The invention discloses a fungicide combination containing polyoxin, which is a fungicide combination containing active component A and active component B, the polyoxin is selected as the active component A, the active component B is selected from any of the following fungicides: ethirimol, 2-cyan-3-amino-3-ethyl aminoacrylate, bromothalonil, zineb, chlorothalonil and dithianon, and moreover, the ratio of the active component A to the active component B in part by weight is 32:1 to 1:64. The fungicide combination can prevent and control a variety of crop diseases, has a remarkable synergistic effect, broadens the antifungal spectrum, and has high activity on downy mildew, epidemic diseases, anthracnose, powdery mildew, leaf spot, fusarium head blight, rice blast and other diseases; and moreover, the dosage of pesticide is reduced, the residue of pesticide on crops is decreased, and thereby the environmental pollution is reduced.