24 results about "Oxazolone" patented technology

The present invention relates to a method for synthesizing a novel primary amide using dioxazolone as a starting material and adding a copper salt catalyst, and more specifically, to a method for producing an environmentally friendly primary amide derivative with a short reaction time, low reaction temperature, and the generation of harmless carbon dioxide as a byproduct. The present invention provides an efficient method that enables the safety of compounds and low-cost synthesis even in large-scale reactions. Furthermore, it suppresses the use of highly corrosive ammonia, which was required in the conventional synthesis of primary amides, while simultaneously providing more environmentally friendly synthesis conditions through a water-added co-solvent system. Furthermore, the organic synthesis method of primary amides according to the present invention can be widely applied to the synthesis of pharmaceutical intermediates, natural products, and low-molecular-weight new drug candidate compounds.

The embodiment of the invention relates to the technical field of synthesis of organic compounds, and particularly discloses a tryptophan derivative and a preparation method thereof, and the tryptophan derivative comprises the following raw materials: 4-methyl phenyl sulfonyl indole, 4-methyl-5-oxazolone and a proper amount of chiral catalyst. According to the embodiment of the invention, sulfuryl indole can be converted into a vinyl imine intermediate with unstable chemical properties after being treated by an alkaline reagent, and then 5-oxazolone is used as a nucleophilic reagent and is added onto the vinyl imine intermediate to synthesize the alpha, beta-substituted tryptophan derivative. According to the synthetic route provided by the embodiment of the invention, the raw materials are cheap and easy to obtain, the price is low, the reaction steps are simple, the conditions are mild, the yield is also greatly improved, the problems of harsh related synthetic reaction conditions and lower yield in the existing scheme for preparing the tryptophan derivative by adopting a chemical synthesis method are solved, and the synthetic route has a wide market prospect.

This invention relates to a novel process for synthesising the product ibodutant shown in the figure below, consisting of a small number of highyield steps involving reagents and solvents with low environmental impact, characterised by the coupling of two portions, compounds (3) and (4), one of which (3) is synthesised by coupling of 6methy1-2- benzo[b]thiophenecarboxylic acid (1) with 1-amino-alpha-alpha-cyclopentan carboxylic acid and subsequent cyclization with oxazolone, while the other, compound (4), is obtained from suitable highly selective functionalisations of 4aminomethy lpiperidine (2)

The invention provides an oxadiazolone compound, a weeding composition and application of the oxadiazolone compound and the weeding composition. The position between sulfonyl and C1 on a benzene ring of the benzoyl compound is substituted by the oxadiazolone group shown in the formula (a) to obtain the oxadiazolone compound, and the oxadiazolone compound not only has unexpected high herbicidal activity to various weeds, but also is relatively safe to various crops such as corn, rice and the like. Experimental results show that the compound provided by the invention has good herbicidal activity, can effectively control barnyard grass, digitaria sanguinalis, piemarker and other weeds at a low dosage, obtains a good herbicidal effect, and is safe to crops.

The invention discloses a synthesis method of furatadone, which comprises the following steps: by taking 1-(4-morpholinyl)-2-propyne as a raw material, carrying out [3 + 2] cycloaddition reaction on the 1-(4-morpholinyl)-2-propyne and di-tert-butyl azodicarboxylate to obtain a 3, 5-disubstituted oxazolone intermediate; then under the action of a Pd / C catalyst, carrying out a hydrogenation reaction of olefin to obtain N-Boc protected AMOZ; finally, the AMOZ protected by N-Boc and 5-nitrofurfural are subjected to a condensation reaction under the action of hydrogen chloride, and the product furaltadone is obtained. The synthesis method is simple, environmentally friendly and suitable for large-scale production.

Disclosed are compounds of Formula (I) or a stereoisomer, tautomer, or salt thereof, wherein each R is independently H or D. Also disclosed are methods of using such compounds to reduce IKZF1-4 protein levels; and pharmaceutical compositions comprising the compounds. The compounds can be used to treat viral infections and proliferative disorders, such as cancer.(I)

The invention discloses a synthesis method of 3-amino oxazolone, which comprises the following steps: dissolving di-tert-butyl azodicarboxylate, a copper-based catalyst and alkali in a solvent under the protection of argon, then adding a ligand and alkyne, stirring and reacting for 5-10 hours at 30 DEG C under a closed condition, then heating to 40-60 DEG C, reacting for 3-18 hours, and carrying out column chromatography separation treatment to obtain the product. The method is used for synthesizing the N-amino oxazolone compound for the first time, has the characteristics of simple reaction steps, easily available raw materials, wide substrate application range and the like, is suitable for synthesizing various 3-amino oxazolone compounds, and is expected to be used for industrial production.

The invention relates to a preparation method of a 3-methoxy-2-substituted quinazolinone compound, which is characterized in that N-methoxybenzamide, 1, 4, 2-dioxazole-5-ketone and 2-((t-butyloxycarbonyl) oxy) methyl methacrylate which are different in substitution are used as reaction raw materials, and the 3-methoxy-2-substituted quinazolinone compound is obtained in one step. Compared with the prior art, the method provided by the invention has the advantages of simpler reaction, relatively mild conditions, less catalyst dosage, no toxicity, lower cost, wide substrate application range and high target substance yield, and can be widely applied to preparation of 3-methoxy-2-substituted quinazolinone compounds.

The invention relates to the technical field of chemical pharmacy and fine chemical preparation. In particular to a method for synthesizing alpha, beta-diamino acid derivatives by iron catalysis, which comprises the following steps of: synthesizing a series of various substituted alpha, beta-diamino acid derivatives by taking various substituted 3-diazoindole-2-ketone, arylamine and oxazolone as raw materials under the catalysis of an iron complex; the problems of dependence on strong acidic conditions and substrate limitation caused by the dependence in the prior art are solved. The reaction is high in yield, mild in condition, wide in substrate application range and simple and convenient to operate. A novel method which is simple, efficient, green and environment-friendly is provided for synthesis of the compounds, and the method can be widely applied to the technical fields of chemical pharmacy and fine chemical engineering preparation.

The invention provides a non-aqueous electrolyte and a lithium ion battery thereof. The non-aqueous electrolyte comprises a lithium salt, an organic solvent and an additive, and the additive comprises an oxazolone compound as shown in a formula IV and at least one cyclic sulfonic anhydride compound as shown in a formula I, a formula II and a formula III, r1-R7 are each independently selected from a hydrogen atom, a halogen atom, a substituted or unsubstituted C1 to C10 alkyl group, a substituted or unsubstituted C2 to C10 alkenyl group, a substituted or unsubstituted C2 to C10 alkynyl group, a substituted or unsubstituted C1 to C10 alkynyl group, a substituted or unsubstituted C1 to C10 alkynyl group, a substituted or unsubstituted C1 to C10 alkynyl group, r8-R10 are respectively and independently selected from hydrogen atoms, amino groups, substituted or unsubstituted C1-C10 alkyl groups, substituted or unsubstituted C2-C10 alkenyl groups, substituted or unsubstituted C2-C10 alkynyl groups and X groups, the structure of the X groups is shown as a formula 5, and * represents a connecting end. According to the non-aqueous electrolyte disclosed by the invention, the cyclic sulfonic anhydride compound and the oxazolone compound are added as additives, so that the high-temperature cycle performance and the high-temperature storage performance of the lithium ion battery can be effectively improved. # imgabs0 #, # imgabs1 # # imgabs2 #.

The present application relates to a kind of synthesis method of organic compound, specifically to a kind of synthesis method of 3-trifluoromethyl pyridine or 3-difluoromethyl pyridine compound. By the pyridine compound shown in formula I, methyl propionic acid ester, dimethyl acetylene dicarboxylate is reacted to prepare the oxazolone-pyridine complex of formula II; With fluoroalkylating agent in the presence of base and solvent, under the condition of photosensitizer, visible light irradiation, at 15~35oC reaction preparation obtains formula III compound, after reaction with acid, preparation obtains the 3-fluoroalkyl substituted pyridine compound shown in formula IV, wherein, R is hydrogen, methyl, methoxy, methylthio, fluorine, chlorine, bromine, iodine, trifluoromethyl, trifluoromethoxy, methoxycarbonyl, nitrile group one or more, or or

The invention belongs to the field of biological medicine, and particularly relates to an oxazolone compound and a preparation method, a pharmaceutical composition and application thereof. The invention provides a compound as shown in a formula (I) or a stereoisomer, a geometric isomer, a tautomer, a deuterated compound, a nitrogen oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or prodrugs of the stereoisomer, the geometric isomer, the tautomer, the deuterated compound, the nitrogen oxide, the solvate, the metabolite and the pharmaceutically acceptable salt of the compound as shown in the formula (I), and also provides a preparation method of the compound. The invention also relates to application of the compound in preparation of drugs for thyroid hormone receptor mediated diseases. According to the compound, good THR-beta agonist activity is maintained, selectivity to THR-alpha and druggability of the compound are improved, and certain activity is shown in an in-vitro molecular level experiment.

The application belongs to the technical field of batteries and relates to an electrolyte and a battery containing the electrolyte. The electrolyte comprises an organic solvent, an electrolyte salt, a first additive and a second additive; the first additive comprises a sulfuryl benzothi-oxazole compound, and the second additive comprises an oxazolone compound. The use of the electrolyte of the application can effectively improve the high-temperature storage performance, high-temperature cycle performance, high-temperature floating performance and low-temperature discharge performance of a lithium ion battery.

Described are activated esters and oxazolone derivatives comprising the non-canonical amino acid, Aib; methods of making such compounds and methods of using such compounds in a process of making a target peptide comprising Aib. In addition, also the use of an activated dipeptide in a coupling reaction to obtain a target peptide, wherein the activated dipeptide comprises Aib, is described.

Provided are: a 3-isoxazolone compound having a trifluoromethyl group at the 4-position of the isoxazolone ring and having specific substituents at the 2-position and the 5-position; and a 5-isoxazolone compound having a trifluoromethyl group at the 4-position of the isoxazolone ring and having specific substituents at the 2-position and the 3-position. Provided is a production method with which it is possible to easily produce a 3-isoxazolone compound and a 5-isoxazolone compound by reacting specific starting materials without producing a byproduct O-substituted compound. A fluorine-containing isoxazolone compound represented by general formula (1).

Provided in the present invention are an oxazolone-substituted pyrimidinamine compound, a preparation method therefor, a pharmaceutical composition thereof and the use thereof. Specifically, provided in the present invention are a compound having a structure as shown in general formula (I), and a racemate, R-isomer, S-isomer, pharmaceutically acceptable salt thereof, or a mixture thereof. The compound has good IDH1 inhibitory activity, and therefore can be used for treating, preventing and relieving diseases related to IDH1 enzyme, especially for treating malignant tumors or other related diseases caused by IDH1 enzyme mutation.

The invention discloses a chiral iridium catalyst as well as a preparation method and application thereof. The chiral iridium catalyst induces a 1, 2, 4-oxazolone compound to be subjected to a tandem polyene cyclization reaction, the asymmetric synthesis of the polycyclic delta-lactam derivative is successfully realized, and the chiral iridium catalyst can be used for constructing natural product-like derivatives with various skeletons. The reaction has certain substrate expansibility, and can continuously construct a polycyclic product with chiral quaternary carbon, so that the reaction has great application potential in organic synthesis, and a new method is provided for subsequent asymmetric total synthesis of natural products.

Compounds of Formula (I) or stereoisomers, tautomers or salts thereof are disclosed. Also disclosed are methods of using such compounds to reduce IKZF1-4 protein levels; and a pharmaceutical composition comprising the compound. The compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer. (I)

The invention provides an oxazolone-substituted pyrimidinamine compound as well as a preparation method, a pharmaceutical composition and application thereof, and particularly provides a compound with a structure as shown in a general formula I, and a racemate, an R-isomer, an S-isomer, a pharmaceutically acceptable salt or a mixture of the racemate, the R-isomer, the S-isomer and the pharmaceutically acceptable salt thereof. The compound has good IDH1 inhibitory activity, so that the compound can be used for treating, preventing and relieving diseases related to IDH1 enzyme, especially malignant tumors or other related diseases caused by IDH1 enzyme mutation. # imgabs0 #

The application discloses a method for preparing dibutyl lauroyl glutamine and application, wherein long-chain alkyl acyl glycine and acetic anhydride are added into a first reaction container containing cyclohexane, a long-chain alkyl cyclization product is prepared by warming and refluxing reaction; the prepared long-chain alkyl cyclization product is added into a second reaction container containing cyclohexane, an alkaline substance and N-butyl acrylamide are further added for reaction, the alkaline substance and solvent are removed after the reaction, and a long-chain alkyl butylamide propenyl oxazolone is prepared; the prepared long-chain alkyl butylamide propenyl oxazolone is put into a third reaction container containing cyclohexane, n-butylamine is further added into the third reaction container for refluxing reaction, and the solvent is evaporated to prepare long-chain alkyl glutamic acid dibutylamide. The application firstly performs ring-closing reaction, then performs Michael addition on a reserved site of the structure, and ingeniously performs chain extension reaction on the structure, and finally obtains a target compound.

The invention discloses a synthesis method of beta alkylamine, and belongs to the field of organic synthesis. According to the method, 3-phenyl-1, 4, 2-dioxazole-5-ketone and 1, 1-disubstituted alkyl olefin are subjected to a mixed coupling reaction in an organic solvent system in the presence of a transition metal catalyst, a nitrogen ligand, a reducing agent, alkali and an additive to synthesize the beta-alkylamine. Cheap cobalt metal is used as a catalyst, a coupling reaction of beta-alkylamine is constructed, and the method has the advantages of mild reaction conditions, high economical efficiency and the like.

The application belongs to the field of molecular biology, discloses a kind of MnO2@UiO-66 composite material and its preparation method and application, solve the technical problem that the detection sensitivity and detection range of organic phosphorus compound are relatively narrow.By the ratio fluorescence system of including MnO2@UiO-66 composite material and Ampliflu Red is used for high sensitivity detection of organic phosphorus pesticide and reducing biological molecule.MnO2 Material not only can be used as the fluorescence quenching agent of UiO-66-NH2, can also catalyze Ampliflu Red reagent to generate fluorescent product isophenoxazone, to enhance its fluorescence signal at 590 nm wavelength.When detecting organic phosphorus, the system also includes alkaline phosphatase and L-ascorbic acid-2-sodium phosphate.When the concentration of phoxim is 1×10 ‑6 -9×10 ‑1 mg / mL, fluorescence linear relationship is good, and the detection limit is as low as 0.33×10 ‑6 mg / mL.The system of the application has the characteristics of accuracy, convenience, sensitivity and stability, and can be applied to the detection of organic phosphorus pesticide in complex environment.

The application discloses a preparation method of N-(2-acetylamino phenyl)-7-azaindole. The method can efficiently and in high yield prepare N-(2-acetylamino phenyl)-7-azaindole through one-step reaction under mild conditions, by taking N-phenyl-7-azaindole and 3-methyl-1,4,2-dioxazol-5-ketone as raw materials, [Ru(p-cymene)Cl2]2 as a main catalyst, AgNTf2 as a cocatalyst, and an alkali metal acetate as a reaction aid.

This application relates to a method for preparing carbamate compounds from dioxazolone derivatives, comprising the following steps: reacting a dioxazolone derivative with a hydroxyl-containing compound in the presence of a catalyst to prepare the carbamate compound. The catalyst includes one or more of dichlorobis(4-methylisopropylphenyl)ruthenium(II), tri(acetylacetonate)ruthenium(III), cyclooctadiene ruthenium(II) chloride, and dichloro(pentamethylcyclopentadienyl)iridium(III) dimers. This synthetic method is universally applicable to the synthesis of carbamate compounds with different group types (such as alkyl, aryl, heteroaryl, etc.), and exhibits high yields and mild reaction conditions.