Belonging to the technical field of pesticides, the invention discloses a Fluopicolide-containing bactericide composition, which includes a primary drug compounded from bactericide A and bactericide B. Specifically, bactericide A and bactericide B are in a ratio of 1-80:1-80. The bactericide A is Fluopicolide, and the bactericide B is any one of: Iprovalicarb, flumorph, cymoxanil, phosethyl-Al, propamocarb, Metalaxyl-M, oxadixyl, hymexazol, enestroburin, SYP-1620, pyraoxystrobin, pyrametostrobin, pyraclostrobin, fluoxastrobin, azoxystrobin and picoxystrobin. Compared with the prior art, the composition provided in the invention is compounded from bactericide A and bactericide B which are used in combination, slows down the generation of Fluopicolide resistance in pathogenic bacteria, prolongs the efficacy duration, and has a very strong synergistic effect.