61 results about "Pivalic acid" patented technology

To provide a photopolymerizable inkjet ink, which contains photopolymerizable monomers containing at least one selected from the following compound group (A) compounds of which are negative for skin sensitization, and at least one selected from the following compound group (B) compounds of which are negative for skin sensitization, wherein the compound group (A) is a compound group consisting of caprolactone-modified dipentaerythritol hexaacrylate, polyethoxylated tetramethylol methane tetraacrylate, ethylene oxide-modified bisphenol A diacrylate, caprolactone-modified hydroxy pivalic acid neopentyl glycol diacrylate, polypropylene glycol diacrylate [CH₂═CH—CO—(OC₃H₆)n-OCOCH═CH₂ (n≈12)], hydroxyethyl acryl amide, trimethylol propane trimethacrylate, and tricyclodecane dimethanol dimethacrylate, and the compound group (B) is a compound group consisting of ethylene oxide-modified phenolacrylate, isostearyl acrylate, ethylene oxide-modified trimethylol propane trimethacrylate, stearyl methacrylate, and glycerin dimethacrylate.

The invention provides a method for recycling sulfuric acid and pivalic acid from byproduct waste acid in the pivalic acid synthetic process. The method includes the steps that organic solvents are added into the waste acid for extraction, an organic phase and a water phase are separated, filter liquor obtained after the water phase is filtered passes through large-hole adsorbent resin, obtained flowing-out liquor is the sulfuric acid which is colorless and transparent, organic solvents are added into the large-hole adsorbent resin obtained after the filter liquor passes through the large-hole adsorbent resin for elution, elution liquor is rectified to recycle the organic solvents, and left liquor is rectified for standby application; the organic phase is firstly rectified to recycle the organic solvents, and left liquor is rectified for standby application; the liquor left after the two times of rectification is mixed, then decompression rectification is carried out on the mixed liquid, and the pivalic acid is accordingly obtained. By means of the method, the aim of environment-friendly processing of the waste acid in the pivalic acid production technology is effectively achieved.

The invention discloses a method for preparing 2,2,6,6-tetramethyl-3,5-heptanedione, which comprises the process of using alkyl pivalate as a solvent without using other solvents Alkyl pivalate and pinacolone are reacted in the presence of an alkali metal alkoxide catalyst, or they are reacted in an amide type solvent or a urea type solvent in the presence of an alkali metal alkoxide catalyst. Also disclosed is a method for preparing 2,2,6,6-tetramethyl-3,5-heptanedione metal using 2,2,6,6-tetramethyl-3,5-heptanedione complex method. The method for preparing 2,2,6,6-tetramethyl-3,5-heptanedione is an industrialized method, wherein alkali metal alkoxides are easy to handle and can be used as Catalyst for the preparation of 2,2,6,6-tetramethyl-3,5-heptanedione from esters and pinacolones.

The invention discloses preparation technology of atorvastatin. The preparation technology comprises the following steps: a first step, the reaction of phenylacetic acid and thionyl chloride is carried out in order to obtain phenylacetyl chloride; a second step, the Friedel-Crafts acylation reaction of phenylacetyl chloride and fluorobenzene is carried out under the action of catalyst, in order to obtain 4-fluorophenyl acetophenone; a third step, 4-fluorophenyl acetophenone is brominated and the brominated 4-fluorophenyl acetophenone is reacted with N-phenyl-isobutyloylacetamide in order to obtain M-4; a fourth step, a reaction is carried out for M-4 and ATS-9 in a cyclohexane, toluene or a mixed solvent of cyclohexane and toluene, pivalic acid is used for catalysis, and a condensation product is obtained. Phenylacetyl chloride and fluorobenzene are reacted in a catalytic action of zeolite molecular sieve, a complexation reaction of the catalyst and products is avoided, reaction yield is improved, and side reactions are few in order to facilitate purification; post-treatment can be carried out for excess M-4 for recycling and reusing, reaction yield is improved, mole proportion of M-4 to ATS-9 and the addition amount of pivalic acid can be adjusted, and final yield of the reaction is improved.

The invention relates to a preparation method for chloro-pivaloyl chloride, in particular to a method that pivalic acid is taken as starting material to synthesize pivaloyl chloride by phosphorus trichloride acyl chlorination; then, gas-phase photocatalysis chlorination is carried out on the pivaloyl chloride by adopting reactive rectification technique; finally the chloro-pivaloyl chloride is prepared by vacuum rectification. The method of the invention can effectively inhibit the generation of multi chlorine substitutes and has simple production technique, safe operation, no pollution, low production cost and high production quality.

The invention provides a preparation process of atorvastatin calcium, which is characterized by being divided into two steps when preparing a condensation compound (4R-cis)-1,1-dimethyl ethyl-6-[2-[2-(4-fluorophenyl)-5-(1-methyl ethyl)-3-phenyl-4-[(phenyl amino)-carbonyl]-1H-pyrrole-1-yl]ethyl]-2,2-dimethyl-1,3-dioxane-4-acetate: 1), adding (4R-cis)-6-aminoethyl-2,2-dimethyl-1,3-dioxane-4-tertbutyl acetate (called ATS-9 for short) into a mixed solvent of n-heptane, tetrahydrofuran and toluene to react with pivalic acid; and 2), adding 4-fluorine-alpha-[2-methyl-1-oxygen-propyl]-gamma-oxo-N,beta-diphenyl phenyl butyramide (called M-4 for short) and rising the temperature for reaction. The invention has the advantage of capability of greatly improving the yield of the intermediate condensation compound and is more in favor of industrialized production.

The invention discloses a treatment and reclamation process of production waste water of tert-amyl peroxypivalate (inhibitor PV), belonging to the technical field of industrial waste water treatment. The process comprises: collecting high-concentration waste water from the drain outlet of a production device, and carrying out stabilization treatment on the high-concentration waste water so as to basically eliminate the risk of severe decomposition of organic peroxides in the waste water; and then separating and recovering tertiary butanol, pero-tertiary butyl, pivalic acid and sodium chloride which meet the industrial quality requirement from the waste water, thereby achieving the recovery and reclamation utilization of pollutants in organic peroxide production waste water. By utilizing the process, organisms are removed, and the waste water of acid and salt is subjected to hydrolysis-contact oxidization treatment and then is subjected to C-Fe micro-electrolysis decoloring treatment, thus the main indexes of discharged water reach the requirement of Chemical Synthesis Pharmacy Industrial Waste Water Pollutant Emission Standard (GB21904-2008) on water pollutant emission limit value of new built enterprises.

The invention relates to a synthesis method of 3, 3-dimethyl-2-butanone by using pivalic acid and glacial acetic acid as raw materials which are catalyzed to react by gas phase under the conditions of normal pressure. The pivalic acid and the glacial acetic acid and water are uniformly mixed up under the normal temperature according to the molar ratio of 1:1:3 to 1:1.4:3; after vaporization, the pivalic acid and the glacial acetic acid and the water are catalyzed to have a decarboxylation reaction and then pinacolone is produced under the normal pressure with the temperature of 380 to 400 DEG C in a fixed bed reactor; the carrier of the catalyst is A12O3; active components are one or two compounds of rare earth metals Ce, Nd, La or oxides thereof; the active component content which is calculated according to the weight of metal oxides takes up 20-30 percent of the weight of the carrier A12O3; the bulk density of the catalyst is 0.47 to 0.5; after analysis, the selectivity of the pinacolone is above 95 percent and then the 3, 3-dimethyl-2-butanone product with the purity of 99 percent can be obtained after the pinacolone is purified by rectification under the normal pressure.

A method for production of pivalic acid comprising the steps of: (a) reacting isobutylene, carbon monoxide, and a first catalyst to produce a reaction mixture; (b) contacting the reaction mixture with water, thereby producing a crude acid product having pivalic acid and oligomeric neo-carboxylic acid; (c) separating the pivalic acid and the oligomeric neo-carboxylic acid from the crude acid product; (d) reacting the oligomeric neo-carboxylic acid with a source of carbon monoxide at a temperature of less than 200° C. in the presence of a second catalyst to produce a C₅ carbocation product, wherein the first and second catalyst are either the same or different; and (e) reacting the C₅ carbocation product with water; thereby producing pivalic acid having an overall yield of at least 80 wt. %.

Production of tepentanoic acid is carried out by C4 cut fraction not containing butadiene, sulfuric acid and carbonic oxide as raw materials, mixing C4 cut fraction not containing butadiene with sulfuric acid, esterification reacting at special temperature and pressure, separating out abstracted liquor containing minor isobutene of upper layer, carbonylation reacting lower layer with carbon monoxide, hydrolyzing and separating to obtain final product. It is simple, costs low and has less consumption.

Disclosed herein is a coating solution for use in forming Bi-based ferroelectric thin films comprises a specified compound, such as triglyme, dipivaloylmethane, pinacol, pivalic acid or hexyleneglycol, in combination with an organometallic compound containing metallic elements of which a Bi-based ferroelectric thin film to be formed is composed. Disclosed also herein is a method of forming Bi-based ferroelectric thin films using the coating solution.

The invention provides a preparation method of 2-methylamino-5-t-butyl-1,3,4-thiadiazole. Pivalic acid directly used as a raw material reacts with methylthiosemicarbazide with solid phosgene or a phosgene dimer or phosgene as an acylation reagent and a cyclization reagent to synthesize 2-methylamino-5-t-butyl-1,3,4-thiadiazole. The preparation method allows highly pure 2-methylamino-5-t-butyl-1,3,4-thiadiazol to be prepared, has the advantages of very high yield, safe operation, very low production cost, solving of the defects of existing production technologies, environmental protection and no pollution.

Disclosed herein is a coating solution for use in forming Bi-based ferroelectric thin films comprises a specified compound, such as triglyme, dipivaloylmethane, pinacol, pivalic acid or hexyleneglycol, in combination with an organometallic compound containing metallic elements of which a Bi-based ferroelectric thin film to be formed is composed. Disclosed also herein is a method of forming Bi-based ferroelectric thin films using the coating solution.

The invention provides an electrochromic copolymer containing dioxythiophene and a 9, 9 '-spirobifluorene structure, the molecular formula of the electrochromic copolymer comprises the following structure: A represents sulfur or oxygen, and m and n both represent the degree of polymerization and are integers between 8 and 100. The preparation method comprises the following steps: (1) adding 3, 4-dioxo-1, 3, 4-thiadiazole and The preparation method comprises the following steps: adding 2, 2 ', 7, 7'-tetrabromo-9, 9 '-spirobifluorene, 3, 4-dibromo ethylene dioxythiophene or 3, 4-dibromo ethylene dithio thiophene, N, N-dimethylacetamide, potassium carbonate, palladium acetate and pivalic acid into a single-mouth flask, carrying out air suction and exchange on the single-mouth flask by using nitrogen or argon, keeping an air exchange atmosphere, sequentially heating and reacting the mixture, cooling to room temperature, dropwise adding into methanol, and carrying out a reaction under the protection of nitrogen or argon so as to obtain a target product, namely the 2, 2', 7, 7 '-tetrabromo-9, 9'-spirobifluorene. Filtering and collecting orange red precipitates; and 2) placing the orange red precipitate in a fat extractor, sequentially dissolving and washing with methanol, n-hexane and chloroform, concentrating a chloroform washing solution, finally dropwise adding into methanol, filtering and collecting the precipitate, thereby obtaining the target product.

The invention discloses a chromium-doped titanium oxygen cluster nano catalytic material, a preparation method and applications thereof. The preparation method comprises the following steps: preparingtitanium oxygen cluster powder by taking pivalic acid as a precursor; and then adding the titanium oxygen cluster powder and chromium chloride into tetrabutyl titanate, carrying out ultrasonic dissolution, and reacting under a boiling condition to prepare the chromium-doped titanium oxygen cluster nano catalytic material, wherein a mass ratio of the titanium oxygen cluster powder to the chromiumchloride is (6-8):1. The chromium-doped composite titanium-oxygen cluster nano catalytic material prepared by the invention has the advantages of low technical cost, environmental friendliness, easiness in operation, high degradation efficiency and multiple types of degraded tetracycline, and overcomes the defects of poor quantum efficiency, poor visible light absorption efficiency, easiness in photo-induced charge combination and the like of the single-molecule photocatalyst. The titanium oxygen cluster compound has a large specific surface area, is easy to form a vacuum position under an illumination condition, has more pores and has high catalytic performance.

The invention relates to a preparation method and device for an iodobenzene dibenzoate derivative. The method includes the steps that 6 mmol of iodobenzene diacetate and 12 mmol of benzoic acid or a benzoic acid derivative or pivalic acid are added into a 25 mL round-bottom flask first, and 5 ml of methyl alcohol is added till benzoic acid or the benzoic acid derivative and iodobenzene diacetate are completely dissolved in methyl alcohol; the round-bottom flask is placed on a rotary evaporator to be heated to 45 DEG C for a reaction of 0.5 h; reduced pressure distillation is carried out to spin-dry the solvent, and it can be seen that a large amount of white solid matter is separated out; the reaction solution and obtained solid matter are poured into a Buchner funnel, the solid matter is washed with 15 ml of methyl alcohol three times, remaining white solid matter is aired, and the iodobenzene dibenzoate derivative is obtained, wherein the benzoic acid derivative is 4-methoxybenzoic acid or 4-methyl benzoic acid or 4-chlorobenzoic acid or 4-fluorobenzoic acid or 4-nitrobenzoic acid. By means of the preparation method and device, the reaction can be completed in one step, and the technological process is simple; conditions are mild, selectivity is high, environmental friendliness is achieved, and the yield is 72-95%.

The invention discloses a method for preparing functionalized thiazole heterocyclic compounds through a Cu (I) catalyzed multi-component cyclization reaction, and applications of the functionalized thiazole heterocyclic compounds, and belongs to the field of chemical synthesis. According to the method, Cu (I) is mainly used for catalysis, protonic acid such as pivalic acid is used as an additive,thioamide, aryl alkyne aldehyde and alcohol can be subjected to a series of domino cyclization reactions under the reaction condition of 55-65 DEG C to obtain the diversified functionalized thiazole heterocyclic compounds. The preparation method is simple to operate, simple and efficient in the used catalytic system, friendly to the environment, wide in substrate application range of thioamide, aryl alkyne aldehyde and alcohol and good in regioselectivity, various functionalized thiazole heterocyclic compounds can be efficiently synthesized, and the compounds have a wide application prospect in the aspects of bioactive molecules and drug development.

The present invention relates to amoxicillin trihydrate compositions having a surface area of from 1.0 to 2.5 m²·g⁻¹ that are free of organic contaminants such as dichloromethane, isopropanol, pivalic acid and triethyl amine and that have a purity of from 97.0% to 99.99%. Furthermore, the present invention relates to a method for the preparation of said amoxicillin trihydrate compositions and to the use of said compositions for the treatment of a bacterial infection.

The invention discloses a preparation method of a 7-amide indole compound. The method comprises the following steps of: in an HFIP solvent, synthesizing the 7-amide indole compound at room temperatureby using [Ru (p-cymene) Cl2] 2 and AgSbF6 as catalysts, using pivalic acid as an additive and using an indole compound and an oxazolone compound as substrates. The reaction raw materials are cheap and easy to obtain; the preparation method is simple; ruthenium is used as the catalyst, so that the reaction cost is low, the yield is high, the operation is simple; and the method is suitable for synthesizing different types of 7-amide indole compounds. The method disclosed by the invention can be used for synthesizing a series of 7-amide indole compounds, and the synthesized product can be used as an intermediate compound for further constructing a complex active compound; and meanwhile, the compound has great drug activity potential.

The invention relates to a method for synthesizing alpha-aminonitrile by adopting AIBN as an individual cyan source. The method comprises the following steps: adding tertiary amine into a container, sequentially adding 2,2'-azodiisobutyronitrile (AIBN), pivalic acid, sodium acetate and molecular sieve, carrying out a reaction at 85-95 DEG C in methanol used as a solvent for 7-9 h, cooling the obtained reaction product to room temperature, and carrying out silica gel column chromatographic separation to obtain the target product. The AIBN is a nontoxic compound containing a cyan group, and is usually used as a free radical initiator. The method for synthesizing a series of alpha-aminonitrile compounds by adopting AIBN as the only cyan source has the advantages of simplicity, no toxicity and high yield.