Preparation method for vilazodone hydrochloride crystal form XI

Abstract

The invention provides a preparation route for a vilazodone hydrochloride crystal form XI: vilazodone hydrochloride with the crystal form XI is obtained by a series of operations such as dilution, pHregulation, crystallization and drying, and the problem that the crystal form XI cannot be obtained by the route of the prior patent. The drug is used for treating or preventing depression, anxiety, bipolar disorder, mania, dementia, mental disorders associated with psychoactive substances, sexual dysfunction, eating disorder, obesity, fibromyalgia, sleep disorder, psychosis-like mental disorders,cerebral infarction, tension, side effects in hypertension treatment, brain diseases, chronic pain, acromegaly, hypogonadism, secondary amenorrhea and premenstrual syndrome.

Description

technical field

[0001] The invention belongs to the technical field of medicinal chemistry, and in particular relates to a preparation method of antidepressant vilazodone hydrochloride crystal form XI. Background technique

[0002] Vilazodone hydrochloride (Vilazodone), chemical name: 5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]-1-piperazinyl]-2-benzo Furocarboxamide hydrochloride, for the treatment of major depressive disorder in adults. The application provides pharmaceutical crystal form XI that can be used for the treatment or prevention of depression, anxiety, bipolar disorder, mania, dementia and mental disorders related to psychoactive substances, sexual dysfunction, eating disorders, obesity, fibromyalgia, sleep disorders disorders, psychotic-like mental disorders, cerebral infarction, tension, side effects of hypertension treatment, brain tonic disorders, chronic pain, acromegaly, hypogonadism, secondary amenorrhea, premenstrual syndrome. Contents of the invention [0...