46 results about "Phenylacetone" patented technology

The invention relates to the technical field of high polymer material chemistry, and discloses a high and low temperature resistant anti-yellowing optical adhesive and a preparation process thereof, the high and low temperature resistant anti-yellowing optical adhesive comprises the following components by weight: 40-60% of modified organic silicon resin, 20-30% of urethane acrylate, 10-15% of alicyclic epoxy resin, 0.5-5% of a nano inorganic filler, 0.8-2.5% of an anti-yellowing composite reagent, and the balance of a solvent. The coating is prepared from the following components in percentage by weight: 0.5 to 1.5 percent of 2-hydroxy-2-methyl-1-phenyl-1-acetone, 0.1 to 0.3 percent of fluorine modified polyacrylate flatting agent and 0.3 to 1.0 percent of chloroplatinic acid-divinyl tetramethyl disiloxane complex catalyst. The preparation method comprises the following steps: mixing alpha, omega-dihydroxy polydimethylsiloxane and phenyltrimethoxysilane according to a mass ratio of 8: 2-7: 3, adding 0.3-1.0% of a chloroplatinic acid-divinyl tetramethyl disiloxane complex catalyst, and raising the temperature by stages under the protection of nitrogen, so that the glass transition temperature of the adhesive can reach 120 DEG C below zero and 125 DEG C, and the temperature of the adhesive can reach 120 DEG C below zero and 125 DEG C below zero. And the long-term service requirement of the optical device in an extreme temperature environment is met.

The invention discloses a preparation process of photoinitiator methyl benzoylformate, which comprises the following steps: carrying out bromination reaction on acetophenone serving as a raw material to obtain 2, 2-dibromo-1-phenylethanone; the method comprises the following steps: carrying out alcoholysis on 2, 2-dibromo-1-phenylethanone in a specific solvent under photocatalysis to obtain high-purity methyl benzoylformate; the preparation process has the advantages of easily available raw materials, mild reaction conditions and simple post-treatment, and is suitable for industrial production.

The invention discloses a waterproof UV (ultraviolet) curing coating and a preparation method thereof, trimethylolpropane triacrylate is used as a reactive diluent, 2-hydroxy-2-methyl-1-phenylacetone is used as a photoinitiator, polyurethane acrylate and modified filler are polymerized in the UV curing process of the coating, and a highly crosslinked waterproof UV curing coating is prepared. A perfluorocarbon chain structure and a hydrogen bond network are introduced into a polyurethane acrylate molecular chain, a molecular-level smooth super-hydrophobic layer is formed on the surface of the coating, and permeation of water molecules can be effectively blocked. The modified filler taking microcrystalline wax as a core and silicon dioxide as a shell is added, so that the wear resistance and scratch resistance of the coating can be remarkably improved, and meanwhile, the micro rough structure and the coating with low surface energy cooperatively construct a super-hydrophobic structure, so that the waterproof performance of the UV curing coating is improved.

The present invention discloses a flavonoid derivative, its microwave preparation method and application, belonging to the technical field of pharmaceutical chemistry. It includes the following steps: S1. Prepare an α-diazo carbonyl compound from a 1-phenyl-2-propanone compound through a diazotization transfer reaction; S2. Heat and react the α-diazo carbonyl compound and 3-hydroxyflavone in a microwave to prepare a flavonoid derivative. The solution of the present invention is applicable to the Wolff rearrangement reaction of α-diazo compounds and alcohol compounds in a microwave, without the need to use traditional kettle reactions, catalysts and excessive substrates, and has the advantages of simple operation, rapid reaction, few by-products, high yield, less time and a wide range of substrate applicability. Moreover, the prepared flavonoid ester compound has excellent anti-cancer effects.

The present application relates to the technical field of perovskite devices, and particularly relates to a packaging method of a perovskite device. The packaging method provided by the present application comprises the following steps: mixing methyl methacrylate, 2-methyl-2-acrylic acid-2-hydroxyethyl ester phosphate and 2-hydroxy-2-methyl-1-phenylpropanone to obtain a packaging slurry; coating the packaging slurry on the surface of the perovskite device, covering a glass plate, and performing light curing. The packaging method can improve the photoelectric current density of the device, thereby improving the efficiency of the device, and can significantly improve the outdoor stability of the device.

The embodiment of the invention discloses a polymer electrolyte for a magnesium battery and the magnesium battery. The polymer electrolyte consists of a eutectic solvent, a cross-linking agent and a photoinitiator, the eutectic solvent is any one of a Mg (TFSI) 2 / N-methylformamide system or a MgCl2 / 2-chlorine-N, N-dimethylacetamide system, and N-methylformamide or 2-chlorine-N, N-dimethylacetamide is a hydrogen bond donor in the eutectic solvent; the crosslinking agent is polyethylene glycol diacrylate, and the photoinitiator is 2, 2-dimethoxy-2-phenyl acetophenone. According to the polymer electrolyte provided by the invention, high ionic conductivity, excellent electrochemical stability and good magnesium ion reversible deposition and dissolution performance are realized, the cycling stability is enhanced, the structural stability is also considered, and the polymer electrolyte has excellent reversibility and application potential in a magnesium battery; and the cycling stability and the energy efficiency of the magnesium battery can be obviously improved.

This invention discloses a high-adhesion optical adhesive for extreme conditions, its preparation method, and its application, belonging to the field of optical adhesive technology. It comprises the following components in parts by weight: 20-30 parts of 2-methyl-6-methylene-1,7-octadien-3-one, 15-25 parts of 1,4-butanediol dimethacrylate, 15-25 parts of tetraethylene glycol dimethacrylate, 5-10 parts of α-methacrylic acid, 5-10 parts of hydroxyethyl methacrylate, 2-5 parts of vinyltriethoxysilane, 0.1-0.5 parts of 1-hydroxycyclohexylphenyl ketone, 0.1-0.5 parts of 2-hydroxy-2-methyl-1-phenyl-1-propanone, and 0.3-0.5 parts of 1-[9-ethyl-6-(2-methylbenzoyl)-9H-carbazole-3-yl]acetone-1-(O-acetyloxime). The optical adhesive of the present invention has excellent bonding performance and can prevent the bonded components from debonding and causing cohesive failure at the bonding joint in humid, steamy, or chemical solvent environments.

This invention discloses a method for preparing and applying o-pyrazolylphenylacetone olefin derivatives. The method involves dispersing o-pyrazolylphenylpropenol compounds, aryl aldehyde compounds, and a catalyst in an organic solvent to react and obtain o-pyrazolylphenylacetone derivatives. The method for synthesizing o-pyrazolylphenylacetone derivatives of this invention has advantages such as inexpensive raw materials, simplicity and efficiency, mild reaction conditions, high atom economy, easy product purification, and green economy. The obtained products can be directly applied as potential drugs in the pharmaceutical field, showing broad application prospects.

A method of cell culture comprising providing cells in a cell culture medium to start a cell culture process, and, maintaining at least one metabolite selected from 3-(4-hydroxyphenyl)lactate, 4-hydroxyphenylpyruvate, phenyllactate, indolelactate, indolecarboxylic acid, homocysteine, 2-hydroxybutyric acid, isovalerate and formate below a concentration C1 in the cell culture medium, wherein C1 is 3 mM and / or (ii) maintaining at least one amino acid selected from phenylalanine, tyrosine, tryptophan, methionine, leucine, serine, threonine and glycine below a concentration C2 in the cell culture medium, wherein C2 is 2 mM.

The invention provides an ultrathin composite diaphragm for a battery and a preparation method thereof, and the preparation method of the ultrathin composite diaphragm for the battery comprises the following steps: uniformly mixing polyamide acid, a template agent, modified MXene and a solvent to obtain a spinning solution; carrying out electrostatic spinning on the spinning solution, carrying out imidization reaction, and removing the template agent to obtain a porous composite fiber membrane; 2-hydroxy-2-methyl-1-phenylacetone is loaded on the obtained porous composite fiber membrane, then the porous composite fiber membrane is soaked in a monomer-containing mixed solution, and the ultrathin composite diaphragm for the battery is obtained through a reaction; wherein the monomer-containing mixed solution is prepared from N-isopropylacrylamide, 2-allyl furan, bismaleimide and N, N '-methylenebisacrylamide, and the monomer-containing mixed solution is prepared from N-isopropylacrylamide, 2-allyl furan, bismaleimide and N, N'-methylenebisacrylamide. According to the preparation method of the ultrathin composite diaphragm for the battery, the obtained diaphragm is good in mechanical property and high in safety.

The invention belongs to the technical field of inverse opal photonic crystal materials, and discloses an anthracene-doped inverse opal structure thin film with a function of rapidly preparing a fluorescent pattern, and a preparation method and application of the anthracene-doped inverse opal structure thin film. The film is formed by compounding a polyacrylate copolymer and a silicon dioxide photonic crystal and etching in hydrofluoric acid. The polyacrylate copolymer is obtained by carrying out bulk polymerization on polyethylene glycol monophenyl acrylate doped with 10-(1-naphthyl) anthracene-9-boric acid and ethoxylated trimethylolpropane triacrylate under the action of a photoinitiator, namely 2-hydroxy-2-methyl-1-phenylacetone. The film has great application potential in the aspects of visual optical anti-counterfeiting and programmable fluorescent switch integration, and is expected to become a new generation of optical anti-counterfeiting label due to the characteristics of rapid patterning and high brightness.

The invention belongs to the technical field of cross-linking agent synthesis, and particularly relates to an efficient and green cross-linking agent BIPB and a preparation method thereof. The efficient and green cross-linking agent BIPB is prepared from the following raw materials: tert-butyl hydroperoxide, 2-hydroxyisopropyl benzene, a perchloric acid solution, epoxy acrylate, reinforced ethylene glycol vinyl ether, 2-hydroxy-2-methyl-1-phenylacetone, a surfactant and petroleum ether. A photocuring system is constructed in the preparation process of a cross-linking agent BIPB, firstly, acrylate groups are grafted on the surface of the cross-linking agent BIPB to achieve efficient absorption of light energy, meanwhile, reinforced ethylene glycol vinyl ether is introduced, in the cross-linking process, dispersion of the cross-linking agent BIPB is improved, aggregation is avoided, and in order to ensure that the photocuring system can achieve reaction, the photocuring system is prepared. The prepared BIPB crystal is subjected to surface treatment through a surfactant, and then 2-hydroxy-2-methyl-1-phenylacetone is adsorbed on the surface of the BIPB crystal, so that efficient and green crosslinking is realized.

The invention relates to the technical field of plastic master batches, in particular to a PET (Polyethylene Terephthalate) color master batch containing ultra-dispersed carbon black and a preparation method of the PET color master batch. The preparation method comprises the following steps: firstly, adding gamma-methacryloxypropyltrimethoxysilane, carbon black powder, a dopamine solution and a titanium reaction solution to obtain a modified titanium dioxide coated carbon black material; and adding thiohydracrylic acid, diethanol amine, dimethylaminoethyl methacrylate and epoxy chloropropane to obtain the thiolated antibacterial substance. 3-bromo-1-propanol, methacryloyl chloride and triphenylphosphine are added, so that the quaternary phosphonium antibacterial substance is obtained. Finally, polyethylene glycol terephthalate, the modified titanium dioxide coated carbon black material, a sulfhydrylation antibacterial substance, a quaternary phosphonium antibacterial substance and a photoinitiator 2-hydroxy-2-methyl-1-phenyl-1-acetone are used as main raw materials, and a finished product is prepared. The finished product prepared by the invention has excellent antibacterial property and color uniformity, so that the finished product has a wide application prospect in the technical field of plastic master batches.

The application discloses a waterproof UV curing paint and a preparation method thereof, wherein trimethylolpropane triacrylate is used as an active diluent, 2-hydroxy-2-methyl-1-phenylpropanone is used as a photoinitiator, polyurethane acrylate and modified fillers are polymerized in a UV curing process of the paint, and a high-crosslinking waterproof UV curing coating is prepared. A perfluorocarbon chain structure and a hydrogen bond network are introduced into a polyurethane acrylate molecular chain, a molecular-level smooth super-hydrophobic layer is formed on the surface of the coating, and the molecular-level smooth super-hydrophobic layer can effectively block the penetration of water molecules. The modified fillers with microcrystalline wax as a core and silicon dioxide as a shell are added, the wear resistance and scratch resistance of the coating can be significantly improved, and meanwhile, the microcrystalline wax and the coating with low surface energy cooperatively construct a super-hydrophobic structure, so that the waterproof performance of the UV curing paint is improved.

The invention discloses an OCA optical adhesive and a production process thereof. The OCA optical adhesive is prepared from the following raw materials in parts by weight: 70 to 80 parts of 2-ethylhexyl acrylate, 20 to 30 parts of methyl methacrylate, 10 to 15 parts of hydroxyethyl acrylate, 7 to 8 parts of acrylic acid, 8 to 10 parts of modified monomer, 1 to 1.5 parts of modified filler, 2 to 3 parts of 2-hydroxy-2-methyl-1-phenyl-1-acetone and 8 to 10 parts of tetrahydrofuran. Double bonds on the modified monomer and double bonds on the surface of the modified filler can react with other monomers in the raw materials, the modified monomer is of a dendritic structure, OCA optical cement molecules can form the dendritic structure, and the modified filler can form a structure that an organic polymer chain is wrapped by an inorganic matter. And through cooperation with an imine structure on the modified monomer, a boric acid ester structure and an imine structure on the modified filler, the prepared OCA optical cement has a very good bending-resistant effect.

The application discloses a preparation method of hydrogenated aldehyde ketone resin without free formaldehyde, belongs to the technical field of aldehyde ketone resin synthesis, and aims to solve the technical problems of high free formaldehyde content, and further improved hydroxyl value stability and transparency in the hydrogenated aldehyde ketone resin in the prior art, and specifically comprises the following steps: under the protection of an inert gas atmosphere, phenylacetone, polyformaldehyde and a solvent are mixed and stirred, the reaction system is heated to 60-75 DEG C, and an inorganic alkali is added into the reaction system. The application is characterized in that the basic aldehyde ketone resin solution prepared by condensation of polyformaldehyde and phenylacetone in a water-free environment with a nickel catalyst is catalytically hydrogenated, not only the hydrogenated aldehyde ketone resin with stable hydroxyl value and extremely low colority is effectively obtained, but also the free formaldehyde content in the hydrogenated aldehyde ketone resin is effectively reduced, and the wide applicability of the hydrogenated aldehyde ketone resin in high-end coatings, adhesives and electronic materials is improved.

This invention belongs to the interdisciplinary field of natural product medicinal chemistry and oral medicine, specifically disclosing the application of uvangoletin in the preparation of anti-periodontalgia drugs. Uvangoletin is 1-(2,4-dihydroxy-6-methoxyphenyl)-3-phenyl-1-propanone, with the molecular formula C. 16 H 16 O4, experiments confirmed that its MIC for Porphyromonas gingivalis was 16 μmol / L, MIC 50 The concentration is 10.28 μmol / L, the MIC for Fusobacterium nucleatum is 16 μmol / L and the MIC50 is 6.86 μmol / L. It has no inhibitory activity against Streptococcus mutans and has selective anti-periodontal pathogenic bacteria characteristics. It can be made into oral preparations such as gels, mouthwashes or toothpaste.

The invention relates to a thermoplastic modified organic silicon material as well as a preparation method and application thereof, and the thermoplastic modified organic silicon material comprises the following raw material components in parts by weight: 10-15 parts of an organic silicon polymer containing disulfide bonds, 40-70 parts of an acrylate monomer and 0.5-1.5 parts of a photoinitiator, the disulfide bond-containing organosilicon polymer is obtained by reacting a disulfide bond-containing silane coupling agent with an organosilicon polymer, and the mass ratio of the disulfide bond-containing silane coupling agent to the organosilicon polymer is 1: (1.6-2); the photoinitiator is at least one of 2-hydroxy-2-methyl-1-phenyl-1-acetone or 2-hydroxy-4 '-(2-hydroxyethoxy)-2-methyl propiophenone, and the photoinitiator is at least one of 2-hydroxy-2-methyl-1-phenyl-1-acetone and 2-hydroxy-4'-(2-hydroxyethoxy)-2-methyl propiophenone. In the presence of a specific photoinitiator, an acrylate monomer is subjected to an in-situ photopolymerization reaction on the surface of the organosilicon polymer containing disulfide bonds, so that the thermoplastic modified organosilicon material has thermoplastic capability.

The application discloses a kind of polybutyl acrylate modified silicone rubber base temperature-resistant heat-insulating coating, which is made of the following ingredients by mass fraction: alpha, omega-dihydroxyl terminated polydimethylsiloxane 100 parts, butyl acrylate 20~40 parts, 2-hydroxy-2-methyl-1-phenyl-1-propanone 0.5~1 part, KY-405, KY-01 or alkylated phenothiazine 1~2 parts, hollow glass microsphere 17.5~40 parts, dibutyltin dilaurate 2 parts, tetraethyl orthosilicate 5 parts;The preparation method of the coating is: adding photoinitiator and reactive diluent into base glue, stirring under ultraviolet light, adding the remaining ingredients in turn, stirring evenly, then brushing and curing. The coating of the application uses butyl acrylate as a reactive diluent, inhibits the increase of system viscosity, increases the addition amount of heat-insulating filler, and improves the temperature resistance and heat-insulating performance of the coating. The preparation method of the application is simple, environmentally friendly and low in cost.

The present invention discloses an easy-to-release aluminum film plate and a preparation method thereof. The method comprises the following steps: step 1, degreasing the surface of the aluminum film plate, then cleaning and drying it; step 2, roller coating the dried aluminum film plate; step 3, ultraviolet curing the aluminum film plate after roller coating; wherein the coating comprises, by weight, 35-40 parts of polyurethane acrylate, 10-20 parts of epoxy acrylate, 15-25 parts of trimethylolpropane triacrylate, 10-15 parts of adipic acid diacrylate, 3-10 parts of anticoagulant, 1-5 parts of 2-hydroxy-2-methyl-1-phenylacetone, 1-3 parts of polydimethylsiloxane, and 5-10 parts of filler; the anticoagulant is prepared by heating and melting dehydroabietic acid and C5 petroleum resin in a preset mass ratio, and grinding them into fine powder after cooling. The present invention aims to achieve efficient demoulding of concrete.

The invention relates to terpenyl acetophenone compounds as well as a preparation method and application thereof, and belongs to the field of medicines. The terpenyl acetophenone compound is prepared by taking ferula ferulae as a raw material for the first time, the colon cancer resisting activity of the terpenyl acetophenone compound is systematically evaluated, and the application of the terpenyl acetophenone compound in development of chemical prevention and treatment drugs related to colon cancer is elaborated. According to the invention, in-vitro HCT-116 and HT-29 cells are used as models to carry out an anti-colon cancer activity test, and the inhibition activity of the prepared terpenyl acetophenone compounds 1-8 on colon cancer cells is evaluated. Results show that the novel terpenyl acetophenone compounds have remarkable anti-colon cancer activity and can be used for developing anti-colon cancer chemopreventive agents or therapeutic drugs.

This invention relates to carbon-13 labeled psychoactive substances, the chemical structural formula of which is: . This invention also provides a method for preparing the aforementioned carbon-13 labeled psychoactive substances, comprising the following steps: (1) 13 C-C3-alanine reacts with Boc2O and a methylating agent to form N-methyl-N-Boc- 13 (2) The product obtained in step (1) is reacted with N,O-dimethylhydroxylamine to obtain an intermediate; (3) The intermediate obtained in step (2) is reacted with a phenyl nucleophile to obtain 13 C-C3-2-N-Boc-methylamino-1-phenyl-1-propanone; (4) The product obtained in step (3) is subjected to a Boc protecting group removal reaction to obtain the carbon 13-labeled psychoactive substance. The present invention also provides the use of the carbon 13-labeled psychoactive substance in detecting the content of methcathinone in biological or environmental samples.

The application discloses a biosynthesis method based on multi-enzyme cascade reaction and belongs to the field of bioengineering. The biosynthesis method based on multi-enzyme cascade reaction has the following steps: S1, adding omega-transaminase to racemic-alpha-phenethylamine until the racemic-alpha-phenethylamine is converted into phenylacetone by (S)-alpha-phenethylamine under the action of the omega-transaminase, and (R)-alpha-phenethylamine is left; S2, adding aldehyde-ketone reductase to the phenylacetone so that the phenylacetone is reduced into (R)-alpha-phenethyl alcohol under the action of the aldehyde-ketone reductase, and glutamate dehydrogenase is added in S1 and S2 to maintain the cycle of coenzyme NADPH / NADP + and the auxiliary substrate alpha-ketoglutarate / glutamate, (R)-alpha-phenethylamine and (R)-alpha-phenethyl alcohol are generated by the three-enzyme one-pot method catalysis of the racemic-alpha-phenethylamine; (R)-alpha-phenethylamine and (R)-alpha-phenethyl alcohol are generated by the three-enzyme co-expression of the catalysis of the engineering bacteria; (R)-alpha-phenethylamine and (R)-alpha-phenethyl alcohol can be synthesized simultaneously, the method can be suitable for various industrial production scenes, and has important industrial application value.

The present invention relates to a modified photoinitiator based on 2-hydroxy-2-methyl-1-phenyl-1-acetone, which has high thermal stability and excellent migration stability and can be used to prepare PDMS membranes. The present invention also relates to a method for preparing the above-mentioned modified photoinitiator, which reacts alkyl chains of different lengths, namely hexyl isocyanate, dodecyl cyanate, and octadecyl isocyanate, with the hydroxyl group of 1173 photoinitiator through an isocyanate bond to introduce an alkyl group into the 1173 photoinitiator, thereby improving the thermal stability and migration stability of the photoinitiator. Through pervaporation testing, it was found that the PDMS membrane prepared with the modified photoinitiator has improved separation performance for butanol.

The preparation method comprises the following steps: mixing N-substituted quinoxaline ketone as shown in a formula (II), an acetophenone compound as shown in a formula (III), DDQ, a solvent and a catalyst, reacting at 80 DEG C for 12 hours, and performing post-treatment on reaction liquid to obtain the 3-alkenylated quinoxaline ketone compound as shown in a formula (I), the method has the advantages of high atom economy, simplicity in operation, less pollution and the like; .

The application discloses a kind of carbon dioxide corrosion inhibitor based on mannich base and its preparation method and application, belong to petroleum chemical industry metal material protection technical field.Main agent mannich base is with 3-amino crotonitrile, 3-hydrazine quinoline, phenylacetone, cinnamaldehyde as main, it is prepared by condensation, mannich two-step reaction, its structure is as shown in formula A.The inhibitor includes by mass percentage:mannich base A 30~40%, alkylamine 8~16%, potassium iodide 0.3~0.6%, surfactant 10~20%, organic solvent 30~60%.Mannich base A synthesis is simple, post-treatment is convenient, molecule contains quinoline, pyrazole, carbonyl, double bond, phenyl functional group simultaneously, can be well adsorbed on carbon steel surface and form dense protective film to prevent the invasion of corrosive medium.Add alkylamine, potassium iodide, surfactant, organic solvent, water solubility increases after compounding, corrosion inhibition effect is enhanced.The corrosion inhibitor has the characteristics such as small amount, high efficiency, wide application range, and has wide application prospect in oil and gas production.

This invention discloses a dihydrochalcone-based oral spray and its preparation method, belonging to the field of oral pharmaceutical formulations. The spray uses 1-(2,4-dihydroxy-6-methoxyphenyl)-3-phenyl-1-propanone and 2',6'-dihydroxy-3',4'-dimethoxydihydrochalcone, isolated and purified from *Sarcandra glabra*, as active ingredients. It is solubilized using a medium-chain triglyceride / polyoxyethylene hydrogenated castor oil / propylene glycol self-microemulsification delivery system, and hydroxypropyl methylcellulose is introduced to enhance mucosal adhesion. This spray can spontaneously form nanoemulsion droplets in oral saliva, selectively inhibiting *Porphyromonas gingivalis* and *Fusobacterium nucleatum*, and is suitable for adjunctive treatment of gingivitis and periodontitis.

The application provides a preparation method of acetophenone, acetophenone prepared by the method and application. The steps comprise: reacting ethylbenzene and an oxygen-containing gas under the action of a catalyst and a cocatalyst, and then performing rectification to obtain acetophenone; wherein the catalyst is a metal acid salt, and the cocatalyst is an alkyl siloxane. The method can effectively reduce the types of impurities, improve the selectivity of acetophenone, and through continuous rectification separation, the content of the obtained acetophenone is greater than or equal to 99.9%, the content of 1-phenyl ethanol is 0-100 ppm, and the content of phenyl acetaldehyde is 0-100 ppm. In the ethylbenzene oxidation reaction, through the research on the reaction mechanism, the acetophenone has the characteristics of high yield and few types of impurities, and high-purity acetophenone is obtained through rectification separation.

The invention discloses a preparation method of hydrogenated aldehyde ketone resin without free formaldehyde, belongs to the technical field of aldehyde ketone resin synthesis, and aims at solving the technical problems that the content of free formaldehyde in hydrogenated aldehyde ketone resin in the prior art is high, and the hydroxyl value stability and transparency need to be further improved. The method specifically comprises the following steps: under the protection of an inert gas atmosphere, mixing and stirring acetophenone, paraformaldehyde and a solvent, heating a reaction system to 60-75 DEG C, and adding inorganic alkali into the reaction system; according to the invention, the nickel catalyst is used for catalytic hydrogenation of the alkaline aldehyde ketone resin solution prepared by condensation of paraformaldehyde and acetophenone in an anhydrous environment, such that the hydrogenated aldehyde ketone resin with stable hydroxyl value and extremely low chroma is effectively obtained, and the content of free formaldehyde in the hydrogenated aldehyde ketone resin is effectively reduced. The wide applicability of the hydrogenated aldehyde ketone resin in high-end coatings, adhesives and electronic materials is improved.

The application discloses a method for synthesizing florfenicol through chemical enzyme coupling, and takes sodium beta-fluoro pyruvic acid salt, p-methyl sulfone benzaldehyde and D-alanine as substrates, under the cascade catalysis of pyruvate decarboxylase and transaminase, florfenicol amine is synthesized through a one-pot method, and florfenicol is synthesized through an amidation reaction. The synthesis route comprises the following steps: under the catalysis of pyruvate decarboxylase, the sodium beta-fluoro pyruvic acid salt and the p-methyl sulfone benzaldehyde are reacted to generate (1R)-3-fluoro-1-hydroxy-1-p-methyl sulfone phenyl-2-propanone; (1R)-3-fluoro-1-hydroxy-1-p-methyl sulfone phenyl-2-propanone and D-alanine are continuously converted into florfenicol amine by the transaminase in the reaction system, and finally, the florfenicol amine is subjected to a one-step chemical amidation reaction to synthesize florfenicol. Compared with the traditional chemical synthesis method of florfenicol, the method has fewer steps, and the steps related to configuration are replaced by high-stereoselective enzyme catalysis, so that the splitting step is saved, the reaction process is more green and environmentally friendly, the atom economy is higher, and the method is suitable for promotion and application.