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2 results about "Carboxybenzyl" patented technology
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Carboxybenzyl is a carbamate which is often used as an amine protecting group in organic synthesis. It is commonly used in peptide synthesis where the carboxybenzyl protection group is introduced by reacting the amine functionality with benzyl chloroformate in the presence of a weak base: Alternatively, as in the Curtius rearrangement, it is made by the trapping of an isocyanate with benzyl alcohol. It is used to protect amines from electrophiles. The protected amine can be deprotected by catalytic hydrogenation or treatment with HBr, yielding a terminal carbamic acid that then readily decarboxylates to yield the free amine. The method was first used by Max Bergmann and Leonidas Zerwas in 1932 for the synthesis of peptides. The abbreviation Z is in honor of Zerwas.
A class of near-infrared molecular probes that specifically bind to human serum albumin, their preparation method and applications
This invention provides a class of near-infrared molecular probes that specifically bind to human serum albumin, their preparation methods, and applications. The near-infrared molecular probes are one of NFH-1, NFH-2, NFH-3, NFH-4, NFH-5, NFH-6, and NFH-7, with the general formula: [Formula omitted for brevity]. In this formula, R is selected from methyl, benzyl, fluorobenzyl, phenethyl, 2,4-dimethylbenzyl, 3-methoxybenzyl, and p-carboxybenzyl. This invention uses a hydroxyl hemicyanine dye as the fluorophore and introduces a series of hydrophobic functional groups (-R) onto the phenolic hydroxyl group to regulate molecular properties to match the hydrophobic domains of human serum albumin. These probes can avoid background interference from endogenous substances in clinical blood samples, improve the signal-to-noise ratio and accuracy of detection, and are simple to prepare, fluorescently sensitive, highly resistant to interference, and highly stable, providing an efficient tool for clinical human serum albumin detection.
Owner:HUNAN PROVINCIAL PEOPLES HOSPITAL
Binuclear copper modified molybdenum germanic acid crystalline material and preparation method and application thereof
The invention discloses a binuclear copper modified molybdenum germanic acid crystalline material as well as a preparation method and application thereof. The molecular formula of the material is [Cu2 (L) 2 (HL) 4 (H2O) 2 (GeMo12O40) 2]. 3H2O; l is 1-(4-carboxyl benzyl)-[4, 4 '] bipyridine chloride; the crystal system is monoclinic; the space group is P21 / n; the cell parameters are as follows: a is equal to 18.0008 (6), b is equal to 20.8877 (6), c is equal to 20.5829 (7), alpha is equal to 90 degrees, beta is equal to 90.2370 (10) degrees, gamma is equal to 90 degrees, and Z is equal to 2. The preparation method comprises the following steps: 1, dissolving germanium oxide, ammonium molybdate, a copper salt and a ligand L in water, and regulating the pH value of the solution by using an acid regulator to obtain a reaction solution; and step 2, reacting the reaction solution in the step 1 in a high-temperature closed environment, and cooling to room temperature after the reaction is finished to obtain the binuclear copper modified molybdenum germanic acid crystalline material. According to the crystalline material synthesized by the invention, Keggin type polyacid GeMo12 and a binuclear copper site are integrated in a single framework, and electrons are directly transferred into the copper site from the polyacid through weak interaction after the polyacid obtains the electrons, so that the catalytic performance is greatly improved.
Owner:BOHAI UNIV