123 results about "Methamphetamine" patented technology

The invention provides a task scheduling method and device based on cloud edge collaboration. The method comprises the steps of obtaining a to-be-allocated task from an edge end; acquiring a time queue of resource load values of the edge end and the cloud end; extracting resource load time sequence characteristics of the edge end and the cloud end; carrying out spatial distance measurement-based detailed feature interaction and resource load time sequence collaborative features based on resource load time sequence features; and according to the resource load time sequence cooperation characteristics, splitting the to-be-allocated task and scheduling the to-be-allocated task to an edge end and a cloud end respectively, so that the edge end and the cloud end perform task execution respectively. According to the method, the edge end resource load time sequence features and the cloud end resource load time sequence features are extracted, the resource load conditions of the cloud end and the edge end are considered, then detailed feature interaction based on spatial distance measurement is carried out, resource load time sequence cooperation features are obtained, flexible splitting and scheduling of tasks are achieved, and the task scheduling efficiency is improved. The overall operation stability of the system can be improved, and the task processing efficiency is improved.

Disclosed are pharmaceutical compositions and formulations of enantiomerically enriched or pure 3,4-methylenedioxymethamphetamine (MDMA) and methods for modulating aggression response behaviors that may be associated with a disorder and / or disease.

The invention discloses a drug-loaded nanogel modified bioprosthetic valve as well as a preparation method and application thereof, and belongs to the technical field of preparation of medical materials and medical instruments. The preparation method comprises the following steps: firstly, synthesizing an active oxygen response monomer by taking thioketal-containing methacrylate and methylprednisone hemisuccinate as raw materials, then synthesizing active oxygen response type drug-loaded nanogel, and then introducing the active oxygen response type drug-loaded nanogel to the surface of the bioprosthetic valve through chemical bonding; in a pathological environment with relatively high active oxygen concentration, a thioketal group in the monomer is decomposed, and methylprednisone hemisuccinate is released at a fixed point, so that inflammatory cell infiltration is reduced, and the anti-inflammatory performance of the bioprosthetic valve is improved; in addition, the nanogel contains a large number of hydrophilic groups, a hydration layer is formed on the surface of the bioprosthetic valve, and the risk of thrombus and blood coagulation can be effectively reduced; the prepared bioprosthetic valve has excellent anti-inflammatory, anti-coagulation and anti-calcification capabilities and stability.

The invention discloses a high-performance lithium iron phosphate composite material and a preparation method thereof, and belongs to the technical field of battery materials. Stirring the modified lithium iron phosphate, the modified carbon nanotube, benzoin dimethyl ether and chloroform, irradiating for 15 minutes under a 365 nm ultraviolet lamp, and drying to obtain a premix; and mixing the premix, glacial acetic acid, polyethylene glycol and DMF, heating to 70-80 DEG C, stirring for 4-6 hours, cooling, filtering, washing, immersing in a zinc acetate solution, standing, filtering, washing and drying to obtain the high-performance lithium iron phosphate composite material. The active substance-modified lithium iron phosphate and the conductive agent-modified carbon nanotube have chemical action, and the premix obtained after the reaction of the active substance-modified lithium iron phosphate and the conductive agent-modified carbon nanotube contains hydroxyl and benzotriazole structures, so that hydrogen bond interaction exists between the premix and the binder, the adhesive force between the premix and the aluminum foil current collector is excellent, and therefore, the performance of the lithium ion battery is improved. The finished battery prepared from the lithium iron phosphate composite material is excellent and stable in electrochemical performance.

The invention relates to the technical field of cable materials, in particular to a flame-retardant silica gel cable material and a preparation method thereof. The silica gel cable material comprises the following components in parts by weight: 80-100 parts of methyl vinyl silicone rubber, 20-40 parts of fumed silica, 20-40 parts of modified magnesium hydroxide, 10-20 parts of silica powder, 2-8 parts of hydroxyl silicone oil, 0.5-3.0 parts of a vulcanizing agent, 0.5-1.5 parts of an anti-aging agent and 1-5 parts of a lubricant. The preparation method comprises the following steps: banburying methyl vinyl silicone rubber, hydroxyl silicone oil, an anti-aging agent and a lubricant to obtain a mixture; banburying the mixture, fumed silica, silica powder, modified magnesium hydroxide and a vulcanizing agent to obtain a rubber compound; the rubber compound is sequentially subjected to first-stage vulcanization and second-stage vulcanization to obtain the silica gel cable material which has excellent flame retardant property and mechanical property, so that the service life of the silica gel cable material is prolonged.

The present invention discloses a method for alkylating polyester materials in which carbonate or carboxylate participates, and relates to comprehensive utilization of waste resources and cascade utilization of raw materials. The product of the method of the present invention is carboxylate and ethylene carbonate or diol. Taking PET as an example, the method uses multiple types of green ionic liquid catalysts, multiple types of carbonate or carboxylate such as dimethyl carbonate (DMC) or dimethyl malonate as methyl sources, and realizes the directional upgrading of PET to DMT under methanol-free conditions, and then DMC captures the generated ethylene glycol in situ, and forms five-membered cyclic ethylene carbonate through dehydration and cyclization. The present invention can be used for the depolymerization upgrading of waste PET materials, and other aromatic or alkyl carboxylic acid compounds (benzoic acid, p-methylbenzoic acid, 4-formylbenzoic acid, cyclohexanoic acid and n-pentanoic acid), similar polyesters and polycarbonates (polyethylene succinate, polyethylene adipate and polyethylene 2,5-furandicarboxylate) are also suitable for the recovery strategy of the present invention.

The invention discloses a drug open set identification method based on an interval variable-free elimination feature selection algorithm. The method comprises the following steps: S1, preparing a sample; s2, carrying out sample spectrum collection; s3, removing abnormal heroin samples and methamphetamine samples, and reducing noise in the spectrum data of the samples; s4, performing feature selection on the preprocessed spectrum by using an interval variable-free elimination feature selection algorithm, and determining a feature spectrum section; s5, selecting samples to construct a prediction set, and taking the remaining drug samples as a correction set; s6, establishing a type identification model by adopting a partial least square method; and step S7, comparing the type identification accuracy of the two drugs. The drug open set identification method based on the interval variable-free elimination feature selection algorithm is convenient to use, the interval variable-free elimination feature selection algorithm can effectively mine information with high correlation with types in a sample library spectrum, and the accuracy and reliability of model open set identification classification are improved.

The invention relates to the technical field of desalting agents, and discloses a crude oil desalting agent and a preparation method thereof. The crude oil desalting agent is obtained by adding melamine modified multi-branch polyether, quaternized carboxyl chitosan modified polyacrylate emulsion and graphene oxide into a reactor and stirring. A silicon-oxygen bond in the melamine modified multi-branch polyether improves the high temperature resistance of the desalting agent; the triazine ring structure of the melamine has good thermal stability; positive charges of quaternary ammonium salt can neutralize negative charges on the surfaces of oil drops, so that the desalting performance of the desalting agent is improved; compared with linear polyether, multi-branch polyether has a better desalting effect; a quaternary ammonium salt group is grafted on carboxymethyl chitosan, so that chitosan has positive and negative charges at the same time, metal cations in crude oil can be adsorbed, negative ions such as naphthenic acid radicals can also be combined, and the desalting performance is improved; and the conjugation effect formed by the double-benzene-ring structure of naphthyl improves the high temperature resistance of the desalting agent.

The invention discloses a temperature-responsive eutectic solvent-water extraction system which is composed of a temperature-responsive eutectic solvent and water, the temperature-responsive eutectic solvent is composed of lidocaine, oleic acid and acetic acid, and the molar ratio of lidocaine to oleic acid to acetic acid is (4-6): (2.5-3.5): (1.5-2.5); and the content of water is 15-25% of the weight of the temperature-responsive eutectic solvent. The extraction system is applied to chitin extraction. The invention further discloses a method for extracting chitin based on the temperature-responsive deep-eutectic solvent-water extraction system and a method for recovering the temperature-responsive deep-eutectic solvent. The temperature-responsive deep-eutectic solvent-water extraction system disclosed by the invention has a very good extraction effect when being used for extracting chitin. The method has a good application prospect, and is of great significance in promoting the process of industrialization of deep eutectic solvent extraction of chitin.

The invention belongs to the technical field of drug detection, and particularly relates to a test strip for detecting O6-monoacetylmorphine and methamphetamine and a detection methamphetamine, the test strip comprises a gold-labeled pad, the surface of the gold-labeled pad is sprayed with an O6-monoacetylmorphine and methamphetamine antibody-three-dimensional dendritic gold nanoparticle conjugate, a mixture of an O6-monoacetylmorphine coating antigen and time-resolved europium fluorescent microsphere-BSA (Bovine Serum Albumin) is sprayed on the NC membrane to serve as a T1 line, a mixture of a methylamphetamine coating antigen and time-resolved europium fluorescent microsphere-BSA is sprayed on the NC membrane to serve as a T2 line, and a mixture of a goat anti-mouse secondary antibody and time-resolved europium fluorescent microsphere-BSA is sprayed on the NC membrane to serve as a C line; a to-be-detected sample is dropped on the surface of the sample pad on the surface of the test strip main body for detection. The O6-monoacetylmorphine and methamphetamine detection efficiency, sensitivity and specificity are high, the operation is simple and convenient, and the method can be applied to combined determination of two drugs in a biological detection material.

The utility model discloses sodium perchlorate production equipment with a mechanical stirring mechanism, which relates to the field of sodium perchlorate production and comprises a transparent glass shell, a first funnel is fixedly mounted at the top end of the transparent glass shell, and a funnel-shaped filter plate is fixedly mounted at the bottom end in the first funnel. The device comprises a transparent glass shell, a hollow cylinder part is arranged in the transparent glass shell, a spiral auger is fixedly installed in the hollow cylinder part, a central column is fixedly installed in the middle of the spiral auger, and a conical part is fixedly installed at the top end of the central column. In the reaction, the collecting shell can continuously collect impurities and spirally convey the impurities to the upper surface of the hopper-shaped filter plate for filtering, and the solution is conveyed together during conveying, so that the dissolving area of chlorine in water can be increased, the efficiency of chlorine participating in the reaction is improved, the yield is further improved, the workload of workers is reduced, and the automation degree of the device is improved.

The utility model provides a diluting device for metacrylic acid ester glue processing. The diluting device for metacrylic acid ester glue processing comprises a supporting table, a diluting box is fixedly connected into the supporting table in a sleeved mode, a conveying pipe is fixedly connected into the diluting box in a sleeved mode, and a feeding hopper is fixedly connected to the top of the conveying pipe in a sleeved mode. According to the diluting device for metacrylic acid ester glue processing, the conveying impeller is arranged, when glue is diluted, the glue is fed into the feeding hopper, and the first motor is started at the moment, so that the first motor can drive the conveying impeller to be in the conveying pipe; according to the glue adding device, glue in the feeding hopper is extruded by the conveying impeller, so that the glue is discharged into the diluting box through the discharging hole, the problem that the glue is difficult to flow due to high viscosity of the glue, and the glue is difficult to add is solved, and the glue adding convenience during glue dilution is improved.

The invention discloses application of lycium barbarum polysaccharide in preparation of a medicine for inhibiting methylamphetamine-induced nerve injury, and relates to the technical field of biological medicines. It is found and proved that lycium barbarum polysaccharide can inhibit methylamphetamine-induced nerve injury, and the effect is remarkable. From the aspect of cell survival, the survival rate of the microglial cells pretreated by the lycium barbarum polysaccharide after METH stimulation is obviously improved. In the molecular mechanism, the lycium barbarum polysaccharide can effectively lower the protein expression level of the METH-induced pyroptosis marker, the content of inflammatory factors IL-1beta and IL-18 can be reduced, and the release of lactic dehydrogenase is reduced. The result shows that the lycium barbarum polysaccharide can alleviate inflammatory response by inhibiting NLRP3 / ASC pathway mediated microglial cell pyroptosis, thereby inhibiting METH-induced nerve injury. The invention provides a new direction for developing METH neurotoxicity intervention medicines.

Disclosed in the present invention are a drug for treating or preventing methamphetamine addiction, and the use. Also disclosed is a new use of an ERK inhibitor. In the present invention, the use of an ERK inhibitor in drug addiction is studied. The inhibitory effect of GDC-0994 in the treatment of methamphetamine addiction is studied by means of methamphetamine addiction models (including a place preference model and a self-administration experiment model), and it is found that the administration of the ERK inhibitor GDC-0994 can significantly reduce the seeking and ingesting of methamphetamine in animals, that is, the ERK inhibitor GDC-0994 can antagonize methamphetamine addiction, this indicates that the inhibition of ERK by GDC-0994 can effectively treat methamphetamine addiction.

The present disclosure relates to 3,4-methylenedioxymethamphetamine (MDMA) or a pharmaceutically acceptable salt and / or solvate thereof, pharmaceutical compositions and dosage forms containing these particles, and methods of using pharmaceutical compositions and dosage forms containing these particles to treat subjects suffering from disorders of the central nervous system.

The disclosure relates to compounds that demonstrate efficacy in blocking PACAP receptors (e.g. PAC1) and associated methods of treating neurological diseases or disorders using the disclosed compounds. The neurological diseases or disorders include, but are not limited to, stress-related diseases (e.g. chronic stress, post-traumatic stress disorder (PTSD), panic disorder, anxiety, or general anxiety disorder), pain-related diseases (e.g. chronic pain, primary headache disorders, or migraines), or addiction (e.g. addiction to a substance (e.g. addiction to cocaine, amphetamines, methamphetamine, methylphenidate, nicotine, alcohol, prescription medication, marijuana, tobacco, or an opioid selected from heroin, fentanyl, codeine, hydrocodone, morphine, oxycodone, hydromorphone, and methadone)).

The present invention discloses a compound for treating methamphetamine addiction and cognitive impairment, its preparation method and application. The new compound NBU513-1 for treating methamphetamine addiction and cognitive impairment induced by the present invention can significantly improve the addictive behavior of mice for methamphetamine, has a therapeutic effect on the cognitive dysfunction caused by methamphetamine, and can be used to prepare a medicine for treating methamphetamine addiction and cognitive impairment induced by methamphetamine. The present invention provides a total synthesis route of compound NBU513-1. Compared with the preparation method of similar compounds in the prior art, the method of the present invention does not need to react with sodium azide, does not produce powerful explosives and highly toxic substances, has high stability and low reaction risk; the method has mild reaction conditions, simple scheme, safe and reliable production and can prepare target products with higher yields, and is suitable for industrial production.

The present invention relates to a method for realizing methamphetamine addiction identification and craving determination on the basis of machine learning. The method comprises the following steps: collecting and pre-processing high-density scalp resting-state electroencephalogram data of a subject to obtain an EEG time series; on the basis of a standard head model, performing source locating on the acquired time series data; using a pre-defined brain template to perform electroencephalogram functional connectivity analysis; using a functional connectivity network to detect the temporal correlation or phase synchronization between a plurality of brain regions; and performing real craving manifestation feature determination on the subject by means of establishing and verifying a machine learning model. The present invention also relates to a corresponding apparatus, a processor and a storage medium therefor. By means of the method, apparatus and processor for realizing methamphetamine addiction identification and craving determination on the basis of machine learning and the storage medium therefor in the present invention, accurate identification of a methamphetamine addict and a craving state thereof can be expected, thereby facilitating the assessment of a treatment effect on methamphetamine addicts, and reducing the recurrence rate.

The application belongs to the technical field of water treatment, and particularly relates to a new psychoactive substance adsorbent and application thereof. The preparation method of the adsorbent comprises the following steps: (1) mixing and reacting activated shrimp shell biomass and ferroferric oxide nano magnetic material, drying, and pyrolyzing to obtain Fe3O4@BC; (2) mixing and reacting Fe3O4@BC and ZIF-8 to obtain Fe3O4@BC@ZIF-8; and (3) mixing and reacting a eutectic solvent with Fe3O4@BC@ZIF-8 to obtain the new psychoactive substance adsorbent. The adsorbent has strong adsorption capacity for 4-methyl methcathinone, methcathinone, amphetamine, methamphetamine and ephedrine, and the adsorption efficiency can reach 98% for 4-methyl methcathinone in particular.

The invention relates to a polymeric nanomaterial that has specific affinity for MeA (methamphetamine) or AMP (amphetamine-derived synthetic drugs) and can exist at the nanoscale, as well as to the synthesis method thereof.

The present application relates to a kind of drug rapid detection method, equipment and medium based on photonic crystal image, comprising: image pre-processing, to locate the position of photonic crystal in image and cut image, so that only photonic crystal is left in the image after cutting;Extract the color feature vector of the photonic crystal, and carry out dimension reduction processing;The color feature vector after dimension reduction is converted, identified and compared based on support vector machine, and the drug identification of the to-be-measured body fluid is completed.The present application is based on the color difference of different drugs and photonic crystal after reaction, judges what kind of drug, such as amphetamine, pseudoephedrine, chloroephedrine, methylcathinone or methamphetamine, contained in the to-be-measured liquid by comparing with standard spectrum, fast, low cost, mass detection, low equipment cost.

The invention provides a method for colorimetrically detecting amphetamine and methyamphetamine in drugs based on furyl probes. The furyl probes in the method are furan-indanone, furan-indene dicyanide and furan-indene cyanide respectively. Wherein before and after amphetamine or methyl amphetamine is added into the probe furan-indanone, the color of the solution is changed from faint yellow to rose red; before and after amphetamine or methyl amphetamine is added into the probe furan-indene dicyanide, the color of the solution is changed from brown yellow to blue; the color of the solution is changed from yellow to orange before and after amphetamine is added into the probe furan-indene cyanogen, and the color of the solution is changed from yellow to green before and after methylamphetamine is added into the probe furan-indene cyanogen. Rapid colorimetric distinguishing of single amphetamine or methyamphetamine and qualitative detection of a mixture of amphetamine and methyamphetamine are achieved. The method has no special limitation in use, can quickly complete qualitative detection without pretreatment of an object to be detected, is simple to operate, economical, practical, high in specificity and sensitivity, stable and repeatable in result, and can be practically applied and popularized.

Disclosed herein are 2-thioxothiazolidine-4-one derivatives, and pharmaceutical compositions thereof. The 2-thioxothiazolidine-4-one derivatives and pharmaceutical compositions thereof may be used to treat or prevent medical disorders such as, for example, Parkinson's disease, and disorders of dopamine homeostasis, such as for example, methamphetamine and cocaine addiction.

The invention relates to the technical field of drug detection, in particular to an environment drug detection and collection reagent and a use method thereof.The environment drug detection and collection reagent comprises 0.05%-5% of a preservative, 0.5%-10% of a scale inhibitor, 0.1%-5% of a surfactant and a pH regulator; the pH value of the drug detection and collection reagent in the environment is 6.5-8.5; the detection and collection reagent for the drugs in the environment is wide in application range, and can be suitable for rapid collection and detection of the drugs such as morphine, methamphetamine, ketamine, cocaine, cannabis sativa, ecaloin, etomidate and dextromethorphan. The drug detection and collection reagent can effectively reduce the detection threshold value of a high-sensitivity detection plate, further improves the sensitivity of drug detection and analysis, and is suitable for further popularization and application.

This invention belongs to the field of biomedicine and discloses for the first time the application of sinapic acid and its derivatives, methyl myrosate and ethyl myrosate, in the prevention and / or treatment of methamphetamine addiction withdrawal. By investigating the conditional position preference behavior of methamphetamine-addicted mice and mice treated with sinapic acid, methyl myrosate, and ethyl myrosate, the inventors demonstrated that sinapic acid and its derivatives, methyl myrosate and ethyl myrosate, can reduce dependence on and cravings for methamphetamine. Therefore, sinapic acid and its derivatives, methyl myrosate and ethyl myrosate, can serve as active ingredients in the preparation of addiction treatment drugs, providing a new option for the prevention and / or treatment of methamphetamine addiction and showing promising clinical application prospects.

The invention discloses an acrylic resin, a photoresist, and a preparation method and application thereof, and belongs to the field of semiconductor technology. The structural formula of the acrylic resin is as follows: wherein n=12-20, and * represents a connection point. The specific fluorine-containing group in the acrylic resin can effectively resist the corrosion of hydrofluoric acid, nitric acid and / or glacial acetic acid, and has a strong resistance to etching solution; the epoxy group can effectively improve the toughness of the photoresist. The photoresist containing the acrylic resin has at least the following advantages: the exposed pattern is insoluble in the developer, the non-exposed area is soluble in the alkaline liquid, and the rinse liquid is pure water. The developer and the rinse liquid are inexpensive compared to the organic system, and are also environmentally friendly, and the post-processing cost is relatively simple. The corresponding preparation method is simple and easy to operate.

This invention provides a method for constructing a donor-acceptor type perylene diimide-based porous conjugated polymer probe and detecting methamphetamine and amphetamine solutions. The method synthesizes donor-acceptor type perylene diimide-based porous conjugated polymer probes with different topologies by combining an electron acceptor perylene diimide derivative and an electron donor aggregation-induced emission fluorophore via a succinate coupling reaction. When used for the detection of methamphetamine and amphetamine, this system exhibits a clear ratiometric fluorescence response, with the fluorescence color gradually changing from yellow-green to orange and orange-red, demonstrating a significant ratiometric fluorescence response. It features fast response speed, high detection sensitivity, good selectivity, and no interference from other common structurally and property-similar substances, enabling the differentiation and identification of methamphetamine and amphetamine.

The present invention discloses a kind of 7-dehydrocholesterol-perylene diimide derivative and its preparation and application of fluorescent film, and utilizes the advantages such as the rigid structure and multiple chiral centers of 7-dehydrocholesterol to connect the conjugated fluorescent molecule with high fluorescence quantum yield, perylene anhydride, through a connecting arm. The synthesized fluorescent compound is used as a sensing element to prepare a fluorescent film, which can be used to detect a variety of banned drugs such as methamphetamines, and is applied to the field of banned drug detection. The present invention is simple to operate, and the reaction conditions are mild. The prepared fluorescent sensor film has high fluorescence quantum yield, good stability, low detection limit, long service life, and high detection sensitivity. It can be applied in sensors for detecting a variety of banned drugs such as methamphetamines. This type of fluorescent sensor film is installed in a portable fluorescence detector for supporting use to achieve rapid detection of banned drugs and improve the detection efficiency of banned drugs.

The application discloses a medicine for treating or preventing methamphetamine addiction and application, and discloses a new use of an ERK inhibitor. The application studies the application of the ERK inhibitor in drug addiction, studies the inhibiting effect of GDC-0994 on treating methamphetamine addiction through a methamphetamine addiction model (including a position preference model and a self-administration experiment model), finds that the ERK inhibitor GDC-0994 can significantly reduce the seeking and intake of methamphetamine of animals, that is, the ERK inhibitor GDC-0994 can antagonize the addiction of methamphetamine, and indicates that the GDC-0994 inhibiting ERK can effectively treat the methamphetamine addiction.

Disclosed herein are 2-thioxothiazolidine-4-one derivatives, and pharmaceutical compositions thereof. The 2-thioxothiazolidine-4-one derivatives and pharmaceutical compositions thereof may be used to treat or prevent medical disorders such as, for example, Parkinson's disease, and disorders of dopamine homeostasis, such as for example, methamphetamine and cocaine addiction.