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35 results about "Phenylalanine+Tyrosine" patented technology
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Novel compound L-4-terazine-phenylalanine, preparation method and application thereof
InactiveCN102627615AGood medicineHigh yieldPeptide preparation methodsOrganic additionFormamidine acetateProtein molecules
The invention discloses a novel amino acid derivative L-4-terazine-phenylalanine (3-(4-(1,2,4,5-tetrazin-3-yl) phenyl)-2-aminopropanoic acid). L-4-cyan-phenylalanine is used as an initial reactant and reacts with formamidine acetate and anhydrous hydrazine under catalysis of sulfur; then the reactants are oxidized by sodium nitrite to generate L-4-1,2,4,5-terazine-phenylalanine. The L-4-1, 2, 4, 5-terazine-phenylalanine is integrated into the biologically active peptide and protein molecules as phenylalanine / tyrosine analogue, and can be applied to on biological orthogonal field based on inverse electronic Diels-Alder reaction as a biomarker; meanwhile, the L-4-1,2,4,5-terazine-phenylalaninethe can be introduced into biologically active peptide as phenylalanine / tyrosine analogue through solid phase polypeptide synthesis method and conduct pharmacological evaluation, so as to improve drug property of certain biologically active peptide.
Owner:LANZHOU UNIVERSITY
Hericium erinaceus mycelium and culture method thereof
ActiveCN104195052AEasy to controlImprove anti-tumor effectFungiMicroorganism based processesDipeptidePhenylalanine+Tyrosine
The invention discloses hericium erinaceus mycelium and a culture method thereof. The hericium erinaceus mycelium contains amino acids and vitamins of relatively high content as well as seven cyclic dipeptides, ergosterol and carboxymethylcellulose activities, wherein the seven cyclic dipeptides are respectively cyc(valine-tyrosine), cyc(leucine-tyrosine), cyc(phenylalanine-tyrosine), cyc(phenylalanine-phenylalanine), cyc(leucine-leucine), cyc(leucine-alanine) and cyc(valine-alanine). The culture method comprises the following steps: culturing a stock strain, culturing a seed strain, culturing a cultispecie strain, performing primary'orientated' biotransformation and performing secondary'orientated' biotransformation. The hericium erinaceus mycelium which is cultured by using the culture method is relatively good in anti-tumor curative effect.
Owner:HUNAN XINHUI PHARMA
Hydroxyl phenylalanine tyrosine urine detecting kit
InactiveCN105181687AMaterial analysis by observing effect on chemical indicatorPhosphomolybdic acidPhenylalanine+Tyrosine
The invention provides a hydroxyl phenylalanine tyrosine urine detecting kit, and the detecting kit is at least mixed from an acidic solution, phospho molybdic acid and / or a soluble salt of phosphomolybdic acid; the acidic solution at least contains H+, Ni2+, Hg+ and NO3-, and the concentration of phosphomolybdic acid and / or the soluble salt of phosphomolybdic acid in the detecting kit is 45-900 mmol / L. The detecting kit has a higher detection accuracy.
Owner:朱建华
Method and device of separating and extracting amino acid products from protein hydrolysates
ActiveCN103787939AHigh yieldComply with environmental emission requirementsOrganic compound preparationAmino-carboxyl compound preparationPhenylalanine+TyrosineTyrosine
The invention discloses a method and device of separating and extracting amino acid products from protein hydrolysates. The method comprises the following steps that amino acid mixed solutions are attenuated by water, flow through an I-shaped column, and are washed, ethanol hydrochloric acid mixed solutions flow through the chromatographic column, collecting fluids are obtained by the combination of washing liquor and the ethanol hydrochloric acid mixed solutions, the collecting fluid is adjusted at the PH of about 5.0 to about 6.0, tyrosine can be acquired through filtration, a filter liquor is neutralized by alkali at the PH of more than 7.0, the filter liquor flows through a III-shaped column, and phenylalanine, tyrosine and / or tryptophan are acquired through separation; the ethanol hydrochloric acid mixed solutions flowed through the I-shaped column is adjusted at the PH of more than 7.0, the ethanol hydrochloric acid mixed solutions flow through a II-shaped column, and light components separation solutions, pulp components separation solutions and propanal components separation solutions can be acquired by the sequential adoption of washing, hydrochloric acid extrication and collecting the scrubbing solution in segments; A subsequent separation is conducted for the separation solutions and all the amino acid products are acquired. The method can increase variety of species and yield rate of a single amino acid, the water body for separation and extraction can be recycled, and waste water meets the requirements of environmental emissions.
Owner:广州博采生物科技有限公司
Maltose substrate specificity improved cyclodextrin glycosyltransferase and preparation method thereof
ActiveCN102965353AIncreased substrate specificityIncrease productionBacteriaTransferasesWild typeTyrosine
The invention discloses maltose substrate specificity improved cyclodextrin glycosyltransferase and a preparation method thereof, and belongs to the field of genetic engineering and enzyme engineering. The 47th lysine (Lys) of CGTase of P.macerans strain HFB05-01 (CTCC NO:M208063) is respectively replaced by phenylalanine (Phe), tyrosine (Tyr) and proline (Pro), so that the output of AA-2G is respectively improved by 17.1%, 22.1% and 32.9%. Compared with the wild CGTase, the mutant strains are more conductive to producing AA-2G for glycosyl donors by utilizing maltose, so that important industrial application prospect is provided.
Owner:JIANGNAN UNIV
Use of cathepsin L inhibitor in preparation of radiotherapeutic sensitization drug
InactiveCN102423489AOvercoming radiation resistanceOrganic active ingredientsGenetic material ingredientsPhenylalanine+TyrosineSensitization drug
Owner:SUZHOU UNIV
Combined ligand, combined bionic chromatography medium and preparation method and application thereof
ActiveCN108558988AImprove adsorption yieldSimple designIon-exchange process apparatusIon-exchanger regenerationN-BromosuccinimidePhenylalanine+Tyrosine
The invention relates to a combined ligand, a combined bionic chromatography medium and a preparation method and application thereof. The combined bionic chromatography medium uses hydrophilic porousmicrospheres as chromatography matrix, is activated by allyl bromide, is brominated and alcoholized by N-bromosuccinimide, and then is coupled with the combined ligand. The sequence of the combined ligand is phenylalanine-tyrosine-glutamic acid-5-aminobenzimidazole. The combined bionic chromatography medium has two functional groups including phenylalanine-tyrosine-glutamic acid tripeptide and aminobenzimidazole, introduces a hydrophobicity charge-inducing ligand while retaining the high selectivity characteristic of a polypeptide ligand to an antibody, makes elution conditions milder, and achieves effective antibody isolation.
Owner:ZHEJIANG UNIV
Metabolically engineered cells for the production of pinosylvin
A genetically engineered micro-organism having an operative metabolic pathway producing cinnamoyl-CoA and producing pinosylvin therefrom by the action of a stilbene synthase is used for pinosylvin production. Said cinnamic acid may be formed from L-phenylalanine by a L-phenylalanine ammonia lyase (PAL) which is one accepting phenylalanine as a substrate and producing cinammic acid therefrom, preferably such that if the PAL also accepts tyrosine as a substrate and forms coumaric acid therefrom, the ratio Km(phenylalanine) / Km(tyrosine) for said PAL is less than 1:1 and if said micro-organism produces a cinammate-4-hydroxylase enzyme (C4H), the ratio Kcat(PAL) / Kcat(C4H) is at least 2:1.
Owner:EVOLVA SA
Tetrapeptide chromatography medium taking phenylalanine-tyrosine-histidine-glutamic acid as functional ligand, and application of tetrapeptide chromatography medium
ActiveCN108905980ALarge adsorption capacityHigh affinityOther chemical processesPeptide preparation methodsPhenylalanine+TyrosineHexamethylenediamine
The invention discloses a tetrapeptide chromatography medium taking phenylalanine-tyrosine-histidine-glutamic acid as a functional ligand, and application of the tetrapeptide chromatography medium; the tetrapeptide chromatography medium can be used for antibody separation. The tetrapeptide chromatography medium is obtained by taking hydrophilic porous microspheres as chromatography matrix, adopting allyl bromide activation and bromo-alcoholization, linking hexamethylenediamine to form a space arm, and then coupling phenylalanine-tyrosine-histidine-glutamic acid as the tetrapeptide ligand. Thetetrapeptide chromatography medium provided by the invention has good binding ability and absorption selection property to an antibody, can absorb the antibody under the neutral condition and efficiently dissociate the antibody under the weak acidic condition, is mild in separation conditions, and can be applied to separation of monoclonal antibodies from cell culture supernatant and separation ofimmunoglobulins from human serum.
Owner:ZHEJIANG UNIV
Method of cell culture
Owner:PFIZER INC
Method for separating immune globulin IgG from human serum
ActiveCN108059673AStrong specificityHigh puritySerum immunoglobulinsPeptide preparation methodsPhenylalanine+TyrosineSerum samples
The invention relates to a method for separating immune globulin IgG from human serum. The method comprises the following steps: 1) diluting the human serum by a buffer solution, adjusting a pH to 6.0to 8.0 and filtering by a filter membrane to obtain a human serum sample; 2) feeding the human serum sample into a chromatographic column, washing by a balancing buffer solution, then eluting by a eluting buffer solution and collecting eluent to obtain the immune globulin IgG solution, the chromatographic column is filled with a combined type bionic chromatography medium, the combined type bionicchromatography medium is prepared from a chromatography matrix and combined type ligand, the chromatography matrix is a hydrophilic porous microsphere with hydroxyl, and a sequence of the combined type ligand is phenylalanine-tyrosine-glutamine-5-aminobenzimidazole; 3) performing utlrafiltration and concentration on the immune globulin IgG solution to obtain the immune globulin IgG. The method can improve an efficiency and a purity for separating the immune globulin IgG from blood.
Owner:ZHEJIANG UNIV
Hydrothorax fluid microparticle metabolite combination, kit and method for diagnosing tuberculous pleurisy
ActiveCN110954605AHigh diagnostic sensitivityHighly specific featuresComponent separationCholic acidPhenylalanine+Tyrosine
The invention relates to a hydrothorax microparticle metabolite combination, a kit and a method for diagnosing tuberculous pleurisy. The pleural effusion microparticle metabolite composition for diagnosing tuberculous pleurisy comprises phenylalanine, tyrosine, methionine, kynurenine, lauroyl carnitine, glycine-binding chenodeoxycholic acid, phosphatidylcholine with the ratio of 36: 7 and lysophosphatidylcholine with the ratio of 20: 2. The kit for diagnosing tuberculous pleurisy comprises an internal standard substance for detecting the concentration of metabolites in the pleural effusion microparticle sample extraction solution. A combined marker provided by the invention has the characteristics of high sensitivity and high specificity for the diagnosis of tuberculous pleurisy, at the same time, can be complementary with a traditional marker adenosine deaminase, and can be used for the auxiliary diagnosis of the tuberculous pleurisy by being combined with the traditional marker adenosine deaminase.
Owner:XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV
Method of cell culture
A method of cell culture comprising providing cells in a cell culture medium to start a cell culture process, and,maintaining at least one metabolite selected from 3-(4-hydroxyphenyl)lactate, 4-hydroxyphenylpyruvate, phenyllactate, indolelactate, indolecarboxylic acid, homocysteine, 2-hydroxybutyric acid, isovalerate and formate below a concentration C1 in the cell culture medium, wherein C1 is 3 mM and / or(ii) maintaining at least one amino acid selected from phenylalanine, tyrosine, tryptophan, methionine, leucine, serine, threonine and glycine below a concentration C2 in the cell culture medium, wherein C2 is 2 mM.
Owner:PFIZER INC
Method for extracting low-sodium plant salt contained in low-nitrite sea asparagus in saline land
InactiveCN104839611AReduce contentReduce conductivityAspharagus cultivationAgriculture gas emission reductionPhenylalanine+TyrosineAsparagus adscendens
The invention provides a method for extracting low-sodium plant salt contained in low-nitrite sea asparagus in a saline land. The method comprises the steps of planting the sea asparagus in the saline land and extracting the plant salt, wherein the step of planting the sea asparagus in the saline land include seed processing and seedling raising, and the plant salt extracting step include subcritical carbon dioxide-liquid ammonia extraction. By adopting the method for extracting the low-sodium plant salt contained in the low-nitrite sea asparagus in the saline land, the planting yield is 3650-3700 kilograms / mu, and the carbon sequestration capacity of absorbing carbon dioxide of plants per hectare is 5.3-5.5 tons. The nitrite content contained in plant bodies is remarkably reduced, and the yield of the obtained plant salt is improved. The sodium chloride content of the obtained plant salt is 38.1-38.9%, and the obtained plant salt is rich of amino acid, proline, phenylalanine and tyrosine.
Owner:WEIFANG YOURONG IND
Method for separating phenylalanine, tyrosine and tryptophan racemates
InactiveCN106000101AImprove the separation effectEasy to operateDispersed particle separationTryptophanChemistry
The invention relates to a method for separating phenylalanine, tyrosine and tryptophan racemates, in particular to a method for separating D,L-amino acid racemates. Cu and L-histidine are used as chiral selectors, beta-cyclodextrin is used as a separating medium, disodium hydrogen phosphate is used as a buffering solution, a ligand exchange method is used so that a ternary complex can be formed through left-handed and right-handed rotation of Cu, L-histidine and a pantozol drug, under the action of the separating medium beta-cyclodextrin, enantiomers are separated through a capillary electrophoresis apparatus, the D,L-amino acid racemates are separated through a ligand exchange capillary electrophoresis method, and Cu, L-histidine and beta-cyclodextrin are used as the chiral selectors, wherein beta-cyclodextrin is used as the separating medium. The method is easy to operate, the chiral selectors are low in price and easy to obtain, dosage of a sample and reagents is small, and the method can be used for in vivo analysis of amino acids and detection of product optical purity.
Owner:SHENYANG INSTITUTE OF CHEMICAL TECHNOLOGY
Water-soluble fertilizer suitable for topdressing of apples in coloring period and application of water-soluble fertilizer
InactiveCN112851428AConducive to topdressingAchieve synthesisAlkali orthophosphate fertiliserAmmonium orthophosphate fertilisersPhenylalanine+TyrosineSucrose
The invention belongs to a water-soluble fertilizer suitable for topdressing of apples in a coloring period and an application thereof. The fertilizer is prepared from the following raw materials: urea, industrial monoammonium, monopotassium phosphate, potassium nitrate, urea phosphate, phenylalanine, tyrosine, urine black acid, abscisic acid, gibberellin, jasmonate, ethylene, cane sugar, sodium nitroprusside and genistein. As a water-soluble topdressing fertilizer, the water-soluble fertilizer disclosed by the invention can realize topdressing in the coloring period of apples so as to realize rapid coloring of the apples, also considers the solubility of each component in the fertilizer, and can avoid the influence on the effect of the water-soluble fertilizer due to precipitation generated by interaction of the raw materials; the product has the advantages that after the bags outside the apples are picked off, leaf picking, fruit turning, flower thinning and film laying are not needed, the apples can be rapidly colored, and the fruits have both the appearance and the quality.
Owner:HENAN XINLIANXIN FERTILIZER
Hybrid ligand, hybrid biomimetic chromedia and preparing method and use thereof
ActiveUS20210009635A1Improve hydrophobicityAssist dissociationPeptide preparation methodsImmunoglobulinsPhenylalanine+TyrosineAntiendomysial antibodies
This invention relates to a hybrid ligand, a hybrid biomimetic chromedia and a preparing method and a use thereof, wherein the hybrid biomimetic chromedia takes hydrophilic porous microsphere as a substrate in chromatography, activated with allyl bromide and undergoing bromo-alcoholization with N-bromosuccinimide, then coupled with the hybrid ligands. The sequence of the hybrid ligand is phenylalanine-tyrosine-glutamine-5-aminobenzimidazole. The hybrid biomimetic chromedia has both of the two functional groups of phenylalanine-tyrosine-glutamine tripeptide and aminobenzimidazole, while maintaining the high antibody selectivity of polypeptide ligand, hydrophobic electric charge inductive ligand is introduced to achieve more moderate elution requirement, realizing effective antibody separation.
Owner:ZHEJIANG UNIV
A combined ligand, combined biomimetic chromatography medium and its preparation method and application
ActiveCN108558988BDensity controllableAntibody affinity is highIon-exchange process apparatusIon-exchanger regenerationN-BromosuccinimidePhenylalanine+Tyrosine
The invention relates to a combined ligand, a combined bionic chromatography medium and a preparation method and application thereof. The combined bionic chromatography medium uses hydrophilic porousmicrospheres as chromatography matrix, is activated by allyl bromide, is brominated and alcoholized by N-bromosuccinimide, and then is coupled with the combined ligand. The sequence of the combined ligand is phenylalanine-tyrosine-glutamic acid-5-aminobenzimidazole. The combined bionic chromatography medium has two functional groups including phenylalanine-tyrosine-glutamic acid tripeptide and aminobenzimidazole, introduces a hydrophobicity charge-inducing ligand while retaining the high selectivity characteristic of a polypeptide ligand to an antibody, makes elution conditions milder, and achieves effective antibody isolation.
Owner:ZHEJIANG UNIV
Anti-tumor grifola frondosa glycoprotein as well as preparation method and application thereof
ActiveCN114230646AEnhance immune responseInhibition of growth in vivoPeptide/protein ingredientsPharmaceutical delivery mechanismPhenylalanine+TyrosineMonosaccharide composition
The invention belongs to the technical field of biological medicine, and discloses anti-tumor grifola frondosa glycoprotein as well as a preparation method and application thereof. The protein content of the anti-tumor grifola frondosa glycoprotein is 54.0 + / -3.0%, the polysaccharide content of the anti-tumor grifola frondosa glycoprotein is 20.3 + / -2.0%, the weight-average molecular weight of the anti-tumor grifola frondosa glycoprotein is 17.5 kDa, and the monosaccharide composition and the molar ratio of fucose to glucosamine hydrochloride to galactose to glucose to mannose to galacturonic acid to glucuronic acid are 2.4: 0.8: 3.9: 72.3: 7.7: 3.2: 9.6. The amino acids are composed of alanine, glycine, threonine, valine, leucine, isoleucine, proline, asparaginic acid, phenylalanine, tyrosine and glutamic acid. The grifola frondosa glycoprotein disclosed by the invention has the effects of enhancing immune response of a tumor body and inhibiting in-vivo growth of breast cancer through in-vivo verification.
Owner:GUANGDONG INST OF MICROBIOLOGY GUANGDONG DETECTION CENT OF MICROBIOLOGY
Hybrid ligand, hybrid biomimetic chromedia and preparing method and use thereof
ActiveUS11034723B2Improve hydrophobicityAssist dissociationOther chemical processesPeptide preparation methodsPhenylalanine+TyrosineAntiendomysial antibodies
This invention relates to a hybrid ligand, a hybrid biomimetic chromedia and a preparing method and a use thereof, wherein the hybrid biomimetic chromedia takes hydrophilic porous microsphere as a substrate in chromatography, activated with allyl bromide and undergoing bromo-alcoholization with N-bromosuccinimide, then coupled with the hybrid ligands. The sequence of the hybrid ligand is phenylalanine-tyrosine-glutamine-5-aminobenzimidazole. The hybrid biomimetic chromedia has both of the two functional groups of phenylalanine-tyrosine-glutamine tripeptide and aminobenzimidazole, while maintaining the high antibody selectivity of polypeptide ligand, hydrophobic electric charge inductive ligand is introduced to achieve more moderate elution requirement, realizing effective antibody separation.
Owner:ZHEJIANG UNIV
A method for isolating immunoglobulin IgG in human serum
ActiveCN108059673BHigh purity of IgGHigh puritySerum immunoglobulinsPeptide preparation methodsPhenylalanine+TyrosineSerum samples
Owner:ZHEJIANG UNIV
A method and equipment for separating and extracting amino acid products from protein hydrolyzate
ActiveCN103787939BHigh yieldComply with environmental emission requirementsOrganic compound preparationAmino-carboxyl compound preparationPhenylalanine+TyrosineTyrosine
Owner:广州博采生物科技有限公司
Application of cannabidiol in development of medicine for improving symptoms after drug addiction withdrawal
InactiveCN113288885ANot addictedNo anxiolyticNervous disorderHydroxy compound active ingredientsPhenylalanine+TyrosineTyrosine
The invention discloses an application of cannabidiol in the aspect of development of drugs for improving symptoms after drug addiction withdrawal, cannabidiol does not have mental activity, does not cause addiction, and has the characteristics of anxiety resistance, depression resistance, convulsion resistance, neuroprotection and psychosis resistance. However, whether cannabidiol can improve withdrawal symptoms by improving metabolism of phenylalanine, tyrosine and tryptophan in the center of a methylamphetamine addict after withdrawal is judged; the conclusion plays an important role in treating the withdrawal symptom of methamphetamine and developing medicines.
Owner:FIRST AFFILIATED HOSPITAL OF KUNMING MEDICAL UNIV
Method for preparing quinoline compounds by catalysis of zirconocene dichloride
ActiveCN110156673BReduce dosageMild reaction conditionsOrganic chemistryPhenylalanine+TyrosinePtru catalyst
The invention discloses a method for preparing quinoline compounds by catalyzing zirconocene dichloride. The method uses 3-butyne-2-ketone compounds and anthranilobenzenethiol compounds as raw materials, As a catalyst, L-phenylalanine, tyrosine, etc. are used as catalyst ligands, N,N-dimethylformamide is used as a solvent, and elemental iodine, hydrogen peroxide, tert-butanol peroxide, etc. are used as oxidants, The quinoline compounds can be prepared efficiently and in high yield. The catalyst used in the present invention is low in cost, stable to air, mild in reaction conditions, and simple in operation. After the reaction is completed, the product is extracted and washed and separated by simple column chromatography to obtain quinoline compounds, which are quinoline compounds The preparation of opens a low-cost and high-efficiency way, and has broad application prospects.
Owner:SHAANXI NORMAL UNIV
A kind of spider silk hydrolyzate and preparation method thereof
ActiveCN107652354BLess process investmentReduce demandPeptide preparation methodsPolymer sciencePhenylalanine+Tyrosine
The invention relates to the technical field of amino acid preparation, in particular to a spider silk hydrolyzate and a preparation method thereof. The spider silk hydrolyzate is prepared by the following steps: crush the spider silk, mix the crushed spider silk with sodium hydroxide solution, hydrolyze at 80-90°C for 4-5 hours, and centrifuge to obtain a hydrolyzate; adjust the hydrolyzate The pH value is 4.0-5.5, and the 200nm membrane is filtered to obtain the spider silk hydrolyzate. The amino acid hydrolysis yield of the preparation process of the present invention is 74.15%-80.89%, and the yield is >70%; in the hydrolyzate, methionine is not detected, except for phenylalanine and tyrosine, the yields of other amino acids are all >60% . That is, the distribution of amino acids in the hydrolyzate is basically consistent with that in spider silk. In the hydrolyzate, small molecule peptides with a molecular weight of 1000‑5000D accounted for 72.18% to 76.69%, indicating that the spider silk hydrolyzate not only maintains the original beauty and medical effects of moisturizing, repairing, firming and anti-wrinkle, but also is easily destroyed Human body absorbs.
Owner:海南蛛王生物开发有限公司 +1
An affinity biomimetic chromatography medium with tetrapeptide as functional ligand
ActiveCN110180505BLarge adsorption capacityHigh affinityIon-exchange process apparatusOther chemical processesPhenylalanine+TyrosineArginine
The invention discloses an affinity biomimetic chromatography medium with a tetrapeptide as a functional ligand, wherein the affinity biomimetic chromatography medium can be used for antibody separation and purification, and the amino acid sequence of the tetrapeptide is phenylalanine-tyrosine-tryptophan-arginine. The preparation method comprises: activating with allyl bromide, carrying out bromination alcoholization, linking a space arm hexanediamine to a polysaccharide gel, and conjugating with an acetylated phenylalanine-tyrosine-tryptophan-arginine tetrapeptide ligand to obtain the tetrapeptide chromatography medium. According to the present invention, the tetrapeptide chromatography medium has good adsorption capacity to antibodies, has high selectivity, can adsorb antibodies under weak alkaline (pH value of 8.0) conditions, can be eluted under weak acidic (pH value of 5.0) conditions, has mild separation conditions, and can be used for isolating immunoglobulins from human serum and isolating monoclonal antibodies in cell culture.
Owner:ZHEJIANG UNIV
Bamboo leaf extract and preparation method and application thereof
ActiveCN113545511AImprove qualityTake advantage ofTobacco preparationTobacco treatmentPectinasePhenylalanine+Tyrosine
The invention discloses a bamboo leaf extract and a preparation method and application thereof, and relates to the technical field of natural product extraction. The bamboo leaf extract comprises a primary bamboo leaf extract obtained by primary extraction with bamboo leaves as raw materials, and a secondary bamboo leaf extract obtained by carrying out secondary processing extraction on primary extraction residues serving as raw materials. The bamboo leaf extract comprises the following raw materials: bamboo leaves, compound enzyme, amino acid, reducing sugar and auxiliaries. The compound enzyme comprises one or more of acidic cellulase, pectinase, beta-glucanase, acidic xylanase, beta-glucosidase and neutral protease, and the amino acid comprises one or more of phenylalanine, tyrosine and proline. According to the bamboo leaf extract and the preparation method and application thereof, secondary processing extraction is carried out on residues obtained after primary extraction of bamboo leaves, resources are fully utilized, and meanwhile the quality of the extract is improved to a certain degree.
Owner:CHONGQING CHINA TOBACCO IND CO LTD +1
A kind of Hericium erinaceus mycelium and its cultivation method
ActiveCN104195052BEasy to controlImprove anti-tumor effectFungiMicroorganism based processesPhenylalanine+TyrosineDipeptide
The invention discloses Hericium erinaceus mycelium and a cultivation method thereof. It contains relatively high content of amino acids and vitamins, and also contains 7 kinds of cyclic dipeptides, ergosterol and carboxymethyl cellulase activity. The 7 kinds of cyclic dipeptides are respectively For: cyclic (valine-tyrosine), cyclic (leucine-tyrosine), cyclic (phenylalanine-tyrosine), cyclic (phenylalanine-phenylalanine), cyclic (leucine‑leucine), ring (leucine‑alanine), ring (valine‑alanine). The cultivation method includes mother strain cultivation, original strain cultivation, cultivar strain cultivation, a "directed" biotransformation process and a secondary "directed" biotransformation process. The cultivated Hericium erinaceus mycelium has good anti-tumor effect.
Owner:HUNAN XINHUI PHARMA
Method for endowing collagen with lasting antibacterial function by using outer wall quaternized cucurbituril
ActiveCN113968906ARetain biological activityBiocideConnective tissue peptidesPolymer sciencePhenylalanine+Tyrosine
The invention discloses a method for endowing collagen with a lasting antibacterial function by using supramolecular chemistry. The method comprises the following steps of firstly preparing cucurbit [7] uril of which the outer wall contains a plurality of short-chain quaternary ammonium groups, then introducing quaternary ammonium groups into the surface of collagen by utilizing the supramolecular inclusion effect of the cucurbit [7] uril on phenylalanine and tyrosine residues, and controlling the number of the quaternary ammonium groups covalently grafted on the outer wall of each cucurbit [7] uril and the length of a covalent connecting arm, and on the premise of not destroying the three-strand helical structure of the natural collagen, enadowing the natural collage with the long-acting antibacterial function.
Owner:SICHUAN UNIV
Metabolic marker for rapidly diagnosing multiple myeloma and application
ActiveCN114878723AEffective early clinical diagnosisHigh sensitivityMaterial analysis using wave/particle radiationComponent separationDiseasePhenylalanine+Tyrosine
The invention provides a metabolic marker for rapidly diagnosing multiple myeloma and application of the metabolic marker. The metabolic marker comprises one or more of phenylalanine, tyrosine and tryptophan. Compared with the prior art, the invention has the following advantages: the invention provides the metabolic marker for rapidly diagnosing multiple myeloma and the application thereof, the marker comes from one or a combination of more of bone marrow tissue and bone marrow supernatant metabolite of a patient, and comprises phenylalanine, tyrosine and tryptophan; the detection of the metabolic marker level can be effectively used for early clinical diagnosis of multiple myeloma diseases, the sensitivity is high, the method is rapid and convenient, the result is accurate and reliable, a basis can be provided for clinical decision making, meanwhile, a certain basis is provided for subsequent fundamental research and clinical research, and potential application and research values are achieved.
Owner:CHINA JAPAN FRIENDSHIP HOSPITAL +1
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