15 results about "Oxazolone" patented technology

The present invention relates to a method for synthesizing a novel primary amide using dioxazolone as a starting material and adding a copper salt catalyst, and more specifically, to a method for producing an environmentally friendly primary amide derivative with a short reaction time, low reaction temperature, and the generation of harmless carbon dioxide as a byproduct. The present invention provides an efficient method that enables the safety of compounds and low-cost synthesis even in large-scale reactions. Furthermore, it suppresses the use of highly corrosive ammonia, which was required in the conventional synthesis of primary amides, while simultaneously providing more environmentally friendly synthesis conditions through a water-added co-solvent system. Furthermore, the organic synthesis method of primary amides according to the present invention can be widely applied to the synthesis of pharmaceutical intermediates, natural products, and low-molecular-weight new drug candidate compounds.

The embodiment of the invention relates to the technical field of synthesis of organic compounds, and particularly discloses a tryptophan derivative and a preparation method thereof, and the tryptophan derivative comprises the following raw materials: 4-methyl phenyl sulfonyl indole, 4-methyl-5-oxazolone and a proper amount of chiral catalyst. According to the embodiment of the invention, sulfuryl indole can be converted into a vinyl imine intermediate with unstable chemical properties after being treated by an alkaline reagent, and then 5-oxazolone is used as a nucleophilic reagent and is added onto the vinyl imine intermediate to synthesize the alpha, beta-substituted tryptophan derivative. According to the synthetic route provided by the embodiment of the invention, the raw materials are cheap and easy to obtain, the price is low, the reaction steps are simple, the conditions are mild, the yield is also greatly improved, the problems of harsh related synthetic reaction conditions and lower yield in the existing scheme for preparing the tryptophan derivative by adopting a chemical synthesis method are solved, and the synthetic route has a wide market prospect.

This invention relates to a novel process for synthesising the product ibodutant shown in the figure below, consisting of a small number of highyield steps involving reagents and solvents with low environmental impact, characterised by the coupling of two portions, compounds (3) and (4), one of which (3) is synthesised by coupling of 6methy1-2- benzo[b]thiophenecarboxylic acid (1) with 1-amino-alpha-alpha-cyclopentan carboxylic acid and subsequent cyclization with oxazolone, while the other, compound (4), is obtained from suitable highly selective functionalisations of 4aminomethy lpiperidine (2)

The invention provides an oxadiazolone compound, a weeding composition and application of the oxadiazolone compound and the weeding composition. The position between sulfonyl and C1 on a benzene ring of the benzoyl compound is substituted by the oxadiazolone group shown in the formula (a) to obtain the oxadiazolone compound, and the oxadiazolone compound not only has unexpected high herbicidal activity to various weeds, but also is relatively safe to various crops such as corn, rice and the like. Experimental results show that the compound provided by the invention has good herbicidal activity, can effectively control barnyard grass, digitaria sanguinalis, piemarker and other weeds at a low dosage, obtains a good herbicidal effect, and is safe to crops.

Disclosed are compounds of Formula (I) or a stereoisomer, tautomer, or salt thereof, wherein each R is independently H or D. Also disclosed are methods of using such compounds to reduce IKZF1-4 protein levels; and pharmaceutical compositions comprising the compounds. The compounds can be used to treat viral infections and proliferative disorders, such as cancer.(I)

The invention relates to the technical field of chemical pharmacy and fine chemical preparation. In particular to a method for synthesizing alpha, beta-diamino acid derivatives by iron catalysis, which comprises the following steps of: synthesizing a series of various substituted alpha, beta-diamino acid derivatives by taking various substituted 3-diazoindole-2-ketone, arylamine and oxazolone as raw materials under the catalysis of an iron complex; the problems of dependence on strong acidic conditions and substrate limitation caused by the dependence in the prior art are solved. The reaction is high in yield, mild in condition, wide in substrate application range and simple and convenient to operate. A novel method which is simple, efficient, green and environment-friendly is provided for synthesis of the compounds, and the method can be widely applied to the technical fields of chemical pharmacy and fine chemical engineering preparation.

The present application relates to a kind of synthesis method of organic compound, specifically to a kind of synthesis method of 3-trifluoromethyl pyridine or 3-difluoromethyl pyridine compound. By the pyridine compound shown in formula I, methyl propionic acid ester, dimethyl acetylene dicarboxylate is reacted to prepare the oxazolone-pyridine complex of formula II; With fluoroalkylating agent in the presence of base and solvent, under the condition of photosensitizer, visible light irradiation, at 15~35oC reaction preparation obtains formula III compound, after reaction with acid, preparation obtains the 3-fluoroalkyl substituted pyridine compound shown in formula IV, wherein, R is hydrogen, methyl, methoxy, methylthio, fluorine, chlorine, bromine, iodine, trifluoromethyl, trifluoromethoxy, methoxycarbonyl, nitrile group one or more, or or

The application belongs to the technical field of batteries and relates to an electrolyte and a battery containing the electrolyte. The electrolyte comprises an organic solvent, an electrolyte salt, a first additive and a second additive; the first additive comprises a sulfuryl benzothi-oxazole compound, and the second additive comprises an oxazolone compound. The use of the electrolyte of the application can effectively improve the high-temperature storage performance, high-temperature cycle performance, high-temperature floating performance and low-temperature discharge performance of a lithium ion battery.

Described are activated esters and oxazolone derivatives comprising the non-canonical amino acid, Aib; methods of making such compounds and methods of using such compounds in a process of making a target peptide comprising Aib. In addition, also the use of an activated dipeptide in a coupling reaction to obtain a target peptide, wherein the activated dipeptide comprises Aib, is described.

The invention discloses a chiral iridium catalyst as well as a preparation method and application thereof. The chiral iridium catalyst induces a 1, 2, 4-oxazolone compound to be subjected to a tandem polyene cyclization reaction, the asymmetric synthesis of the polycyclic delta-lactam derivative is successfully realized, and the chiral iridium catalyst can be used for constructing natural product-like derivatives with various skeletons. The reaction has certain substrate expansibility, and can continuously construct a polycyclic product with chiral quaternary carbon, so that the reaction has great application potential in organic synthesis, and a new method is provided for subsequent asymmetric total synthesis of natural products.

Compounds of Formula (I) or stereoisomers, tautomers or salts thereof are disclosed. Also disclosed are methods of using such compounds to reduce IKZF1-4 protein levels; and a pharmaceutical composition comprising the compound. The compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer. (I)

The application discloses a method for preparing dibutyl lauroyl glutamine and application, wherein long-chain alkyl acyl glycine and acetic anhydride are added into a first reaction container containing cyclohexane, a long-chain alkyl cyclization product is prepared by warming and refluxing reaction; the prepared long-chain alkyl cyclization product is added into a second reaction container containing cyclohexane, an alkaline substance and N-butyl acrylamide are further added for reaction, the alkaline substance and solvent are removed after the reaction, and a long-chain alkyl butylamide propenyl oxazolone is prepared; the prepared long-chain alkyl butylamide propenyl oxazolone is put into a third reaction container containing cyclohexane, n-butylamine is further added into the third reaction container for refluxing reaction, and the solvent is evaporated to prepare long-chain alkyl glutamic acid dibutylamide. The application firstly performs ring-closing reaction, then performs Michael addition on a reserved site of the structure, and ingeniously performs chain extension reaction on the structure, and finally obtains a target compound.

The invention discloses a synthesis method of beta alkylamine, and belongs to the field of organic synthesis. According to the method, 3-phenyl-1, 4, 2-dioxazole-5-ketone and 1, 1-disubstituted alkyl olefin are subjected to a mixed coupling reaction in an organic solvent system in the presence of a transition metal catalyst, a nitrogen ligand, a reducing agent, alkali and an additive to synthesize the beta-alkylamine. Cheap cobalt metal is used as a catalyst, a coupling reaction of beta-alkylamine is constructed, and the method has the advantages of mild reaction conditions, high economical efficiency and the like.

The application discloses a preparation method of N-(2-acetylamino phenyl)-7-azaindole. The method can efficiently and in high yield prepare N-(2-acetylamino phenyl)-7-azaindole through one-step reaction under mild conditions, by taking N-phenyl-7-azaindole and 3-methyl-1,4,2-dioxazol-5-ketone as raw materials, [Ru(p-cymene)Cl2]2 as a main catalyst, AgNTf2 as a cocatalyst, and an alkali metal acetate as a reaction aid.

This application relates to a method for preparing carbamate compounds from dioxazolone derivatives, comprising the following steps: reacting a dioxazolone derivative with a hydroxyl-containing compound in the presence of a catalyst to prepare the carbamate compound. The catalyst includes one or more of dichlorobis(4-methylisopropylphenyl)ruthenium(II), tri(acetylacetonate)ruthenium(III), cyclooctadiene ruthenium(II) chloride, and dichloro(pentamethylcyclopentadienyl)iridium(III) dimers. This synthetic method is universally applicable to the synthesis of carbamate compounds with different group types (such as alkyl, aryl, heteroaryl, etc.), and exhibits high yields and mild reaction conditions.