176 results about "Dermatitis repens" patented technology

The invention relates to a novel application of animal bifidobacterium subsp. Lactis BGI-N3, in particular to an application of the animal bifidobacterium subsp. Lactis BGI-N3 in preparation of a preparation for relieving skin allergy. The invention finds that the bifidobacterium animalis subsp. Lactis BGI-N3 has a very remarkable effect in the aspect of relieving skin allergy, and the effect is specifically shown as follows: in an atopic dermatitis animal model, the dermatitis score, scratching times and percutaneous water loss are remarkably reduced, and the atopic dermatitis skin tissue damage condition is relieved; the immune organ edema condition is improved, the levels of Th2 type cell factors and inflammatory factors IL-6, TNF-alpha and IFN-gamma related to dermatitis are reduced, and the immune balance of the body is recovered; expression of fibroin and endothelial protein in skin tissue is improved, and the skin barrier is repaired; the level of antibacterial peptide in skin tissues is recovered, and the antibacterial activity of the skin is enhanced. Meanwhile, compared with a traditional chemical medicine for treating atopic dermatitis, the animal bifidobacterium subsp. Lactis BGI-N3 has no side effects such as weight loss, immune organ atrophy, immune imbalance and the like.

The invention relates to a traditional Chinese medicine composition for treating allergic dermatitis. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicines in parts by weight: 5-35 parts of fried coix seeds, 5-35 parts of concha margaritifera, 1-30 parts of honeysuckle stems, 1-30 parts of smoked plums, 1-30 parts of fructus liquidambaris, 1-25 parts of fructus forsythiae, 1-25 parts of radix paeoniae rubra, 1-25 parts of raw sanguisorba officinalis, 1-25 parts of radix glehniae, 1-25 parts of radix ophiopogonis and 1-25 parts of raw radix polygonati officinalis. 1-25 parts by weight of talc and 1-25 parts by weight of lophatherum gracile. The traditional Chinese medicine composition has the effects of clearing heat, cooling blood without bitter cold, dispelling wind, eliminating dampness without hurting stomach, detoxifying, relieving itching and nourishing yin, is safe in clinical use, and has no adverse effect on liver and kidney.

The invention belongs to the technical field of external preparations, and provides compound itching-relieving cream as well as a preparation method and application thereof. The compound itching-relieving ointment is prepared from the following components in parts by weight: 3 to 6 parts of rhizoma coptidis, 9 to 15 parts of radix scutellariae, 9 to 15 parts of radix et rhizoma rhei, 3 to 6 parts of herba schizonepetae, 3 to 6 parts of herba menthae, 1 to 3 parts of cortex moutan, 1 to 3 parts of sandalwood and 0.5 to 1 part of borneol. The compound antipruritic ointment has the effects of cooling, relieving itching, detoxifying and diminishing swelling, and is used for treating itching and eczema dermatitis itching caused by biting of various small insects such as mosquitoes and the like. According to the compound antipruritic ointment disclosed by the invention, a plurality of components are in synergistic interaction, so that a multi-target and multi-layer treatment effect is realized. The traditional Chinese medicine composition can be used for cooling, relieving itching, detoxifying and diminishing swelling from the source while quickly relieving itching, and a comprehensive and effective solution is provided for itching.

The invention, which belongs to the technical field of medical image processing and computer vision, discloses a multispectral imaging-assisted post-radiotherapy skin injury early detection system comprising a multispectral data acquisition module, a deep tissue feature extraction module, a three-dimensional lesion segmentation module and a space-time tracking evaluation module. The subcutaneous 2.5 cm depth tissue information is obtained through multispectral imaging at the wave band of 400-1350nm, blood perfusion, melanin concentration, collagen structure and other physiological parameters are inversed based on the radiation transfer theory, a three-dimensional medical image segmentation algorithm is adopted to achieve three-dimensional accurate segmentation of an injury area, a spatio-temporal evolution model is established to predict the injury development trend, and the damage development trend is predicted. The radioactive skin injury can be detected in the subclinical period, the detection time window is advanced by 5.2 days on average, the occurrence rate of severe dermatitis is reduced by 65%, and a basis is provided for clinical timely intervention.

The invention relates to cream for repairing radiodermatitis and a preparation method of the cream, and belongs to the technical field of biomedical skin treatment. The cream consists of the following components in percentage by weight: 8% of glycerin monostearate, 6% of stearic acid, 5% of white vaseline, 4% of liquid wax, 1-2% of tea tree oil, 1-2% of eugenol, 1-2% of vitamin E, 3% of trehalose, 8% of polyethylene glycol (PEG-400), 10% of glycerol, 0.5% of methylparaben, 1% of triethanolamine and the balance of purified water. According to the cream disclosed by the invention, the natural traditional Chinese medicine component eugenol and the natural substance vitamin E are utilized to synergistically enhance the anti-oxidation and bacteriostatic effects, and the tea tree oil, the trehalose and other effective components are utilized to repair radiodermatitis from multiple aspects of anti-inflammation, bacteriostasis, antioxidation, promotion of skin barrier repair and the like. The cream is simple in component, good in treatment effect, high in safety and convenient to produce and process, and can be popularized and applied to treatment of radiodermatitis.

The invention relates to the technical field of Chinese herbal medicine preparations, and particularly discloses Chinese herbal medicine emulsifiable paste for treating dermatitis and a preparation method thereof.The emulsifiable paste contains core raw materials and matrix auxiliary materials, the core raw materials comprise radix sophorae flavescentis, fructus kochiae, cortex phellodendri, honeysuckle flowers, herba portulacae and licorice roots, and the matrix auxiliary materials comprise an oil phase, a water phase, an emulsifier, a humectant, a pH regulator and a preservative. The preparation method comprises the following steps: preparing a Chinese herbal medicine extracting solution, respectively preparing an oil phase and a water phase, emulsifying, mixing and cooling to obtain a finished product. The cream is prepared from natural Chinese herbal medicines through scientific extraction and preparation, is high in safety, can effectively treat dermatitis, and is uniform in texture, good in stability and comfortable to use.

A perilla leaf-derived nanovesicle and the use thereof in the preparation of a product with anti-inflammatory efficacy. The nanovesicle can be phagocytosed and internalized by HaCaT cells, reduce the levels of ROS and inflammatory factors in HaCaT cells, and exert an anti-inflammatory effect. Meanwhile, the nanovesicle has excellent transdermal properties, and thus can effectively alleviate and treat psoriatic dermatitis symptoms in mice. The nanovesicle can also be added as an active ingredient to different matrices to form compositions.

Methods are provided for treating moderate to severe atopic dermatitis of the hands and / or feet in a subject. In one aspect, the methods include administering to the subject one or more doses of an interleukin-4 receptor (anti-IL-4R) antagonist, such as an anti-IL-4R antibody or antigen-binding fragment thereof.

The application provides a drying method of Chuanxiong medicinal material and application of Chuanxiong or its extract in preparation of an external medicine for treating atopic dermatitis. The drying method of Chuanxiong medicinal material improves Chuanxiong processing efficiency, shortens processing period, obtains by-product Chuanxiong extract in addition to preparation of decoction pieces, reduces energy consumption and lowers production cost. The Chuanxiong essential oil and Chuanxiong extract are both composed of small molecule components, have good affinity to skin, are absorbed through skin quickly, can quickly relieve symptoms such as itching and skin damage caused by atopic dermatitis, and are natural, safe and free of side effects. Meanwhile, the small molecule components contained in the Chuanxiong essential oil and Chuanxiong extract have good lipophilicity, have softening effect on the thickened stratum corneum caused by atopic dermatitis, and are more conducive to drug absorption. In addition, the Chuanxiong essential oil and Chuanxiong extract are simple to prepare and low in price.

The invention belongs to the technical field of pharmacy, and mainly relates to a traditional Chinese medicine composition ointment for treating bacterial fungal infection and dermatitis and a preparation method thereof. The traditional Chinese medicinal materials such as the sophora flavescens, the blackberry lily, the cortex dictamni, the gallnut, the fructus cnidii, the aloe, the cortex pseudolaricis, the fructus kochiae, the cortex phellodendri, the typhonium giganteum, the radix stemonae, the hedyotis diffusa, the spina gleditsiae and the rhizoma smilacis glabrae which are subjected to biological fermentation can inhibit the growth of fungi and also can relieve itching and relieve swelling; the traditional Chinese medicine has small side effects; ti / ZIF-8 is also added, so that the antibacterial effect is more obvious; the traditional Chinese medicine composition can be used for treating acute and chronic dermatitis, eczema, dermatophytosis, tinea manuum, foot sweat, fungal infection, skin itch, papule, plaque papule, erythroderma and intractable skin stubborn dermatitis caused by various bacteria and fungi, red swelling and itching caused by mosquito bite, and inhibiting candida albicans, staphylococcus aureus and the like. In general, the method has a very wide application prospect in the field.

The present invention relates generally to maqui berry for use in the treatment or prevention of skin diseases, wherein maqui berry may be the primary natural active ingredient. Particular embodiments as disclosed herein find application in, inter alia, the prophylaxis and the treatment of skin diseases, in particular, dermatitis, atopic dermatitis (neurodermatitis), dermatitis solaris, eczema, hand eczema, lichen planus, lupus erythematosus, psoriasis, urticaria, itching, scabies, age spot, freckles and dry / atopic skin of humans. In particular, the present invention relates to the use of maqui berry extract in the manufacture of a medicament or dietary supplement for use in treating or preventing said skin diseases or defects.

The application discloses application of a human lactoferricin peptide in anti-inflammatory soothing and skin barrier repair. The application relates to the field of biotechnology, and provides application of a polypeptide or a biological material related to the polypeptide in preparation of a product with anti-inflammatory soothing and / or skin barrier repair functions; the polypeptide is a human lactoferricin peptide derived from a filtrate of a yeast fermentation lysate product, and an amino acid sequence of the polypeptide is shown as SEQ ID NO:1. The polypeptide has intervention potential on inflammation related to dermatitis and eczema, especially on atopic dermatitis. The polypeptide can be applied to the fields of medicines and cosmetics.

The invention belongs to the technical field of traditional Chinese medicine preparations, and particularly relates to Chinese herbal medicine emulsifiable paste for dermatitis and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following raw materials: radix sophorae flavescentis, cortex phellodendri, cortex dictamni, fructus cnidii, fructus kochiae, radix scutellariae, radix paeoniae rubra, radix salviae miltiorrhizae, herba schizonepetae, radix saposhnikoviae Systematic design is carried out aiming at complex pathogenesis of seborrheic dermatitis, medicinal materials such as radix sophorae flavescentis and cortex phellodendri are used for synergistically clearing heat and drying dampness, malassezia is inhibited, and lipid control and bacteriostasis are carried out from the source; radix scutellariae, radix salviae miltiorrhizae and the like are combined to cool and activate blood and control inflammation for a long time; the herba schizonepetae, the radix saposhnikoviae and the like are added for targeted itching relieving and secondary injury reduction; in the dosage form, a low-oil-burden matrix composed of light grease such as jojoba oil and squalane is adopted, the texture is light and thin, hair follicles are not blocked, and phytosterol is introduced to synchronously repair the skin barrier; according to the system, the use comfort and compliance are remarkably improved while permeation of active ingredients is guaranteed.

Provided herein are compositions and their use for the treatment of human skin, particularly facial skin, to alleviate the symptoms of cosmetic or dermatologic skin conditions. The compositions include black willow bark extract, cat's claw extract, and dragon's blood extract. The compositions ameliorate skin conditions including acne, rosacea, blemish, dermatitis, eczema, or the like.

The application relates to the technical field of medical materials, and discloses a functionalized hydrogel for treating atopic dermatitis and a preparation method and application thereof, the preparation method comprising the following steps: taking g-C3N4 powder as raw material to prepare C3N4 gel with a three-dimensional network structure; taking g-C3N4 powder and CDs powder as raw material, adding a matrix solution, and uniformly ultrasonically dispersing; adding a crosslinking agent solution to make the solution fully undergo crosslinking reaction to prepare a CDs / g-C3N4 crosslinking solution; pouring the above-mentioned CDs / g-C3N4 crosslinking solution into the above-mentioned C3N4 gel, standing for gelation, forming a functionalized modified carbon nitride gel three-dimensional network structure, and freeze-drying to obtain a functionalized three-dimensional crosslinking hydrogel. The functionalized three-dimensional crosslinking hydrogel prepared by the application has the advantages of degradability and the ability to penetrate through an intact skin barrier; and can be used for treating atopic dermatitis.

This invention discloses a strain of Bifidobacterium animalis subspecies TRT-2A with allergy-relieving effects and its extracellular vesicle applications. The strain TRT-2A is deposited at the China Center for Type Culture Collection (CCTCC) on November 21, 2025, with accession number CCTCC NO:M 20252645. This strain is highly acid-resistant and exhibits good tolerance to artificial gastric and intestinal fluids. It effectively inhibits bacteria, particularly Streptococcus pyogenes, Streptococcus agalactiae, and / or Escherichia coli. Experimental results show that this strain can alleviate hormone-dependent dermatitis and effectively improve dermatitis symptoms such as erythema and desquamation. Furthermore, extracellular vesicles prepared using TRT-2A can effectively improve skin elasticity and reduce wrinkles. Therefore, the Bifidobacterium animalis subspecies TRT-2A of this invention has multiple functions and is worthy of further promotion and application.

This invention discloses an essence for repairing hormone-induced facial dermatitis and its application, belonging to the field of cosmetics and skin repair technology. The essence uses deionized water as the main solvent, with butylene glycol and glycerin as the core moisturizing base. It is compounded with five major active ingredients: niacinamide, Bacillus ferment precipitate, mussel extract, sodium hyaluronate, and allantoin, supplemented with auxiliary components such as 1,3-propylene glycol, capryloyl hydroxamic acid, 1,2-hexanediol, ethylhexylglycerin, disodium EDTA, and ethanol. Through scientific compounding, a synergistic repair system is formed, achieving integrated effects of skin barrier repair, anti-inflammatory soothing, microecological balance regulation, deep moisturizing and water locking, and redness reduction and stabilization. The formula of this invention is gentle and non-irritating, free of hormones, fragrances, pigments, and strong allergens, suitable for use on hormone-induced facial dermatitis, dermatitis-prone skin, and severely sensitive skin. The product has good stability, high safety, and is suitable for industrial production, possessing significant skin repair value and promising market application prospects.

The invention discloses a radiodermatitis dermatoscope imageomics prediction method and system and an application program, the system comprises a hardware module and a software module, the hardware module comprises a dermatoscope image acquisition device, and the dermatoscope image acquisition device is used for acquiring a high-resolution dermatoscope image of a radiotherapy treatment area of a patient; the software module is integrated in an application program of a mobile terminal and comprises a radiomics feature extraction module used for extracting quantitative features from dermatoscope images; the parameter calculation module is used for calculating radiomics parameters associated with the skin microstructure change; and the risk prediction module is used for constructing an interpretable machine learning risk prediction model and inputting the patient feature data and the radiomics parameters into the risk prediction model to generate a personalized radiodermatitis risk score for the patient. According to the invention, accurate prediction of acute radiodermatitis is realized.

The invention discloses a compound for regulating the activity of micro RNA-124, the compound has a structure as shown in a formula (I), and the compound can be used for preventing or treating inflammatory diseases. Comprising but not limited to inflammatory bowel disease, rheumatoid arthritis, Crohn's disease, ulcerative colitis, multiple sclerosis, Alzheimer's disease, Paragins disease, osteoarthritis, atherosclerosis, ankylosing spondylitis, psoriasis, dermatitis, Sjogren syndrome, bronchitis, asthma and inflammation associated with colon cancer; the compounds are useful for treating colon cancer, and in particular inflammatory bowel disease, rheumatoid arthritis, Crohn's disease, ulcerative colitis, multiple sclerosis, osteoarthritis, ankylosing spondylitis, psoriasis, Sjogren syndrome, bronchitis, and inflammation associated with colon cancer.

This invention relates to double-stranded oligonucleotides complementary to JAK1 that result in the regulation of JAK1 expression. Regulation of JAK1 expression is beneficial for a range of medical disorders, including inflammatory bowel disease, organ transplant rejection, graft-versus-host disease, multiple sclerosis, rheumatoid arthritis (RA), juvenile idiopathic arthritis, psoriasis, dermatitis, diabetic nephropathy, systemic lupus erythematosus (SLE), dry eye disease, cancer, myelofibrosis, and asthma. The invention also includes compositions comprising double-stranded oligonucleotides and therapeutic methods using double-stranded oligonucleotides.

The invention relates to application of azole drugs in preparation of antifungal drugs, and belongs to the technical field of research and development of antifungal drugs. According to the application of the glycyrrhetinic acid combined with the azoles in preparation of the antifungal drugs, the glycyrrhetinic acid combined with the itraconazole, the voriconazole and the posaconazole shows a good synergistic effect or antagonistic effect on aspergillus, ectobottle dermatitis, candida and cryptococcus neoformans, and the application of the glycyrrhetinic acid combined with the itraconazole, the voriconazole and the posaconazole in preparation of the antifungal drugs is disclosed. And a research and development direction is provided for preparing medicines for resisting aspergillus, ectobottle dermatitis, candida and cryptococcus neoformans.

The present invention relates to an antisense oligonucleotide targeting an interleukin 4 receptor and the use thereof. The antisense oligonucleotide (ASO) molecule has a length of 16-22 bases and is specifically paired with a specific region of a target gene (interleukin 4 receptor). The ASO is used for treating diseases associated with IL-4Rα, which includes, but is not limited to, asthma (including eosinophilic asthma), atopic dermatitis, eosinophilic esophagitis, sinusitis, nasal polyps, prurigo nodularis, urticaria, chronic obstructive pulmonary disease, bullous pemphigoid, pruritus, and gastritis.

The invention discloses a nursing bed for preventing bedsores and cleaning excreta in time, a massage structure is arranged on a nursing bed body, and a urination opening is formed in the edge of the massage structure. The invention relates to the technical field of nursing beds, and has the beneficial effects that a negative pressure suction device and a matched drying function enable urine of a patient to be removed in time, so that the skin wetting time is shortened, the occurrence rate of urinary tract infection and perineum dermatitis is reduced, the cost of adult diapers is reduced, and the defects caused by the adult diapers are overcome. Automatic massage and electrical stimulation solve the problem of passively preventing bedsores, the electrical stimulation is particularly suitable for completely paralyzed patients, muscle atrophy can be effectively delayed, the effect of promoting blood circulation is achieved, and the frequency of turning over is reduced.

The invention relates to the field of medical instruments, in particular to a scalp disease treatment cap which comprises a cap body, a massage air bag layer and a flexible medicine coating layer, the massage air bag layer and the medicine coating layer are both located on the inner side of the cap body, and the massage air bag layer is located between the cap body and the medicine coating layer. A plurality of medicine filling gaps are formed in the surface, away from the massage air bag layer, of the medicine coating layer. By means of the scheme, the hindering influence of crust on medicine absorption is reduced, medicine absorption is promoted, and the regression speed of dermatitis diseases is increased.

The invention relates to the field of medicines, in particular to a stem cell factor composite medicine composition for treating allergic dermatitis and a preparation method thereof. The composite pharmaceutical composition is prepared from the following raw materials in parts by weight: 5 to 10 parts of stem cell factors, 2 to 6 parts of agilawood extract, 1 to 3 parts of forskolin and 0.1 to 0.3 part of stabilizer. The pharmaceutical composition can effectively inhibit bacteria, relieve pain and relieve itching, and can remarkably relieve itching and inflammation caused by allergic dermatitis by inhibiting release of inflammatory factors.

The invention discloses bifidobacterium animalis subsp. Lactis CCMXJ2003 as well as a composition and application thereof, and belongs to the technical field of microbial preparations. In order to screen a specific probiotic strain which can form efficient synergy with 2 '-fucosyllactose and has good viability and an immunoregulation function, and construct a precise micro-ecological intervention scheme aiming at atopic dermatitis immunopathology key links, the invention provides a microecological intervention method for the atopic dermatitis immunopathology key links. The invention provides the bifidobacterium animalis subsp. Lactis CCMXJ2003 capable of efficiently utilizing the 2 '-fucosyllactose, and an in-vivo experiment proves that the composition of the 2'-fucosyllactose and the bifidobacterium animalis subsp. Lactis CCMXJ2003 shows an obvious enhancement effect in the aspect of relieving the specific dermatitis; the compound has a wide application prospect in prevention and / or treatment of atopic dermatitis.

This invention belongs to the field of biomedical nanomaterials and radiation damage drugs, specifically relating to a magnesium-ethylene glycol tetraacetic acid (EGTA) nanomedicine, its preparation method, and its applications. This study proposes using magnesium-EGTA nanomedicine to treat radiation dermatitis. EGTA's chelating ability for calcium ions is significantly higher than that of magnesium ions and other metal ions. Its unique ion selectivity provides an important theoretical basis and application potential for targeting and inhibiting mitochondrial calcium overload in the pathological process of radiation dermatitis. Magnesium ions are cofactors of many enzymes and have anti-inflammatory, collagen synthesis-promoting, and angiogenesis-enhancing effects. This study constructs a Mg-EGTA-based nanomedicine system, utilizing EGTA's stronger chelating ability for calcium ions, thereby achieving targeted regulation of mitochondrial calcium homeostasis through a calcium-magnesium ion intelligent replacement mechanism in response to calcium overload, providing new ideas and methods for the prevention and treatment of radiation dermatitis.

The invention relates to the technical field of medical image processing, and discloses a facial dermatitis skin lesion area and color difference objective evaluation system and method based on image recognition, and the system comprises an image collection and standardization unit which is used for obtaining a facial image and processing the image through an enhancement channel and a fidelity channel; the face region recognition unit is used for recognizing the graph subjected to channel enhancement processing to obtain a face skin region and a face non-skin region; the skin lesion region segmentation unit is used for acquiring a plurality of typical skin lesion points in the facial skin region according to a preset selection strategy, taking pixel color data of the typical skin lesion points as skin lesion color features, and performing region expansion on the typical skin lesion points according to the skin lesion color features and a preset expansion strategy to obtain a skin lesion region; acquiring a skin lesion area of the facial skin area; and the skin lesion area calculation unit is used for obtaining a skin lesion area proportion result according to the facial skin area and the corresponding skin lesion area.

The invention discloses an application of a BET (Brunauer, Emmett and Teller) inhibitor NHWD-870 in resisting skin aging or dermatitis. Researches prove that the NHWD-870 is prepared into an aqueous solution to be applied to the back skin of a mouse, and a good effect of resisting ultraviolet-induced skin aging and dermatitis symptoms is achieved. The application of the BET inhibitor NHWD-870 in skin aging and senile dermatitis is provided for the first time, a new medicine is provided for resisting skin aging and senile dermatitis, and the medicine is good in curative effect, safe, reliable and free of side effects.

The present invention belongs to the technical field of medicine, and in particular relates to a novel aromatic ring derivative containing an amide substitution or a pharmaceutically acceptable salt thereof. The diseases comprise, but are not limited to, inflammatory or autoimmune diseases such as psoriasis, psoriatic arthritis, dermatitis, lupus erythematosus, inflammatory bowel disease, hidradenitis suppurativa, rheumatoid arthritis, and uveitis. The structure of the compound of formula I is as described in the claims and the description. The aromatic ring derivative containing an amide substitution provided in the present invention is used as a novel TYK2 inhibitor, has a good TYK2 inhibitory effect, has a good therapeutic effect in an in vivo model of psoriasis and asthma animals, and has good druggability, high stability and good safety.