335 results about "Methyl formate" patented technology

The invention provides an electrolytic hydrogen production device and an operation method thereof. The electrolytic hydrogen production device comprises a proton exchange membrane flow battery, a first proton exchange membrane electrolytic bath, a second proton exchange membrane electrolytic bath, a positive electrode electrolyte water tank, a negative electrode electrolyte water tank, a methanol storage tank and a control switching device, the proton exchange membrane flow battery is used for performing reversible redox reaction on the positive electrode electrolyte and the negative electrode electrolyte to realize charging and discharging; an anode chamber of the first proton exchange membrane electrolytic cell is used for carrying out oxidation reaction on methanol to obtain methyl formate and hydrogen ions; a cathode chamber of the second proton exchange membrane electrolytic cell is used for reducing hydrogen ions to obtain hydrogen; the positive electrode electrolyte water tank is used for carrying out oxidation-reduction reaction on the positive electrode electrolyte and realizing circulation; the negative electrode electrolyte water tank is used for carrying out oxidation-reduction reaction on the negative electrode electrolyte and realizing circulation; the control switching device is used for controlling the operation mode of the device. The device is high in safety and volatility absorption capacity and large in energy storage capacity.

The invention belongs to the field of biological pharmacy and biological conversion, and particularly relates to a lipase mutant and application thereof. The lipase CALB mutant disclosed by the invention is obtained by carrying out single-point mutation or combined mutation on the 40th site, the 134 site, the 154 site, the 189th site, the 278th site and the 281 site of an amino acid sequence as shown in SEQ ID NO.1. Compared with a wild type, the mutant has the advantage that the stereoselectivity is greatly improved when the mutant is used for catalyzing racemization 3-cyclohexene-1-methyl formate to produce (S)-3-cyclohexene-1-formic acid. Compared with a traditional chemical method for preparing (S)-3-cyclohexene-1-formic acid, the lipase CALB mutant provided by the invention is high in stereoselectivity, mild in reaction condition, environment-friendly, low in equipment requirement, capable of greatly reducing the production cost and wide in application prospect in industrial application.

The invention relates to a method and device for preparing formic acid and hydrogen through electrolysis. According to the method, an alkaline electrolyte containing methanol is electrolyzed, a cathode electrode for electrolysis takes foamed nickel as a base material to load iron-cobalt-nickel nanoparticles, an anode electrode takes foamed nickel as a base material to load cobalt-nickel particles, and a cathode chamber generates hydrogen; and collecting the electrolyte obtained after electrolysis in the anode chamber in the electrolysis device for bipolar membrane electrodialysis, and obtaining a primary formic acid solution in the acid chamber of the bipolar membrane electrodialysis device. The device comprises an electrolysis device and a bipolar membrane electrodialysis device, a cathode electrode, a first bipolar membrane, a positive membrane, a negative membrane, a second bipolar membrane and an anode electrode are sequentially arranged in the bipolar membrane electrodialysis device, and an acid chamber, a salt chamber and an alkali chamber are sequentially divided among the first bipolar membrane, the positive membrane, the negative membrane and the second bipolar membrane. Compared with an existing methyl formate hydrolysis method for preparing formic acid, an intermediate methyl formate is toxic to a human body, formic acid and hydrogen can be safely prepared, and production safety accidents are prevented.

The invention relates to the field of biomass energy and chemical industry, in particular to an efficient methanol preparation method based on biomass graded catalytic conversion and cycle coupling. The method comprises the following steps: in a graded catalytic oxidation reaction system, mixing a biomass raw material with a composite vanadium-based catalyst, water, oxygen and circulating methanol for reaction to generate a gas-liquid mixture containing methyl formate; recycling methyl formate by using a gradient variable-pressure rectification separation system; carrying out an interface hydrogenation reaction under the action of a copper-zinc-LTA hierarchical pore catalyst to generate methanol; finally, part of methanol is purified and recycled through membrane separation. The method realizes efficient conversion from biomass to methanol, has the advantages of mild reaction conditions, low energy consumption, high yield and good catalyst stability, and opens up a new path for industrialization of preparation of methanol from biomass.

The invention discloses a high-impact material prepared from recycled polypropylene and a preparation method of the high-impact material, and relates to the field of materials. When recycled polypropylene is used for preparing the high-impact material, firstly, polypropylene is grafted with vinyl diphenylphosphine, then the grafted polypropylene is reacted with 1-(3-chlorphenyl)-2-propyn-1-ol, and then the reacted polypropylene is reacted with 6-(methyl formate) pyridine-3-boric acid to obtain modified polypropylene; secondly, the calcium carbonate pretreated by 3-aminopropyltrimethoxysilane reacts with 3-thiophenecarboxaldehyde, thiophene, 6-(thiophene-2-yl) pyridine-2-carboxylic acid and 6-(3-thienyl) pyridine-2-formaldehyde are polymerized on the surface of the calcium carbonate, and modified calcium carbonate is obtained; and finally, carrying out melt blending on recycled polypropylene, modified polypropylene, modified calcium carbonate, sodium cyanide and bismaleimide, and carrying out extrusion granulation to obtain the high-impact material. The high-impact material prepared by the invention has good impact resistance, aging resistance and antibacterial property.

The invention discloses incombustible water-based aerosol spray paint and a preparation method thereof, and relates to the technical field of spray paint. When the non-combustible water-based aerosol spray paint is prepared, firstly, p-(triethoxysilyl) acetophenone reacts with trimethylchlorosilane, and then the reaction product and tetramethyl tetravinyl cyclotetrasiloxane are subjected to ring opening polymerization to obtain modified polysiloxane; grafting epoxy resin with 4-vinyl-methyl benzoate, reacting with modified polysiloxane to obtain modified epoxy resin, and emulsifying to obtain a modified epoxy resin emulsion; secondly, reacting the silicon dioxide subjected to acylating chlorination with 4-hydroxy-2, 2, 6, 6-tetramethylpiperidine nitroxide free radicals, reacting with 3-(3-thienyl) propionaldehyde, and reacting with thiophene and 3-vinyl thiophene to obtain modified silicon dioxide; and finally, mixing the modified epoxy resin emulsion, pure water, the modified silicon dioxide, a curing agent and a photoinitiator to prepare the incombustible water-based aerosol spray paint.

The invention discloses an anti-yellowing PVB (Polyvinyl Butyral) adhesive for laminated glass and a preparation method thereof, and relates to the technical field of adhesives. The yellowing-resistant PVB glue for the laminated glass has the advantages that the yellowing resistance is high; the modified PVB / nano silicon dioxide composite material is prepared from the following raw materials in parts by weight: 55 to 65 parts of modified PVB resin, 4 to 6 parts of modified nano silicon dioxide, 15 to 20 parts of dioctyl adipate, 0.5 to 1 part of a compound antioxidant, 0.3 to 0.8 part of an ultraviolet absorbent UV-327, 0.2 to 0.5 part of a silane coupling agent KH-560, 0.3 to 0.6 part of ethylene bis stearamide, 0.1 to 0.3 part of 2-benzimidazole methyl carbamate, 3 to 5 parts of tris (1-chloro-2-propyl) phosphate and 0.1 to 0.3 part of nano titanium dioxide. 5 to 8 parts of isopropanol; 0.8 to 1.2 parts of polycarbodiimide. The special modified PVB resin and the nano silicon dioxide are matched with the auxiliary agents such as the compound antioxidant, the anti-yellowing performance of the PVB glue for the laminated glass is remarkably improved through precise process preparation, the components have a synergistic effect, the process is controllable, the product performance is stable, and the cohesiveness is good.

The invention discloses cyclohexene formate esterase, a mutant of cyclohexene formate esterase and application of cyclohexene formate esterase in production of (S)-3-cyclohexene-1-formic acid. According to the cyclohexene formate esterase and the mutant disclosed by the invention, 100-400g / L of racemic 3-cyclohexene-1-methyl formate can be split by taking wet thalli subjected to induced expression or crude enzyme liquid obtained by ultrasonically crushing the wet thalli as a catalyst, so that (S)-3-cyclohexene-1-formic acid with chemical purity and optical purity reaching 99% or above is synthesized. The enzyme activity of the cyclohexene formate esterase mutant provided by the invention is further improved, the reaction time and the catalyst dosage are obviously reduced compared with those of a substrate with the same catalysis concentration before mutation, the reaction condition is mild, the operation is relatively simple and convenient, and the cyclohexene formate esterase mutant has a very good industrial application prospect.

The invention relates to a kettle residue recovery process of methyl carbamate, and belongs to the technical field of chemical engineering, the kettle residue recovery process of methyl carbamate comprises the following steps: adding the kettle residue of methyl carbamate into water, stirring for dissolving, adding chloroform, extracting, standing for layering, taking an oil phase dissolved with methyl carbamate at the lower layer, cooling to room temperature, filtering, washing, and drying to obtain the methyl carbamate. Drying to constant weight to obtain recycled methyl carbamate; and adjusting the pH value of an upper water phase composed of impurities such as urea, biuret and triuret to 7.5-8 by using a pH regulator, introducing into a sealed reaction tank filled with a modified mesoporous molecular sieve, adsorbing at normal temperature and normal pressure, filtering, and treating the filtrate at 60-80 DEG C to obtain the recycled and treated urea. The whole preparation process is simple and controllable, and the methyl carbamate and the urea in the kettle residues of the methyl carbamate are recycled.

The invention provides a preparation method of dicarbonyl cyclopentadienyl cobalt, which comprises the following steps: adding cobalt salt, a reducing agent, methyl formate and a catalyst into a high-pressure reaction kettle, keeping the reaction kettle in an inert gas atmosphere, and heating and stirring; cooling the high-pressure reaction kettle to room temperature, discharging gas, filtering reaction liquid, and putting filtrate into a normal-pressure reaction device in an inert gas atmosphere; and adding a cyclopentadiene monomer into the normal-pressure reaction device, carrying out heating reaction, filtering after the reaction is finished, and carrying out post-treatment on the obtained filtrate to obtain a dicarbonyl cyclopentadienyl cobalt crude product. The operation risk is reduced, the operation is simple, and the synthesis efficiency is high; cheap and easily available cobalt salt is used as a raw material, and a relatively cheap catalyst is used, so that the synthesis cost is low, and the method is suitable for industrial large-scale popularization and application.

The invention relates to the technical field of materials, and discloses an antibacterial material containing modified 3-aminofuran-2-methyl formate and a preparation method thereof.The preparation method comprises the steps that modified 3-aminofuran-2-methyl formate, acrylic resin and talcum powder are extruded and granulated in a double-screw extruder, then granules are subjected to compression molding in a press vulcanizer, and the antibacterial material containing modified 3-aminofuran-2-methyl formate is obtained. The antibacterial material containing the modified 3-amino furan-2-methyl formate is obtained. Benzoxazine in the modified 3-aminofuran-2-methyl formate can form a heat-resistant phenolic resin structure at a high temperature, so that the modified 3-aminofuran-2-methyl formate has a relatively good flame-retardant effect; a three-dimensional network structure formed by boron-oxygen bonds contained in the flame retardant has high flame retardance of high oxygen index, low toxicity, low smoke and low calorific value; the carbon nano tube also has a relatively good flame-retardant effect; wherein the ferrocene group and the 3-aminofuran-2-methyl formate in the compound have a relatively good antibacterial effect.

The invention discloses a high-flexibility PET decorative film and a preparation method thereof, and belongs to the technical field of PET decorative films. According to the high-flexibility PET decorative film, the self-made flame retardant and 1, 3-benzene-5-boric acid are pre-polymerized to obtain a prepolymer, then the prepolymer, ethylene glycol and terephthalic acid are mixed to react, and then (4-carboxyl-2-nitrophenyl) malonaldehyde is used for blocking to obtain flame-retardant PET. The preparation method comprises the following steps: carrying out a pre-mixing reaction on flame-retardant PET and a modified nucleating agent, internally mixing the pre-mixed material with an antioxidant and a lubricant, carrying out extrusion granulation, and carrying out melt extrusion, sheet casting, two-way stretching and heat setting by using a double-screw extruder to obtain a PET base film; and finally, plating aluminum on the PET base film. The self-made flame retardant is obtained by enabling amino siloxane and 9, 10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide to react with each other; the modified nucleating agent is obtained by modifying calcium carbonate with glycine; the high-flexibility PET decorative film prepared by the invention has good flexibility, flame retardance and antistatic property.

The invention relates to the technical field of catalyst materials and discloses a low-temperature catalyst for preparing methyl formate through methanol dehydrogenation as well as a preparation method and application of the low-temperature catalyst. The low-temperature catalyst comprises Cu nano-particles and a composite metal oxide attached outside the Cu nano-particles, the composite metal oxide comprises CaO and CeO2. When the low-temperature catalyst disclosed by the invention is used for catalyzing methanol dehydrogenation to prepare methyl formate, the reaction can be realized at a relatively low temperature, and the low-temperature catalyst has relatively high methyl formate selectivity.

The invention provides a process for synthesizing alpha-chloro-alpha-acetyl-gamma-butyrolactone and co-producing methyl formate from aminopyrimidine mother liquor and application of the process, and relates to the technical field of chlorination of alpha-acetyl-gamma-butyrolactone. The preparation method comprises the following steps: mixing aminopyrimidine mother liquor and alpha-acetyl-gamma-butyrolactone, carrying out chlorination reaction, and standing for layering to obtain an alpha-chloro-alpha-acetyl-gamma-butyrolactone layer and a water layer; and (b) adding methanol into the obtained water layer, and carrying out esterification reaction to obtain methyl formate. The method solves the technical problems that in the prior art, baking soda is consumed during chlorination of alpha-acetyl-gamma-butyrolactone, the cost of formic acid adopted in an esterification process is high, and sodium formate contained in the aminopyrimidine mother liquor is not recycled. The technical effects of eliminating the use of more expensive intermediate raw materials, namely baking soda and formic acid, recycling sodium formate in the aminopyrimidine mother liquor and co-producing and synthesizing methyl formate are achieved.

The invention discloses a method for preparing 4-methoxycarbonyl-2-methylthiophene-3-sulfonamide, comprising the following steps: 1. preparing a sodium disulfide solution for standby; 2. reacting 4-amino-5-methylthiophene-3-methyl formate with sodium nitrite to obtain a diazo solution for standby; 3. reacting sodium disulfide with the diazo solution prepared in step 2 to obtain 3,3'-disulfide-bis[4-methoxycarbonyl-2-methylthiophene]; 4. reacting 3,3'-disulfide-bis[4-methoxycarbonyl-2-methylthiophene] with sulfonyl chloride; 5. adding water to separate layers, and treating the organic layer with ammonia to obtain 4-methoxycarbonyl-2-methylthiophene-3-sulfonamide. The invention provides a new preparation route for 4-methoxycarbonyl-2-methylthiophene-3-sulfonamide, wherein sulfur dioxide or chlorine is not used in the preparation process, thereby improving operational safety, reducing environmental pressure, reducing production costs, and being suitable for industrial production.

The continuous production heat pump assisted integrated extractive distillation device is adopted to realize high-purity separation and recovery of the diethyl ether-methyl formate-n-pentane azeotrope, and separation is realized by utilizing the characteristic that the extraction agent has great influence on the relative volatility of the diethyl ether-methyl formate-n-pentane azeotrope. The purity of the separated diethyl ether, n-pentane and methyl formate reaches 99.9% or above, high-purity recycling of the extraction agent can be achieved, the separation cost is greatly reduced, and the method is low in energy consumption and flexible to operate.

The invention provides a corrosion-resistant film, a pipe and a preparation method and application of the corrosion-resistant film, the corrosion-resistant film at least contains modified LCP, the modified LCP comprises p-hydroxybenzoic acid, 6-hydroxy-2-naphthoic acid and 3, 4-dihydroxythiophene methyl diformate, the p-hydroxybenzoic acid, the 6-hydroxy-2-naphthoic acid and the 3, 4-dihydroxythiophene methyl diformate are used as raw materials, and the 6-hydroxy-2-naphthoic acid and the 3, 4-dihydroxythiophene methyl diformate are used as raw materials. And the molar ratio of the 2, 4-dihydroxy thiophene methyl dicarboxylate is (60-80): (5-40): (0.5-3). The corrosion-resistant thin film provided by the invention is excellent in mechanical property and corrosion resistance, and the corrosion-resistant pipe provided by the invention is high in combining capacity with the thin film and good in corrosion resistance.

Described herein are methods of synthesizing a P2X3 antagonist wherein the P2X3 antagonist is a methyl (S)-2-((2-(2, 6-difluoro-4-(methylcarbamoyl) phenyl)-7-methylimidazo [1, 2-a] pyridin-3-yl) methyl) morpholine-4-formate (Compound 1), or a pharmaceutically acceptable salt or co-crystal thereof.

The invention discloses a heterogeneous catalyst for preparing methyl formate through CO esterification and a preparation method and application of the heterogeneous catalyst, and belongs to the field of methyl formate synthesis. The heterogeneous catalyst comprises a palladium active component, an auxiliary agent and a carrier, the auxiliary agent is selected from La and / or Ce; the loading capacity of the palladium active component is 0.01-0.6% of the mass of the carrier; and the loading capacity of the auxiliary agent is 0.01-10% of the mass of the carrier. Compared with a catalyst auxiliary agent reported in the literature, the rare earth auxiliary agent disclosed by the invention can enhance the interaction between the precious metal and the carrier, effectively improve the utilization rate of the precious metal, reduce the dosage of the precious metal and the production cost of the catalyst, and remarkably improve the economical efficiency of the technology. The preparation method disclosed by the invention is simple in process, easy to realize large-scale amplification and excellent in catalyst performance, and can be applied to a production technology for preparing methyl formate through CO esterification.

The present application relates to a kind of chalcone amide alpha-glucosidase inhibitors and its preparation and application, the inhibitor structural formula is: preparation method specifically is (1) after 2-hydroxyacetophenone, sodium hydroxide and methyl p-formylbenzoate are reacted, intermediate in formula (a) is obtained after post-processing;(2) intermediate in formula (a) is dissolved in organic solvent and potassium hydroxide is reacted, after reaction, intermediate in formula (b) is obtained after post-processing;(3) intermediate in formula (b) and substituted aniline are dissolved in organic solvent, after reaction, the inhibitor shown in formula (c) is obtained after post-processing.Compared with prior art, the compound of the present application is novel, and experiments show that it has good alpha-glucosidase inhibitory activity, and can be used for preparing alpha-glucosidase activity inhibiting drug.

The invention relates to the technical field of organic synthesis, and particularly provides a thiophene-containing tetraarylethene compound as well as a preparation method and application thereof. According to the invention, two phenyl groups of tetraphenylethylene are replaced by methyl formate thiophene groups, and the substituted tetraarylethylene compound has more remarkable photochromic and mechanochromic dual functions through the interaction of a specific substituent group at the position 2 of thiophene and a large conjugated group formed by four aromatic rings; and light-operated double-color display in a polymer mechanism can be realized. The mechanochromism of the compound does not depend on ultraviolet light, when the compound is subjected to mechanical force, the molecular accumulation mode and conjugate planarity are changed, and the color change can be directly observed by naked eyes. Different from traditional tetraphenyl ethylene force-induced discoloration recessive fluorescence change, the dominant color change can be used in the fields of visual stress monitoring, anti-counterfeiting marks, inkless writing materials, safe ink and the like in ultraviolet-free environments (such as indoor and closed spaces), and the application prospect is wide.

The invention relates to the field of organic synthesis, in particular to a synthetic method of (2R, 4S)-N-BOC-4-hydroxypiperidine-2-methyl formate. The synthesis method of (2R, 4S)-N-BOC-4-hydroxypiperidine-2-methyl formate comprises the following steps: mixing a material A, a material B, potassium carbonate, sodium iodide and a solvent, and reacting to obtain a material C; mixing the material C, the material D, triethylamine and a solvent, and reacting to obtain a material E; mixing the material E, ammonia water and a solvent, and reacting to obtain a material F; and mixing the material F, di-tert-butyl dicarbonate, a palladium carbon catalyst and a solvent, and carrying out a reaction to obtain the (2R, 4S)-N-BOC-4-hydroxypiperidine-2-methyl formate. The process route is easy to operate and has no special dangerous reaction. Reaction materials are cheap and easy to obtain, and the prepared product is high in purity.

The present invention provides a blowing agent for producing extruded polystyrene foam having low lambda over time and low foam density. [Solution] The foaming agent comprises (a) a first co-foaming agent consisting of (a) about 50% to about 70% by weight of HFO and / or HFCO having three or four carbon atoms, (b) about 2% to about 15% by weight of methyl formate, (c) a second co-foaming agent consisting of about 20% to about 30% by weight of dimethyl ether, isobutane and combinations thereof, and (d) a third co-foaming agent consisting of about 2% to about 25% by weight of carbon dioxide, acetone and combinations thereof.

The invention discloses a kind of recycling polypropylene to prepare high-impact material and preparation method thereof, relate to the field of materials. When the present invention uses recycling polypropylene to prepare high-impact material, first, polypropylene is grafted with vinyl diphenylphosphine, then reacted with 1-(3-chlorophenyl)-2-propyn-1-ol, and then reacted with 6-(methyl formate) pyridine-3-boric acid to obtain modified polypropylene; Secondly, calcium carbonate pretreated with 3-aminopropyltrimethoxysilane and 3-thiophene carboxaldehyde are reacted, and thiophene, 6-(thiophene-2-yl) pyridine-2-carboxylic acid, and 6-(3-thienyl) pyridine-2-carboxaldehyde are polymerized on the surface of calcium carbonate to obtain modified calcium carbonate; Finally, recycled polypropylene, modified polypropylene, modified calcium carbonate, sodium cyanide, and bismaleimide are melt-blended, and then extrusion granulation is performed to obtain high-impact material; The high-impact material prepared by the present invention has good impact resistance, anti-aging performance and antibacterial performance.

The present invention relates to a method for synthesizing methyl formate, and belongs to the technical field of fine chemicals. The synthesis method comprises the following steps: (1) adding a water-soluble metal complex catalyst, water, a solvent and methanol into a reactor, introducing carbon monoxide, controlling the reaction pressure, reaction temperature and reaction time to react, and obtaining a reaction solution; (2) after the reaction is completed, the reaction solution of step (1) is separated into two layers of water and oil by extraction, and the oil phase is distilled to obtain methyl formate; the structure of the metal complex catalyst is as follows:; wherein M is V, Cr or Mn. The present invention adopts a water-soluble metal complex catalyst, takes methanol-water as a substrate, controls the reaction pressure after introducing carbon monoxide, and reacts at a relatively low reaction temperature; after the reaction is completed, methyl formate is obtained by liquid separation and distillation. The efficient synthesis of methyl formate is achieved, and the yield can reach more than 98%.

The invention discloses a dual stimulus-responsive supramolecular gel temporary plugging agent and a preparation method thereof, and relates to the technical field of oil-gas field development. The supramolecular gel temporary plugging agent comprises the following components in percentage by mass: 5wt%-10wt% of a tertiary amine surfactant; the temperature response authigenic acid accounts for 0.2 wt%-2wt%; and the balance of water. Wherein the tertiary amine surfactant is prepared by reacting fatty acid and N, N-dimethyl-1, 3-diaminopropane according to the molar ratio of 1: 1, and the temperature response authigenic acid is composed of methyl formate, ethyl formate, methyl acetate, ethyl acetate and the like; the dual-stimulus-responsive supramolecular gel temporary plugging agent disclosed by the invention has the plugging strength of 4.3 MPa, takes water as a solvent, and is simple in process, high in yield, strong in environmental protection property, stable in performance and low in cost.

The invention discloses (E)-1, 4-diether olefin and a preparation method thereof, and the (E)-1, 4-diether olefin is obtained by using 1, 3-diene as a raw material and carrying out electrochemical reaction in the presence of an electrolyte and a solvent, wherein the 1, 2, 4-trimethyl-1, 3- The structural formula of the 1, 3-diene is as follows: R1 is phenyl, p-fluorophenyl, p-chlorphenyl, p-bromophenyl, p-methylphenyl, p-methoxyphenyl, p-trifluoromethylphenyl, p-trifluoromethoxyphenyl, p-acetoxyphenyl, p-methyl formate phenyl, p-cyanophenyl, p-pinacol borate phenyl, p-phenylphenyl, o-oxybenzyl phenyl and o-methoxyphenyl; r1 is one of 1, 2-naphthyl; the solvent is a mixed solvent containing methanol. The preparation method of (E)-1, 4-diether olefin has high E-selectivity and 1, 4-selectivity, and an electro-catalysis mode is adopted, so that the use of a stoichiometric toxic, expensive or dangerous oxidant is avoided.

The present application belongs to the technical field of fermented fruit juice, and particularly relates to a method for preparing high-quality probiotic fermented strawberry juice based on magnetic field assistance. The present application first uses Lactobacillus plantarum CTCF-LP-1 to perform static fermentation on the strawberry juice to be fermented in a fermentation device for more than 24 hours, and then places the fermentation device in a static magnetic field. The static magnetic field reduces the generation of organic acid components by Lactobacillus plantarum during the fermentation process of the strawberry juice, reduces the acidity, and improves the fermentation quality of the strawberry juice. The magnetic field strength of the static magnetic field is 1.0-2.5 mT, and the fermentation time in the static magnetic field is 0.5-1.5 h. After the static fermentation and the magnetic field treatment, the content of malic acid, isocitric acid, glutaconic acid and other organic acid components in the fermented strawberry juice is significantly reduced, while the content of alcohol and ester components such as n-octanol, 2-phenylethanol, methyl benzoate, 3-hexyl hexanoate and butyl valerate is increased, the types of aroma components are more abundant, and the taste and quality of the strawberry juice are significantly improved.

The preparation method comprises the following steps: 1, adding tartaric acid, an acid-binding agent and a first organic solvent into a reaction container, uniformly mixing, cooling, dropwise adding a mixed solution of triphosgene and the first solvent into the reaction container under the condition that the temperature does not exceed 10 DEG C, and reacting for 1-2 hours at the temperature of 20-30 DEG C, so as to obtain 5-(methoxycarbonyl)-2-oxo-1, 3-dioxolane-4-methyl formate, namely the 5-(methoxycarbonyl)-2-oxo-1, 3-dioxolane-4-methyl formate, namely the 5-(methoxycarbonyl)-2-oxo-1, 3-dioxolane-4-methyl formate. After dropwise adding, heating to room temperature, stirring, and concentrating filtrate to obtain an intermediate; and 2, adding the intermediate, a second organic solvent, a catalyst and methanol into a reflux reaction container with a water knockout drum and a condenser, carrying out heating reflux reaction to separate water, concentrating the reaction liquid after the reaction is finished to obtain a crude product, adding the crude product into a first organic solvent, carrying out heating reflux, filtering to remove insoluble substances while the crude product is hot, cooling and crystallizing the filtrate, carrying out suction filtration, and drying to obtain the target product. The method has the advantages that the synthesis method is simple and easy to implement, the post-treatment method is easy to operate, and the product is high in purity and good in yield.

The invention discloses a quinazoline-4-one compound containing 1,2,4-triazole [3,4-b] [1,3,4] thiadiazole, a preparation method thereof and antibacterial activity thereof. The compound is represented by general formula (I), and quinazoline-4-one, 1,2-dibromoethane, methyl 4-piperidinate, 80% hydrazine hydrate, potassium hydroxide, carbon disulfide and different aromatic acids are used as raw materials to prepare the target compound through a five-step reaction. The invention introduces an active 1,2,4-triazole [3,4-b] [1,3,4] thiadiazole unit into the quinazoline-4-one structure, and synthesizes a series of quinazoline-4-one compounds containing 1,2,4-triazole [3,4-b] [1,3,4] thiadiazole units, and the compounds have good antibacterial activity.