39 results about "Butyramide" patented technology

The invention discloses application of 3-chloro-N-ethyl-N-(o-tolyl) butyramide in preparation of a product for treating tumors, and belongs to the technical field of medicines for treating tumors. The technical problem to be solved is to provide a new application of the 3-chloro-N-ethyl-N-(o-tolyl) butyramide. The key point of the technical scheme is the application of the 3-chloro-N-ethyl-N-(o-tolyl) butyramide in preparation of a product for treating tumors.

The invention relates to the field of preparation of fluxapyroxad, and discloses a preparation method of fluxapyroxad. The preparation method comprises the following steps: 1, heating 4, 4-difluoro-3-oxobutanamide and triethyl orthoformate in an organic solvent for reaction to obtain a compound a; 2, adding the compound a into a mixed solution of methylhydrazine and an organic solvent under an ice bath condition, and then reacting under a heating condition; and after the reaction is completed, evaporating out the solvent and concentrating to obtain a compound b. 3, under the action of an alkaline reagent and a metal catalyst, adding the compound b and 2-bromochlorobenzene into an organic solvent, and heating for condensation reaction to generate a compound c; and 4, adding the compound c and 3, 4, 5-trifluorophenylboronic acid into a solvent to carry out Suzuki reaction under the protection of nitrogen and the action of an alkaline reagent and a metal catalyst. And after the reaction is completed, evaporating out the solvent and concentrating to obtain the fluxapyroxad. The method disclosed by the invention has the characteristics of overall economy, environmental protection, safety and high efficiency, and also has relatively strong industrial application potential.

The application relates to the technical field of anticorrosive paint and discloses long-acting aging-resistant acrylic anticorrosive paint and a production process thereof, wherein the long-acting aging-resistant acrylic anticorrosive paint comprises the following components by weight: 40-50 parts of acrylic emulsion, 4-8 parts of polyester resin, 4-8 parts of amino resin, 3-4 parts of film-forming aid, 20-25 parts of modified talcum powder, 10-12 parts of solvent and 4-5 parts of auxiliary agent; the modified talcum powder is obtained by modifying talcum powder with a modifier, wherein the modifier comprises 2-[(2-methoxy-4-nitrophenyl)amino]ethanol and / or hydroxybutyryl amide phenyl ether. The above technical scheme solves the problem of poor anticorrosive performance of the acrylic anticorrosive paint in the prior art.

The present disclosure relates to novel benzoxazole derivatives comprising 4-amino-butanamide and anti-inflammatory use thereof.

The invention provides a preparation method of 2, 2-difluoroethyl pyrrolidone, and the preparation method comprises the following steps: reacting difluoroethylamine with 4-chlorobutyryl chloride to obtain 4-chloro-N-(2, 2-difluoroethyl) butyramide; then, the 4-chloro-N-(2, 2-difluoroethyl) butyramide is subjected to a reaction in a sodium hydride dispersion solution, and 2, 2-difluoroethyl pyrrolidone is obtained; the preparation method is simple in reaction route, free of catalyst, mild in reaction condition and environmentally friendly, the obtained 2, 2-difluoroethyl pyrrolidone is high in purity and yield, the purity is larger than 90%, the yield is larger than 80%, and the 2, 2-difluoroethyl pyrrolidone can be used as an additive of lithium ion battery electrolyte.

The application belongs to the field of pharmaceutical chemical industry and particularly relates to a preparation method of enzalutamide. In the application, N-BOC-2-aminoisobutyramide is used as a starting material to form a ring with phenyl chlorothioformate to obtain 5,5-dimethyl-1-tert-butoxycarbonyl-2-thione imidazole-4-ketone, the obtained product is further subjected to nucleophilic substitution with 2-trifluoromethyl-4-bromobenzonitrile, is deprotected, and is subjected to nucleophilic substitution with 2-fluoro-4-bromobenzamide to obtain enzalutamide. The method uses N-BOC-2-aminoisobutyramide as a starting material, does not produce disubstituted impurities, has higher conversion rate, can obtain a product with high yield, and is more suitable for industrial amplification.

The invention relates to a preparation method of a photo-crosslinking agent compound (N-(19-(3-(butyl-3-alkyn-1-yl)-3H-diazacyclopropane-3-yl)-4, 16-dioxo-7, 10, 13-trioxo-3, 17-diazacylalkyl)-4-(7-oxo-7H-furan [3, 2-g] benzopyran-9-yl) oxy) butyramide), which comprises the following steps: by taking xanthoxyl as a starting material, reacting at the temperature of 60-80 DEG C for 1-2 hours, and then adding a catalyst, thereby obtaining the photo-crosslinking agent compound. The method comprises the following steps: sequentially carrying out condensation with fragments such as methyl 4-chlorobutyrate, BOC-ethylenediamine, polyoxydipropionic acid and diaziridine, so as to obtain a high-purity compound with a photo-crosslinking probe effect. The preparation method provided by the invention has the advantages of mild and controllable reaction conditions, high yield and no column chromatography purification operation in post-treatment purification, and is suitable for industrial large-scale production.

The application discloses a kind of bionic immune regulation double-network hydrogel and its preparation method and application, its preparation method is: GelMA-SPD and HAMA-NB are dissolved, join photo-crosslinking agent, crosslinking is carried out under light, obtain double-network hydrogel;GelMA-SPD is methacrylated gelatin-spermidine;HAMA-NB is methacrylated hyaluronic acid N-(2-aminoethyl)-4-[4-(hydroxymethyl)-2-methoxy-5-nitrophenoxy]-butyramide.The hydrogel prepared in the application has good biocompatibility, and the preparation process is simple, and can be degraded.The hydrogel of the application can be applied to tissue repair material or tissue engineering scaffold, and is expected to solve the immune rejection problem in the process of tissue organ transplantation, and is conducive to reducing inflammatory reaction and promoting the rapid healing of tissue trauma.

The present invention relates to sunscreen compositions containing a triazine based UV-filter such as ethylhexyl triazon (EHT) and diethylhexyl butamido triazone (DBT) and one or more cosmetic oils, characterized in that at least one of the cosmetic oils is isoamyl caprylate caprate. Said compositions exhibit an improved water repellency (lotus effect).

The application discloses a nitrilase mutant and application thereof in synthesis of chiral cyanoamide, wherein the nitrilase mutant has mutations in any or any of the following amino acid positions corresponding to the amino acid sequence shown in SEQ ID NO. 1: 54th, 118th, 120th, 139th, 148th, 168th, 170th, 194th, 197th, 198th, 202th and / or 225th, compared with the amino acid sequence of wild-type nitrilase amine. The mutant constructed by the application can efficiently catalyze 3-substituted-glutaronitrile compounds to generate (S)-3-substituted-4-cyanobutyramide compounds. The application solves the problem of insufficient enzyme catalytic activity in the prior art, and provides an efficient scheme for green synthesis of chiral cyanoamide.

This invention discloses a highly efficient method for synthesizing proxalutamide intermediates, belonging to the field of pharmaceutical synthesis technology. First, dimethyl malonate and 2-chloro-5-nitropyridine are used as raw materials, condensed in the presence of potassium carbonate to generate dimethyl 2-(5-nitropyridine-2-yl)malonate. This is then reacted with tert-butyl acrylate and acid-hydrolyzed to obtain 4-(5-nitropyridine-2-yl)butyric acid. After activation with N,N'-carbonyl diimidazole, it is coupled with aminoacetaldehyde dimethyl acetal to form N-(2,2-dimethoxyethyl)-4-(5-nitropyridine-2-yl)butyramide. Then, a cyclization reaction mediated by phosphorus pentoxide and methanesulfonic acid is used to generate crude 2-(3-(5-nitropyridine-2-yl)propyl)oxazole. After purification, the nitro group is reduced by catalytic hydrogenation, and finally, it reacts with 1,5-naphthalenedisulfonic acid to form a salt, yielding the proxalutamide intermediate. This method achieves highly efficient synthesis of proxalutamide intermediates.

This invention belongs to the field of organic synthesis technology, specifically relating to a method for preparing phenelzine, comprising the following steps: using (2E / 2Z)-2-(4-cyano-2-methoxybenzyl)-3-oxobutyramide and 2-chloro-4-amino-5-methylpyridine as raw materials, reacting to obtain 5-chloro-4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-1,4-dihydro-1,6-naphthidine-3-carboxamide; subsequently, under the action of a resolving agent, reacting to generate (4S)-5-chloro-4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-1,4-dihydro-1,6-naphthidine-3-carboxamide; finally, reacting with ethanol under the action of a base to obtain phenelzine. This method avoids the use of expensive chiral column resolution, has short steps, low cost, and is suitable for industrial production.

This invention relates to the preparation of high-purity levetiracetam (S)-2-(2-oxo-1-pyrrolidine)butyramide. The preparation of the high-purity levetiracetam begins with 2-(2-oxopyrrolidine-1-yl)butyric acid as the starting material. Through esterification and ammonolysis, a racemic levetiracetam is obtained, which is then resolved by R-mandelic acid to yield high-purity levetiracetam with a chiral content of over 99.9%, a chiral isomer content of less than 0.05%, and no chloride detected. The chiral isomer (R)-2-(2-oxo-1-pyrrolidine)butyramide recovered after resolution can be racemed and further resolved by R-mandelic acid for the preparation of levetiracetam, achieving a total yield of over 90%. The recovered R-mandelic acid can be reused repeatedly, significantly reducing the consumption of resolving agent. This reaction has a short procedure, is easy to operate, and has a stable yield, which significantly reduces the cost of preparing levetiracetam. In addition, it has a very high chiral content, making it suitable for large-scale industrial production.

The invention relates to a preparation method of tris (ethyl methyl amino) tert-butylamide niobium, which comprises the following steps: (1) reacting niobium pentachloride, ethylene glycol dimethyl ether, zinc chloride and tert-butylamine to obtain a niobium-based complex; and (2) reacting the niobium-based complex with methyl ethyl amino lithium to obtain the tri (ethyl methyl amino) tert-butylamide niobium. By optimizing the preparation method of tris (ethyl methyl amino) tert-butylamide niobium in the prior art, the method has the advantages of simple and easily available raw materials, avoidance of the use of toxic and harmful reagents such as pyridine and toluene, simple reaction steps, mild reaction conditions, high reaction speed, no need of extremely high-temperature or low-temperature environment, high yield and high yield, and the product can be obtained by only two steps. And the obtained target product has high yield and purity, and is beneficial to industrial large-scale production.

The present invention provides a polyimide precursor composition for producing an aromatic polyimide film in which light transmittance and / or heat resistance is improved. The polyimide precursor composition comprises: a polyimide precursor having a repeating unit represented by formula (I); a solvent A selected from among 1,3-dimethyl-2-imidazolidinone, 3-methoxy-N,N-dimethylpropanamide, 1-butyl-2-pyrrolidone, N,N-diphenylformamide, N,N-diethylbenzamide, benzanilide, and 1-phenyl-2-pyrrolidone; and a solvent B selected from among N,N-dimethylpropionamide, N,N-diethylformamide, N,N-diethylacetamide N,N-dimethylisobutylamide, N,N-diethylpropionamide, and tetramethyl urea. (In the formula, R1 and R2 are each a hydrogen atom or the like, and not less than 50 mol% of X1 is an aromatic group and / or not less than 50 mol% of Y1 is an aromatic group.)

The present invention relates to a method for producing enantiomerically enriched cyclobutylamine of formula (I) from alpha-tert-cyclobutanone and reacting said enantiomerically enriched cyclobutylamine to obtain enantiomerically enriched cyclobutyramide. Such compounds are useful intermediates in the synthesis of microbicidal thiazole compounds. (I)

The invention relates to a method for efficiently recovering N, 2, 3-trimethyl-2-isopropyl butyramide from crystallization mother liquor, which is characterized in that after a solvent is simply concentrated and recovered, a sublimation device is used for operation, the low-content crystallization mother liquor generated during industrial production of cooling agent N, 2, 3-trimethyl-2-isopropyl butyramide (WS-23) is recycled, the yield of 2, 2, 3-trimethyl-2-isopropyl butyramide is further increased, and the yield of 2, 2, 3-trimethyl-2-isopropyl butyramide is increased. 3, the yield of trimethyl-2-isopropyl butyramide is increased, the emission of three wastes and the production cost are reduced, the current concept of green production and green development is met, the operation is simple, the cost is low, the stability is good, and the remarkable industrial production advantage is achieved.

The application provides a synthesis method and application of L-2-aminobutyric acid and L-2-aminobutyric acid amide hydrochloride, and belongs to the technical field of synthesis of chiral drug intermediates. The method for synthesizing L-2-aminobutyric acid by an enzyme method comprises the following steps: mixing raw materials, reacting, and separating to obtain L-2-aminobutyric acid, wherein the raw materials comprise crotonic acid, L-phenylalanine, a solvent and L-phenylalanine deaminase, and can further comprise an ammonium salt. The method has the advantages of cheap and easily available materials, high reaction selectivity, high atom utilization rate, high yield, good product quality and the like, and successfully solves the production problems of low material reaction selectivity, waste of isomer separation materials and high material cost in the traditional process.

The invention discloses a method for synthesizing N-octyl pyrrolidone by taking succinic anhydride as a raw material, and the method comprises the following steps: step S1, carrying out acylation reaction on a mixture containing succinic anhydride and octylamine to obtain N-octyl succinamic acid; s2, carrying out reduction reaction on a mixture containing N-octyl succinamic acid, a catalyst I, a reducing agent and a solvent to obtain 4-hydroxy-N-octyl butyramide; and S3, carrying out a dehydration reaction on the mixture containing the 4-hydroxy-N-octyl butyramide, the catalyst II and the water-carrying agent to obtain the N-octyl pyrrolidone. The invention discloses a synthesis method of N-octyl pyrrolidone. The N-octyl pyrrolidone is prepared by taking succinic anhydride as a raw material through three-step continuous reaction of solvent-free acylation reaction, catalytic hydrogenation and molecular sieve dehydration.

This invention discloses a single molecular weight heterobifunctional PEG (X-PEG-Y) linker DBCO-PEG45-NHS Ester(N-{138-[(2,5-dioxanetetrahydro-1H-pyrrolo-1-yl)oxy]-138-oxonyl-3,6,9,12,15,18,21,24,27,30,33,36,39,42,45,48,51,54,57,60,63,66,69,72,75,78,81,84,87,90,93,96,99,102,105,108,111,114,117,120,123,126,129,132,135-tetradecanoyloxa-1-octadecanoyl-1-yl}-4-oxonyl-4-{11-azatricyclic[10.4.0.0]} 4,9 This invention relates to the synthesis of hexadecene-1(12),4(9),5,7,13,15-hexaden-2-ynthin-11-yl)butyramide, and pertains to the field of organic synthesis. The bioorthogonal chemical reaction of DBCO reagents with hydrophilic polyethylene glycol (PEG) chains with azides has been widely used due to its mild reaction conditions, rapid reaction rate, and good biocompatibility. This invention successfully prepared a novel DBCO heterobifunctional molecule, DBCO-PEG45-NHS Ester, with a total yield of ~20% and a scale of hundreds of grams through twelve conventional transformations including protection, substitution, addition, condensation, and deprotection. This route is simple to operate and operates under mild reaction conditions, representing a novel synthetic process with significant economic benefits and market potential.

The invention discloses a synthesis method of 3-methyl-2-pyrrolidone, and belongs to the technical field of chemical synthesis. The synthesis method comprises the following synthesis steps: a ring opening step: 3-methyl-gamma-butyrolactone and an ammonia source react in a high-pressure kettle to obtain 3-methyl-4-hydroxybutyramide, the reaction temperature is 120-150 DEG C, the pressure is 5-10 bar, and the reaction time is 6-12 hours; a chlorination step: reacting the 3-methyl-4-hydroxybutyramide with a combined chlorinating agent in anhydrous toluene at 0-5 DEG C for 2-4 hours, heating to 20-30 DEG C, and reacting for 1-2 hours to obtain 3-methyl-4-chlorobutyramide; and a cyclization step: carrying out reflux reaction on the 3-methyl-4-chlorobutyramide and organic alkali in absolute ethyl alcohol for 4-8 hours to obtain the 3-methyl-2-pyrrolidone. Wherein the 3-methyl-gamma-butyrolactone can be prepared from isoprene through three-step reaction of epoxidation, hydrolysis and oxidation. The method has the advantages of economical raw materials, simple steps and mild conditions, the purity of the 3-methyl isomer exceeds 99%, the solvent can be recycled, and the method is suitable for industrial production and can be expanded to preparation of other 3-substituted-2-pyrrolidone derivatives.

The present invention relates to a cosmetic or pharmaceutical composition comprising at least one cosmetically or pharmaceutically acceptable excipient and a photoprotective system consisting of: (a) 5,6,5′,6′-tetraphenyl-3,3′-(1,4-phenylene)-bis[1,2,4]triazine, (b) 2,4-bis[4-(2-ethylhexyloxy)-2-hydroxyphenyl]-6-(4-methoxyphenyl)-1,3,5-triazine, (c) hexyl 2-[4-(diethylamino)-2-hydroxybenzoyl]benzoate, and (d) a solar filter selected from the group comprised of ethylhexyl triazone, diethylhexyl butamido triazone and 2-ethylhexyl salicylate, wherein the photoprotective system represents between 4% and 20% by weight of the composition relative to the total weight of the composition.

The present invention provides a preparation method of isobutyramide thiazolyl resorcinol, which belongs to the technical field of organic synthesis. The method provided by the present invention is to carry out an amidation reaction with 2-aminothiazole and isobutyryl chloride under the action of an inorganic base to obtain intermediate 1; to obtain intermediate 2 with resorcinol and a halogenating agent under the action of a catalyst; and then to carry out a coupling reaction using intermediate 1 and intermediate 2 under a 0-valent palladium catalyst and an organic solvent to obtain isobutyramide thiazolyl resorcinol. The method provided by the present invention has a short route, low cost of raw materials and catalysts used, good environmental protection, and high-purity isobutyramide thiazolyl resorcinol can be obtained by filtration and recrystallization after the coupling reaction, without the need for a complicated post-processing process, and is easy to operate. The results of the examples show that the overall yield of the method provided by the present invention reaches more than 70%, and the HPLC purity is greater than 99%.

Provided herein are compounds, including compounds of any of the formulae described herein (e.g., Formula (I)), and pharmaceutically acceptable salts, stereoisomers, tautomers, solvates, hydrates, and isotopically labeled derivatives thereof. Compounds provided herein can act as potentiators of voltage-gates potassium channels (e.g., Kv7 potassium channels such as Kv7.2 / Kv7.3) and are therefore useful in the treatment and / or prevention of diseases, disorders, and conditions (e.g., diseases, disorders, and conditions associated with Kv7 potassium channel dysfunction).

The utility model discloses a condenser for preparing butyramide, and relates to the technical field of chemical medicine production equipment. Comprising an outer tank body, a cooling cylinder is longitudinally suspended in an inner cavity of the outer tank body, an air inlet pipe is arranged at the bottom of the outer tank body and communicated with the bottom of the cooling cylinder, an air outlet pipe is arranged on the upper portion of the outer tank body and communicated with the upper portion of the cooling cylinder, and the air outlet pipe is communicated with the side wall of the air inlet pipe. A plurality of evenly-distributed heat dissipation blades are fixedly arranged on the outer wall of the cooling cylinder in the longitudinal direction of the axis in a penetrating mode. Cooling liquid for cooling the heat dissipation blades is cooled by the cooling box B and then enters the cooling box A through the water purifying box and the cooling agent barrel again, then cyclic utilization of the cooling liquid is achieved, butyramide steam enters the cooling barrel through the air inlet pipe, heat of the butyramide steam is conducted into the cooling liquid in the inner cavity of the outer tank body through the heat dissipation blades, and the butyramide steam is cooled. And the cooled and liquefied butyramide is collected at the bottom of the cooling cylinder, so that the cooling process is simplified, and the cooling efficiency of the butyramide is improved.

The present invention relates to the field of heat recovery devices, and specifically to a device for recovering heat produced by methyl oxidation butanamide, comprising a butanamide reactor with a coil and a U-shaped heat exchanger, wherein the butanamide reactor is connected to a mixer, and a coil is provided inside the butanamide reactor, and the output mixture of the mixer enters the area outside the coil in the butanamide reactor for reaction. The present invention prolongs the reaction time of the material through the butanamide coil reactor coil, so that the material fully reacts and releases heat; and with the help of an agitator, the heat released by the first step of the reaction is transferred to the heat absorbed by the second step of the reaction, so that the heat of the methyl oxidation butanamide reaction can be fully utilized, saving heating steam and reducing energy consumption. The U-shaped heat exchanger reduces the amount of cooling water while ensuring the temperature of the methyl oxidation butanamide, saving water consumption. A sleeve heat compensation heater is added to the inlet of the main reactor to maintain the stability and efficiency of the main reaction process; and one high-pressure heat exchanger is reduced, saving equipment investment.

The invention provides a method for synthesizing diethylhexyl butyrylamide triazinone by using ethylhexyl triazinone in one step. The method is short in reaction path, simple in process, mild in reaction condition, easy to control and high in reaction yield. And the use of high-cost catalysts and high-risk and high-pollution chemicals is avoided. The production cost is effectively reduced, the economic value is improved, and green chemical engineering is realized.