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179 results about "Cannabinoid receptor" patented technology
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Cannabinoid receptors, located throughout the body, are part of the endocannabinoid system, which is involved in a variety of physiological processes including appetite, pain-sensation, mood, and memory.
Method of relieving analgesia and reducing inflamation using a cannabinoid delivery topical liniment
InactiveUS6949582B1Good effectSafe and effectiveBiocideHydroxy compound active ingredientsSide effectCannabinoid receptor
A method of relieving analgesia and reducing inflammation using a cannabinoid delivery topical liniment composition containing from about 97.5% to about 99.5% by weight a 70% monohydric alcohol solution, and from about 0.5% to about 2.5% by weight of a synergistic cannabinoid mixture extracted from the female plant Cannabis sativa L, including in combination: 9-Tetrahydrocannabinol (delta-9-THC), 9-THC Propyl Analogue (THC-V), Cannabidiol (CBD), Cannabidiol Propyl Analogue (CBD-V), Cannabinol (CBN), Cannabichromene (CBC), Cannabichromene Propyl Analogue (CBC-V), Cannabigerol (CBG), terpenoids, and flavonoids. The liniment is applied topically, preferably by spraying, and the constituents of the mixture are absorbed through the skin and interact with cannabinoid receptors in the body and tissues of a human patient to produce therapeutic analgesic and anti-inflammatory effects without undesirable psychotropic side effects.
Owner:WALLACE WALTER H
Heteroindanes: a new class of potent cannabimimetic ligands
One aspect of the invention is concerned with cannabimimetic heteroindane analogs having affinities and / or selectivities for a cannabinoid receptor. A further aspect of the invention is concerned with pharmaceutical preparations employing the inventive analogs and methods of administering therapeutically effective amounts of the inventive analogs to provide a physiological effect.
Owner:UNIV OF CONNECTICUT
Substituted amides
Owner:MERCK SHARP & DOHME LLC
Use for Cannabinoid
InactiveUS20090306221A1High activityLess degree of activityBiocideNervous disorderDiseaseCannabinoid
The present invention relates to the use of one or more cannabinoids in the manufacture of medicaments for use in 0 the treatment of diseases and conditions benefiting from inverse agonism of the CB1 and / or the CB2 cannabinoid receptor. Preferably the cannabinoid is a cannabidiol (CBD) type compound or derivative thereof.
Owner:GW PHARMA LTD
Use for Cannabinoid
The invention relates to the use of one or more cannabinolds in the manufacture of medicaments for use in the treatment of diseases and conditions benefiting from neutral antagonism of the CB, cannabinoid receptor. Preferably the cannabinoid is tetrahydrocannabivarin (THCV). Preferably the diseases and conditions to be treated are taken from the group: obesity, schizophrenia, epilepsy, cognitive disorders such as Alzheimer's, bone disorders, bulimia, obesity associated with type n diabetes (non-insulin dependant diabetes) and in the treatment of drug, alcohol and nicotine abuse or dependency.
Owner:GW PHARMA LTD
Use for cannabinoid
ActiveUS9168278B2High activityLess degree of activityBiocideNervous disorderDiseaseCannabinoid receptor
The invention relates to the use of one or more cannabinoids in the manufacture of medicaments for use in the treatment of diseases and conditions benefiting from neutral antagonism of the CB, cannabinoid receptor. Preferably the cannabinoid is tetrahydrocannabivarin (THCV). Preferably the diseases and conditions to be treated are taken from the group: obesity, schizophrenia, epilepsy, cognitive disorders such as Alzheimer's, bone disorders, bulimia, obesity associated with type II diabetes (non-insulin dependant diabetes) and in the treatment of drug, alcohol and nicotine abuse or dependency.
Owner:GW PHARMA LTD
3-Carbamoyl-2-Pyridone Derivative
ActiveUS20080103139A1Excellent in transdermal absorbency absorbencyExcellent in absorbency oral absorbencyBiocideSenses disorderHydrogenExternal application
The present invention provides compounds having an agonistic activity to the cannabinoid receptor, which is represented by the formula (I): wherein R1 is optionally substituted C1-C8 alkyl and the like; R2 is C1-C6 alkyl; R3 is C1-C6 alkyl and the like; or R2 and R3 taken together with the adjacent carbon atoms may form an optionally substituted 5 to 10 membered non-aromatic carbon ring; R4 is hydrogen and the like; G is a group selected from the groups shown by the formula and the like: wherein R5 is hydrogen and the like; X1 is a single bond and the like; X2 is optionally substituted C1-C8 alkylene that may be replaced by one or two groups of -O-, or -N(R6)-, wherein R6 is hydrogen, and the like; X3 is a single bond and the like; a pharmaceutically acceptable salt or a solvate thereof, and pharmaceutical compositions, atopic dermatitis treating agents, and anti-pruritus agents, especially anti-pruritus agents for oral use and for external application, which each contains the said compound as an active ingredient.
Owner:SHIONOGI & CO LTD
Use for cannabinoid
ActiveUS20160220529A1High activityLow toxicityNervous disorderMetabolism disorderDiseaseCannabinoid receptor
The invention relates to the use of one or more cannabinolds in the manufacture of medicaments for use in the treatment of diseases and conditions benefiting from neutral antagonism of the CB, cannabinoid receptor. Preferably the cannabinoid is tctrahydrocannabivarin (THCV). Preferably the diseases and conditions to be treated are taken from the group: obesity, schizophrenia, epilepsy, cognitive disorders such as Alzheimer's, bone disorders, bulimia, obesity associated with type II diabetes (non-insulin dependant diabetes) and in the treatment of drug, alcohol and nicotine abuse or dependency.
Owner:GW PHARMA LTD
Cannabinoid receptor inverse agonists and neutral antagonists as therapeutic agents for the treatment of bone disorders
The present invention pertains to cannabinoid (CB) receptor inverse agonists and neutral antagonists, and especially CB1 and CB2 inverse agonists and neutral antagonists; such as, for example, certain pyrazole compounds; their use in the inhibition of osteoclasts (for example, the inhibition of the survival, formation, and / or activity of osteoclasts), and / or in the inhibition of bone resorption; their use in connection with treatment of bone disorders, such as conditions mediated by osteoclasts (e.g., increased osteoclast activity) and / or characterised by (e.g., increased) bone resorption, such as osteoporosis (e.g., osteoporosis not associated with inflammation; e.g., osteoporosis associated with a genetic predisposition, sex hormone deficiency, or ageing), cancer associated bone disease, and Paget's disease of bone.
Owner:ABERDEEN THE UNIV COURT OF THE UNIV OF
Pyrazole analogs acting on cannabinoid receptors
InactiveUS7393842B2Inhibit bindingBlock biological actionBiocideNervous disorderPyrimidine analogueCannabinoid receptor
One aspect of the invention is concerned with cannabimimetic pyrazole analogs. Another aspect of the invention is concerned with new and improved pyrazole analogs having high affinities and / or selectivities for the CB1 cannabinoid receptor. A further aspect of the invention is concerned with pharmaceutical preparations employing the inventive analogs and methods of administering therapeutically effective amounts of the inventive analogs to provide a physiological effect.
Owner:UNIV OF CONNECTICUT
Substituted 2,3-diphenyl pyridines
Novel compounds of the structural formula (I) are antagonists and / or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present invention are useful as centrally acting drugs in the treatment of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders including multiple sclerosis and Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis, cerebral vascular accidents, and head trauma, anxiety disorders, stress, epilepsy, Parkinson s disease, movement disorders, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, the treatment of obesity or eating disorders, as well as the treatment of asthma, constipation, chronic intestinal pseudo-obstruction, and cirrhosis of the liver.
Owner:MERCK SHARP & DOHME CORP
Novel compounds as cannabinoid receptor ligands
Disclosed herein are cannabinoid receptor ligands of formula (I)wherein A1, A5, Rx, X4, and z are as defined in the specification. Compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
Owner:ABBVIE INC
Novel compounds as cannabinoid receptor ligands
Disclosed herein are cannabinoid receptor ligands of formula (I)wherein L1, A1, R1g, z, R2, R3, and R4 are as defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also presented.
Owner:ABBVIE INC
Novel Tricyclic Modulators of Cannabinoid Receptors
The compounds of the invention are modulators of cannabinoid receptors CB1 or CB2. The compounds can be used for the prevention or treatment of, e.g., pain, cancer, skin diseases, weight-associated disorders, chemical addictions, psychiatric disorders, neurodegenerative disorders, bone diseases, and inflammatory diseases. The compounds of the invention can further be used to study these diseases and disorders, as well as cannabinoid receptor biology, by coupling the compounds to, e.g., imaging agents.
Owner:UNIVERSITY OF MONTANA
Substituted pyrimidines
Owner:MERCK SHARP & DOHME CORP
Novel compounds as cannabinoid receptor ligands
The present application relates to cannabinoid receptor ligands of formula (I)wherein X1, A1, Rx, R2, R3, R4, and z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions.
Owner:ABBVIE INC
Novel compounds as cannabinoid receptor ligands
InactiveUS20080287510A1Organic active ingredientsBiocideCannabinoid receptorCannabinoid receptor ligand
Owner:ABBVIE INC
Novel compounds as cannabinoid receptor ligands
Disclosed herein are cannabinoid receptor ligands of formula (I)wherein A1, A5, Rx, X4, and z are as defined in the specification. Compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
Owner:ABBVIE INC
Imidazole compounds and uses thereof
InactiveUS20050026983A1Not affect characteristicBiocideOrganic active ingredientsDiseaseBiochemistry
Compounds of Formula (I) that act as cannabinoid receptor ligands and their uses in the treatment of diseases linked to the activation of the cannabinoid receptors in animals are described herein.
Owner:PFIZER INC
Hair and/or scalp treatment compositions
Hair and / or scalp treatment compositions comprise an antidandruff agent, an effective amount of a cannabinoid receptor (CBR) activating agent and a cosmetically acceptable diluent or carrier. Alternatively, the compositions may be shampoo compositions comprising from 3 to 50 wt % surfactant, a CB receptor activating agent and a cosmetically acceptable diluent or carrier, provided that the CB receptor activating agent is not palmitoylethanolamide. The compositions are useful in the treatment and / or prevention of the symptoms of dandruff and can reduce scalp itch, a symptom which is typically associated with dandruff.
Owner:UNILEVER HOME & PERSONAL CARE USA DIV OF CONOPCO IN C
Compounds as cannabinoid receptor ligands
Disclosed herein are cannabinoid receptor ligands of formula (I)wherein Y, X1, X2, X3, R1, and R2 are as defined in the specification. Compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
Owner:ABBVIE INC
Compounds as cannabinoid receptor ligands
Disclosed herein are cannabinoid receptor ligands of formula (I)wherein Ring A and R1 are as defined in the specification. Compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions are also described.
Owner:ABBVIE INC
Compounds as cannabinoid receptor ligands and uses thereof
Owner:ABBVIE INC
Compounds as cannabinoid receptor ligands
Disclosed herein are cannabinoid receptor ligands of formula (I)wherein A1 and Rx are as defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also presented.
Owner:ABBVIE INC
Compounds as cannabinoid receptor ligands
Owner:ABBVIE INC
Compounds as cannabinoid receptor ligands
Cannabinoid receptor ligands of formula (I)wherein Ring A and R1 are as defined in the specification. Compositions including such compounds, and methods of treating conditions and disorders using such compounds and compositions are also described.
Owner:ABBVIE INC
Indoles are cannabinoid receptor ligands
Owner:ABBVIE INC
Sulfamoyl Benzamides and Methods of Their Use
Novel sulfamoyl benzamide compounds, pharmaceutical compositions containing the sulfamoyl benzamide compounds, and methods of their pharmaceutical use are disclosed. In certain embodiments, the sulfamoyl benzamide compounds are agonists and / or ligands of cannabinoid receptors and may be useful, inter alia, for treating and / or preventing pain, gastrointestinal disorders, inflammation, auto-immune diseases, ischemic conditions, immune-related disorders, hypertension, neurological disorders, and neurodegenerative diseases, for providing cardioprotection against ischemic and reperfusion effects, for inducing apoptosis in malignant cells, for inhibiting mechanical hyperalgesia associated with nerve injury, and as an appetite stimulant.
Owner:APOLOR CORP
Phenyl derivatives and methods of use
InactiveUS20060074086A1Useful in treatmentBiocideUrea derivatives preparationPreventing painStimulant
Novel phenyl compounds, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the compounds are agonists and / or ligands of cannabinoid receptors and may be useful, inter alia, for treating and / or preventing pain, gastrointestinal disorders, genitourinary disorders, inflammation, glaucoma, auto-immune diseases, ischemic conditions, immune-related disorders, and neurodegenerative diseases, for providing cardioprotection against ischemic and reperfusion effects, for inducing apoptosis in malignant cells, and as an appetite stimulant.
Owner:APOLOR CORP
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