26 results about "Butyramide" patented technology

The invention discloses application of 3-chloro-N-ethyl-N-(o-tolyl) butyramide in preparation of a product for treating tumors, and belongs to the technical field of medicines for treating tumors. The technical problem to be solved is to provide a new application of the 3-chloro-N-ethyl-N-(o-tolyl) butyramide. The key point of the technical scheme is the application of the 3-chloro-N-ethyl-N-(o-tolyl) butyramide in preparation of a product for treating tumors.

The application relates to the technical field of anticorrosive paint and discloses long-acting aging-resistant acrylic anticorrosive paint and a production process thereof, wherein the long-acting aging-resistant acrylic anticorrosive paint comprises the following components by weight: 40-50 parts of acrylic emulsion, 4-8 parts of polyester resin, 4-8 parts of amino resin, 3-4 parts of film-forming aid, 20-25 parts of modified talcum powder, 10-12 parts of solvent and 4-5 parts of auxiliary agent; the modified talcum powder is obtained by modifying talcum powder with a modifier, wherein the modifier comprises 2-[(2-methoxy-4-nitrophenyl)amino]ethanol and / or hydroxybutyryl amide phenyl ether. The above technical scheme solves the problem of poor anticorrosive performance of the acrylic anticorrosive paint in the prior art.

The present disclosure relates to novel benzoxazole derivatives comprising 4-amino-butanamide and anti-inflammatory use thereof.

The invention provides a preparation method of 2, 2-difluoroethyl pyrrolidone, and the preparation method comprises the following steps: reacting difluoroethylamine with 4-chlorobutyryl chloride to obtain 4-chloro-N-(2, 2-difluoroethyl) butyramide; then, the 4-chloro-N-(2, 2-difluoroethyl) butyramide is subjected to a reaction in a sodium hydride dispersion solution, and 2, 2-difluoroethyl pyrrolidone is obtained; the preparation method is simple in reaction route, free of catalyst, mild in reaction condition and environmentally friendly, the obtained 2, 2-difluoroethyl pyrrolidone is high in purity and yield, the purity is larger than 90%, the yield is larger than 80%, and the 2, 2-difluoroethyl pyrrolidone can be used as an additive of lithium ion battery electrolyte.

The application discloses a kind of bionic immune regulation double-network hydrogel and its preparation method and application, its preparation method is: GelMA-SPD and HAMA-NB are dissolved, join photo-crosslinking agent, crosslinking is carried out under light, obtain double-network hydrogel;GelMA-SPD is methacrylated gelatin-spermidine;HAMA-NB is methacrylated hyaluronic acid N-(2-aminoethyl)-4-[4-(hydroxymethyl)-2-methoxy-5-nitrophenoxy]-butyramide.The hydrogel prepared in the application has good biocompatibility, and the preparation process is simple, and can be degraded.The hydrogel of the application can be applied to tissue repair material or tissue engineering scaffold, and is expected to solve the immune rejection problem in the process of tissue organ transplantation, and is conducive to reducing inflammatory reaction and promoting the rapid healing of tissue trauma.

The present invention relates to sunscreen compositions containing a triazine based UV-filter such as ethylhexyl triazon (EHT) and diethylhexyl butamido triazone (DBT) and one or more cosmetic oils, characterized in that at least one of the cosmetic oils is isoamyl caprylate caprate. Said compositions exhibit an improved water repellency (lotus effect).

The application discloses a nitrilase mutant and application thereof in synthesis of chiral cyanoamide, wherein the nitrilase mutant has mutations in any or any of the following amino acid positions corresponding to the amino acid sequence shown in SEQ ID NO. 1: 54th, 118th, 120th, 139th, 148th, 168th, 170th, 194th, 197th, 198th, 202th and / or 225th, compared with the amino acid sequence of wild-type nitrilase amine. The mutant constructed by the application can efficiently catalyze 3-substituted-glutaronitrile compounds to generate (S)-3-substituted-4-cyanobutyramide compounds. The application solves the problem of insufficient enzyme catalytic activity in the prior art, and provides an efficient scheme for green synthesis of chiral cyanoamide.

This invention discloses a highly efficient method for synthesizing proxalutamide intermediates, belonging to the field of pharmaceutical synthesis technology. First, dimethyl malonate and 2-chloro-5-nitropyridine are used as raw materials, condensed in the presence of potassium carbonate to generate dimethyl 2-(5-nitropyridine-2-yl)malonate. This is then reacted with tert-butyl acrylate and acid-hydrolyzed to obtain 4-(5-nitropyridine-2-yl)butyric acid. After activation with N,N'-carbonyl diimidazole, it is coupled with aminoacetaldehyde dimethyl acetal to form N-(2,2-dimethoxyethyl)-4-(5-nitropyridine-2-yl)butyramide. Then, a cyclization reaction mediated by phosphorus pentoxide and methanesulfonic acid is used to generate crude 2-(3-(5-nitropyridine-2-yl)propyl)oxazole. After purification, the nitro group is reduced by catalytic hydrogenation, and finally, it reacts with 1,5-naphthalenedisulfonic acid to form a salt, yielding the proxalutamide intermediate. This method achieves highly efficient synthesis of proxalutamide intermediates.

This invention belongs to the field of organic synthesis technology, specifically relating to a method for preparing phenelzine, comprising the following steps: using (2E / 2Z)-2-(4-cyano-2-methoxybenzyl)-3-oxobutyramide and 2-chloro-4-amino-5-methylpyridine as raw materials, reacting to obtain 5-chloro-4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-1,4-dihydro-1,6-naphthidine-3-carboxamide; subsequently, under the action of a resolving agent, reacting to generate (4S)-5-chloro-4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-1,4-dihydro-1,6-naphthidine-3-carboxamide; finally, reacting with ethanol under the action of a base to obtain phenelzine. This method avoids the use of expensive chiral column resolution, has short steps, low cost, and is suitable for industrial production.

This invention relates to the preparation of high-purity levetiracetam (S)-2-(2-oxo-1-pyrrolidine)butyramide. The preparation of the high-purity levetiracetam begins with 2-(2-oxopyrrolidine-1-yl)butyric acid as the starting material. Through esterification and ammonolysis, a racemic levetiracetam is obtained, which is then resolved by R-mandelic acid to yield high-purity levetiracetam with a chiral content of over 99.9%, a chiral isomer content of less than 0.05%, and no chloride detected. The chiral isomer (R)-2-(2-oxo-1-pyrrolidine)butyramide recovered after resolution can be racemed and further resolved by R-mandelic acid for the preparation of levetiracetam, achieving a total yield of over 90%. The recovered R-mandelic acid can be reused repeatedly, significantly reducing the consumption of resolving agent. This reaction has a short procedure, is easy to operate, and has a stable yield, which significantly reduces the cost of preparing levetiracetam. In addition, it has a very high chiral content, making it suitable for large-scale industrial production.

The present invention relates to a method for producing enantiomerically enriched cyclobutylamine of formula (I) from alpha-tert-cyclobutanone and reacting said enantiomerically enriched cyclobutylamine to obtain enantiomerically enriched cyclobutyramide. Such compounds are useful intermediates in the synthesis of microbicidal thiazole compounds. (I)

The invention relates to a method for efficiently recovering N, 2, 3-trimethyl-2-isopropyl butyramide from crystallization mother liquor, which is characterized in that after a solvent is simply concentrated and recovered, a sublimation device is used for operation, the low-content crystallization mother liquor generated during industrial production of cooling agent N, 2, 3-trimethyl-2-isopropyl butyramide (WS-23) is recycled, the yield of 2, 2, 3-trimethyl-2-isopropyl butyramide is further increased, and the yield of 2, 2, 3-trimethyl-2-isopropyl butyramide is increased. 3, the yield of trimethyl-2-isopropyl butyramide is increased, the emission of three wastes and the production cost are reduced, the current concept of green production and green development is met, the operation is simple, the cost is low, the stability is good, and the remarkable industrial production advantage is achieved.

This invention discloses a single molecular weight heterobifunctional PEG (X-PEG-Y) linker DBCO-PEG45-NHS Ester(N-{138-[(2,5-dioxanetetrahydro-1H-pyrrolo-1-yl)oxy]-138-oxonyl-3,6,9,12,15,18,21,24,27,30,33,36,39,42,45,48,51,54,57,60,63,66,69,72,75,78,81,84,87,90,93,96,99,102,105,108,111,114,117,120,123,126,129,132,135-tetradecanoyloxa-1-octadecanoyl-1-yl}-4-oxonyl-4-{11-azatricyclic[10.4.0.0]} 4,9 This invention relates to the synthesis of hexadecene-1(12),4(9),5,7,13,15-hexaden-2-ynthin-11-yl)butyramide, and pertains to the field of organic synthesis. The bioorthogonal chemical reaction of DBCO reagents with hydrophilic polyethylene glycol (PEG) chains with azides has been widely used due to its mild reaction conditions, rapid reaction rate, and good biocompatibility. This invention successfully prepared a novel DBCO heterobifunctional molecule, DBCO-PEG45-NHS Ester, with a total yield of ~20% and a scale of hundreds of grams through twelve conventional transformations including protection, substitution, addition, condensation, and deprotection. This route is simple to operate and operates under mild reaction conditions, representing a novel synthetic process with significant economic benefits and market potential.

The present invention relates to a cosmetic or pharmaceutical composition comprising at least one cosmetically or pharmaceutically acceptable excipient and a photoprotective system consisting of: (a) 5,6,5′,6′-tetraphenyl-3,3′-(1,4-phenylene)-bis[1,2,4]triazine, (b) 2,4-bis[4-(2-ethylhexyloxy)-2-hydroxyphenyl]-6-(4-methoxyphenyl)-1,3,5-triazine, (c) hexyl 2-[4-(diethylamino)-2-hydroxybenzoyl]benzoate, and (d) a solar filter selected from the group comprised of ethylhexyl triazone, diethylhexyl butamido triazone and 2-ethylhexyl salicylate, wherein the photoprotective system represents between 4% and 20% by weight of the composition relative to the total weight of the composition.

Provided herein are compounds, including compounds of any of the formulae described herein (e.g., Formula (I)), and pharmaceutically acceptable salts, stereoisomers, tautomers, solvates, hydrates, and isotopically labeled derivatives thereof. Compounds provided herein can act as potentiators of voltage-gates potassium channels (e.g., Kv7 potassium channels such as Kv7.2 / Kv7.3) and are therefore useful in the treatment and / or prevention of diseases, disorders, and conditions (e.g., diseases, disorders, and conditions associated with Kv7 potassium channel dysfunction).

The utility model discloses a condenser for preparing butyramide, and relates to the technical field of chemical medicine production equipment. Comprising an outer tank body, a cooling cylinder is longitudinally suspended in an inner cavity of the outer tank body, an air inlet pipe is arranged at the bottom of the outer tank body and communicated with the bottom of the cooling cylinder, an air outlet pipe is arranged on the upper portion of the outer tank body and communicated with the upper portion of the cooling cylinder, and the air outlet pipe is communicated with the side wall of the air inlet pipe. A plurality of evenly-distributed heat dissipation blades are fixedly arranged on the outer wall of the cooling cylinder in the longitudinal direction of the axis in a penetrating mode. Cooling liquid for cooling the heat dissipation blades is cooled by the cooling box B and then enters the cooling box A through the water purifying box and the cooling agent barrel again, then cyclic utilization of the cooling liquid is achieved, butyramide steam enters the cooling barrel through the air inlet pipe, heat of the butyramide steam is conducted into the cooling liquid in the inner cavity of the outer tank body through the heat dissipation blades, and the butyramide steam is cooled. And the cooled and liquefied butyramide is collected at the bottom of the cooling cylinder, so that the cooling process is simplified, and the cooling efficiency of the butyramide is improved.

The invention provides a method for synthesizing diethylhexyl butyrylamide triazinone by using ethylhexyl triazinone in one step. The method is short in reaction path, simple in process, mild in reaction condition, easy to control and high in reaction yield. And the use of high-cost catalysts and high-risk and high-pollution chemicals is avoided. The production cost is effectively reduced, the economic value is improved, and green chemical engineering is realized.

The present invention relates to the use of anthranilic acid in a process for preparing a compound selected from copper phthalocyanine, quinacridone, 2-[(2-methoxy-4-nitrophenyl)diazenyl]-N-(2-methoxyphenyl)-3-oxobutanamide (PY74), and 2-({2-oxo-1-[(2-oxo-2,3-dihydro-1H-benzimidazole-5-yl)carbamoyl]propyl}diazenyl)benzoic acid (PY151). In particular, the anthranilic acid is produced or obtained from a microorganism.

The invention relates to a crystal form B of (S)-2-aminobutanamide hydrochloride, a preparation method of the crystal form B and a method for preparing levetiracetam by using the novel crystal form. The novel crystal form can improve the reaction yield and product purity of subsequent levetiracetam.

The invention provides a preparation method of diethylhexyl butyramido triazinone, and relates to the technical field of ultraviolet absorbers, the preparation method comprises the following steps: S1, providing an intermediate, and heating the intermediate and isooctyl p-aminobenzoate in a first solvent for reaction to obtain a product solution; s2, adjusting the pH value of the product solution to 6-8, washing with water, taking an organic phase, dehydrating, and adding a weakly alkaline substance to remove impurities, so as to obtain a pretreated solution; s3, performing desolvation treatment on the pretreatment solution to obtain a product solution, and performing melt forming, crushing and drying on the product solution to obtain the diethylhexyl butyrylamide triazinone. In the technical scheme provided by the invention, impurities in the organic phase can be further reduced by adopting the impurity removal step; the desolventizing is performed after the previous washing and impurity removing step is completed, so that solvent impurities are prevented from being introduced, and the problem of residue of the impurities and the solvent in the desolventizing process is reduced.

The invention discloses a preparation method of 3, 3-dimethyl-2-oxobutyric acid (3, 3-dimethyl-2-oxobutyric acid). The method comprises the following steps: under an acidic condition, carrying out oximation reaction on 3, 3-dimethyl-2-butanone and a sodium nitrite solution under the catalysis of cation exchange resin to obtain 3, 3-dimethyl-2-oxobutanal oxime; the preparation method comprises the following steps: under the catalytic action of protonic acid, carrying out Beckmann rearrangement on 3, 3-dimethyl-2-oxobutanal oxime to obtain 3, 3-dimethyl-2-ketobutyramide; in the presence of an inorganic acid sodium nitrite solution, 3, 3-dimethyl-2-ketobutyramide is hydrolyzed to obtain the final oxidation product 3, 3-dimethyl-2-oxobutyric acid. The cation exchange resin with smaller steric hindrance is used as a catalyst for enol conversion in the oximation reaction process, and the problem that an original catalytic system only adapts to a single acetyl aromatic system is solved. The universality of a reaction substrate is improved, and possibility is provided for synthesizing drug intermediates, natural products and the like containing polyfunctional groups.

The utility model relates to the technical field of imazethapyr production, in particular to a butyramide dehydration device in imazethapyr production, which comprises a dehydration kettle, a dehydration distillation treatment structure and a toluene receiving tank, the dehydration distillation treatment structure is fixedly arranged on the ground close to one side of the dehydration kettle, a safety explosion-proof structure is arranged on the outer side of the dehydration kettle, and the toluene receiving tank is arranged on the outer side of the dehydration kettle. A weighing and discharging structure is arranged at the top end of the dehydration kettle. According to the butyramide dehydration device in imazethapyr production, the fixing frame is made of aluminum alloy materials, the dehydration kettle is vertically supported above the base in a welding mode, the outer frame is formed by aluminum alloy rods in a lap joint mode, and therefore the outer frame forms a structure wrapping the internal dehydration kettle; and a certain protection effect can be achieved when violent reaction or explosion occurs, so that when butyramide and sodium chlorate are stirred in the butyramide dehydration device in imazethapyr production to complete mixing, the harm caused by explosion is reduced, and the use safety of the butyramide dehydration device in imazethapyr production is improved.

This invention relates to a method for preparing methionine, comprising contacting a solution or suspension containing 2-amino-4-(methylthio)butyronitrile and / or 2-amino-4-(methylthio)butyramide with water in the presence of a catalyst to obtain a mixture containing methionine, wherein the catalyst comprises CeO2-containing particles, wherein the BET surface area of ​​the CeO2-containing particles is 175 to 300 ± 10% m² as measured according to DIN ISO 9277-5 (2003). 2 / g, average maximum Feret diameter xF 最大,平均 The range is from 3±10% to 40±10% nm, and the average minimum Feret diameter xF 最小,平均 The mean maximum Feret diameter is 2 ± 10% to 30 ± 10% nm. F最大,平均 and average minimum Feret diameter x F最小,平均 Both were measured according to DIN ISO 9276-6 (2012).