99 results about "Methyl formate" patented technology

The present invention provides a blowing agent for producing extruded polystyrene foam having low lambda over time and low foam density. [Solution] The foaming agent comprises (a) a first co-foaming agent consisting of (a) about 50% to about 70% by weight of HFO and / or HFCO having three or four carbon atoms, (b) about 2% to about 15% by weight of methyl formate, (c) a second co-foaming agent consisting of about 20% to about 30% by weight of dimethyl ether, isobutane and combinations thereof, and (d) a third co-foaming agent consisting of about 2% to about 25% by weight of carbon dioxide, acetone and combinations thereof.

The invention relates to the field of organic synthesis, in particular to a synthetic method of (2R, 4S)-N-BOC-4-hydroxypiperidine-2-methyl formate. The synthesis method of (2R, 4S)-N-BOC-4-hydroxypiperidine-2-methyl formate comprises the following steps: mixing a material A, a material B, potassium carbonate, sodium iodide and a solvent, and reacting to obtain a material C; mixing the material C, the material D, triethylamine and a solvent, and reacting to obtain a material E; mixing the material E, ammonia water and a solvent, and reacting to obtain a material F; and mixing the material F, di-tert-butyl dicarbonate, a palladium carbon catalyst and a solvent, and carrying out a reaction to obtain the (2R, 4S)-N-BOC-4-hydroxypiperidine-2-methyl formate. The process route is easy to operate and has no special dangerous reaction. Reaction materials are cheap and easy to obtain, and the prepared product is high in purity.

The objective is to provide a fragrance composition that has high reproducibility of the fragrance of forsythia flowers and excellent palatability. [Solution] The forsythia flower fragrance composition comprises (A) methyl salicylate and / or ethyl salicylate, (B) methyl benzoate and / or ethyl benzoate, and (C) linalool and / or limonene, wherein the total content of component (A) and component (B) is 50 to 90% by mass, and the mass ratio (A / B) is 1 to 10.

The invention relates to the technical field of organic chemical synthesis, in particular to a catalyst and a process for preparing methyl glycolate and co-producing methyl formate through methanol dehydrogenation coupling oxalate hydrogenation, which comprises the following steps: S1) providing a coal-to-ethylene glycol device which comprises a methanol rectifying tower, a DMO synthesis system, a DMO refining system, a DMO hydrogenation reactor and a condensing system; s2) taking methanol extracted from a methanol rectifying tower as a raw material, and carrying out anaerobic dehydrogenation reaction under the action of the catalyst in any one of claims 1-2 or the catalyst prepared by the preparation method in claim 3 to obtain methyl formate, H2 and CO; and S3) by taking dimethyl oxalate extracted from a DMO refining system as a raw material, carrying out hydrogenation reaction under the action of the catalyst in any one of claims 4-5 or the catalyst prepared by the preparation method in claim 6 to obtain methyl glycolate and methanol.

The invention discloses a dithiocarbamate nickel (II) complex as well as a preparation method and application thereof, the chemical formula of the nickel (II) complex is [NiIILCl], and L is (E)-2-(phenyl (pyridine-2-yl) methylene) hydrazino methyl dithioformate. The nickel (II) complex is mild in synthesis condition and high in target yield. In-vitro MTT activity evaluation proves that the introduction of copper ions has a synergistic effect on the anticancer activity of the nickel (II) complex, so that the activity of the nickel (II) complex is improved from a micromole level to a nanomole level, and the amplification is as high as 200 times or more. Cell scratch experiments prove that the nickel (II) complex and copper (II) ions are combined for use, so that the migration resistance is achieved. A nickel (II) complex and copper ion combination strategy provided by the invention not only has a direct killing effect on cancer cells, but also can effectively inhibit the migration ability of the cancer cells, and shows huge application potential in the field of cancer treatment.

Described herein are processes for the synthesis of P2X3 antagonists, wherein the P2X3 antagonist is methyl (S)-2-((2-(2,6-difluoro-4-(methylcarbamoyl)phenyl)-7-methylimidazo[1,2-a]pyridin-3-yl)methyl)morpholine-4-carboxylate (Compound 1), or a pharmaceutically acceptable salt or co-crystal thereof.

The application discloses an organic complex of different metals LTG-RuCe and a preparation method and application thereof, and belongs to the technical field of catalysts. The preparation method of the organic complex of different metals LTG-RuCe comprises the following steps: synthesizing a ligand HL by using methyl formylbenzoate, 2-acetylpyridine, ethanol, potassium hydroxide and ammonia water; synthesizing a ligand [Ru(HL)2]·(PF6)2 by using trichlororuthenium, the ligand HL, methanol, potassium hydroxide and HPF6; and synthesizing the organic complex of different metals LTG-RuCe by using cerium nitrate hexahydrate, the ligand [Ru(HL)2]·(PF6)2 and N,N-dimethylformamide. The organic complex of different metals LTG-RuCe synthesized by the application has high CO2 catalytic activity, good repeatability and a structure which is not easy to collapse; and the method for preparing the organic complex of different metals provided by the application has high yield and strong operability.

The application relates to a synthesis method of a compound 4-bromo-5-(trifluoromethyl) thiophene-2-carboxylic acid methyl ester, characterized in that the synthesis method takes 4,5-dibromothiophene-2-methyl ester as raw material, takes cuprous halide as a catalyst, takes diphenyl(trifluoromethyl)sulfonium triflate as a trifluoromethyl reagent, and reacts at a selected temperature, so that 4-bromo-5-(trifluoromethyl) thiophene-2-carboxylic acid methyl ester is generated with high selectivity. The method is high in atom economy, simple to operate, high in regioselectivity, relatively mild in reaction conditions, and very suitable for industrial scale production.

The present application relates to the technical field of polyurethane coating, in particular to a waterproof polyurethane composite coating and a preparation process thereof. The preparation process of the waterproof polyurethane composite coating comprises the following steps: preparing quercetin grafted composite filler, preparing modified isophorone diisocyanate solution and preparing polyurethane composite coating. In the present application, polybutylene adipate, dimethylol butyric acid and dibutyltin dilaurate are mixed with the modified isophorone diisocyanate solution to carry out pre-polymerization, then 2-hydroxy-5-substituted long-chain fatty acyloxy methyl benzoate is added to carry out reaction, long-chain fatty acyloxy and methyl benzoate structure are introduced into the polyurethane molecular chain, trimethylolpropane is added to carry out crosslinking reaction, finally, 1,4-butanediol is added as a chain extender to react with the remaining -NCO to prepare the polyurethane composite coating, which can effectively improve the water resistance and adhesion of the polyurethane composite coating.

This invention relates to the field of seawater desalination technology, specifically to a high-permeability and selective reverse osmosis membrane and its preparation method. The high-permeability and selective reverse osmosis membrane is obtained by sequentially immersing a porous support layer in an aqueous solution and an oil solution for interfacial polymerization, thereby forming a desalination layer on the surface of the porous support layer. This invention increases the compatibility of the water / oil phases by adding N-methylpyrrolidone to the aqueous phase and methyl benzoate to the oil phase, thereby reducing the surface tension of the two phase solutions, promoting the diffusion of amine monomers into the organic phase, and altering the surface morphology and polymer chain aggregation state of the separation layer. This results in a higher roughness and cross-linking degree of the desalination layer, and improved permeability and selectivity.

The present invention relates to a salt and crystal form of an AT2R agonist and use thereof in pharmaceutics, and specifically relates to a salt and crystal form of methyl ((4-fluoro-5-isobutyl-3-(4-((2-(trifluoromethyl)-1H-imidazol-1-yl)methyl)phenyl)thiophen-2-yl)sulfonyl)carbamate (a compound represented by formula (I)) and use thereof in pharmaceutics.

The invention relates to the field of ferric ion detection, and particularly provides a fluorescent probe for detecting ferric ions as well as a preparation method and application of the fluorescent probe. The fluorescent probe shows good performance, and is low in detection limit, high in selectivity and sensitivity and strong in anti-interference capability. The preparation method comprises the following steps: dissolving 3, 6-carbazole methyl dicarboxylate and sodium hydride in an organic solvent, stirring and heating at normal temperature, slowly dropwise adding a bis (4-fluorophenyl) sulfone solution until the bis (4-fluorophenyl) sulfone solution is completely added, reacting for a certain period of time, adding an obtained product into water, stirring, filtering to obtain a brown solid, and sequentially carrying out Soxhlet extraction, column chromatography purification, stirring reflux and vacuum drying to obtain the target product. The fluorescent probe is obtained. The powdery fluorescent probe material is dissolved in water and mixed with a solution to be detected, the fluorescence emission spectrum of the mixed solution is detected, and ferric ions in the solution are detected through the change of fluorescence intensity.

The present application provides a kind of singlet oxygen activated photo-cage chemiluminescence molecule, which has the structure shown in formula (I), wherein X is hydrogen or halogen, PC represents photo-cage group, R 1 It is an electron-withdrawing group containing oxygen and / or nitrogen, R 2 It is selected from adamantane, cyclobutane, methyl cyclobutyl formate and tetrahydrothiopyran-1,1-dioxide. The chemiluminescence molecule is activated by singlet oxygen and triggered by light of a specific wavelength, and through the processes of oxidation, photolysis, electron transfer, etc., an excited state benzoate structure is generated, which emits blue-green light when returning to the ground state. 2 Group, photo-cage group and R 1 Electron-withdrawing group synergistic effect, oxidation, photolysis, electron transfer, etc. process, generate excited state benzoate structure, it emits blue-green light when returning to the ground state.

The present application relates to a kind of preparation methods of 3,4-dihydroxy-5-methoxybenzoic acid methyl ester, with gallic acid as raw material, it is reacted with trimethyl orthoformate or trimethyl orthoacetate, trimethyl orthoformate or trimethyl orthoacetate can realize the protection of adjacent diphenol hydroxyl on one hand, on the other hand, carboxyl esterification and 5-hydroxyl are methylated, form the methyl ester of 5-phenolic hydroxyl methylation and 3,4-orthoester protection benzoic acid shown in formula 1a or formula 1b, further by acidic solution treatment, deprotection is carried out, and the target product 3,4-dihydroxy-5-methoxybenzoic acid methyl ester is prepared.The preparation method is mild in reaction condition, process is simple, easy to operate, product yield and purity are high, solve the wastewater problem in borax protection method, and avoid using toxic dimethyl sulfate for methylation, process condition is simple, easy to operate, convenient for industrialization, with very high application value.

To provide a method for producing a polyether compound having a reactive silicon group, which can suppress deterioration of physical properties of a cured product.SOLUTION: Contacting an initiator having active hydrogen with an alkylene oxide-containing starting material, polymerizing alkylene oxides in the alkylene oxide-containing starting material with the initiator, and converting the hydroxyl groups of the resulting hydroxyl group-containing starting material into groups having reactive silyl groups, wherein the methyl formate content of the alkylene oxide-containing starting material is less than 20ppm based on the total mass of the alkylene oxide-containing starting material.

Disclosed is a synthetic method of sulfamerazine, relating to the technical field of drug preparation. Acetone and methyl formate are used as initial raw materials, and subjected to condensation reaction to obtain a compound 2; the compound 2 is subjected to addition reaction in a medium of methyl hydrogen sulfate to obtain a compound 3; the compound 3 is subjected to cyclization reaction in a medium of sulfaguanidine to obtain a compound 4; and the compound 4 is subjected to acidification in an acidic medium to obtain the sulfamerazine.

The invention provides a continuous treatment production system for an alcohol ester byproduct in production of preparing ethylene glycol from synthesis gas. The invention also provides a treatment experiment system for the alcohol ester by-product in the production of preparing ethylene glycol from synthesis gas. The invention further provides a treatment production method for the alcohol ester byproduct in the production of preparing ethylene glycol from synthesis gas. The invention further provides a treatment experiment method for the alcohol ester by-product in the production of preparing ethylene glycol from synthesis gas. The invention further provides a formate and a use thereof. According to the treatment method for the alcohol ester byproduct in the production of preparing ethylene glycol from synthesis gas, provided by the invention, the methyl formate-containing byproduct does not need to be separated into pure components, so that dimethyl carbonate can be recycled to the greatest extent, and the difficulty of purifying formate is greatly reduced.

The invention discloses an anti-UV TAC film and a preparation method thereof, and belongs to the technical field of TAC optical films. The anti-UV TAC film is prepared from the following raw materials in parts by mass: 100 parts of cellulose triacetate, 10 to 20 parts of cellulose p-formyl benzoate, 650 to 700 parts of solvent, 70 to 120 parts of cosolvent, 15 to 25 parts of plasticizer and 1 to 3 parts of ultraviolet absorbent, the cellulose p-formylbenzoate is prepared by carrying out transesterification reaction on cellulose and methyl p-formylbenzoate; the ultraviolet absorbent is prepared by carrying out condensation reaction on 4-carboxyl benzotriazole and amino at one end of a diamine derivative of phenylphosphoryl. According to the invention, a halogen-free high-molecular-weight ultraviolet absorbent is designed and synthesized, and the halogen-free high-molecular-weight ultraviolet absorbent and cellulose p-formyl benzoate form a synergistic effect, so that anti-ultraviolet active components are not easy to physically migrate, and the cellulose triacetate film is ensured to have high light transmittance and good ultraviolet barrier property.

The invention relates to the technical field of organic synthesis, in particular to a preparation method of cyclopropyl formaldehyde, which comprises the following steps: by taking methyl cyclopropyl formate as a raw material, red aluminum as a reducing agent and toluene as a solvent, carrying out heat preservation reaction under the protection of nitrogen and controlling the reaction temperature to be not more than-78 DEG C; after the reaction is finished, firstly carrying out quenching reaction by using absolute ethyl alcohol, then adding a saturated ammonium chloride solution for further quenching reaction, then adjusting the pH value to be acidic, layering, collecting a water phase, extracting, combining the collected organic phase, drying, filtering, and then carrying out distillation treatment on the material liquid, so as to obtain the product. And rectifying the material liquid without the extracting agent to obtain a cyclopropyl formaldehyde product. The process method can reduce the cost, is suitable for industrial production, and greatly improves the yield and purity of the cyclopropyl formaldehyde product.

The present application relates to a kind of preparation methods of 4-acetamido-5-chloro-2-methoxybenzoic acid methyl ester, steps include: S1, m-amino phenol is reacted with acetic anhydride to generate m-acetylamino phenol;S2, the m-acetylamino phenol is reacted with carbon dioxide to generate 4-acetylamino salicylic acid;S3, the 4-acetylamino salicylic acid is reacted with dimethyl sulfate to generate 2-methoxy-4-acetylamino benzoic acid methyl ester;S4, the 2-methoxy-4-acetylamino benzoic acid methyl ester is reacted with hydrochloric acid to generate 4-acetamido-5-chloro-2-methoxybenzoic acid methyl ester.The preparation method of the present application not only improves product quality and production efficiency, but also reduces cost, simplifies operation, and is friendly to environment, with significant industrial application prospect and market competitiveness.

The invention discloses plant-based hairline cream and a preparation method thereof, and relates to the technical field of cosmetics. When the plant-based hairline cream is prepared, black sesame is cleaned and crushed, and then the crushed black sesame reacts with a sodium hydroxide solution and a hydrochloric acid solution in sequence to obtain black sesame pigment; coating the nanometer perlite powder loaded with the black sesame pigment with ethyl orthosilicate to obtain silicon dioxide coated nanometer perlite powder; the preparation method comprises the following steps: sequentially reacting carboxymethyl cellulose with 2-iodoethane-1-amine and imidazole-4-methyl formate to obtain imidazolium salt cellulose; and finally emulsifying glycerol, sodium hyaluronate, 1, 3-butanediol, vitamin E, sweet almond oil, imidazolium salt cellulose and liquid paraffin, uniformly mixing with the silicon dioxide coated nano perlite powder, and standing to prepare the plant-based hairline cream. The plant-based hairline cream prepared by the invention has excellent makeup holding capacity, moisturizing capacity and antibacterial capacity.

The utility model mainly relates to the technical field of tail gas treatment, and provides a methyl carbamate ammonia-containing tail gas treatment device which structurally comprises an operation support, a Roots blower is fixedly arranged at the bottom of the operation support, material grooves are fixedly formed in the front side and the rear side of the right end of the operation support respectively, and transition pipes are fixedly arranged at the bottoms of the material grooves. The bottom of the transition pipe is fixedly connected with a feeding port in the right end of the auger conveyor, methyl carbamate powder in the trough and the transition pipe is conveyed into the collecting barrel through the auger conveyor, the powder is raised and scattered in the collecting barrel, and the powder is conveyed through the auger conveyor and scattered in the collecting barrel. At the moment, the Roots blower is matched with the exhaust pipe, air exhaust treatment is carried out in the collecting barrel through the filter cartridge and the dust filtering cloth bag, and air in the collecting barrel is pumped into the dilute acid spraying kettle to be treated.

The invention belongs to the technical field of alkali wastewater treatment of photoinitiators, and discloses a method for treating alkali wastewater generated in the production process of methyl benzoylformate, which comprises the following steps: standing and filtering the alkali wastewater generated in the production process of methyl benzoylformate, adding a flocculating agent and acid at the same time, adjusting the pH value to 6-7, stirring, precipitating and carrying out suction filtration to obtain refined mother liquor; heating the refined mother liquor for rectification, and collecting fractions and residual liquid; condensing the fractions, heating and purifying to obtain methanol, and reusing the methanol in the production of methyl benzoylformate; the residual liquid is heated and rectified, a fraction and a base solution are collected, and the fraction is rectified water; cooling the base solution, and preserving heat until the base solution does not cake any more and suspension exists in the base solution; the rectified water is reused for methyl benzoylformate production; carrying out suction filtration on the rectification base solution obtained in the previous step to obtain kettle liquid and inorganic salt crystals, collecting the inorganic salt crystals, and separating to obtain sodium sulfate solids; the method solves the problems of low methanol recovery rate, high organic matter residue, difficulty in solid waste treatment and the like in the alkali wastewater.

The application belongs to the technical field of medicine synthesis, and particularly relates to a synthesis method of 5-bromopyrimidine-4-carboxylic acid. 4-hydroxypyrimidine-6-methyl ester is used as a starting material, 5-bromo-4-hydroxypyrimidine-6-methyl ester is obtained through a bromination reaction, and then 5-bromopyrimidine-4-carboxylic acid is obtained through hydroxyl chlorination and hydrolysis dehalogenation. In the application, the problems of many by-products and great separation difficulty in the traditional synthesis process are avoided. Through accurate control of reaction conditions in each step, the reaction selectivity and product yield are effectively improved, the purity of the target product can reach more than 98%, the raw materials are easy to obtain and low in cost, the reaction conditions are mild and easy to operate, special and expensive equipment is not needed, the safety is high, the application is friendly to the environment, and the industrialized production is easy to realize.

The application discloses a local high-concentration lithium metal battery electrolyte and a preparation method and application thereof. The electrolyte comprises a lithium salt, an organic solvent, an additive and a diluent; the organic solvent comprises at least one of methyl formate, methyl acetate, methyl propionate, methyl butyrate, ethyl propionate, ethyl acetate, ethyl butyrate, methyl trifluoroacetate and ethyl trifluoroacetate; the additive comprises at least one of fluoroethylene carbonate, lithium difluorobisoxalate phosphate and lithium difluorophosphate; and the diluent is a fluorine-containing ether compound. The local high-concentration electrolyte has the advantages of high-voltage resistance of high-concentration electrolyte and inhibition of corrosion of sulfonimide-based electrolyte on aluminum foil, meanwhile, the problems of high viscosity, low conductivity and poor impregnation with a separator of high-concentration electrolyte are overcome, the cycle performance and low-temperature performance of the lithium metal battery are significantly improved, and the local high-concentration electrolyte is particularly suitable for application in a low-temperature high-voltage lithium battery. The preparation method is simple, the cost is low, and the method is suitable for industrial production.

The invention discloses a preparation method of an aminothiophene compound, which comprises the following steps: dissolving 4-bromothiophene-3-methyl formate in an organic solvent, and reacting the 4-bromothiophene-3-methyl formate with methyl cyanoformate under the action of organic lithium to obtain 4-bromo-3-(methoxycarbonyl) thiophene-2-methyl formate; the preparation method comprises the following steps: dissolving 4-bromine-3-(methoxycarbonyl) thiophene-2-methyl formate in an organic solvent, and carrying out Buchwald reaction on the 4-bromine-3-(methoxycarbonyl) thiophene-2-methyl formate and an aminating agent under the protection of N2 and the action of alkali, a phosphine ligand and a palladium catalyst; and after the reaction is finished, carrying out a reaction under an acidic condition to obtain the 4-amino-3-(methoxycarbonyl) thiophene-2-methyl formate. The raw materials are easy to obtain, the whole route is shortened to two steps compared with an existing synthesis process, the synthesis efficiency of the compound 3 is remarkably improved, and the yield of the compound 3 is also greatly improved and at least reaches about 50%.

The application provides a perovskite solar cell doped with 3-amino-2-thiophene methyl formate and a preparation method thereof. The amino group, the ester group, the nitrogen atom, the oxygen atom and the sulfur atom on the thiophene in the 3-amino-2-thiophene methyl formate can be coordinated with cation and anion vacancy defects in the perovskite to synergistically passivate defects on the surface and the grain boundary of the perovskite crystal, reduce trap state density, inhibit non-radiative recombination of the perovskite film and prolong carrier lifetime. The introduction of the dopant can promote the growth of a high-quality perovskite film, obtain a perovskite film with better crystallinity and fewer grain boundaries, promote light absorption and carrier transport and improve the photoelectric conversion efficiency of the doped perovskite solar cell. The 3-amino-2-thiophene methyl formate can also improve the hydrophobicity of the perovskite film and the aging resistance of the perovskite film under the conditions of light, heating, water vapor and oxygen, and improve the environmental stability, light stability and thermal stability of the doped perovskite solar cell.

The manufacturing method of the light-transmitting waterproof glue of the present invention includes: providing raw materials: acrylate, methyl carbamate, crosslinking agent, ultraviolet absorber, antioxidant and plasticizer; mixing the above raw materials evenly in proportion to form a viscous solution; and stirring, adjusting, extruding and roll-pressing the viscous solution to form the light-transmitting waterproof glue. This method is simple and low-cost, and the prepared glue has improved high light transmittance, excellent waterproof performance and strong adhesive force.

The invention discloses a preparation method of a Co3O4 (at) Z-ZIS catalyst for preparing methyl formate by co-conversion of CO2 and methanol through photo-thermal catalysis. Gasification fine slag generated after coal gasification is subjected to drying, screening, acid pickling, water washing, drying, alkaline leaching, water washing and drying processes to synthesize Na-P1 type zeolite. The preparation method comprises the following steps: growing indium zinc sulfide on Na-P1 type zeolite in situ by adopting a hydrothermal method, and loading Co metal oxide by adopting the hydrothermal method to finally prepare the novel efficient photo-thermal catalyst Co3O4 (at) Z-ZIS. Compared with the existing industrial catalyst, the catalyst Co3O4 (at) Z-ZIS shows excellent photo-thermal catalytic performance under the mild conditions of normal pressure and lower temperature. When the catalyst is applied to a reaction for preparing methyl formate through partial oxidative dehydrogenation of methanol in a CO2 atmosphere, the catalytic efficiency is remarkably improved.

The feeding device comprises a base, a metering pump assembly is fixedly arranged in the middle of the upper end of the base, and a second motor is fixedly arranged at the upper end of one side of the metering pump assembly. A first raw material tank and a second raw material tank are fixedly arranged at the upper end, located on one side of the metering pump assembly, of the base, the first raw material tank and the second raw material tank are symmetrically arranged, a first raw material pipe is fixedly arranged below the exterior of the first raw material tank, and a second raw material pipe is fixedly arranged below the exterior of the second raw material tank; the first raw material pipe is communicated with the second raw material pipe, a second connecting pipe is fixedly arranged outside the joint of the first raw material pipe and the second raw material pipe, one end of the second connecting pipe is communicated with the metering pump assembly, and the structure solves the problems that raw materials are not convenient enough to add, and the raw materials in the raw material tank are easy to precipitate.