Pulsatilla saponin composition and application thereof in preparation of medicine for treating skin diseases

A technology of Pulsatilla saponins and composition, applied in the field of medicine, can solve problems such as ambiguity, and achieve significant therapeutic effect and excellent effect

Pending Publication Date: 2022-07-29
广西馨海药业科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Anemoside B4 (Anemoside B4, B4) and Pulsatilla saponin B5 (Hederasaponin C, HSC) are its main active ingredients, and it is a pentacyclic triterpenoid saponin with pharmacological activity extracted from the perennial herbaceous plant Pulsatilla pulsatillae of the family Ranunculaceae. The role of pulsatilla in skin barrier protection remains unclear

Method used

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  • Pulsatilla saponin composition and application thereof in preparation of medicine for treating skin diseases
  • Pulsatilla saponin composition and application thereof in preparation of medicine for treating skin diseases
  • Pulsatilla saponin composition and application thereof in preparation of medicine for treating skin diseases

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Embodiment Construction

[0023] The present invention will be further described in detail below with reference to the accompanying drawings, so that those skilled in the art can implement it with reference to the description.

[0024] It should be understood that terms such as "having", "comprising" and "including" as used herein do not exclude the presence or addition of one or more other elements or combinations thereof.

[0025] It should be noted that the experimental methods described in the following embodiments are conventional methods unless otherwise specified, and the reagents and materials can be obtained from commercial sources unless otherwise specified.

[0026] 1 Test material

[0027] 1.1 Experimental animals

[0028] SPF healthy male BALB / C mice, weighing 19-21g, 8-9 weeks old, were purchased from Beijing Weitong Lihua Laboratory Animal Technology Co., Ltd. All experimental animals were raised in a controlled environment at room temperature of 18-24℃, The humidity was 40%-50%. Durin...

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Abstract

The invention discloses a pulsatilla saponin composition. The pulsatilla saponin composition comprises pulsatilla saponin B4 and pulsatilla saponin B5 in a weight ratio of (3-9): 1. The invention further discloses a medicine containing the pulsatilla saponin composition and application of the medicine. According to the application disclosed by the invention, oxazolone and 2, 4-dinitrofluorobenzene (DNFB) are respectively utilized to prepare two specific dermatitis mouse models (Atopics, AD), imiquimod is utilized to prepare a mouse psoriasis model, the protective effects and possible mechanisms of pulsatilla saponin B4 and pulsatilla saponin B5 on skin diseases are discussed, and a theoretical basis is provided for treating the skin diseases.

Description

technical field [0001] The present invention relates to the technical field of medicine. More specifically, the present invention relates to a Pulsatilla saponin composition and its application in preparing a medicine for treating skin diseases. Background technique [0002] Dermatology is an inflammatory skin disease with genetic predisposition, recurrent attacks, and itching characteristics. Its severe itching clinical symptoms seriously affect the quality of life of patients and their families. It is currently believed that genetic, environmental, immune and skin barrier disruptions are involved in the pathogenesis of various skin diseases. The main principle of clinical treatment is to improve the skin barrier and regulate immunity, but there is still a lack of safe and effective drugs. Moisturizing preparations or antibiotics and hormone drugs are mostly used to relieve symptoms. Skin diseases mainly include atopic dermatitis, psoriasis and other skin inflammatory dis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61P17/00A61P29/00A61P17/06
CPCA61K31/704A61P17/00A61P29/00A61P17/06A61K2300/00
Inventor 高红伟苑仁祎坤杨世林
Owner 广西馨海药业科技有限公司
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