150 results about "Butyramide" patented technology

The invention discloses a new synthesizing technique of chiral drug (S)-alpha-ethyl-2-oxo-1-pyrrolidine acetamide ( left Piracetam) intermediate (S)-(+)-2-aminobutanamide hydrochlorate, which comprises the following steps: adopting 2-brobutyrate as initial raw material; aminating; esterifying; ammonolyzing; detaching; looping; obtaining the object compound; making mixed rotary free alkaline (+-)-2-aminobutanamide; adopting half-quantum resolution method to connect chemical detaching salt to evolve salt; removing the detaching agent through alkalization; obtaining the (S)-(+)-2-aminobutanamide hydrochlorate with optical activity; using the mother liquor to make the product. The invention improves the receiving rate and saves the cost of raw material with simply technical operation and low cost, which resolves the resolved mother liquor after racemic action again to reduce the pollution of environment, therefore fitting for industrialized manufacturing.

There is described an electrorheological fluid comprising particles of a composite material suspended in an electrically insulating hydrophobic liquid. The composite particles are metal salts of the form M1_xM2_2-2xTiO(C₂O₄)₂ where M1 is selected from the group consisting of Ba, Sr and Ca and wherein M2 is selected from the group consisting of Rb, Li, Na and K, and the composite particles further include a promoter selected from the group consisting of urea, butyramide and acetamide.

A preparing method of Idelalisib (I) is disclosed. The preparing method includes following steps of: subjecting R-2-hydroxybutyrate (II) and 6-amino-9H-purine to nucleophilic substitution under actions of a leaving agent and an acid-binding agent to produce an intermediate S-2-(N-9H-purin-6-yl)aminobutyrate (III); subjecting the intermediate (III) and 2-amino-6-fluorobenzoic acid to amidation under actions of a catalyst to produce S-2-(N-9H-purin-6-yl)amino-N-(2-carboxyl-3-fluorophenyl)butyramide (IV); subjecting the intermediate (IV) to a cyclization reaction in acetic anhydride; and performing a substitution reaction with phenylamine to obtain the Idelalisib (I). The preparing method has characteristics of easily available raw materials, simple and concise process, capability of being economical and environmental friendly, and suitability for industrial production.

The invention discloses application of an amide compound, an extraction composition containing the amide compound and an extraction system. The extraction composition contains N,N-dicyclohexyl-butyramide and a diluents, but does not contain neutral phosphorus oxide as shown in the formula A. According to the amide compound or the extraction composition containing the amide compound, the extractionand back-extraction of lithium from Lithium-containing brine can be performed, the Lithium extraction rate of Lithium-containing brine is above 83.89%, and the distribution coefficient of Lithium-Magnesium is above 521; and when back-extraction of lithium is performed by the adoption of HCl, the back-extraction rate is above 91.74%, the corrosion to equipment is small, and the application of theamide compound, the extraction composition and the extraction system are suitable for industrial operation requirements (Please see the formula A in the specification.).

The invention relates to an oxiracetam compound and a new method thereof. In the method, 3-chloro-2-hydroxy propionitrile is used as an initial raw material. The method comprises the following steps of: synthesizing 4-hydroxyl-2-pyrrolidone through 4-chloro-3-hydroxyl-butylamide; and then synthesizing oxiracetam. The invention overcomes the defects of complicated preparation process, trouble steps, high cost, low product purity and difficult purification of the prior art.

The invention provides a preparation method of an ionic liquid for absorbing SO2, and an application of the ionic liquid in absorbing SO2. The preparation method of the ionic liquid comprises the steps of uniformly mixing one of aluminium chloride, zinc chloride, lithium chloride, aluminum sulfate, zinc sulfate, lithium sulfate, aluminium nitrate, zinc nitrate and lithium nitrate with one or two of urea, propanamide, butyramide, caprolactam, N,N-dimethylformamide and N,N-dimethylacetamide at a molar ratio of 1:(1-10) or 1:(0.5-3):(1-7), conducting reaction for 1-10h at 70-150 DEG C, conducting vacuum drying on an obtained solution at 40-60 DEG C, and obtaining the ionic liquid. The ionic liquid is mainly used for quickly and efficiently absorbing SO2. With the adoption of the ionic liquid as an SO2 absorbent, requirements on equipment required for absorbing SO2 are simple, the operational conditions are mild, the absorption efficiency is high, the cost is low, the ionic liquid can be recycled, and waste liquid and waste water discharge and other problems do not exist, and the ionic liquid is suitable for industrial production, meets the requirements of green chemical development of the contemporary society, and has good economic and social benefits.

The invention provides a preparation process of atorvastatin calcium, which is characterized by being divided into two steps when preparing a condensation compound (4R-cis)-1,1-dimethyl ethyl-6-[2-[2-(4-fluorophenyl)-5-(1-methyl ethyl)-3-phenyl-4-[(phenyl amino)-carbonyl]-1H-pyrrole-1-yl]ethyl]-2,2-dimethyl-1,3-dioxane-4-acetate: 1), adding (4R-cis)-6-aminoethyl-2,2-dimethyl-1,3-dioxane-4-tertbutyl acetate (called ATS-9 for short) into a mixed solvent of n-heptane, tetrahydrofuran and toluene to react with pivalic acid; and 2), adding 4-fluorine-alpha-[2-methyl-1-oxygen-propyl]-gamma-oxo-N,beta-diphenyl phenyl butyramide (called M-4 for short) and rising the temperature for reaction. The invention has the advantage of capability of greatly improving the yield of the intermediate condensation compound and is more in favor of industrialized production.

The invention relates to a preparation method of a 3R-amino substituted butyrylamide derivative. The preparation method of the 3R-amino substituted butyrylamide derivative comprises the following steps: carrying out hydrogenation reduction on enamine II for preparing 3R,3S-amino substituted butyrylamide racemate III; carrying out resolution, and filtering, so as to obtain 3R-amino substituted butyrylamide R(-) mandelate with high ee% value, alkalifying to obtain the 3R-amino substituted butyrylamide derivative; and oxidizing the obtained mother liquor, so as to obtain enamine II in a recycling manner, and repeating oxidation-reduction cycle for multiple times until products at specified yield are obtained. The preparation method of the 3R-amino substituted butyrylamide derivative has the advantages that a cyclic method is utilized for converting 3S-amino substituted butyrylamide racemate or 3R,3S-amino substituted butyrylamide mixture in any ratio into the 3R-amino substituted butyrylamide derivative with high ee% value, so that the mother liquor is effectively utilized; meanwhile, an expensive catalyst or asymmetric reductive amination with high demand condition does not need to be adopted, thereby being beneficial to reduction of cost and clean production.

The present invention provides a method for synthesizing (R)-N-BOC-3-amino-4-(2,4,5-trifluorophenyl) butyric acid (I) by transaminase method, in which 3-oxo-4- (2,4,5-trifluorophenyl) methyl butyrate (IV) is a starting material, reacted with nitrogen-protected piperazine to obtain 3-oxo-4-(2,4,5-trifluorophenyl) butane Amide intermediate (III); (III) reacts in the presence of amino donor and transaminase, and is converted into 3-amino-4-(2,4,5-trifluorophenyl) butyramide intermediate (II); with ( The amide of II) is hydrolyzed into an acid, and the amino group is protected by BOC to obtain the target intermediate (I); wherein the protecting group of piperazine in formula (III) and formula (II) is C1-4 alkoxycarbonyl, benzyloxycarbonyl or methyl. The invention has the advantages of ingenious design, simple and efficient synthesis route, simple and easy process flow, and environmental protection, and provides a new method for industrial scale production of formula (III).

The invention provides a method for industrially improving the production efficiency of N,2,3-trimethyl-2-isopropyl butyramide. The method comprises the following steps: (1) adding 2,3-dimethyl-2-isopropyl-butyronitrile and polyphosphoric acid, which are reaction materials, into a reaction kettle, slowly adding dimethyl carbonate dropwise under the conditions of heating and stirring, adding water dropwise in batches after finishing dropwise adding, continuing to preserve the heat at the temperature of 110-180 DEG C for 12 hours, stopping heating; (2) reducing the temperature of the reaction kettle to lower than 90 DEG C after finishing the reaction, slowly adding a sodium hydroxide aqueous solution of 30% dropwise until the PH value of a system reaches 7, adding ethyl acetate, fully stirring, removing an aqueous phase, cooling, crystalizing to obtain a finished product of the N,2,3-trimethyl-2-isopropyl butyramide. The adding mode of the dimethyl carbonate is changed to slowly adding dropwise, proper amount of water is added in batches after finishing adding the dimethyl carbonate dropwise, so that the reaction speed and the conversion efficiency of the 2,3-dimethyl-2-isopropyl-butyronitrile are both greatly improved.

The invention discloses an efficient cleanup additive for a gas well and a preparing method of the efficient cleanup additive. The method comprises the following steps: adding 2-5% by volume of a base agent namely perfluoro alkyl butyrylamide-propyl dimethylamine ammonia chloride-sodium sulfonate into a reactor; uniformly mixing, heating, keeping the temperature in the reactor between 80 DEG C and 100 DEG C, and then adding 5-8% by volume of ethanol, 84-91% by volume of water and 2-3% by volume of methyl propyl dibutyl fatty acid ammonium; reacting for 3 to 5 hours while agitating so as to obtain colorless transparent liquid. The preparing technology is simple, the materials are easy to obtain, and the effect of reducing the damage of aggressive water to a hyposmosis gas reservoir is obvious; through the adoption of the cleanup additive for gas well fracturing, the surface tension and extrusion pressure are reduced, and the backflow of operational liquid is facilitated.

The invention provides a method for preparing levetiracetam, comprising the following steps of: taking 2-bromine butyric acid as a raw material, subjecting to ammonolysis reaction, concentrating till drying, adding carbinol, crystallizing and drying so as to obtain 2-amino butyramide solid; dissolving the 2-amino butyramide solid in the carbinol, resolving and salifying by utilizing L-(+) - tartaric acid under the existence of a catalyst so as to obtain S-(+)-2- amino butyramide tartrate; and putting the S-(+)-2- amino butyramide tartrate into an aprotic solvent, adding anhydrous sodium sulfate and tetrabutyl amonium bromide, reacting with 4-chlorobutyryl chloride under an alkaline condition, filtering, decompressing filtrate, recovering the aprotic solvent, adding acetone into the surplus filtrate, recrystallizing and drying so as to obtain levetiracetam solid. The preparation method provided by the invention has the advantages of short reaction step, mild reaction condition, low cost and high yield.

Compounds of the formula I, in which W, X and Y have the meanings indicated in Claim 1, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.

The invention discloses application of amide compounds to the preparation of quorum sensing activity inhibitors. Oceanobacillus sp. XC22919 fermentation broth is utilized for separation and purification to prepare compounds 2-methyl-N-(2'-phenethyl)butyramide and 3-methyl-N-(2'-phenethyl)butyramide, which do not inhibit the growth of chromobacterium violaceum CV026 within a concentration range from 0Mu g/mL to 70Mu g/mL, but can remarkably reduce the generation of chromobacterium violaceum purpurin; moreover, as concentration is gradually increased, the effect of inhibiting the generation of purpurin is higher; within a concentration range from 0Mu g/mL to 100Mu g/mL, the compounds do not affect the growth of pseudomonas aeruginosa PAO1, but can remarkably decrease the expression of the virulence factor of pseudomonas aeruginosa, and can remarkably decrease the expressions of virulence factors such as pyocyanin, elastase, proteolytic enzyme and organism membranes, and the effect of the compounds in inhibiting quorum sensing is concentration-dependence.

The invention discloses a key material of a modified straw flocculant and a technical method for same. The key material includes, by weight part ratio: ozonized ultrapure water, straw powder, phenyl succinic acid, nonyl phenol sulfosuccinic monoester disodium salt, N-(2-methphenyl)trichloroacetamide, 1-amino-2-bromo-4-[(4-methphenyl)amino]-9,10-anthracenedione, 1-amino-4-bromoanthraquinone, 3,5-dimethoxybromobenzene, berkelium nano particles, 1-amino-2-bromo-4-hydroxyanthraquinone, 2-[(4-chloro-2-nitrophenyl)azo]-N-(2,3-dihydro-2-oxy-1H-benzoimidazole-5-yl)-3-oxo-butanamide, and 2-[[4-cyclohexylamino-9,10-dihydro-9,10-dioxy-1-anthryl]amino]-5-ethoxybenzenesulfonic sodium salt. The key material herein achieves synchronization of an organic flocculant during production and avoids complex steps of producing and purifying a bio-flocculant and compounding the bio-flocculant with the organic flocculant to complete the production of the compound flocculant, thereby reducing synthesize process and reducing cost.

The invention provides a preparation method of zolpidem. The method comprises the following steps: malononitrile and 2-methacrolein which are used as raw materials undergo a 1,4-addition reaction to prepare 2-methyl-4,4-dicyano-n-butyraldehyde, the 2-methyl-4,4-dicyano-n-butyraldehyde and N,N-dimethyl-4-p-methylphenyl-4-oxo-3-amino-n-butyramide undergo a two-stage dehydration condensation reaction, and the obtained reaction product and an acid binding agent undergo an elimination agent to prepare the zolpidem. The method of the invention has the advantages of cheap and easily available raw materials, short process flow, mild reaction conditions, simplicity in operation, low cost, low amount of three wastes, greenness, environmental protection, good selectivity, high yield and high purity of the product, and facilitation of industrial production of the zolpidem.

The invention relates to the technical field of pharmaceutical preparation, in particular to a preparation method of an antiepileptic drug. The synthesis process of levetiracetam designed by the invention takes (S)-2-(4-chlorobutyramide) butyric acid as an initial raw material, pyridine as an alkali and (Boc)2O as an activating reagent of carboxylic acid, an ammonium salt is added to prepare (S)-2-(4-chlorobutyramide) butyramide, and finally a cyclization reaction is carried out in the presence of alkali to obtain levetiracetam. The process does not need chemical resolution, does not use highly toxic or corrosive chemical reagents, is simple to operate, mild in conditions, environment-friendly and high in finished product quality, and is suitable for industrial production.

The invention discloses an extraction composition, an extraction system and application thereof. The extraction composition disclosed by the invention comprises an extraction agent and a neutral phosphorus oxide compound of formula A as shown in the description, wherein the extraction agent comprises N,N-di(2-ethylhexyl) acetamide and N,N-dihexyl butyramide. As a mixture of amide compounds and the neutral phosphorus oxide compound of specific structures is adopted as the extraction agent, the extraction rate for Li of lithium-containing brine is 86% or greater, and can be up to 93.58% at most; the lithium-magnesium allocation coefficient is as high as 500 or greater, and can be up to 773 at most; when lithium is reextracted with HCl, the reextraction rate is 86% or greater, the extraction and reextraction properties for extracting lithium from the lithium-containing brine are greatly improved, the cost is reduced, and industrial production can be relatively well met.