4 results about "Oxazolone" patented technology

Disclosed are compounds of Formula (I) or a stereoisomer, tautomer, or salt thereof, wherein each R is independently H or D. Also disclosed are methods of using such compounds to reduce IKZF1-4 protein levels; and pharmaceutical compositions comprising the compounds. The compounds can be used to treat viral infections and proliferative disorders, such as cancer.(I)

The application discloses a method for preparing dibutyl lauroyl glutamine and application, wherein long-chain alkyl acyl glycine and acetic anhydride are added into a first reaction container containing cyclohexane, a long-chain alkyl cyclization product is prepared by warming and refluxing reaction; the prepared long-chain alkyl cyclization product is added into a second reaction container containing cyclohexane, an alkaline substance and N-butyl acrylamide are further added for reaction, the alkaline substance and solvent are removed after the reaction, and a long-chain alkyl butylamide propenyl oxazolone is prepared; the prepared long-chain alkyl butylamide propenyl oxazolone is put into a third reaction container containing cyclohexane, n-butylamine is further added into the third reaction container for refluxing reaction, and the solvent is evaporated to prepare long-chain alkyl glutamic acid dibutylamide. The application firstly performs ring-closing reaction, then performs Michael addition on a reserved site of the structure, and ingeniously performs chain extension reaction on the structure, and finally obtains a target compound.

The application discloses a preparation method of N-(2-acetylamino phenyl)-7-azaindole. The method can efficiently and in high yield prepare N-(2-acetylamino phenyl)-7-azaindole through one-step reaction under mild conditions, by taking N-phenyl-7-azaindole and 3-methyl-1,4,2-dioxazol-5-ketone as raw materials, [Ru(p-cymene)Cl2]2 as a main catalyst, AgNTf2 as a cocatalyst, and an alkali metal acetate as a reaction aid.

This application relates to a method for preparing carbamate compounds from dioxazolone derivatives, comprising the following steps: reacting a dioxazolone derivative with a hydroxyl-containing compound in the presence of a catalyst to prepare the carbamate compound. The catalyst includes one or more of dichlorobis(4-methylisopropylphenyl)ruthenium(II), tri(acetylacetonate)ruthenium(III), cyclooctadiene ruthenium(II) chloride, and dichloro(pentamethylcyclopentadienyl)iridium(III) dimers. This synthetic method is universally applicable to the synthesis of carbamate compounds with different group types (such as alkyl, aryl, heteroaryl, etc.), and exhibits high yields and mild reaction conditions.