4 results about "Carboxybenzyl" patented technology

This invention provides a class of near-infrared molecular probes that specifically bind to human serum albumin, their preparation methods, and applications. The near-infrared molecular probes are one of NFH-1, NFH-2, NFH-3, NFH-4, NFH-5, NFH-6, and NFH-7, with the general formula: [Formula omitted for brevity]. In this formula, R is selected from methyl, benzyl, fluorobenzyl, phenethyl, 2,4-dimethylbenzyl, 3-methoxybenzyl, and p-carboxybenzyl. This invention uses a hydroxyl hemicyanine dye as the fluorophore and introduces a series of hydrophobic functional groups (-R) onto the phenolic hydroxyl group to regulate molecular properties to match the hydrophobic domains of human serum albumin. These probes can avoid background interference from endogenous substances in clinical blood samples, improve the signal-to-noise ratio and accuracy of detection, and are simple to prepare, fluorescently sensitive, highly resistant to interference, and highly stable, providing an efficient tool for clinical human serum albumin detection.

The invention discloses a binuclear copper modified molybdenum germanic acid crystalline material as well as a preparation method and application thereof. The molecular formula of the material is [Cu2 (L) 2 (HL) 4 (H2O) 2 (GeMo12O40) 2]. 3H2O; l is 1-(4-carboxyl benzyl)-[4, 4 '] bipyridine chloride; the crystal system is monoclinic; the space group is P21 / n; the cell parameters are as follows: a is equal to 18.0008 (6), b is equal to 20.8877 (6), c is equal to 20.5829 (7), alpha is equal to 90 degrees, beta is equal to 90.2370 (10) degrees, gamma is equal to 90 degrees, and Z is equal to 2. The preparation method comprises the following steps: 1, dissolving germanium oxide, ammonium molybdate, a copper salt and a ligand L in water, and regulating the pH value of the solution by using an acid regulator to obtain a reaction solution; and step 2, reacting the reaction solution in the step 1 in a high-temperature closed environment, and cooling to room temperature after the reaction is finished to obtain the binuclear copper modified molybdenum germanic acid crystalline material. According to the crystalline material synthesized by the invention, Keggin type polyacid GeMo12 and a binuclear copper site are integrated in a single framework, and electrons are directly transferred into the copper site from the polyacid through weak interaction after the polyacid obtains the electrons, so that the catalytic performance is greatly improved.

The invention discloses a luminescent crystal material with functions of simultaneously detecting Fe < 3 + > and organic amine as well as a preparation method and application of the luminescent crystal material. According to the photochromic and AIE bifunctional organic ligand based on 4, 4 '-((9H-fluorene-9-subunit) methylene) bis (1-(4-carboxyl benzyl) pyridine-1-onium) chloride, the preparation method and the product of the photochromic and AIE luminous crystal material capable of detecting organic amine and Fe < 3 + > are provided, the synthesis route is simple and easy to control, the product yield can reach 38.4%, and the preparation method is suitable for industrial production and popularization. Compared with the prior art, the crystal material is simple, convenient and reliable in detection. Firstly, the quenching constant of luminescence enhanced detection of aqueous phase Fe < 3 + > can reach-1.46 * 10 < 4 > M <-1 >, the detection limit is as low as 4.18 * 10 <-6 > M, and the material is a photochromic luminescent crystal material for relatively sensitive detection of Fe < 3 + > at present. Secondly, the volatile organic amine can be visually detected. The HOF is light yellow, and the HOF shows gradually deepened yellow after di-n-propylamine, dimethylamine and trimethylamine are detected.

The invention discloses a color-changeable coordination polymer with an interdigital structure and capable of adsorbing cationic dye and sensing temperature and a preparation method of the color-changeable coordination polymer, and belongs to the technical field of chemistry, and the coordination polymer has the following chemical formula: [Mn4 (H2L1) 2 (L2) 4 (H2O) 4]. (H2O) 4. A certain amount of Mn (CH3COO) 2.4 H2O, 1, 1 '-bis (4-carboxylbenzyl)-4, 4'-bipyridine dichloride (H2L1Cl2), (3, 5-dicarboxylphenyl)-(4-(2 '-carboxylphenyl)-benzyl) ether (H3L2) and a certain amount of deionized water are sealed and heated in a reaction kettle for a period of time, after the reaction is finished, natural cooling is performed to room temperature, light yellow crystals are obtained, and the purity of the crystals is high. The color-changeable coordination polymer has an interdigital structure and can adsorb cationic dye and sense temperature. The synthesis method disclosed by the invention is simple to operate, good in repeatability, high in product yield, green and environment-friendly, and water is used as a solvent (no toxic organic solvent is needed). The coordination polymer can generate water-induced discoloration and solvent-induced discoloration phenomena, can adsorb cationic dye methylene blue, can be used for temperature sensing, and has a good application prospect.