The invention relates to the field of pesticides, in particular to an insect and disease prevention pesticide and a method for manufacturing the same. The method includes finely grinding nux vomica, soaking the ground nux vomica, slicing ginger and chopping china-tree leaves, chilies and artemisia scoparia respectively; sequentially adding the nux vomica, the ginger, the china-tree leaves, the chilies and the artemisia scoparia into boiling water, continuing stirring the boiling water, stewing the water with the materials until the yellow green water turns orange and stopping heating the water for about 2-3 hours to obtain mixed liquid when the water turns dark reddish brown; percolating and filtrating the mixed liquid to remove residues by a 120-mesh copper sieve; and filling the mixed liquid in cans and sealing the cans to obtain finished products. The water needs to be stewed for 10 minutes after each raw material is added, and then the follow-up other raw material can be added into the water. The insect and disease prevention pesticide and the method have the advantages that the insect and disease prevention pesticide is efficient, is broad in spectrum, low in toxicity and free of pollution and residual hazard, and effects of insect killing, sterilization, disease resistance and yield increasing are integrated; the insect and disease prevention pesticide realizes a remarkable effect for controlling red spider mites, cotton aphids, cabbage worms and the like; and the pesticide is manufactured from the natural plants, is good in pest control effect, does not harm human bodies, and adverse effects caused by chemical pesticides are modified.