10 results about "Psychoactive substance" patented technology

The application discloses a method for determining 15 new psychoactive substances in saliva by solid phase supported liquid-liquid extraction (SLE) combined with ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS / MS), which specifically uses a mixed solution of methyl tert-butyl ether and n-hexane as an elution solvent, adopts solid phase supported liquid-liquid extraction to pretreat saliva samples, and then adopts UPLC-MS / MS to detect the collected eluent, so as to realize qualitative and quantitative determination of the new psychoactive substances in saliva. The method has the advantages of rapidness, accuracy, high sensitivity and simple operation, the detection limit of the method is 0.2-0.5 ng / mL, can meet the domestic and foreign limit requirements, and provides technical support for monitoring and investigation of the new psychoactive substances in saliva.

The application belongs to the technical field of water treatment, and particularly relates to a new psychoactive substance adsorbent and application thereof. The preparation method of the adsorbent comprises the following steps: (1) mixing and reacting activated shrimp shell biomass and ferroferric oxide nano magnetic material, drying, and pyrolyzing to obtain Fe3O4@BC; (2) mixing and reacting Fe3O4@BC and ZIF-8 to obtain Fe3O4@BC@ZIF-8; and (3) mixing and reacting a eutectic solvent with Fe3O4@BC@ZIF-8 to obtain the new psychoactive substance adsorbent. The adsorbent has strong adsorption capacity for 4-methyl methcathinone, methcathinone, amphetamine, methamphetamine and ephedrine, and the adsorption efficiency can reach 98% for 4-methyl methcathinone in particular.

This invention belongs to the field of environmental monitoring and forensic science testing, specifically relating to a magnetic walnut shell biochar material, its preparation method, and its application. The preparation method involves first pulverizing the walnut shell biochar, modifying it with phosphoric acid, and then loading it with Fe3O4 via a co-precipitation method to obtain the magnetic material. Using this as a magnetic solid-phase extraction adsorbent, combined with gas chromatography-mass spectrometry (GC-MS), it can achieve efficient enrichment and accurate detection of 11 cathinone-type new psychoactive substances in environmental water and urine. The detection process is simple to operate, has a high recovery rate, and strong anti-interference ability.

The present application relates to a deuterium-labeled psychoactive substance, which has a chemical structural formula as shown in the description.The present application also provides a preparation method of the deuterium-labeled psychoactive substance, which comprises the following steps: (1) removing the methyl group of sufentanil under the action of a demethylating agent to generate a demethylated intermediate; (2) reacting the demethylated intermediate with a deuterated methyl reagent to generate the deuterium-labeled sufentanil.The present application also provides the use of the deuterium-labeled sufentanil in detecting the content of sufentanil in biological samples or environmental samples.

The present invention describes the development of a method for the detection of psychotropic substances having an isatin or indazole core. A further purpose of the invention is a kit for the determination of these psychotropic substances.

The application relates to the technical field of analytical chemistry, and specifically discloses a high-resolution mass spectrometry analysis method for simultaneously determining multiple psychoactive substances and metabolites thereof, which comprises the following steps: S1, sample pretreatment: pretreating a complex matrix sample to obtain a to-be-tested solution; S2, data acquisition: after the to-be-tested solution is separated by ultra-high performance liquid chromatography, a mass spectrometer is used to perform Full MS / dd-MS2 mass spectrometry data acquisition in a data-dependent acquisition mode; S3, database construction and comparison: based on standard information of multiple target psychoactive substances and metabolites thereof, a special database containing accurate parent ion mass, chromatographic retention time and multi-stage characteristic fragment ion information of each target compound is constructed; the mass spectrometry data acquired in the step S2 is compared and analyzed with the information in the special database to obtain a comparison result; and S4, qualitative determination: based on the comparison result of the step S3, whether the target compound exists in the complex matrix is determined and identified according to a preset qualitative determination criterion.

This invention relates to carbon-13 labeled psychoactive substances, the chemical structural formula of which is: . This invention also provides a method for preparing the aforementioned carbon-13 labeled psychoactive substances, comprising the following steps: (1) 13 C-C3-alanine reacts with Boc2O and a methylating agent to form N-methyl-N-Boc- 13 (2) The product obtained in step (1) is reacted with N,O-dimethylhydroxylamine to obtain an intermediate; (3) The intermediate obtained in step (2) is reacted with a phenyl nucleophile to obtain 13 C-C3-2-N-Boc-methylamino-1-phenyl-1-propanone; (4) The product obtained in step (3) is subjected to a Boc protecting group removal reaction to obtain the carbon 13-labeled psychoactive substance. The present invention also provides the use of the carbon 13-labeled psychoactive substance in detecting the content of methcathinone in biological or environmental samples.

The application discloses a construction method and application of a carfentanyl mouse withdrawal model, and belongs to the field of biological medicine technology and animal model construction; carfentanyl is injected into the mouse, and the injection period is 6 days; 2 injections are injected every day in the first 5 days, and the interval between the injections is 12 hours; the injection dose of each injection on the nth day is n times of the injection dose of each injection on the first day; one injection is injected on the sixth day, and the injection dose is the same as the injection dose of each injection on the fifth day; the withdrawal is carried out after the injection is completed to obtain the carfentanyl mouse withdrawal model; the model of the application has fewer drug administration days, fewer drug administration times and uses less medicine, compared with the model constructed in the foregoing research; the model of the application has fewer drug administration days, fewer drug administration times and uses less medicine, and provides more economical, more efficient and more comprehensive reference evidence for the addiction and harmfulness of carfentanyl; the model can be widely applied to related researches such as pharmacological action evaluation or drug treatment of carfentanyl and similar new psychoactive substances.

This invention discloses a method for preparing a nanoplasmic metasurface biosensor and its application in the detection of new psychoactive substances, belonging to the field of environmental monitoring technology. The invention forms a nanoplasmic metasurface by fabricating a nanopore array and a plasmonic-active metal layer on the sensor surface. The metal nanostructure generates a strong local electromagnetic field enhancement effect under photoexcitation. Subsequently, a stable, non-specific adsorption-resistant biological interface is formed through modification with a carboxyl / methoxy mixed thiol-polyethylene glycol self-assembled monolayer. After activation with N-hydroxysuccinimide / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide, the surface carboxyl groups are converted into active esters, facilitating covalent coupling of specific monoclonal antibodies against the target substance. Finally, antibody coupling allows the sensor to capture the target analyte through antigen-antibody specific binding, causing a change in the interfacial refractive index, which in turn leads to a shift in the plasmonic resonance peak, achieving optical signal conversion.

The invention discloses a sewage analysis-based automatic extraction and detection device for new psychoactive substances, which comprises a material taking assembly, a grabbing assembly is fixedly mounted at the upper end of the material taking assembly, the grabbing assembly is used for facilitating a user to grab the material taking assembly, an extraction and detection assembly is mounted at the rear end of the material taking assembly, and the material taking assembly comprises a shell; a water pump used for extracting sewage is arranged in the shell, the extraction detection assembly comprises an outer wall mounted on the shell, an extraction assembly used for extracting new psychoactive substances in the sewage is arranged in the outer wall, and a liquid chromatograph used for detecting the new psychoactive substances in the sewage is mounted on one side of the outer wall. By arranging the solid-phase extraction column, the vacuum pump and the liquid chromatograph, when the automatic extraction and detection device for the new psychoactive substances based on sewage analysis is used, sewage can be extracted on site, and the new psychoactive substances in the sewage can be directly extracted and detected.