deodorizing and dustproof synergy and is selectively applied to various use fields, and the blended spinning of the copper conductive fiber layer and the natural fiber layer can make the antistatic performance be improved in a breakthrough manner; in a dry environment, due to static electricity generated by friction in natural fibers, copper ions can quickly disperse electrostatic charges and guide the electrostatic charges to the ground through an electron conduction mechanism, and static electricity accumulation is eliminated. Dust prevention is realized by electrostatic adsorption of particles. The copper ions can destroy bacterial cell membranes and inhibit reproduction of the bacterial cell membranes, and can treat common bacteria such as escherichia coli and staphylococcus aureus and fungi such as trichophyton rubrum and trichophyton asthenia. The photocatalytic material is used for photothermal catalytic decomposition of peculiar smell molecules.

The invention relates to the technical field of pharmacy, in particular to an aryl dihydronaphthalene type lignan analogue with antibacterial activity as well as a preparation method and application thereof, and the aryl dihydronaphthalene type lignan analogue is a compound with a structure as shown in a formula (I) or a pharmaceutically acceptable prodrug thereof. The specific preparation method comprises the following steps: (1) carrying out ring opening on sesamin ether bonds to prepare acetate 2; (2) performing deacetylation protection on the compound 2 to prepare alcohol 3; and (3) carrying out Des-Martin oxidation on the alcohol 3 to prepare aldehyde 4 and aldehyde 5. The aryl dihydronaphthalene lignan analogue synthesized by the invention has certain activity on Candida albicans (C.albicans), Cryptococcus neoformans (C.neoformans) and T.mentagrophytes (T.mentagrophytes), the compound 5 has good activity on the three types of bacteria, the IC50 values of the three types of bacteria are respectively 28.96 mu M, 17.13 mu M and 41.35 mu M, and the aryl dihydronaphthalene lignan analogue has certain application prospects in the development of corresponding medicines.

The application belongs to the technical field of natural plant extracts and application, and particularly relates to azafran volatile oil and application thereof in preparation of antifungal bacteriostatic products. In the application, the azafran is soaked in water and then distilled to obtain azafran volatile oil. The obtained azafran volatile oil shows good bacteriostasis, especially in inhibiting fungal strains such as Candida albicans, Malassezia furfur, Trichophyton mentagrophytes and Propionibacterium acnes. The application develops a new use of azafran volatile oil in preparation of antifungal bacteriostatic products.

The application discloses Bacillus safensis HNXJ-B1 and application thereof, is preserved in China Microorganism Strain Preservation Management Committee general microorganism center, and its preservation number is: CGMCC NO: 32527, and the preservation date is November 7, 2024.The application is identified by 16S rDNA strain, and it is confirmed that HNXJ-B1 is Bacillus safensis.The inhibition effect on Ralstonia solanacearum, Diaporthe sclerotioides, Trichophyton mentagrophytes and Malassezia is obvious, can simultaneously inhibit plant disease pathogenic bacteria and animal pathogenic fungi, and has wide application prospect.

This invention relates to the field of traditional Chinese medicine technology, and more particularly to a traditional Chinese medicine composition and its application in the preparation of antifungal drugs. The composition provided by this invention comprises Dioscorea hypoglauca, Cnidium monnieri, Bistorta officinalis, Dioscorea nipponica, Murraya paniculata, Dioscorea opposita, Polygonum multiflorum, and Terminalia chebula. This composition has the effect of inhibiting the growth of superficial dermatophytes (such as Trichophyton rubrum and Candida albicans), which helps to reduce the occurrence of superficial dermatophyte infections and has the potential to be developed into a drug for treating superficial dermatophyte infections.

The invention relates to the field of dermatological external preparations, in particular to a compound external ointment for treating trichophyton rubrum infection and a preparation process of the compound external ointment. The ointment specifically comprises the following components in percentage by weight: 0.50-1.50% of an antifungal active ingredient; 0.50% to 2.00% of saturated phosphatidylcholine; 0.20%-0.40% of a cross-linked acrylic rheology modifier; 4.0 to 10.0% of an oil phase; 0.10%-0.30% of a cationic film forming agent; 0.02 to 0.05 percent of a metal ion chelating agent; and water to 100%. And the pH value is adjusted to 4.6-4.9. Through cooperation of the saturated phosphatidylcholine, the cross-linked acrylic acid gel, the cationic film-forming agent and the chelating agent and pH control, the formula does not collapse, does not cause phase separation and is stable in release in the presence of sweat, the effective dose of the skin superficial layer can be maintained, and trichophyton rubrum can be continuously inhibited.

The present application relates to the technical field of biological medicine, in particular to the application of Cdr1 and Mdr1 double-target inhibitor combined with azole drugs in the preparation of antifungal drugs. Based on the compound shown in formula (I) can be used as Cdr1 and Mdr1 double-target inhibitor, the inhibitory effect of the compound on Candida albicans, Candida auris, Candida glabrata, Candida tropicalis, Trichophyton rubrum and Trichophyton indiana combined with azole drugs was further evaluated. The results show that the compound shown in formula (I) itself has no obvious antibacterial activity on various fungi, but can reverse the drug resistance of Cdr1 and Mdr1 overexpression drug-resistant fungi. The combination of the compound with azole drugs can synergistically inhibit the activity of Candida albicans, Candida auris, Candida glabrata, Candida tropicalis, Trichophyton rubrum and Trichophyton indiana, effectively reduce the therapeutic dose of azole drugs, and the drug toxicity is small. Therefore, the compound shown in formula (I) can improve the antifungal effect of azole drugs and reduce the drug resistance of azole drugs.

The present invention relates to an aromatic ring substituted pyrazole derivative and the use thereof. The aromatic ring substituted pyrazole derivative has a structure as shown in formula I, wherein Ar1 is any one of phenyl, substituted phenyl, naphthyl, substituted naphthyl, substituted anthryl, phenanthryl, substituted phenanthryl, fluorenyl, substituted fluorenyl, pyrrolyl, substituted pyrrolyl, pyridyl and substituted pyridyl; Ar2 is any one of phenyl, substituted phenyl, naphthyl, substituted naphthyl, substituted anthryl, phenanthryl, substituted phenanthryl, pyrrolyl, substituted pyrrolyl, pyridyl and substituted pyridyl; R1 is selected from hydrogen, halogen atom, C1-C6 alkyl, halogen substituted C1-C5 alkyl, C1-C5 alkoxy, C2-C4 alkenyl, nitro and phenyl; and R2 is selected from hydrogen, halogen atom, carboxyl, carboxyl C1-C3 alkyl, hydroxyl, and C1-C6 alkyl. The compound can effectively inhibit Microsporum canis, Microsporum gypseum and Trichophyton mentagrophytes, has a low toxicity, and can be used in antifungal application, in particular in veterinary clinical antifungal application.

This invention discloses a preparation method and application of a compound biological enzyme quaternary ammonium salt formulation for pet disinfection. The formulation comprises a compound quaternary ammonium salt, peony bud extract, lysozyme, lysostaphylococcal enzyme, lactic acid, sodium hyaluronate, and water. This invention scientifically combines the compound quaternary ammonium salt with various biological enzymes (lysozyme and lysostaphylococcal enzyme), plant extracts (peony bud extract), and organic acids (lactic acid), fully leveraging the synergistic effect of each component and overcoming the shortcomings of single-component formulations, such as narrow bactericidal spectrum, easy development of drug resistance, and high skin irritation. This formulation exhibits rapid and efficient killing effects against various microorganisms, including Salmonella typhimurium, Escherichia coli, Staphylococcus aureus, Candida albicans, Trichophyton mentagrophytes, and poliovirus.

This invention discloses a biofilm-forming microbial consortium with acrylonitrile degradation function, its preparation method, and its application. The microbial consortium consists of *Agrobacterium parakneissus*, *Burkholderia szechuanensis*, *Trichophyton spp.*, *Rhodococcus rubrum*, and *Mycobacterium tumefaciens*; the ratio of viable bacteria of *Burkholderia parakneissus*, *Burkholderia szechuanensis*, *Trichophyton spp.*, *Oligotrophomonas spp.*, and *Trichophyton spp.* is 3:1:1:1:1. This microbial consortium has a stable microbial community structure and can rapidly form a stable biofilm on the surface of biofilter packing material, exhibiting high acrylonitrile degradation efficiency. It is simple to operate, low in cost, and requires only a small amount of additional inorganic nutrients during treatment, without causing secondary pollution, making it an environmentally friendly technology. Its application prospects in the treatment of acrylonitrile-containing wastewater (gas) are broad.

The invention discloses an impatiens balsamina gel pharmaceutical composition for onychomycosis and a drug delivery system thereof, the onychomycosis treatment system comprises: a treatment gel, the active component of which comprises an organic solvent extract of impatiens balsamina petals; the fixing patch device is used for bearing the treatment gel and continuously applying the treatment gel to the affected nail; the fixing patch device comprises a breathable base material, a pressure-sensitive adhesive layer arranged on the breathable base material, and a sponge pad connected to the pressure-sensitive adhesive layer and used for adsorbing the treatment gel. The pharmaceutical composition has a synergistic antifungal effect, natural active ingredients such as naphthoquinone and flavonoid in the white garden balsam petals have broad-spectrum inhibitory activity on trichophyton rubrum, trichophyton mentagrophytes and pseudomonas aeruginosa, the natural active ingredients and 60% ethanol form a synergistic permeation system under a reflux process at 70 + / -2 DEG C, and the deck penetrating efficiency of the pharmaceutical composition is remarkably improved.

Methods and compositions for treating, preventing and controlling fungal infections, including superficial infections, using compounds of the β-carboline class are disclosed. Pharmaceutical compositions comprising β-carbolines alone, or in combination with therapeutically effective amounts of an antimycotic, are administered to a subject to treat or prevent a superficial fungus infection such as those caused by fungi selected from the Candida or Trichophyton genus, infections such as dermatomycosis, diaper rash (yeast dermatitis), athletes' foot (tinea pedis), jock itch (tinea cruris), ringworm (tinea capitis) and cutaneous candidiasis. Methods of treating, preventing or controlling fungal infections in a plant are also disclosed, wherein a composition comprising an agriculturally acceptable amount of a β-carboline and a fungicide is administered to the plant and / or the locus of the plant, β-carbolines having the following formula are preferred. (Formula I).

The invention discloses a CYP51B copy number variation-based antifungal drug MIC value prediction method and a CYP51B copy number variation-based antifungal drug MIC value prediction device, and the method comprises the following steps: obtaining second-generation sequencing data of a plurality of trichophyton indicum strains, the second-generation sequencing data comprising CYP51B gene copy number of each strain, and measuring the MIC measured value of each strain for at least one target antifungal drug, and determining the CYP51B copy number variation-based antifungal drug MIC value of each strain according to the CYP51B copy number variation-based antifungal drug MIC value. Constructing a training data set; the copy number of the CYP51B gene and the MIC measured value are respectively calculated to obtain a log < 2 > (copy ratio) value and a log < 2 > (MIC value); a log2 (copy ratio) value is taken as an independent variable X, log2 (MIC value) is taken as a dependent variable Y, a unary linear regression model equation: Y = aX + b is obtained through least square fitting based on the training data set, a is a regression coefficient, and b is an intercept. The method has the beneficial effects that the log2 (copy ratio) value of the CYP51B gene is calculated through a bioinformatics process only by obtaining genome sequencing data of a strain, and the log2 (copy ratio) value can be substituted into a preset linear regression equation to obtain an MIC predicted value in real time.

The application discloses a Cnidii Fructus extract-mediated synthesized nano-silver material and a preparation method and application thereof. The nano-silver material is in a spherical core-shell structure, the inside of which is aggregated silver ions, and the outside of which is covered with Cnidii Fructus extract. The nano-silver material is synthesized by Cnidii Fructus extract and silver nitrate, and the average particle size is 44.6 nm. The nano-silver material has good antifungal activity on Trichophyton rubrum, Trichophyton mentagrophytes and Candida albicans, and the minimum inhibitory concentrations (MIC 90 ) are 3.125 μg / mL, 3.125 μg / mL and 0.78125 μg / mL, respectively. The Cnidii Fructus extract, which is commonly used in the treatment of tinea, is used to synthesize nano-silver, the synthesis method is simple, the particle size is small, the stability is good, and the nano-silver is highly dispersed. The preparation method is green and environment-friendly, and can be popularized on a large scale as the preparation of high-efficiency antifungal materials.

The present invention relates to a pharmaceutical preparation based on the use of an active ingredient from the family of phosphonium salts derived from Michael acceptors. These four molecules have dermatophyte inhibitory activity of up to 99.9% inhibition of the fungal population intended for use in the treatment of nail fungus, dermatophytes. The CPS molecule inhibits Trichophyton ruhrum at a concentration of 0.031 mg / mL, and also Microsporum canis at a concentration of 0.062 mg / mL. The other compounds CP1, CP3, and CP4 inhibit Trichophyton ruhrum and Microsporum canis at a concentration of 0.25 mg / mL. Compound CP1 inhibits Candida albicans at a concentration of 0.25 mg / mL. Furthermore, these molecules have no lytic or toxic effect on dermatophytes, particularly Trichophyton rubrum, Microsporum canis, and Candida albicans. These synthetic molecules are used as a remedy and treatment for nail diseases caused by dermatophytes, specifically Trichophyton rubrum, Microsporum canis, and Candida albicans.

This invention discloses a gut microbial biomarker, product, and application related to non-alcoholic fatty liver disease (NAFLD), belonging to the biomedical field. The microbial biomarker includes one or more of *Streptococcus pharyngis*, *Bacteroides foetida*, *Bifidobacterium adolescentis*, and *Trichophyton* bacteria. This invention provides a kit including detection reagents for detecting the relative abundance of the aforementioned microbial biomarkers. This invention also provides a product for diagnosing NAFLD, a predictive system for assessing the risk of NAFLD in a test subject, and a computer program product related to NAFLD. The product provided by this invention has good feasibility and accuracy, can effectively assess the risk of NAFLD, and provides a new tool for clinical diagnosis.

The present invention relates to a natural antifungal formulation made with a combination of essential oils, tinctures, and hydrosols obtained from aromatic and medicinal plant species for the control and treatment of the fungus Trichophyton rubrum, the causative agent of athlete's foot. The essential oils of Thymus vulgaris L., Tagetes lunulata Ort., and Syzygium aromaticum (L.) Merr. & LM Perr. that comprise it exhibit antifungal activity by inhibiting fungal growth. In addition, the essential oil of Lavandula angustifolia Mill. and Salvia rosmarinus Spenn., along with the hydrosol of Salvia rosmarinus Spenn., have an anti-inflammatory effect. This is a natural alternative with no adverse effects and can be used by immunocompromised individuals and those with chronic illnesses.

The application provides a monoclonal antibody specifically recognizing a cyst and an egg / sporocyst of a sheep trichophyton and application thereof, the provided monoclonal antibody can positively react to a soluble antigen of a whole protein of a trichophyton adult and a soluble antigen of an egg / sporocyst, and simultaneously covers two key development stages of the adult and the egg / sporocyst. A complete parasite life cycle detection system can be established, and a clinical sample detection rate is significantly improved (experiments show that the detection rate is improved by 35-40%). Moreover, a detection window period is 7-10 days earlier than that of a traditional method. Meanwhile, the application provides an ELISA detection kit and a detection method thereof, the ELISA detection kit and the detection method thereof are high in sensitivity, convenient to operate, can greatly improve detection efficiency, and have a good industrial application prospect.

This invention relates to the preparation and use of a phenylpyrazole derivative. Specifically, this invention relates to an N-substituted phenylpyrazole derivative of formula (I) or its isotopically labeled compound, or its optical isomers, geometric isomers, tautomers, or mixtures of isomers, or its agronomically acceptable salt, and the use of said compound in the preparation of insecticides for pest control. Such compounds can achieve better pest control effects at lower dosages, particularly against pests of the orders Lepidoptera, Coleoptera, Homoptera, Hemiptera, Thysanoptera, Isoptera, Diptera, Hymenoptera, Trichophyton, Pseudocoptera, Orthoptera, Blattodea, Silicaria, Acari, and Nematodes.

A compound with broad-spectrum antibacterial activity and its antibacterial composition are provided. The compound with broad-spectrum antibacterial activity has formula (I), which are antibacterial drug source compounds with a broad antibacterial spectrum, good antibacterial activity, suitable in vivo pharmacokinetics, and significant in vivo therapeutic effects. Preferred compound BAB159 has good antibacterial activity against Staphylococcus, Clostridium perfringens, Enterococcus, Bacillus, Streptococcus, Haemophilus, Candida krusei, Aspergillus niger, and Trichophyton, which is comparable or better than the listed drugs. The combination of preferred compound BAB159 and polymyxin E exhibits significantly enhanced synergistic antibacterial activity, especially against multidrug-resistant strains.