28 results about "Psychoactive substance" patented technology

The application discloses a method for determining 15 new psychoactive substances in saliva by solid phase supported liquid-liquid extraction (SLE) combined with ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS / MS), which specifically uses a mixed solution of methyl tert-butyl ether and n-hexane as an elution solvent, adopts solid phase supported liquid-liquid extraction to pretreat saliva samples, and then adopts UPLC-MS / MS to detect the collected eluent, so as to realize qualitative and quantitative determination of the new psychoactive substances in saliva. The method has the advantages of rapidness, accuracy, high sensitivity and simple operation, the detection limit of the method is 0.2-0.5 ng / mL, can meet the domestic and foreign limit requirements, and provides technical support for monitoring and investigation of the new psychoactive substances in saliva.

The invention discloses a molecularly imprinted membrane of a new psychoactive substance and a preparation method and application of the molecularly imprinted membrane, the molecularly imprinted membrane comprises a membrane substrate and an adsorption material layer arranged on the membrane substrate, and the material of the adsorption material layer comprises 3, 3 ', 4', 4 '-tetramethyl-3, 3', 4 '-tetramethyl-3, 3'-tetramethyl-3, 3 '-tetramethyl-3, 3'- The molecularly imprinted polymer is prepared by using 2, 4-methylenedioxyphenylethylamine as an alternative template and using a bulk polymerization method. The novel molecularly imprinted membrane prepared by combining a molecularly imprinted technology and a separation technology is used as a membrane extraction material, and integrates the advantages of a membrane extraction technology and an imprinting technology, so that the problems that a membrane material is easy to pollute and low in selectivity are solved, and the novel molecularly imprinted membrane is suitable for being used as a membrane extraction material. The method shows the capability of accurately identifying a target analyte in the membrane separation process, has the advantages of high efficiency, stability, repeatability and the like, and provides a new technical means and potential application for identifying and detecting common forbidden drugs in a water body.

The invention discloses an aptamer sensor for detecting a novel psychoactive substance ketamine and application of the aptamer sensor. Belongs to the technical field of poison detection. The aptamer sensor for detecting the novel psychoactive substance ketamine is successfully established by taking a two-dimensional nano material as a fluorescence quencher and a carrier, chemically coupling the two-dimensional nano material with a double-chain nucleic acid aptamer through a liquid-phase amidation reaction and carrying out surface passivation treatment, so that the chemical coupling efficiency is greatly improved; and the stability and the sensitivity of the sensor are enhanced. In addition, when the sensor is introduced into complex biological matrixes such as blood, urine and saliva, the system does not display non-specific signals, and compared with a physical adsorption system, the KET in complex biological fluid can be reliably detected, and a new thought and method are provided for reliable detection of other novel psychoactive substances.

The application belongs to the technical field of water treatment, and particularly relates to a new psychoactive substance adsorbent and application thereof. The preparation method of the adsorbent comprises the following steps: (1) mixing and reacting activated shrimp shell biomass and ferroferric oxide nano magnetic material, drying, and pyrolyzing to obtain Fe3O4@BC; (2) mixing and reacting Fe3O4@BC and ZIF-8 to obtain Fe3O4@BC@ZIF-8; and (3) mixing and reacting a eutectic solvent with Fe3O4@BC@ZIF-8 to obtain the new psychoactive substance adsorbent. The adsorbent has strong adsorption capacity for 4-methyl methcathinone, methcathinone, amphetamine, methamphetamine and ephedrine, and the adsorption efficiency can reach 98% for 4-methyl methcathinone in particular.

The invention relates to a medicine with drug rehabilitation and relapse prevention effects as well as a preparation method and application thereof, and belongs to the field of medicines. The medicine comprises rotundine and salts and is prepared through a chemical synthesis method, and experiments prove that the medicine preparation has the effects of treating opioid substances including heroin, morphine, dolantin, methadone and the like as well as other psychoactive substances, such as opioid and the like. Independent or addiction formed by cocaine, amphetamine stimulants, wine, smoke, cannabis sativa, sedative and hypnotic drugs and the like has the effects of detoxifying, relieving symptoms, inhibiting psychological craving and reducing relapse rate.

The invention relates to a carbon 13 isotope labeling internal standard substance of PMMA (polymethyl methacrylate) and metabolite thereof. The invention further provides a corresponding preparation method and application. The invention fills the technical blank of PMMA / PMA exclusive isotope internal standard, promotes the mental active substance detection to develop towards the direction of higher sensitivity, lower error and stronger judicial credibility through the precise design and application of the carbon 13 labeled standard substance, and has great social value for public safety and health management.

This invention belongs to the field of environmental monitoring and forensic science testing, specifically relating to a magnetic walnut shell biochar material, its preparation method, and its application. The preparation method involves first pulverizing the walnut shell biochar, modifying it with phosphoric acid, and then loading it with Fe3O4 via a co-precipitation method to obtain the magnetic material. Using this as a magnetic solid-phase extraction adsorbent, combined with gas chromatography-mass spectrometry (GC-MS), it can achieve efficient enrichment and accurate detection of 11 cathinone-type new psychoactive substances in environmental water and urine. The detection process is simple to operate, has a high recovery rate, and strong anti-interference ability.

The invention relates to a C13 isotope labeling internal standard substance of MAMP and metabolite thereof. The invention further provides a corresponding preparation method and application. The invention fills the technical blank of MAMP / AMP exclusive isotope internal standard, promotes the development of mental active substance detection towards the direction of higher sensitivity, lower error and stronger judicial credibility through the precise design and application of the C13 labeled standard substance, and has great social value for public safety and health management.

The present application relates to a deuterium-labeled psychoactive substance, which has a chemical structural formula as shown in the description.The present application also provides a preparation method of the deuterium-labeled psychoactive substance, which comprises the following steps: (1) removing the methyl group of sufentanil under the action of a demethylating agent to generate a demethylated intermediate; (2) reacting the demethylated intermediate with a deuterated methyl reagent to generate the deuterium-labeled sufentanil.The present application also provides the use of the deuterium-labeled sufentanil in detecting the content of sufentanil in biological samples or environmental samples.

The present invention describes the development of a method for the detection of psychotropic substances having an isatin or indazole core. A further purpose of the invention is a kit for the determination of these psychotropic substances.

The invention provides a method for detecting new piperazine psychoactive substances in levofloxacin eye drops. The detection method comprises the following steps: S1, mixing the piperazine new psychoactive substance with a diluent to prepare mixed solutions with different concentrations as reference substance solutions; s2, detecting each reference substance solution by adopting a liquid chromatograph-mass spectrometer, and carrying out regression analysis on the concentration of each reference substance solution according to the spectrogram peak area of each reference substance solution to obtain a standard curve; step S3, under the same test condition as the step S2, detecting the levofloxacin eye drops by adopting a liquid chromatograph and mass spectrometer to obtain spectrogram peak area detection data of the piperazine new psychoactive substances in the levofloxacin eye drops; and substituting detection data into the standard curve to obtain the concentration of the piperazine new psychoactive substances in the levofloxacin eye drops. The detection method is high in accuracy.

The application relates to the technical field of analytical chemistry, and specifically discloses a high-resolution mass spectrometry analysis method for simultaneously determining multiple psychoactive substances and metabolites thereof, which comprises the following steps: S1, sample pretreatment: pretreating a complex matrix sample to obtain a to-be-tested solution; S2, data acquisition: after the to-be-tested solution is separated by ultra-high performance liquid chromatography, a mass spectrometer is used to perform Full MS / dd-MS2 mass spectrometry data acquisition in a data-dependent acquisition mode; S3, database construction and comparison: based on standard information of multiple target psychoactive substances and metabolites thereof, a special database containing accurate parent ion mass, chromatographic retention time and multi-stage characteristic fragment ion information of each target compound is constructed; the mass spectrometry data acquired in the step S2 is compared and analyzed with the information in the special database to obtain a comparison result; and S4, qualitative determination: based on the comparison result of the step S3, whether the target compound exists in the complex matrix is determined and identified according to a preset qualitative determination criterion.

The invention discloses a metabolite for identifying a tryptamine new psychoactive substance 4-HO-DET in a zebrafish body and application of the metabolite, and relates to the technical field of zebrafish. The situation that new psychoactive substances (NPS) are abused in a large amount due to uncontrolled conditions in the global range causes serious social, medical and environmental problems. Tryptamine substances as a large class of new psychoactive substances are rapidly metabolized after being ingested by a human body, and the concentration of raw drugs reserved in biological samples of hair, urine, blood and the like of the human body is extremely low, so that certain difficulty is brought to detection and monitoring of the new psychoactive substances of the tryptamine substances. At present, metabolism detection of tryptamine new psychoactive substances is less at home and abroad, and only a small part of tryptamine substances are controlled. Therefore, research on the metabolic process of the tryptamine substances, analysis of the metabolites and metabolic pathways of the tryptamine substances and determination of the metabolic markers of the tryptamine substances play an important role in drug banning work. Aiming at 4-HO-DET, a zebra fish in-vivo metabolism model is established, and the metabolism process is simulated.

This invention relates to carbon-13 labeled psychoactive substances, the chemical structural formula of which is: . This invention also provides a method for preparing the aforementioned carbon-13 labeled psychoactive substances, comprising the following steps: (1) 13 C-C3-alanine reacts with Boc2O and a methylating agent to form N-methyl-N-Boc- 13 (2) The product obtained in step (1) is reacted with N,O-dimethylhydroxylamine to obtain an intermediate; (3) The intermediate obtained in step (2) is reacted with a phenyl nucleophile to obtain 13 C-C3-2-N-Boc-methylamino-1-phenyl-1-propanone; (4) The product obtained in step (3) is subjected to a Boc protecting group removal reaction to obtain the carbon 13-labeled psychoactive substance. The present invention also provides the use of the carbon 13-labeled psychoactive substance in detecting the content of methcathinone in biological or environmental samples.

The application discloses a construction method and application of a carfentanyl mouse withdrawal model, and belongs to the field of biological medicine technology and animal model construction; carfentanyl is injected into the mouse, and the injection period is 6 days; 2 injections are injected every day in the first 5 days, and the interval between the injections is 12 hours; the injection dose of each injection on the nth day is n times of the injection dose of each injection on the first day; one injection is injected on the sixth day, and the injection dose is the same as the injection dose of each injection on the fifth day; the withdrawal is carried out after the injection is completed to obtain the carfentanyl mouse withdrawal model; the model of the application has fewer drug administration days, fewer drug administration times and uses less medicine, compared with the model constructed in the foregoing research; the model of the application has fewer drug administration days, fewer drug administration times and uses less medicine, and provides more economical, more efficient and more comprehensive reference evidence for the addiction and harmfulness of carfentanyl; the model can be widely applied to related researches such as pharmacological action evaluation or drug treatment of carfentanyl and similar new psychoactive substances.

This invention discloses a method for preparing a nanoplasmic metasurface biosensor and its application in the detection of new psychoactive substances, belonging to the field of environmental monitoring technology. The invention forms a nanoplasmic metasurface by fabricating a nanopore array and a plasmonic-active metal layer on the sensor surface. The metal nanostructure generates a strong local electromagnetic field enhancement effect under photoexcitation. Subsequently, a stable, non-specific adsorption-resistant biological interface is formed through modification with a carboxyl / methoxy mixed thiol-polyethylene glycol self-assembled monolayer. After activation with N-hydroxysuccinimide / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide, the surface carboxyl groups are converted into active esters, facilitating covalent coupling of specific monoclonal antibodies against the target substance. Finally, antibody coupling allows the sensor to capture the target analyte through antigen-antibody specific binding, causing a change in the interfacial refractive index, which in turn leads to a shift in the plasmonic resonance peak, achieving optical signal conversion.

The present invention provides a method for analyzing multiple new psychoactive substances in foods by gas chromatography-mass spectrometry, which mainly solves the problems of extracting new psychoactive substances from foods and removing the influencing factors such as proteins, fats, and inorganic minerals in foods. By adopting a unique pretreatment method in combination with gas chromatography / mass spectrometry and other means for detection, accurate detection and analysis of more than 20 cannabinoids and cathinones can be achieved.

The invention relates to new 4-(piperazin-1-yl)-2-(trifluoromethyl)-1H-indoles and 4-(piperazin-1-yl)-2-(trifluoromethyl)-1H-benzimidazoles represented by formula (I), wherein all symbols and variables are as defined in the description. The compounds can find use in a method of prevention and / or treatment of diseases selected from the group consisting of Alzheimer's disease, Parkinson's disease, Levy body dementia, dementia-related psychosis, schizophrenia, delusional syndromes and other psychotic conditions related and not related to taking psychoactive substances, depression, anxiety disorders of various aetiology, sleep disorders of various aetiology.

The application belongs to the field of environmental sample detection, and discloses a method for simultaneously detecting 20 kinds of benzene amphetamine, piperazine and benzodiazepine psychoactive substances in water bodies. The method simultaneously extracts and detects 20 kinds of benzene amphetamine, piperazine and benzodiazepine psychoactive substances in water bodies by using dispersion liquid liquid microextraction and high performance liquid chromatography mass spectrometry. The average recovery rate of the 20 target compounds is 71.5% to 108%, the standard deviation is 0.7% to 4.8%, the detection limit is 1.5 to 10.5 ng / L, and the quantitative limit is 6.0 to 42.2 ng / L. The method has high recovery rate, high sensitivity and good repeatability, and can be used for detecting benzene amphetamine, piperazine and benzodiazepine psychoactive substances in water bodies.

The invention discloses a sewage analysis-based automatic extraction and detection device for new psychoactive substances, which comprises a material taking assembly, a grabbing assembly is fixedly mounted at the upper end of the material taking assembly, the grabbing assembly is used for facilitating a user to grab the material taking assembly, an extraction and detection assembly is mounted at the rear end of the material taking assembly, and the material taking assembly comprises a shell; a water pump used for extracting sewage is arranged in the shell, the extraction detection assembly comprises an outer wall mounted on the shell, an extraction assembly used for extracting new psychoactive substances in the sewage is arranged in the outer wall, and a liquid chromatograph used for detecting the new psychoactive substances in the sewage is mounted on one side of the outer wall. By arranging the solid-phase extraction column, the vacuum pump and the liquid chromatograph, when the automatic extraction and detection device for the new psychoactive substances based on sewage analysis is used, sewage can be extracted on site, and the new psychoactive substances in the sewage can be directly extracted and detected.

The invention discloses a metabolite for identifying a tryptamine new psychoactive substance 4-HO-DET human liver microsome model and application of the metabolite, and relates to the technical field of liver microsomes. The situation that new psychoactive substances (NPS) are abused in a large amount due to uncontrolled conditions in the global range causes serious social, medical and environmental problems. The tryptamine substance 4-HO-DET, as a large class of new psychoactive substances, is rapidly metabolized after being ingested by a human body, and the concentration of an original drug reserved in biological samples such as hair, urine and blood of the human body is extremely low, so that certain difficulty is brought to detection and monitoring of the tryptamine new psychoactive substances. At present, metabolism detection of tryptamine new psychoactive substances is less at home and abroad, and only a small part of tryptamine substances are controlled. Therefore, research on the metabolic process of the tryptamine substances, analysis of the metabolites and metabolic pathways of the tryptamine substances and determination of the metabolic markers of the tryptamine substances play an important role in drug banning work. A human liver microparticle in-vitro model is established for 4-HO-DET, and the metabolic process is simulated.

Device for detecting psychoactive substances in liquids, characterized by, that the device measures the electrical conductivity of a liquid, These measurements are evaluated to detect possible adulteration of the liquid by psychoactive substances. and issues a warning via an automated feedback system if a potential contamination is detected.

The present invention provides a pretreatment method for detecting cathinone-type new psychoactive substances in tea. First, the present invention studied the extraction method and found that the pH value of the extraction solution significantly affects the results, requiring it to be within the range of 5.0 to 6.0. Second, the present invention utilizes a purification combination of anhydrous calcium chloride + N-propylethylenediamine (PSA) + nano-ferroferric oxide-loaded graphitized carbon black (GCB@Fe3O4). This method not only leverages the superparamagnetic properties, large specific surface area, and numerous adsorption sites of magnetic nano-adsorbent materials, but also effectively adsorbs interfering substances in the tea matrix. These methods include: anhydrous calcium chloride can form chelate precipitates with the main matrix components of tea leaves, such as polyphenols, flavonoids, pigments, and some alkaloids; GCB and PSA can chelate metal ions, further removing organic acids, pigments, and metal ions. This method is more efficient and rapid than other methods.

The present invention belongs to the field of identification of new addictive chemical substances. Aiming at the problem that the key steps of current new psychoactive substances rely on manual experience, resulting in too long sample analysis time, the present invention proposes a method and system for identifying and quickly comparing new psychoactive substances based on big data, including a data automatic acquisition module, an NPS data storage module based on HBase, an NPS molecular structure analysis module, an NPS intelligent comparison module, an NPS result feedback and warning module, and an application terminal; the data automatic acquisition module, the NPS data storage module based on HBase, the NPS molecular structure analysis module, the NPS intelligent comparison module, and the NPS result feedback and warning module are all deployed on a distributed server in a microservices architecture, and each module realizes data interaction through an API interface. The present invention can timely discover and handle potential new addictive substances.

The invention relates to a C13 isotope labeling internal standard substance of MDMA and metabolite thereof. The invention further provides a corresponding preparation method and application. According to the invention, the technical blank of an MDMA / MDA exclusive isotope internal standard is filled up, through the precise design and application of the C13 labeled standard substance, the detection of the psychoactive substance is promoted to develop towards the direction of higher sensitivity, lower error and stronger judicial credibility, and the C13 labeled standard substance has great social value for public safety and health management.

Provided are methods comprising presenting a sensory environment to an individual experiencing the effects of a psychoactive agent, monitoring the neural status, the physiological status, or both, of the individual, and presenting a modified sensory environment to the individual based on the monitoring. In certain embodiments, the agent is a psychedelic agent. According to some embodiments, presenting a sensory environment to the individual comprises presenting to the individual a visual stimulus, an auditory stimulus, a tactile stimulus, an olfactory stimulus, or any combination thereof. In certain embodiments, presenting a modified sensory environment to the individual comprises presenting a customized sensory environment to the individual in real-time based on the monitoring. In some embodiments, the individual is suffering from a mental health condition selected from depression, anxiety, post-traumatic stress disorder (PTSD), addiction, and any combination thereof. Systems that find use in practicing the methods of the present disclosure are also provided.