Gabapentin analogues for fibromy algia and other disorders

A human and disease technology, applied in the fields of muscular system diseases, neuromuscular system diseases, sexual diseases, etc., can solve the problems of disappointing clinical trial results, limited success of fibromyalgia, etc.
CN1720038AInactive Publication Date: 2006-01-11WARNER-LAMBERT CO
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
WARNER-LAMBERT CO
Publication Date
2006-01-11
Estimated Expiration
Not applicable · inactive patent

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Abstract

This invention provides compounds of formulas (I) and (II) or the salt thereof acceptable in pharmacy, and the new use thereof for the treatment of fibromyalgia or others.
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Description

technical field

[0001] The present invention relates to the use of α2δ ligands in the treatment of fibromyalgia and other central nervous system disorders. Background technique

[0002] Fibromyalgia (FM) is a chronic syndrome characterized by protracted pain, nonrestorative sleep, mood disturbance, and fatigue. The main symptoms of fibromyalgia include pain, sleep, mood disturbance, and fatigue. The syndromes associated with fibromyalgia include irritable bowel syndrome and migraine. The success of treating fibromyalgia with single agents has been limited and clinical trial results have been disappointing. Based on the current understanding of the mechanisms and pathways involved in fibromyalgia, it is believed that there is a need for multiple drugs that target key symptoms such as pain, sleep disturbance, mood disturbance, and fatigue. Patients with fibromyalgia are often sensitive to drug side effects, a feature that may be related to the pathology of the condition (Ba...

Claims

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