77 results about "Butyramide" patented technology

The invention provides a preparation method of 2-pyrrolidone, which comprises the following steps: by taking gamma-butyrolactone and liquid ammonia as raw materials, premixing to generate 4-hydroxybutyramide, then removing excessive liquid ammonia, and then dehydrating the 4-hydroxybutyramide to synthesize the 2-pyrrolidone. According to the method disclosed by the invention, the 2-pyrrolidone is synthesized by firstly deaminating and then dehydrating, so that the contents of light and heavy components are effectively reduced, and the yield can reach 95% or above.

The invention belongs to the technical field of chemical engineering, and discloses a cooling agent N, 2, 3-trimethyl-2-isopropyl butyramide and a synthesis method and application thereof, and the synthesis method comprises the following steps: adding propionitrile and isopropyl bromide into a reaction kettle, and reacting under the low-temperature liquid ammonia condition of-30-50 DEG C to obtain an intermediate DIPPN; carrying out purification and distillation on the intermediate DIPPN; reacting the purified and distilled intermediate DIPPN with dimethyl polyphosphate at the temperature of 100-140 DEG C, neutralizing with acid, separating, and filtering to obtain a crude product; the crude product is crystallized and dried, and the cooling agent N, 2, 3-trimethyl-2-isopropyl butyramide is obtained; the problem of low yield in the prior art is solved, and the problem of high acid value of amidation of methanol and concentrated sulfuric acid as a catalyst in the prior art is also solved.

The invention discloses application of 3-chloro-N-ethyl-N-(o-tolyl) butyramide in preparation of a product for treating tumors, and belongs to the technical field of medicines for treating tumors. The technical problem to be solved is to provide a new application of the 3-chloro-N-ethyl-N-(o-tolyl) butyramide. The key point of the technical scheme is the application of the 3-chloro-N-ethyl-N-(o-tolyl) butyramide in preparation of a product for treating tumors.

The invention provides a preparation method of a photocatalytic degradation material for treating cefradine-containing wastewater. The preparation method comprises the following steps: (1) synthesizing N-mercapto-3-butyrylamide pyrrole; step [2], preparing a Bi2GdO3SeI nanocrystal; and (3) loading poly [N-sulfydryl-3-butyrylamide pyrrole-2, 5-di (p-methylbenzene methylene)] on the surface of the foamed nickel matrix, and assembling the Bi2GdO3SeI nanocrystal. The photocatalytic degradation material prepared by the method disclosed by the invention has outstanding cefradine ultraviolet light and visible light degradation performance.

The invention provides a method for synthesizing N,3,3-trimethyl-2-oxobutyramide. 3,3-dimethyl-2-oxobutyric acid is used as a raw material, and methylamine hydrochloride is reacted with an organic base and a condensing agent to generate N,3,3-trimethyl-2-oxobutyramide. The yield of N,3,3-trimethyl-2-oxobutyramide generated by the synthesis method of the invention is high, the yield reaches 82%, the reaction conditions are mild, it is suitable for scaled-up production, and no highly toxic raw materials are used, which is safe and environmentally friendly.

The invention provides a refining method of diethylhexyl butyrylamide triazinone, and belongs to the technical field of cosmetics. Comprising the following steps: carrying out reactive crystallization on an impurity-containing compound shown in formula III in a first solution, and filtering to separate out crystal crystals to obtain a compound shown in formula IV; wherein the first solution is formed by dissolving hydrogen chloride in a second solvent; and reacting the compound of formula IV with an alkaline compound solution to obtain a refined compound of formula III. According to the method, impurities are removed in a mode of salifying and crystallizing hydrogen chloride and diethyl hexyl butyrylamide triazinone which are dissolved in a second solvent; and neutralizing hydrogen chloride in the formed salt to obtain the high-purity diethylhexyl butyrylamide triazinone, so that the purity of the diethylhexyl butyrylamide triazinone is improved.

The invention relates to the field of preparation of fluxapyroxad, and discloses a preparation method of fluxapyroxad. The preparation method comprises the following steps: 1, heating 4, 4-difluoro-3-oxobutanamide and triethyl orthoformate in an organic solvent for reaction to obtain a compound a; 2, adding the compound a into a mixed solution of methylhydrazine and an organic solvent under an ice bath condition, and then reacting under a heating condition; and after the reaction is completed, evaporating out the solvent and concentrating to obtain a compound b. 3, under the action of an alkaline reagent and a metal catalyst, adding the compound b and 2-bromochlorobenzene into an organic solvent, and heating for condensation reaction to generate a compound c; and 4, adding the compound c and 3, 4, 5-trifluorophenylboronic acid into a solvent to carry out Suzuki reaction under the protection of nitrogen and the action of an alkaline reagent and a metal catalyst. And after the reaction is completed, evaporating out the solvent and concentrating to obtain the fluxapyroxad. The method disclosed by the invention has the characteristics of overall economy, environmental protection, safety and high efficiency, and also has relatively strong industrial application potential.

The application relates to the technical field of anticorrosive paint and discloses long-acting aging-resistant acrylic anticorrosive paint and a production process thereof, wherein the long-acting aging-resistant acrylic anticorrosive paint comprises the following components by weight: 40-50 parts of acrylic emulsion, 4-8 parts of polyester resin, 4-8 parts of amino resin, 3-4 parts of film-forming aid, 20-25 parts of modified talcum powder, 10-12 parts of solvent and 4-5 parts of auxiliary agent; the modified talcum powder is obtained by modifying talcum powder with a modifier, wherein the modifier comprises 2-[(2-methoxy-4-nitrophenyl)amino]ethanol and / or hydroxybutyryl amide phenyl ether. The above technical scheme solves the problem of poor anticorrosive performance of the acrylic anticorrosive paint in the prior art.

The present disclosure relates to novel benzoxazole derivatives comprising 4-amino-butanamide and anti-inflammatory use thereof.

The invention provides a preparation method of 2, 2-difluoroethyl pyrrolidone, and the preparation method comprises the following steps: reacting difluoroethylamine with 4-chlorobutyryl chloride to obtain 4-chloro-N-(2, 2-difluoroethyl) butyramide; then, the 4-chloro-N-(2, 2-difluoroethyl) butyramide is subjected to a reaction in a sodium hydride dispersion solution, and 2, 2-difluoroethyl pyrrolidone is obtained; the preparation method is simple in reaction route, free of catalyst, mild in reaction condition and environmentally friendly, the obtained 2, 2-difluoroethyl pyrrolidone is high in purity and yield, the purity is larger than 90%, the yield is larger than 80%, and the 2, 2-difluoroethyl pyrrolidone can be used as an additive of lithium ion battery electrolyte.

The application belongs to the field of pharmaceutical chemical industry and particularly relates to a preparation method of enzalutamide. In the application, N-BOC-2-aminoisobutyramide is used as a starting material to form a ring with phenyl chlorothioformate to obtain 5,5-dimethyl-1-tert-butoxycarbonyl-2-thione imidazole-4-ketone, the obtained product is further subjected to nucleophilic substitution with 2-trifluoromethyl-4-bromobenzonitrile, is deprotected, and is subjected to nucleophilic substitution with 2-fluoro-4-bromobenzamide to obtain enzalutamide. The method uses N-BOC-2-aminoisobutyramide as a starting material, does not produce disubstituted impurities, has higher conversion rate, can obtain a product with high yield, and is more suitable for industrial amplification.

The invention discloses a method for preparing diethylhexyl butyrylamide triazinone, which comprises the following steps: S1, in the presence of an organic acid-binding agent, carrying out substitution reaction on N-tert-butyl-4-aminobenzamide and cyanuric chloride in a non-polar solvent at-10 DEG C to 60 DEG C for 1-6 hours to obtain an untreated substitution reaction mixture; and S2, adding isooctyl p-aminobenzoate into the substitution reaction mixture obtained in the step S1, and carrying out a reaction at 15-120 DEG C for 3-15 h so as to finally prepare the diethylhexyl butyramido triazinone. According to the method, the organic acid-binding agent is used, so that the substitution reaction is more stable, byproducts are fewer, and the product purity is higher. Meanwhile, due to the adoption of the organic acid-binding agent, a non-polar solvent can be conveniently used in the step of substitution reaction, so that a substitution reaction mixture can be directly subjected to next-step reaction with isooctyl p-aminobenzoate without treatment, and the one-pot preparation of the diethylhexyl butyrylamide triazinone is realized.

The invention relates to a preparation method of a photo-crosslinking agent compound (N-(19-(3-(butyl-3-alkyn-1-yl)-3H-diazacyclopropane-3-yl)-4, 16-dioxo-7, 10, 13-trioxo-3, 17-diazacylalkyl)-4-(7-oxo-7H-furan [3, 2-g] benzopyran-9-yl) oxy) butyramide), which comprises the following steps: by taking xanthoxyl as a starting material, reacting at the temperature of 60-80 DEG C for 1-2 hours, and then adding a catalyst, thereby obtaining the photo-crosslinking agent compound. The method comprises the following steps: sequentially carrying out condensation with fragments such as methyl 4-chlorobutyrate, BOC-ethylenediamine, polyoxydipropionic acid and diaziridine, so as to obtain a high-purity compound with a photo-crosslinking probe effect. The preparation method provided by the invention has the advantages of mild and controllable reaction conditions, high yield and no column chromatography purification operation in post-treatment purification, and is suitable for industrial large-scale production.

The invention relates to the field of heat recovery devices, in particular to a device for recovering heat produced by methyl butyramide oxide, which comprises a butyramide reactor with a coil pipe and a U-shaped heat exchanger, the butyramide reactor is communicated with a mixer, the coil pipe is arranged in the butyramide reactor, and the U-shaped heat exchanger is communicated with the butyramide reactor. And an output mixture of the mixer enters an external area of the coil pipe in the butyramide reactor for reaction. According to the invention, the reaction time of materials is prolonged through the butyramide coil reactor coil, so that the materials fully react to release heat; heat released by the first-step reaction is transferred to heat absorbed by the second-step reaction by virtue of the stirrer, so that the reaction heat of the methyl oxidation butyramide is fully utilized, heating steam is saved, and energy consumption is reduced. The U-shaped heat exchanger ensures the temperature of the methyl butyramide oxide, reduces the use amount of cooling water and saves water consumption at the same time. A sleeve thermal compensation heater is additionally arranged at the inlet of the main reactor to maintain the stability and efficiency of the main reaction process; and one high-pressure heat exchanger is reduced, so that the equipment investment is saved.

The application discloses a kind of bionic immune regulation double-network hydrogel and its preparation method and application, its preparation method is: GelMA-SPD and HAMA-NB are dissolved, join photo-crosslinking agent, crosslinking is carried out under light, obtain double-network hydrogel;GelMA-SPD is methacrylated gelatin-spermidine;HAMA-NB is methacrylated hyaluronic acid N-(2-aminoethyl)-4-[4-(hydroxymethyl)-2-methoxy-5-nitrophenoxy]-butyramide.The hydrogel prepared in the application has good biocompatibility, and the preparation process is simple, and can be degraded.The hydrogel of the application can be applied to tissue repair material or tissue engineering scaffold, and is expected to solve the immune rejection problem in the process of tissue organ transplantation, and is conducive to reducing inflammatory reaction and promoting the rapid healing of tissue trauma.

The present invention relates to sunscreen compositions containing a triazine based UV-filter such as ethylhexyl triazon (EHT) and diethylhexyl butamido triazone (DBT) and one or more cosmetic oils, characterized in that at least one of the cosmetic oils is isoamyl caprylate caprate. Said compositions exhibit an improved water repellency (lotus effect).

The application discloses a nitrilase mutant and application thereof in synthesis of chiral cyanoamide, wherein the nitrilase mutant has mutations in any or any of the following amino acid positions corresponding to the amino acid sequence shown in SEQ ID NO. 1: 54th, 118th, 120th, 139th, 148th, 168th, 170th, 194th, 197th, 198th, 202th and / or 225th, compared with the amino acid sequence of wild-type nitrilase amine. The mutant constructed by the application can efficiently catalyze 3-substituted-glutaronitrile compounds to generate (S)-3-substituted-4-cyanobutyramide compounds. The application solves the problem of insufficient enzyme catalytic activity in the prior art, and provides an efficient scheme for green synthesis of chiral cyanoamide.

The invention discloses a synthesis method of an antibody-coupled drug connexon with an aldehyde group, and belongs to the technical field of chemical synthesis of drugs. The preparation method comprises the following steps: synthesizing 4-(4-formylphenoxy) butyric acid by taking p-hydroxybenzaldehyde as an initial raw material, then carrying out amidation reaction on the 4-(4-formylphenoxy) butyric acid and Boc-ethylenediamine to generate 4-(4-formylphenoxy)-N-(2-pivalamidoethyl) butyramide, and carrying out acidic deprotection reaction to remove Boc groups, thereby obtaining the 4-(4-formylphenoxy)-N-(2-pivalamidoethyl) butyramide. According to the present invention, with the method, the basis is provided for the variety expansion of the antibody-coupled drug connexon, and the good application prospect is provided.

This invention discloses a highly efficient method for synthesizing proxalutamide intermediates, belonging to the field of pharmaceutical synthesis technology. First, dimethyl malonate and 2-chloro-5-nitropyridine are used as raw materials, condensed in the presence of potassium carbonate to generate dimethyl 2-(5-nitropyridine-2-yl)malonate. This is then reacted with tert-butyl acrylate and acid-hydrolyzed to obtain 4-(5-nitropyridine-2-yl)butyric acid. After activation with N,N'-carbonyl diimidazole, it is coupled with aminoacetaldehyde dimethyl acetal to form N-(2,2-dimethoxyethyl)-4-(5-nitropyridine-2-yl)butyramide. Then, a cyclization reaction mediated by phosphorus pentoxide and methanesulfonic acid is used to generate crude 2-(3-(5-nitropyridine-2-yl)propyl)oxazole. After purification, the nitro group is reduced by catalytic hydrogenation, and finally, it reacts with 1,5-naphthalenedisulfonic acid to form a salt, yielding the proxalutamide intermediate. This method achieves highly efficient synthesis of proxalutamide intermediates.

This invention belongs to the field of organic synthesis technology, specifically relating to a method for preparing phenelzine, comprising the following steps: using (2E / 2Z)-2-(4-cyano-2-methoxybenzyl)-3-oxobutyramide and 2-chloro-4-amino-5-methylpyridine as raw materials, reacting to obtain 5-chloro-4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-1,4-dihydro-1,6-naphthidine-3-carboxamide; subsequently, under the action of a resolving agent, reacting to generate (4S)-5-chloro-4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-1,4-dihydro-1,6-naphthidine-3-carboxamide; finally, reacting with ethanol under the action of a base to obtain phenelzine. This method avoids the use of expensive chiral column resolution, has short steps, low cost, and is suitable for industrial production.

The invention provides a preparation method of diethyl hexyl butyrylamide triazinone. The preparation method comprises the following steps: (1) reacting cyanuric chloride with para aminobenzoic acid to prepare an intermediate I; (2) reacting the intermediate I with thionyl chloride to obtain an intermediate II; and (3) reacting the intermediate II with tert-butylamine and isooctanol to obtain the diethylhexyl butyrylamide triazinone. The process disclosed by the invention has the advantages of easily available raw materials, high yield, simplicity in operation, low cost and easiness in industrialization.

This invention relates to the preparation of high-purity levetiracetam (S)-2-(2-oxo-1-pyrrolidine)butyramide. The preparation of the high-purity levetiracetam begins with 2-(2-oxopyrrolidine-1-yl)butyric acid as the starting material. Through esterification and ammonolysis, a racemic levetiracetam is obtained, which is then resolved by R-mandelic acid to yield high-purity levetiracetam with a chiral content of over 99.9%, a chiral isomer content of less than 0.05%, and no chloride detected. The chiral isomer (R)-2-(2-oxo-1-pyrrolidine)butyramide recovered after resolution can be racemed and further resolved by R-mandelic acid for the preparation of levetiracetam, achieving a total yield of over 90%. The recovered R-mandelic acid can be reused repeatedly, significantly reducing the consumption of resolving agent. This reaction has a short procedure, is easy to operate, and has a stable yield, which significantly reduces the cost of preparing levetiracetam. In addition, it has a very high chiral content, making it suitable for large-scale industrial production.

The invention belongs to the field of organic synthesis, and particularly relates to a synthesis method of an N, N-dimethyl-3-phenyl-4-(2-thienyl) butyramide compound. The preparation method comprises the following steps: mixing an N, N-dimethyl cinnamamide compound as shown in a formula 1 and a 2-methylthiophene compound as shown in a formula 2 with an organic solvent (N, N-dimethyl formamide) in the presence of a catalytic amount of lithium bis (trimethylsilyl) amide and cesium bis (trimethylsilyl) amino, and reacting to synthesize the N, N-dimethyl cinnamamide compound as shown in a formula 3. The structural formula of the N, N-dimethyl-3-phenyl-4-(thiophene-2-yl) butyramide compound is shown in the specification. According to the invention, a catalytic amount of Bronsted base (LiN (SiMe3) 2 / CsN (SiMe3) 2) is adopted to realize the 1, 4-addition reaction of extremely weak acidic benzyl C (sp3)-H bond of 2-methylthiophene and N, N-dimethyl cinnamamide, and the alkali metal catalyst shows obvious selectivity.

The invention relates to a preparation method of tris (ethyl methyl amino) tert-butylamide niobium, which comprises the following steps: (1) reacting niobium pentachloride, ethylene glycol dimethyl ether, zinc chloride and tert-butylamine to obtain a niobium-based complex; and (2) reacting the niobium-based complex with methyl ethyl amino lithium to obtain the tri (ethyl methyl amino) tert-butylamide niobium. By optimizing the preparation method of tris (ethyl methyl amino) tert-butylamide niobium in the prior art, the method has the advantages of simple and easily available raw materials, avoidance of the use of toxic and harmful reagents such as pyridine and toluene, simple reaction steps, mild reaction conditions, high reaction speed, no need of extremely high-temperature or low-temperature environment, high yield and high yield, and the product can be obtained by only two steps. And the obtained target product has high yield and purity, and is beneficial to industrial large-scale production.

The present invention discloses a method for synthesizing 2-aminobutyramide, which is characterized in that the method comprises the following specific steps: S1. Dissolve butyramide in an organic solvent, and then add a catalyst and stir evenly to obtain reaction solution A; S2. Add an ammonia source to the organic solvent to obtain reaction solution B; S3. Add the reaction solution A and reaction solution B to a high-pressure reactor and heat for reaction; S4. After the reaction, cool, discharge, and remove the solvent to obtain the crude product of 2-aminobutyramide; S5. Recrystallize the crude product of 2-aminobutyramide, filter, and dry to obtain the crystals of 2-aminobutyramide hydrochloride; S6. Neutralize the crystals of 2-aminobutyramide hydrochloride to obtain 2-aminobutyramide. The synthesis method provided by the present invention has simple process, high safety and high yield.

The present invention provides a polyimide precursor composition for producing an aromatic polyimide film in which light transmittance and / or heat resistance is improved. The polyimide precursor composition comprises: a polyimide precursor having a repeating unit represented by formula (I); a solvent A selected from among 1,3-dimethyl-2-imidazolidinone, 3-methoxy-N,N-dimethylpropanamide, 1-butyl-2-pyrrolidone, N,N-diphenylformamide, N,N-diethylbenzamide, benzanilide, and 1-phenyl-2-pyrrolidone; and a solvent B selected from among N,N-dimethylpropionamide, N,N-diethylformamide, N,N-diethylacetamide N,N-dimethylisobutylamide, N,N-diethylpropionamide, and tetramethyl urea. (In the formula, R1 and R2 are each a hydrogen atom or the like, and not less than 50 mol% of X1 is an aromatic group and / or not less than 50 mol% of Y1 is an aromatic group.)

The present invention belongs to the field of waste resource utilization, and specifically relates to a method for treating α-pyrrolidone distillation residues, the residues including N-methyl-2-pyrrolidone, 3-methyl-2-pyrrolidone, 4-methyl-2-pyrrolidone, 4-pyrrolidone-based butanamide, oligomers and heavy components. The above method comprises the following steps: S1: separating and treating the distillation residues to obtain a first mixture including N-methyl-2-pyrrolidone, 3-methyl-2-pyrrolidone and 4-methyl-2-pyrrolidone, and a second mixture including 4-pyrrolidone-based butanamide, oligomers and heavy components. S2: hydroxylating or aminating the first mixture, and then reacting with boric acid to obtain a lubricating oil antiwear agent. S3: The second mixture is subjected to oxidation and saponification to obtain a saponified product. The present invention makes full use of the useful components in the distillation residues, can reduce resource waste and environmental pollution, and improve economic benefits.

The invention provides an application of a chitosan oligosaccharide amino methylthio butyramide derivative in plant salt stress resistance, and belongs to the technical field of agricultural biologication.The derivative is used for relieving oxidative damage of salt stress to plants and specifically has the following effects that (1) the content of malondialdehyde in plants is reduced; (2) the activity of superoxide dismutase and peroxidase is improved; (3) promoting seed germination and seedling growth; the derivative is formed by connecting carboxyl of methionine and amino of chitosan oligosaccharide through an amido bond, the derivative is 2-amino-4-methylthio butyryl chitosan oligosaccharide, the chitosan oligosaccharide is methionine polymer chitosan oligosaccharide, and the deacetylation degree is larger than or equal to 90%; the polymerization degree of the methionine polymer chitosan oligosaccharide is 10 to 18; the invention provides a methionine carrier which is used for loading methionine into plants and improving the salt stress resistance of the plants.