The invention belongs to the field of plant protection, and relates to an agricultural composition containing antibiotics and plant source materials, wherein antibiotic is one or several selected from abamectin, ivermectin, milbemectin, pleocidin, nikkomycin, liuyangmycin, streptomycin, polyoxins, chunleimeisu, jinggangmeisu, ningnanmycin and the like; the plant source material is one or several of smashing material, crude extract, or active ingredient of derris, thunder god vine, tobacco, pyrethrum, tagetes, crofton weed, radix stemonae, cayenne, macleaya cordata, radix sophorae flavescentis and the like. The composition provided by the invention expresses well synergism in a certain matching range, and has excellent control efficiency for crop diseases and pests.