6 results about "Radiodermatitis" patented technology

This invention belongs to the field of biomedical nanomaterials and radiation damage drugs, specifically relating to a magnesium-ethylene glycol tetraacetic acid (EGTA) nanomedicine, its preparation method, and its applications. This study proposes using magnesium-EGTA nanomedicine to treat radiation dermatitis. EGTA's chelating ability for calcium ions is significantly higher than that of magnesium ions and other metal ions. Its unique ion selectivity provides an important theoretical basis and application potential for targeting and inhibiting mitochondrial calcium overload in the pathological process of radiation dermatitis. Magnesium ions are cofactors of many enzymes and have anti-inflammatory, collagen synthesis-promoting, and angiogenesis-enhancing effects. This study constructs a Mg-EGTA-based nanomedicine system, utilizing EGTA's stronger chelating ability for calcium ions, thereby achieving targeted regulation of mitochondrial calcium homeostasis through a calcium-magnesium ion intelligent replacement mechanism in response to calcium overload, providing new ideas and methods for the prevention and treatment of radiation dermatitis.

This invention discloses a method for preparing and applying a dual-network sprayable hydrogel for the repair of radiation-induced skin damage. The hydrogel introduces aldehyde groups into Polygonatum odoratum polysaccharide via sodium periodate oxidation, causing it to chemically crosslink with the amino groups of quaternized chitosan to form a first-layer network. Simultaneously, sodium alginate is introduced into the system, and calcium ions are used to crosslink and construct a second-layer physical crosslinking network. This invention achieves instant gelation upon injection under physiological conditions, effectively avoiding the operational complexity caused by pre-mixed crosslinking agents and optimizing gel performance. The resulting hydrogel exhibits significantly improved mechanical and adhesive properties. In vitro cell experiments and in vivo animal experiments show that this sprayable hydrogel can effectively promote cell proliferation and migration, effectively maintain macrophage mitochondrial dysfunction caused by ionizing radiation, and possesses good antioxidant and anti-inflammatory activities, demonstrating broad application prospects in the repair and treatment of radiation dermatitis.

This invention belongs to the field of animal model construction technology, specifically providing a method for constructing and using a mouse radiation dermatitis model. The method involves irradiating localized areas of healthy mice with X-rays at a dose rate of 5.128 Gy / min in fractionated doses every other day, with a total dose of 30-49 Gy, to establish a mouse radiation dermatitis model. This invention uses a fractionated X-ray irradiation mode commonly used in clinical radiotherapy, which can stably induce radiation dermatitis of varying degrees. Skin damage is significantly dependent on the irradiation dose. A total dose of 30 Gy is optimal, and after 35 days of development, a standardized model closely resembling clinical grade II radiation dermatitis can be constructed. This method is simple to operate, has good reproducibility, and a low animal mortality rate. It can realistically simulate the skin damage process of clinical radiotherapy, providing a reliable basis for research on the mechanism of radiation dermatitis and is suitable for the screening and identification of related preventive and therapeutic drugs.

A topical cream or ointment is provided that provides for the binding to CB1 and / or CB2 receptors for the soothing of pain, inflammation of smooth muscle, tendons, ligaments, skeletal muscle, endothelial cell, synovial cell, peripheral nerve fibers, reduction of endothelial bruising, promotion of healing of endothelial bruising, and dermatological itch sensation wherein the improvement comprises providing the effect of cannabinoid using plant extracts. A topically administered formulation is also provided for treating anal mucosal inflammation, soothing of pain, inflammation of anal mucosal inflammation; reducing keratinocyte apoptosis; treating viral-associated epithelial damage, treating radiation dermatitis; and treating chemotherapy-induced dermatitis.

The utility model provides a device for after tumor radiotherapy chest shielding and protection. The main frame whole of device is U shape structure, and the four arounds of main frame are fixed with edge board, soft pad, and the inside of main frame is fixed with top support, bottom support, edge support respectively, and left, right chest guard seat is fixed with top support, bottom support, edge support respectively with connecting rod, and chest guard is connected with left, right chest guard seat respectively, and rectangular frame is connected with main frame, and the edge board on both sides of main frame is fixed with braces, magic tape, and connecting band is fixed on neck fixed band, and main frame is connected with neck fixed band through hanging ear, hook and connecting band. The device is combined with the chest guard of main frame and rectangular frame, which forms a gap of 3-5cm between the device and the skin, protects the external preparation applied on the skin, prevents radioactive dermatitis infection and protects the privacy of the patient, has a reasonable structure design, is simple and practical to operate, and can be widely applied in clinical treatment.

The present application relates to a kind of biological active microneedle patch for repairing radiation dermatitis and its preparation method and application, belong to biomedical material technical field.The microneedle patch of the present application includes backing layer and needle tip layer, wherein the material of backing layer is methacrylated hyaluronic acid with photo-crosslinking characteristics, the material of needle tip layer is silk fibroin and hyaluronic acid, and loaded with chlorogenic acid and adipose stem cell exosome as core bioactive component.The microneedle patch of the present application has excellent mechanical properties and biological activity, can minimally invasive penetration skin keratin layer barrier, realize the accurate delivery and sustained release of active ingredient to damaged tissue deep layer.Microneedle patch improves the problem of insufficient mechanical strength of natural polymer microneedle through the composite structure of "methacrylated hyaluronic acid backing + silk fibroin needle tip", realizes the synergistic effect of antioxidant, anti-inflammatory and extracellular matrix homeostasis reconstruction through "chlorogenic acid + adipose stem cell exosome", and can be used for repairing radiation dermatitis.