Squarylium cyanine chemical sensor used for Fe<3+> detection and preparation method thereof

A chemical sensor, squaraine technology, applied in chemical instruments and methods, carboxylate preparation, organic compound preparation, etc., to achieve the effects of easy control of reaction conditions, good promotion prospects, excellent optical properties and photostability

Inactive Publication Date: 2012-11-28
CHANGZHOU UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention in order to solve existing for Fe 3+ detection of chemical sensor def

Method used

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  • Squarylium cyanine chemical sensor used for Fe&lt;3+&gt; detection and preparation method thereof
  • Squarylium cyanine chemical sensor used for Fe&lt;3+&gt; detection and preparation method thereof
  • Squarylium cyanine chemical sensor used for Fe&lt;3+&gt; detection and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0026] (1) Preparation of intermediate 1,3,5-trihydroxy-2,4-di(p-carboxybenzyl)benzene

[0027] Weigh 0.4328g (0.0034mol) of phloroglucinol and 1.1598g (0.0070mol) of 4-(chloromethyl)benzoic acid, and add 20ml of absolute ethanol into a two-necked flask, and at the same time add 0.1083g of KI, Make the mass ratio of potassium iodide to phloroglucinol 0.25:1, heat, reflux, and stir with a constant temperature heating magnetic stirrer for 20 hours, and the obtained product is a yellow liquid. After the solution was cooled to room temperature, there was a small amount of insoluble solids in the flask. After filtration, the obtained filtrate was rotary evaporated in a rotary evaporator to finally obtain a yellow viscous liquid, which was used for the next reaction.

[0028] (2) Preparation of symmetrical 2,4,6-trihydroxy-3,5-di(p-carboxybenzyl)benzene) squaraine dye

[0029] Mix 1.4970 g (0.0038 mol) of the intermediate obtained in the previous step with 0.2138 g (0.0019 mol) of ...

Embodiment 2

[0031] (1) Preparation of intermediate 1,3,5-trihydroxy-2,4-di(p-carboxybenzyl)benzene

[0032] Weigh 0.6493g (0.0051mol) of phloroglucinol, 1.7392g (0.010mol) of 4-(chloromethyl)benzoic acid, 30ml of absolute ethanol, add them to a two-necked flask, and add 0.3247g of KI at the same time, Make the mass ratio of potassium iodide to phloroglucinol 0.5:1, heat, reflux, and stir with a constant temperature heating magnetic stirrer for 24 hours, and the obtained product is a yellow liquid. After the solution was cooled to room temperature, there was a small amount of insoluble solids in the flask. After filtration, the obtained filtrate was rotary evaporated in a rotary evaporator to finally obtain a yellow viscous liquid, which was used for the next reaction.

[0033] (2) Preparation of symmetrical 2,4,6-trihydroxy-3,5-di(p-carboxybenzyl)benzene) squaraine dye

[0034] Mix 2.3640g (0.006mol) of the intermediate obtained in the previous step with 0.3421g (0.003mol) of squaraine, ...

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Abstract

Belonging to the field of chemical analysis and test, the invention relates to a squarylium cyanine chemical sensor used for Fe<3+> detection and a preparation method thereof. The squarylium cyanine chemical sensor has a symmetrically structured 2, 4, 6-trihydroxy-3, 5-di(p-carboxybenzyl)phenyl)squarylium cyanine compound. The preparation method of the squarylium cyanine chemical sensor used for Fe<3+> detection consists of: preparation of an intermediate 1, 3, 5- trihydroxy-2, 4-di(p-carboxybenzyl)phenyl; and preparation of bis(2, 4, 6-trihydroxy-3, 5-di(p-carboxybenzyl)phenyl)squarylium cyanine. The squarylium cyanine compound provided in the invention has a simple synthesis method and easily controllable reaction conditions, and by means of a simple treatment, a pure product can be obtained. The obtained squarylium cyanine compound has excellent optical performance and optical stability. The squarylium cyanine compound provided in the invention contains carboxyl and hydroxyl groups, has certain water-solubility, and has good selectivity for iron ions.

Description

technical field [0001] The present invention specifically relates to a kind of for Fe 3+ A detected squarylium chemical sensor and a preparation method thereof belong to the field of chemical analysis and testing. Background technique [0002] Iron is necessary to maintain the normal physiological function or tissue structure of the human body. It is an important component in hemoglobin, myosin and cytochrome, and is one of the essential trace elements for the human body. Studies have shown that iron deficiency can cause iron deficiency anemia and aplastic anemia, which can cause weakness in limbs and asthma symptoms. For this reason, the government departments of various countries attach great importance to it, and take various effective measures to improve the iron intake environment of the people, such as adding trace salt in people's daily necessary table salt or food. However, excessive intake of iron will accumulate in the brain, kidney, liver and other parts and cau...

Claims

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Application Information

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IPC IPC(8): C07C65/40C07C51/373C09B23/10G01N21/78
Inventor 李忠玉吴春晖徐松唐明杰
Owner CHANGZHOU UNIV
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