52 results about "Butyramide" patented technology

The invention provides a preparation method of 2-pyrrolidone, which comprises the following steps: by taking gamma-butyrolactone and liquid ammonia as raw materials, premixing to generate 4-hydroxybutyramide, then removing excessive liquid ammonia, and then dehydrating the 4-hydroxybutyramide to synthesize the 2-pyrrolidone. According to the method disclosed by the invention, the 2-pyrrolidone is synthesized by firstly deaminating and then dehydrating, so that the contents of light and heavy components are effectively reduced, and the yield can reach 95% or above.

The invention discloses application of 3-chloro-N-ethyl-N-(o-tolyl) butyramide in preparation of a product for treating tumors, and belongs to the technical field of medicines for treating tumors. The technical problem to be solved is to provide a new application of the 3-chloro-N-ethyl-N-(o-tolyl) butyramide. The key point of the technical scheme is the application of the 3-chloro-N-ethyl-N-(o-tolyl) butyramide in preparation of a product for treating tumors.

The invention relates to the field of preparation of fluxapyroxad, and discloses a preparation method of fluxapyroxad. The preparation method comprises the following steps: 1, heating 4, 4-difluoro-3-oxobutanamide and triethyl orthoformate in an organic solvent for reaction to obtain a compound a; 2, adding the compound a into a mixed solution of methylhydrazine and an organic solvent under an ice bath condition, and then reacting under a heating condition; and after the reaction is completed, evaporating out the solvent and concentrating to obtain a compound b. 3, under the action of an alkaline reagent and a metal catalyst, adding the compound b and 2-bromochlorobenzene into an organic solvent, and heating for condensation reaction to generate a compound c; and 4, adding the compound c and 3, 4, 5-trifluorophenylboronic acid into a solvent to carry out Suzuki reaction under the protection of nitrogen and the action of an alkaline reagent and a metal catalyst. And after the reaction is completed, evaporating out the solvent and concentrating to obtain the fluxapyroxad. The method disclosed by the invention has the characteristics of overall economy, environmental protection, safety and high efficiency, and also has relatively strong industrial application potential.

The application relates to the technical field of anticorrosive paint and discloses long-acting aging-resistant acrylic anticorrosive paint and a production process thereof, wherein the long-acting aging-resistant acrylic anticorrosive paint comprises the following components by weight: 40-50 parts of acrylic emulsion, 4-8 parts of polyester resin, 4-8 parts of amino resin, 3-4 parts of film-forming aid, 20-25 parts of modified talcum powder, 10-12 parts of solvent and 4-5 parts of auxiliary agent; the modified talcum powder is obtained by modifying talcum powder with a modifier, wherein the modifier comprises 2-[(2-methoxy-4-nitrophenyl)amino]ethanol and / or hydroxybutyryl amide phenyl ether. The above technical scheme solves the problem of poor anticorrosive performance of the acrylic anticorrosive paint in the prior art.

The present disclosure relates to novel benzoxazole derivatives comprising 4-amino-butanamide and anti-inflammatory use thereof.

The invention provides a preparation method of 2, 2-difluoroethyl pyrrolidone, and the preparation method comprises the following steps: reacting difluoroethylamine with 4-chlorobutyryl chloride to obtain 4-chloro-N-(2, 2-difluoroethyl) butyramide; then, the 4-chloro-N-(2, 2-difluoroethyl) butyramide is subjected to a reaction in a sodium hydride dispersion solution, and 2, 2-difluoroethyl pyrrolidone is obtained; the preparation method is simple in reaction route, free of catalyst, mild in reaction condition and environmentally friendly, the obtained 2, 2-difluoroethyl pyrrolidone is high in purity and yield, the purity is larger than 90%, the yield is larger than 80%, and the 2, 2-difluoroethyl pyrrolidone can be used as an additive of lithium ion battery electrolyte.

The application belongs to the field of pharmaceutical chemical industry and particularly relates to a preparation method of enzalutamide. In the application, N-BOC-2-aminoisobutyramide is used as a starting material to form a ring with phenyl chlorothioformate to obtain 5,5-dimethyl-1-tert-butoxycarbonyl-2-thione imidazole-4-ketone, the obtained product is further subjected to nucleophilic substitution with 2-trifluoromethyl-4-bromobenzonitrile, is deprotected, and is subjected to nucleophilic substitution with 2-fluoro-4-bromobenzamide to obtain enzalutamide. The method uses N-BOC-2-aminoisobutyramide as a starting material, does not produce disubstituted impurities, has higher conversion rate, can obtain a product with high yield, and is more suitable for industrial amplification.

The invention relates to a preparation method of a photo-crosslinking agent compound (N-(19-(3-(butyl-3-alkyn-1-yl)-3H-diazacyclopropane-3-yl)-4, 16-dioxo-7, 10, 13-trioxo-3, 17-diazacylalkyl)-4-(7-oxo-7H-furan [3, 2-g] benzopyran-9-yl) oxy) butyramide), which comprises the following steps: by taking xanthoxyl as a starting material, reacting at the temperature of 60-80 DEG C for 1-2 hours, and then adding a catalyst, thereby obtaining the photo-crosslinking agent compound. The method comprises the following steps: sequentially carrying out condensation with fragments such as methyl 4-chlorobutyrate, BOC-ethylenediamine, polyoxydipropionic acid and diaziridine, so as to obtain a high-purity compound with a photo-crosslinking probe effect. The preparation method provided by the invention has the advantages of mild and controllable reaction conditions, high yield and no column chromatography purification operation in post-treatment purification, and is suitable for industrial large-scale production.

The invention relates to the field of heat recovery devices, in particular to a device for recovering heat produced by methyl butyramide oxide, which comprises a butyramide reactor with a coil pipe and a U-shaped heat exchanger, the butyramide reactor is communicated with a mixer, the coil pipe is arranged in the butyramide reactor, and the U-shaped heat exchanger is communicated with the butyramide reactor. And an output mixture of the mixer enters an external area of the coil pipe in the butyramide reactor for reaction. According to the invention, the reaction time of materials is prolonged through the butyramide coil reactor coil, so that the materials fully react to release heat; heat released by the first-step reaction is transferred to heat absorbed by the second-step reaction by virtue of the stirrer, so that the reaction heat of the methyl oxidation butyramide is fully utilized, heating steam is saved, and energy consumption is reduced. The U-shaped heat exchanger ensures the temperature of the methyl butyramide oxide, reduces the use amount of cooling water and saves water consumption at the same time. A sleeve thermal compensation heater is additionally arranged at the inlet of the main reactor to maintain the stability and efficiency of the main reaction process; and one high-pressure heat exchanger is reduced, so that the equipment investment is saved.

The application discloses a kind of bionic immune regulation double-network hydrogel and its preparation method and application, its preparation method is: GelMA-SPD and HAMA-NB are dissolved, join photo-crosslinking agent, crosslinking is carried out under light, obtain double-network hydrogel;GelMA-SPD is methacrylated gelatin-spermidine;HAMA-NB is methacrylated hyaluronic acid N-(2-aminoethyl)-4-[4-(hydroxymethyl)-2-methoxy-5-nitrophenoxy]-butyramide.The hydrogel prepared in the application has good biocompatibility, and the preparation process is simple, and can be degraded.The hydrogel of the application can be applied to tissue repair material or tissue engineering scaffold, and is expected to solve the immune rejection problem in the process of tissue organ transplantation, and is conducive to reducing inflammatory reaction and promoting the rapid healing of tissue trauma.

The present invention relates to sunscreen compositions containing a triazine based UV-filter such as ethylhexyl triazon (EHT) and diethylhexyl butamido triazone (DBT) and one or more cosmetic oils, characterized in that at least one of the cosmetic oils is isoamyl caprylate caprate. Said compositions exhibit an improved water repellency (lotus effect).

The application discloses a nitrilase mutant and application thereof in synthesis of chiral cyanoamide, wherein the nitrilase mutant has mutations in any or any of the following amino acid positions corresponding to the amino acid sequence shown in SEQ ID NO. 1: 54th, 118th, 120th, 139th, 148th, 168th, 170th, 194th, 197th, 198th, 202th and / or 225th, compared with the amino acid sequence of wild-type nitrilase amine. The mutant constructed by the application can efficiently catalyze 3-substituted-glutaronitrile compounds to generate (S)-3-substituted-4-cyanobutyramide compounds. The application solves the problem of insufficient enzyme catalytic activity in the prior art, and provides an efficient scheme for green synthesis of chiral cyanoamide.

The invention discloses a synthesis method of an antibody-coupled drug connexon with an aldehyde group, and belongs to the technical field of chemical synthesis of drugs. The preparation method comprises the following steps: synthesizing 4-(4-formylphenoxy) butyric acid by taking p-hydroxybenzaldehyde as an initial raw material, then carrying out amidation reaction on the 4-(4-formylphenoxy) butyric acid and Boc-ethylenediamine to generate 4-(4-formylphenoxy)-N-(2-pivalamidoethyl) butyramide, and carrying out acidic deprotection reaction to remove Boc groups, thereby obtaining the 4-(4-formylphenoxy)-N-(2-pivalamidoethyl) butyramide. According to the present invention, with the method, the basis is provided for the variety expansion of the antibody-coupled drug connexon, and the good application prospect is provided.

This invention discloses a highly efficient method for synthesizing proxalutamide intermediates, belonging to the field of pharmaceutical synthesis technology. First, dimethyl malonate and 2-chloro-5-nitropyridine are used as raw materials, condensed in the presence of potassium carbonate to generate dimethyl 2-(5-nitropyridine-2-yl)malonate. This is then reacted with tert-butyl acrylate and acid-hydrolyzed to obtain 4-(5-nitropyridine-2-yl)butyric acid. After activation with N,N'-carbonyl diimidazole, it is coupled with aminoacetaldehyde dimethyl acetal to form N-(2,2-dimethoxyethyl)-4-(5-nitropyridine-2-yl)butyramide. Then, a cyclization reaction mediated by phosphorus pentoxide and methanesulfonic acid is used to generate crude 2-(3-(5-nitropyridine-2-yl)propyl)oxazole. After purification, the nitro group is reduced by catalytic hydrogenation, and finally, it reacts with 1,5-naphthalenedisulfonic acid to form a salt, yielding the proxalutamide intermediate. This method achieves highly efficient synthesis of proxalutamide intermediates.

This invention belongs to the field of organic synthesis technology, specifically relating to a method for preparing phenelzine, comprising the following steps: using (2E / 2Z)-2-(4-cyano-2-methoxybenzyl)-3-oxobutyramide and 2-chloro-4-amino-5-methylpyridine as raw materials, reacting to obtain 5-chloro-4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-1,4-dihydro-1,6-naphthidine-3-carboxamide; subsequently, under the action of a resolving agent, reacting to generate (4S)-5-chloro-4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-1,4-dihydro-1,6-naphthidine-3-carboxamide; finally, reacting with ethanol under the action of a base to obtain phenelzine. This method avoids the use of expensive chiral column resolution, has short steps, low cost, and is suitable for industrial production.

This invention relates to the preparation of high-purity levetiracetam (S)-2-(2-oxo-1-pyrrolidine)butyramide. The preparation of the high-purity levetiracetam begins with 2-(2-oxopyrrolidine-1-yl)butyric acid as the starting material. Through esterification and ammonolysis, a racemic levetiracetam is obtained, which is then resolved by R-mandelic acid to yield high-purity levetiracetam with a chiral content of over 99.9%, a chiral isomer content of less than 0.05%, and no chloride detected. The chiral isomer (R)-2-(2-oxo-1-pyrrolidine)butyramide recovered after resolution can be racemed and further resolved by R-mandelic acid for the preparation of levetiracetam, achieving a total yield of over 90%. The recovered R-mandelic acid can be reused repeatedly, significantly reducing the consumption of resolving agent. This reaction has a short procedure, is easy to operate, and has a stable yield, which significantly reduces the cost of preparing levetiracetam. In addition, it has a very high chiral content, making it suitable for large-scale industrial production.

The invention relates to a preparation method of tris (ethyl methyl amino) tert-butylamide niobium, which comprises the following steps: (1) reacting niobium pentachloride, ethylene glycol dimethyl ether, zinc chloride and tert-butylamine to obtain a niobium-based complex; and (2) reacting the niobium-based complex with methyl ethyl amino lithium to obtain the tri (ethyl methyl amino) tert-butylamide niobium. By optimizing the preparation method of tris (ethyl methyl amino) tert-butylamide niobium in the prior art, the method has the advantages of simple and easily available raw materials, avoidance of the use of toxic and harmful reagents such as pyridine and toluene, simple reaction steps, mild reaction conditions, high reaction speed, no need of extremely high-temperature or low-temperature environment, high yield and high yield, and the product can be obtained by only two steps. And the obtained target product has high yield and purity, and is beneficial to industrial large-scale production.

The present invention discloses a method for synthesizing 2-aminobutyramide, which is characterized in that the method comprises the following specific steps: S1. Dissolve butyramide in an organic solvent, and then add a catalyst and stir evenly to obtain reaction solution A; S2. Add an ammonia source to the organic solvent to obtain reaction solution B; S3. Add the reaction solution A and reaction solution B to a high-pressure reactor and heat for reaction; S4. After the reaction, cool, discharge, and remove the solvent to obtain the crude product of 2-aminobutyramide; S5. Recrystallize the crude product of 2-aminobutyramide, filter, and dry to obtain the crystals of 2-aminobutyramide hydrochloride; S6. Neutralize the crystals of 2-aminobutyramide hydrochloride to obtain 2-aminobutyramide. The synthesis method provided by the present invention has simple process, high safety and high yield.

The present invention provides a polyimide precursor composition for producing an aromatic polyimide film in which light transmittance and / or heat resistance is improved. The polyimide precursor composition comprises: a polyimide precursor having a repeating unit represented by formula (I); a solvent A selected from among 1,3-dimethyl-2-imidazolidinone, 3-methoxy-N,N-dimethylpropanamide, 1-butyl-2-pyrrolidone, N,N-diphenylformamide, N,N-diethylbenzamide, benzanilide, and 1-phenyl-2-pyrrolidone; and a solvent B selected from among N,N-dimethylpropionamide, N,N-diethylformamide, N,N-diethylacetamide N,N-dimethylisobutylamide, N,N-diethylpropionamide, and tetramethyl urea. (In the formula, R1 and R2 are each a hydrogen atom or the like, and not less than 50 mol% of X1 is an aromatic group and / or not less than 50 mol% of Y1 is an aromatic group.)

The invention provides an application of a chitosan oligosaccharide amino methylthio butyramide derivative in plant salt stress resistance, and belongs to the technical field of agricultural biologication.The derivative is used for relieving oxidative damage of salt stress to plants and specifically has the following effects that (1) the content of malondialdehyde in plants is reduced; (2) the activity of superoxide dismutase and peroxidase is improved; (3) promoting seed germination and seedling growth; the derivative is formed by connecting carboxyl of methionine and amino of chitosan oligosaccharide through an amido bond, the derivative is 2-amino-4-methylthio butyryl chitosan oligosaccharide, the chitosan oligosaccharide is methionine polymer chitosan oligosaccharide, and the deacetylation degree is larger than or equal to 90%; the polymerization degree of the methionine polymer chitosan oligosaccharide is 10 to 18; the invention provides a methionine carrier which is used for loading methionine into plants and improving the salt stress resistance of the plants.

The present invention relates to a method for producing enantiomerically enriched cyclobutylamine of formula (I) from alpha-tert-cyclobutanone and reacting said enantiomerically enriched cyclobutylamine to obtain enantiomerically enriched cyclobutyramide. Such compounds are useful intermediates in the synthesis of microbicidal thiazole compounds. (I)

The invention relates to a method for efficiently recovering N, 2, 3-trimethyl-2-isopropyl butyramide from crystallization mother liquor, which is characterized in that after a solvent is simply concentrated and recovered, a sublimation device is used for operation, the low-content crystallization mother liquor generated during industrial production of cooling agent N, 2, 3-trimethyl-2-isopropyl butyramide (WS-23) is recycled, the yield of 2, 2, 3-trimethyl-2-isopropyl butyramide is further increased, and the yield of 2, 2, 3-trimethyl-2-isopropyl butyramide is increased. 3, the yield of trimethyl-2-isopropyl butyramide is increased, the emission of three wastes and the production cost are reduced, the current concept of green production and green development is met, the operation is simple, the cost is low, the stability is good, and the remarkable industrial production advantage is achieved.

The application provides a synthesis method and application of L-2-aminobutyric acid and L-2-aminobutyric acid amide hydrochloride, and belongs to the technical field of synthesis of chiral drug intermediates. The method for synthesizing L-2-aminobutyric acid by an enzyme method comprises the following steps: mixing raw materials, reacting, and separating to obtain L-2-aminobutyric acid, wherein the raw materials comprise crotonic acid, L-phenylalanine, a solvent and L-phenylalanine deaminase, and can further comprise an ammonium salt. The method has the advantages of cheap and easily available materials, high reaction selectivity, high atom utilization rate, high yield, good product quality and the like, and successfully solves the production problems of low material reaction selectivity, waste of isomer separation materials and high material cost in the traditional process.

The invention discloses a method for synthesizing N-octyl pyrrolidone by taking succinic anhydride as a raw material, and the method comprises the following steps: step S1, carrying out acylation reaction on a mixture containing succinic anhydride and octylamine to obtain N-octyl succinamic acid; s2, carrying out reduction reaction on a mixture containing N-octyl succinamic acid, a catalyst I, a reducing agent and a solvent to obtain 4-hydroxy-N-octyl butyramide; and S3, carrying out a dehydration reaction on the mixture containing the 4-hydroxy-N-octyl butyramide, the catalyst II and the water-carrying agent to obtain the N-octyl pyrrolidone. The invention discloses a synthesis method of N-octyl pyrrolidone. The N-octyl pyrrolidone is prepared by taking succinic anhydride as a raw material through three-step continuous reaction of solvent-free acylation reaction, catalytic hydrogenation and molecular sieve dehydration.

The invention belongs to the field of organic synthesis, and particularly relates to a synthesis method and application of an N, 3-diphenyl-4 (2-thienyl) butyramide compound. # imgabs0 is used for realizing one-pot synthesis of an N, N-dimethyl-3-phenyl-4-(2-thienyl) butyrylamide compound as shown in a formula 3 by adopting an N, N-dimethyl cinnamamide compound as shown in a formula 1 and 2-methylthiophene as shown in a formula 2 under the action of a catalytic amount of Bronsted alkali (LiN (SiMe3) 2 / CsN (SiMe3) 2); the compound 3 is acidified by HCl to generate a 3-phenyl-4-(2-thienyl) butyric acid compound as shown in a formula 4; and 4, synthesizing the N, 3-diphenyl-4 (2-thienyl) butyramide compound as shown in a formula 5 with an aniline compound under the action of SOCl2 and DMF. The invention provides an N, 3-diphenyl-4 (2-thienyl) butyramide compound for regulating and controlling the biological activity of plant pathogens in agriculture, horticulture, sanitation and forestry and a determination method of the N, 3-diphenyl-4 (2-thienyl) butyramide compound.

This invention discloses a single molecular weight heterobifunctional PEG (X-PEG-Y) linker DBCO-PEG45-NHS Ester(N-{138-[(2,5-dioxanetetrahydro-1H-pyrrolo-1-yl)oxy]-138-oxonyl-3,6,9,12,15,18,21,24,27,30,33,36,39,42,45,48,51,54,57,60,63,66,69,72,75,78,81,84,87,90,93,96,99,102,105,108,111,114,117,120,123,126,129,132,135-tetradecanoyloxa-1-octadecanoyl-1-yl}-4-oxonyl-4-{11-azatricyclic[10.4.0.0]} 4,9 This invention relates to the synthesis of hexadecene-1(12),4(9),5,7,13,15-hexaden-2-ynthin-11-yl)butyramide, and pertains to the field of organic synthesis. The bioorthogonal chemical reaction of DBCO reagents with hydrophilic polyethylene glycol (PEG) chains with azides has been widely used due to its mild reaction conditions, rapid reaction rate, and good biocompatibility. This invention successfully prepared a novel DBCO heterobifunctional molecule, DBCO-PEG45-NHS Ester, with a total yield of ~20% and a scale of hundreds of grams through twelve conventional transformations including protection, substitution, addition, condensation, and deprotection. This route is simple to operate and operates under mild reaction conditions, representing a novel synthetic process with significant economic benefits and market potential.

The invention discloses a synthesis method of 3-methyl-2-pyrrolidone, and belongs to the technical field of chemical synthesis. The synthesis method comprises the following synthesis steps: a ring opening step: 3-methyl-gamma-butyrolactone and an ammonia source react in a high-pressure kettle to obtain 3-methyl-4-hydroxybutyramide, the reaction temperature is 120-150 DEG C, the pressure is 5-10 bar, and the reaction time is 6-12 hours; a chlorination step: reacting the 3-methyl-4-hydroxybutyramide with a combined chlorinating agent in anhydrous toluene at 0-5 DEG C for 2-4 hours, heating to 20-30 DEG C, and reacting for 1-2 hours to obtain 3-methyl-4-chlorobutyramide; and a cyclization step: carrying out reflux reaction on the 3-methyl-4-chlorobutyramide and organic alkali in absolute ethyl alcohol for 4-8 hours to obtain the 3-methyl-2-pyrrolidone. Wherein the 3-methyl-gamma-butyrolactone can be prepared from isoprene through three-step reaction of epoxidation, hydrolysis and oxidation. The method has the advantages of economical raw materials, simple steps and mild conditions, the purity of the 3-methyl isomer exceeds 99%, the solvent can be recycled, and the method is suitable for industrial production and can be expanded to preparation of other 3-substituted-2-pyrrolidone derivatives.

The present invention relates to a cosmetic or pharmaceutical composition comprising at least one cosmetically or pharmaceutically acceptable excipient and a photoprotective system consisting of: (a) 5,6,5′,6′-tetraphenyl-3,3′-(1,4-phenylene)-bis[1,2,4]triazine, (b) 2,4-bis[4-(2-ethylhexyloxy)-2-hydroxyphenyl]-6-(4-methoxyphenyl)-1,3,5-triazine, (c) hexyl 2-[4-(diethylamino)-2-hydroxybenzoyl]benzoate, and (d) a solar filter selected from the group comprised of ethylhexyl triazone, diethylhexyl butamido triazone and 2-ethylhexyl salicylate, wherein the photoprotective system represents between 4% and 20% by weight of the composition relative to the total weight of the composition.