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Method for analyzing 37 fentanyl new psychoactive substances in hair

A technology of active substances and analysis methods, applied in the field of detection of fentanyl-like new psychoactive substances, can solve the problems of fast metabolism of fentanyl-like substances and short detection time limit, and achieve easy storage, long detection window, and easy collection Effect

Active Publication Date: 2020-08-04
ACADEMY OF FORENSIC SCIENCE
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

However, fentanyl substances are metabolized quickly in blood and urine, and the detection time is short

Method used

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  • Method for analyzing 37 fentanyl new psychoactive substances in hair
  • Method for analyzing 37 fentanyl new psychoactive substances in hair
  • Method for analyzing 37 fentanyl new psychoactive substances in hair

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Experimental program
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preparation example Construction

[0046] Preparation of mixed reference substance solution: Precisely pipette 37 kinds of reference substances, add methanol to dilute into mixed reference substance solutions with mass concentrations of 4, 10, 20, 100, 200, 400, 1000, 2000, 2500, 4000ng / mL, stand-by;

[0047] Preparation of extraction solution: mix ammonium formate solution with methanol and acetonitrile to obtain extraction solution;

[0048] Preparation of mixed internal standard solution: precise pipetting of fentanyl-d 5 , desmethylfentanyl-d 5 and U-47700-d 3 Appropriate amount, add the above extraction solution to prepare a mixed internal standard solution with a mass concentration of 10 ng / mL;

[0049] (2) Sample preparation:

[0050] Accurately weigh 20 mg of the pretreated hair sample to be tested and place it in a 2 mL test tube, add an appropriate amount of grinding beads, and 1 mL of the mixed internal standard solution prepared in step (1), freeze and grind in a homogenizer, then centrifuge, an...

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Abstract

The invention discloses a method for analyzing 37 fentanyl new psychoactive substances in hair. The method comprises the following steps: (1) preparing a solution; (2) preparing a sample; and (3) carrying out liquid chromatography-tandem mass spectrometry analysis on a to-be-detected sample solution, a to-be-detected standard curve solution and a to-be-detected blank solution prepared in the step(2), and establishing an analysis method for determining 37 fentanyl new psychoactive substances in the sample solution. The high-sensitivity and high-selectivity HPLC-MS / MS qualitative and quantitative analysis method is established by taking fentanyl new psychoactive substances as research objects and hair as a biological detection material, and is applied to detection and analysis of specific cases so that related technical support is provided for related fields such as judicial expertise and the like.

Description

technical field [0001] The invention relates to the technical field of detection of fentanyl-like new psychoactive substances, in particular to an analysis method for 37 fentanyl-like new psychoactive substances in hair. Background technique [0002] New psychoactive substances (NPS) refer to emerging drugs whose chemical structure is similar to but not identical to other traditional psychoactive drugs, and are "legal" substitutes for internationally controlled drugs. Taking the chemical structure as the basic classification basis, NPS mainly include phenethylamines, cathinones, piperazines, fentanyls, etc. As a large category of new psychoactive substances, synthetic opioids (especially fentanyl-like new psychoactive substances) are synthesized in large quantities. They have similar chemical structures and properties to traditional controlled drugs, but they are covered with "legal" Outerwear has become a new target for criminals. However, there are few studies on the ana...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/06G01N30/72G01N30/86
CPCG01N30/02G01N30/06G01N30/72G01N30/8679
Inventor 施妍秦楠向平刘伟沈敏
Owner ACADEMY OF FORENSIC SCIENCE
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