2 results about "Furaltadone" patented technology

The invention discloses a synthesis method of furatadone, which comprises the following steps: by taking 1-(4-morpholinyl)-2-propyne as a raw material, carrying out [3 + 2] cycloaddition reaction on the 1-(4-morpholinyl)-2-propyne and di-tert-butyl azodicarboxylate to obtain a 3, 5-disubstituted oxazolone intermediate; then under the action of a Pd / C catalyst, carrying out a hydrogenation reaction of olefin to obtain N-Boc protected AMOZ; finally, the AMOZ protected by N-Boc and 5-nitrofurfural are subjected to a condensation reaction under the action of hydrogen chloride, and the product furaltadone is obtained. The synthesis method is simple, environmentally friendly and suitable for large-scale production.

This invention belongs to the field of biomedical technology and discloses a method for preparing furazolidone hydrochloride. This method involves introducing nicotinamide or saccharin as a co-crystal forming agent during the salt formation crystallization process. Under specific solvent systems and pH conditions, crystallization is carried out through programmed cooling to obtain a pharmaceutical co-crystal with a two-dimensional supramolecular hydrogen bond network structure. The obtained product is blocky or spherical, with good flowability, high chemical stability, and gradual and controllable dissolution. This method is feasible, the product meets pharmaceutical requirements, and it improves formulation performance and drug safety.