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Application of cannabidiol in development of medicine for improving symptoms after drug addiction withdrawal

A technology of cannabidiol and withdrawal symptoms, which is applied in the field of application of cannabidiol in the development of drugs for improving drug addiction withdrawal symptoms, can solve problems such as not having psychoactive effects, and achieve the effect of improving withdrawal symptoms

Inactive Publication Date: 2021-08-24
FIRST AFFILIATED HOSPITAL OF KUNMING MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Cannabidiol (CBD) is a chemical component extracted from the cannabis plant. Unlike THC in cannabis, cannabidiol is not psychoactive, not addictive, and has anti-anxiety and anti-depressant properties. , anticonvulsant, neuroprotective and antipsychotic properties, but whether cannabidiol can improve withdrawal symptoms by improving central metabolism of phenylalanine, tyrosine and tryptophan in methamphetamine addicts , there is no research report at home and abroad

Method used

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  • Application of cannabidiol in development of medicine for improving symptoms after drug addiction withdrawal
  • Application of cannabidiol in development of medicine for improving symptoms after drug addiction withdrawal
  • Application of cannabidiol in development of medicine for improving symptoms after drug addiction withdrawal

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Experimental program
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Embodiment

[0024] Cannabidiol significantly improved the metabolism of phenylalanine, tyrosine and tryptophan in the hippocampus of methamphetamine withdrawal mice;

[0025] 1) Experimental animals: 6-8-week-old Jiangkang male C57 / BL mice, weighing 25 g, purchased from Hunan Slake Jingda Experimental Animal Co., Ltd. The animals were kept in an independent micro-barrier system, and were given 12 hours of alternating light and dark light in an environment with recommended temperature and humidity, and the animals were given free access to water and food.

[0026] 2) The drugs used are: cannabidiol (purchased from Hongbao Biotechnology Co., Ltd., Yuxi City, Yunnan Province, with a purity of 99%) and methamphetamine with a purity of 98%, (provided by the Public Security Bureau of Yunnan Province);

[0027] Preparation and dosage of cannabidiol: First dissolve 250mg of cannabidiol in a mixed solution of 20ml of absolute ethanol and polysorbate-80 (1:1), then add physiological saline to dilut...

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Abstract

The invention discloses an application of cannabidiol in the aspect of development of drugs for improving symptoms after drug addiction withdrawal, cannabidiol does not have mental activity, does not cause addiction, and has the characteristics of anxiety resistance, depression resistance, convulsion resistance, neuroprotection and psychosis resistance. However, whether cannabidiol can improve withdrawal symptoms by improving metabolism of phenylalanine, tyrosine and tryptophan in the center of a methylamphetamine addict after withdrawal is judged; the conclusion plays an important role in treating the withdrawal symptom of methamphetamine and developing medicines.

Description

technical field [0001] The invention belongs to the field of drugs for treating drug addiction, and in particular relates to the application of cannabidiol in the development of drugs for improving symptoms after drug addiction withdrawal. Background technique [0002] Methamphetamine (Methamphetamine, Meth), commonly known as "ice"; methamphetamine addiction is a recurrent chronic brain disease, mainly characterized by persistent neuropsychiatric dysfunction, abnormal behavior and persistent drug use craving psychology; In the early stage of withdrawal, there are strong withdrawal symptoms, showing symptoms such as general pain, increased respiratory secretions, chills, and diarrhea, which can also cause psychological changes such as anxiety and depression; persistent and strong withdrawal symptoms during the withdrawal period , is the most important reason for hindering drug addicts from detoxification, and is also an important factor affecting the effect of drug addicts' ...

Claims

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Application Information

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IPC IPC(8): A61K31/05A61P25/36A61P25/22A61P25/24A61P25/08A61P25/18A61P25/00
CPCA61K31/05A61P25/00A61P25/08A61P25/18A61P25/22A61P25/24A61P25/36
Inventor 周勇王昆华俞珏华张尊月杨继青陈明会熊普
Owner FIRST AFFILIATED HOSPITAL OF KUNMING MEDICAL UNIV
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