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A collective procurement management system which permits multiple potential purchasers of a specific item or service to submit orders for the item or service on an ongoing basis. As orders enter the system, they are grouped such that potential purchasers are may “cooperate” in generating a collective bulk order so that all participants may obtain discount/volume pricing. Once a threshold level of order volume is obtained as a result of multiple orders, the grouped order is submitted to the supplier for fulfillment. The order is then fulfilled at a volume pricing level although individual portions of the collective order are routed to a plurality of purchasers. The present invention also includes a Reverse Auction Process (RAP) which, in one embodiment, operates to allow potential purchasers to select a product or service and set a maximum price that they are willing to pay for the same. Following submission of this information to the system, possibly including orders for the same item from other potential buyers, potential vendors bid to supply the item to the relevant buyers requesting the item.

An integrated circuit structures formed by chemical mechanical polishing (CMP) process, which comprises a conductive pathway recessed in a dielectric substrate, wherein the conductive pathway comprises conductive transmission lines encapsulated in a transmission-enhancement material, and wherein the conductive pathway is filled sequentially by a first layer of the transmission-enhancement material followed by the conductive transmission line; a second layer of transmission-enhancement material encapsulating the conductive transmission line and contacting the first layer of the transmission-enhancement material, wherein the transmission-enhancement material is selected from the group consisting of high magnetic permeability material and high permittivity material. Such integrated circuit structure may comprise a device structure selected from the group consisting of capacitors, inductors, and resistors. Preferably, the transmission-enhancement material comprises MgMn ferrites, MgMnAl ferrites, barium strontium titanate, lead zirconium titanate, titanium oxide, tantalum oxide, etc.

Methods of treatment of tissue with electromagnetic radiation (EMR) to produce lattices of EMR-treated islets in the tissue are disclosed. Also disclosed are devices and systems for producing lattices of EMR-treated islets in tissue, and cosmetic and medical applications of such devices and systems.

The present invention provides a variety of microscale bioreactors (microfermentors) and microscale bioreactor arrays for use in culturing cells. The microfermentors include a vessel for culturing cells and means for providing oxygen to the interior of the vessel at a concentration sufficient to support cell growth, e.g., growth of bacterial cells. Depending on the embodiment, the microfermentor vessel may have various interior volumes less than approximately 1 ml. The microfermentors may include an aeration membrane and optionally a variety of sensing devices. The invention further provides a chamber to contain the microfermentors and microfermentor arrays and to provide environmental control. Certain of the microfermentors include a second chamber that may be used, e.g., to provide oxygen, nutrients, pH control, etc., to the culture vessel and/or to remove metabolites, etc. Various methods of using the microfermentors, e.g., to select optimum cell strains or bioprocess parameters are provided. The invention provides microreactors having a variety of different designs, some of which incorporate active stirring and/or have the capability to operate in batch or fed-batch mode. The invention further provides an apparatus and methods for simultaneous operation of a plurality of microreactors, with monitoring of the individual microreactors during a run. The invention further provides methods of performing gene expression analysis on cells cultured in microreactors.

An online interactive system comprising a business referral and income generation system linked to one or more listed web sites of businesses in a particular locality or geographical area. Revenue is generated by way of such methods as: Merchants listing their web sites in one or more web site directories for multiple communities; banner ads; local and national coupons issued by merchants; classified job listings; classified realty listings; “4 Sale” ads; and fees for supplemental services called “Extended Services” serving to provide interactive capabilities to static web sites. The system enables quicker and substantially automated and on-line self-posting, design, selection, updating and payment for listings, ads and coupons, among other things.

The present invention relates to methods for treating carcinomas or adenocarcinomas using at least one anti-TNF antibody.

Bromine-containing compounds, added to the coal, or to the boiler combustion furnace, are used to enhance the oxidation of mercury, thereby enhancing the overall removal of mercury in downstream pollution control devices. The method is applicable to utility power plants equipped with wet FGD systems, as well as those plants equipped with spray dryer absorber FGD systems.

Embodiments of the invention relate to a vehicle comprising a plurality of inclined rotors that are operable to provide at least one of thrust and torque vectoring according to a desired thrust and/or torque vectors.

The method includes a bonus game associated with a base game that allows players to use skill and memory to determine the outcome of the bonus game. Players are prompted at the beginning of the bonus game to select at least a first and then a second game space from an array of game spaces, revealing previously hidden indicia. The player continues the selections for a predetermined period of time or until some event occurs, terminating the selections. Bonus payouts are awarded in the event the revealed indicia match. Alternative embodiments include allowing players to qualify for a “sneak peek”, wherein all or some hidden indicia on the game space array are revealed for a short period of time, and random shuffling of the indicia to different game spaces.

The invention relates to industrial lubricant and grease compositions containing high viscosity index polyalphaolefins (HVI-PAO). The use of HVI-PAOs in industrial oils and greases application provides advantages in improved shear stability, wear property, foam property, energy efficiency and improved overall performance.

A substantially planar electrochemical test strip for determination of the presence and/or quantity of an analyte in a sample is provided that has a first electrode, a first connector including two contact pads, and a first conductive lead extending between the first electrode and the first connector to establish a path for conduction of an electrical signal between the first electrode and the first connector; a second electrode, a second connector including one or more contact pads, and a second conductive lead extending between the second electrode and the second connector to establish a path for conduction of an electrical signal between the second electrode and the second connector, and a sample chamber for receiving a sample. The first and second electrode are disposed to contact a sample within the sample chamber such that an electrochemical signal is generated. The contact pad or pads of the second connector are between the contact pads of the first connector when viewed in the plane of the test strip. A meter having contacts for use with the electrochemical test strip, and a combination of a meter and an electrochemical test strip are also provided.

The invention relates to a pumping device for introduction of a fluid into a base layer, in particular into a base layer containing gas, for the production of gas-permeable structures in the base layer. The pumping device is arranged on a transportation vehicle having a separate drive unit, including a pump motor and a pump, whereby a speed/torque converter is arranged between pump and pump motor. A hydrodynamic device, in particular a hydrodynamic converter, is used in place of a transmission for speed/torque conversion.

A variety of methods and systems related to genomic profile information and related participants are described. Participants can be encouraged to allow access to their genomic profile information in a variety of ways. A peer-to-peer genomic profile information network can be implemented. A collection of genomic profile information for a large number of participants can be built, and anonymity of the participants can be maintained. Participants can maintain custodial control over their genomic profile information. Comparative tools and groups can help participants identify and communicate with other participants having similar information.

A system and method for displaying thumbnail images of the video output of one or more software applications in a window or similar graphical interface to allow the user of a computer system to conveniently and quickly monitor the overall status and progress of several software applications that are running simultaneously. The thumbnail images are generated from the VRAM associated with the software application and are preferably displayed with information corresponding to the associated software application. The thumbnail images may be static or generated at regular intervals according to user preference and the status of the software application.

A toothbrush includes a handle, and a head at an end of the handle having a thickness, a first surface, and an opposed second surface. Tooth cleaning elements extend outwardly from the first surface and have a length. A tissue cleanser is positioned on the second surface and has a plurality of tissue engaging elements and a height. A head height includes the thickness of the head, the length of the tooth cleaning elements, and the height of the tissue cleanser, and is less than 17.7 mm.

The invention relates to a method for the transmission of multimedia messages in a communication system from a transmitting terminal (MS1) to a receiving terminal (RH, MS2). The communication system comprises at least a first communication network (NW1), a second communication network (NW2) and a multimedia message switching centre (MMSC). In the first communication network (NW1), at least a first address type is used as the terminal address, and in the second communication network (NW2), at least a second address type is used as the terminal address. In the method, the address of the receiving terminal (RH, MS2) is annexed to said multimedia message. The multimedia message is further supplemented with data on the type of said address, wherein the multimedia message is transmitted from the transmitting terminal (MS1) to said multimedia message switching centre (MMSC), in which the type of the address of the receiving terminal (RH, MS2) is examined, and said address type is used to select the communication network (NW1, NW2) to be used in the transmission of the message from the multimedia message switching centre (MMSC) to the receiving terminal (RH, MS2).

A media content database is created and maintained by comparing the media items from two related media streams. Segments of media items from the streams are sampled and stored. Samples from one stream are matched against samples from the other stream to identify any repeating content in the streams. A reviewer observes the matched samples representing the repeating content and provides identifying meta-data for that content. The identified media content is then added to the media content database, where it can be used at a later time in an application that requires media content recognition.

Described herein are guidewire positioning and support devices, method for using them, method of treating a subject using them, and systems including such guidewire positioning and support devices. These devices typically include a rotatable distal tip region that may include one or more wedges. The wedges may be extendable from the rotatable distal tip. The distal end of the device may be steerable, and may be steered while still rotating the distal end of the device. The wedges (which may include sharp forward-cutting blades and blunt lateral portions) can be extended from the distal housing and locked in any position (extended, partially extended or retracted) and rotated clockwise and/or counterclockwise while locked in a retracted, extended or partially extended position. The distal region of the device may also be controllable steered from the proximal end of the device. Systems including these guidewire support catheters are also described, as are method of using them, including methods of treating chronic total occlusions.

A powered air purifying respirator system for use with at least one filter system includes: a housing including at least one inlet port and at least one outlet port; a motorized air flow system to draw air into the housing via the at least one inlet port; a control system in communicative connection with the motorized air flow system; and a filter system sensor in communicative connection with the control system. The filter system sensor provides information to the control system relating to the type of the at least one filter system upon fluid connection thereof with the housing. The control system can control the motorized air flow system at least in part on the basis of the type of filter system sensed by the filter system sensor. Another powered air purifying respirator system for use with at least one filter system includes: a housing including at least one inlet port and at least one outlet port; a motorized air flow system to draw air into the housing via the at least one inlet port; a control system in communicative connection with the motorized air flow system; and a pressure sensor in communicative connection with the control system to provide information to the control system relating to ambient pressure. The control system can, for example, control the motorized air flow system at least in part on the basis of the information relating to ambient pressure.

Two-component systems are described which are suitable for underlining, adhesive bonding of the crimped fold and sealing of auto body sections, particularly for crimped fold sealing of add-on vehicle parts. The two-component systems attain the requisite grip strength for mounting the add-on parts on the body as well as the requisite strength and dimensional stability for the production process up to and with the CIP passage, within the predetermined cycle time, on the basis of cross-linking of the sealant composition twice. In one embodiment, the surface of the two-component system is pre-cross-linked by a UV-induced reaction and by the cross-linking of the two-component system to the extent of portability. In addition, two-component systems are described which cross-link intentionally only partially up to a consistency that permits a rugged course of the process through cleaning baths and which harden completely only by means of a further hardening process, for instance in the CIP forced circulation oven.

An IV catheter introducer having a retractable needle holder and a tubular plunger that are held by a detent structure in a preferred positional relationship prior to and during insertion of the catheter. Following insertion, the plunger is pushed past the detent structure, permitting a compressed spring to force the needle holder upwardly into the plunger. A vented end cap in the plunger permits rapid venting of air displaced during retraction of the needle holder. The needle holder includes a flash chamber that is easily viewable through a clear plastic housing. Wings are provided on the housing to facililate one-handed operation of the device. A method for assembling the subject catheter introducer is also disclosed.