17 results about "Radiodermatitis" patented technology

The invention relates to cream for repairing radiodermatitis and a preparation method of the cream, and belongs to the technical field of biomedical skin treatment. The cream consists of the following components in percentage by weight: 8% of glycerin monostearate, 6% of stearic acid, 5% of white vaseline, 4% of liquid wax, 1-2% of tea tree oil, 1-2% of eugenol, 1-2% of vitamin E, 3% of trehalose, 8% of polyethylene glycol (PEG-400), 10% of glycerol, 0.5% of methylparaben, 1% of triethanolamine and the balance of purified water. According to the cream disclosed by the invention, the natural traditional Chinese medicine component eugenol and the natural substance vitamin E are utilized to synergistically enhance the anti-oxidation and bacteriostatic effects, and the tea tree oil, the trehalose and other effective components are utilized to repair radiodermatitis from multiple aspects of anti-inflammation, bacteriostasis, antioxidation, promotion of skin barrier repair and the like. The cream is simple in component, good in treatment effect, high in safety and convenient to produce and process, and can be popularized and applied to treatment of radiodermatitis.

The invention discloses a core-shell nano-enzyme composite spray gel dressing and a preparation method and application thereof.The dressing comprises a component A prepared from sodium alginate, N-isopropylacrylamide PNIPAM, core-shell nano-enzyme and curcumin and a component B of a divalent metal salt solution, and the component A and the component B are sprayed at the same time to form the core-shell nano-enzyme composite spray gel dressing. The preparation method of the core-shell nano enzyme comprises the following steps: mixing potassium ferrocyanide, ferric trichloride and polyvinylpyrrolidone to obtain a Prussian blue nano particle precursor solution; carrying out ultrasonic emulsification treatment and replacement on the curcumin core solution and the Prussian blue nanoparticle precursor solution; and freeze-drying to obtain the core-shell nano-enzyme. Through rapid ionic crosslinking of sodium alginate and divalent metal ions and the temperature-sensitive phase change characteristic of the temperature-sensitive polymer poly (N-isopropylacrylamide), the gel dressing is rapidly formed, the damaged skin is effectively covered and protected, the excellent antioxidant, anti-inflammatory and antibacterial capabilities are achieved, and the healing cycle of the radiodermatitis wound can be remarkably shortened.

The invention provides a marker for diagnosing and treating radiodermatitis and application of the marker. The relation between SENP5 and radiodermatitis is researched for the first time, it is found that SENP5 is in positive correlation with occurrence and development of radiodermatitis, an SENP5 overexpression group shows better radiation resistance, skin cells are protected, and damage caused by radiation is relieved. The SENP5 is mainly used for promoting DNA damage repair by mediating an HR repair pathway. Besides, the SENP5 knocked-down cell line is successfully constructed by designing shRNA for specifically knocking down the SENP5 expression level, and it is proved that after SENP5 knocked-down skin cells are irradiated by 60Co rays, the cell survival level is lowered, the homologous recombination repair pathway is obviously inhibited, the NF-kappa B pathway is obviously activated, and the inflammation level is improved. Therefore, SENP5 is represented as an anti-radiation gene in skin cells, and SENP5 can be used as a biomarker of radiodermatitis for early diagnosis of radiodermatitis and targeted preparation of drugs for radiodermatitis.

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a composition for topical application containing sucralfate wet gel. The invention relates to a local application composition containing sucralfate wet gel, which is prepared from the following components in percentage by mass: 15 to 25 percent of sucralfate wet gel, 10 to 18 percent of polyethylene glycol, 0.2 to 0.5 percent of polyethylene glycol stearate, 0.1 to 0.21 percent of sodium methyl p-hydroxybenzoate, 0.01 to 0.023 percent of sodium propyl p-hydroxybenzoate and the balance of purified water. The sucralfate wet gel dressing is smeared on a non-infected and carefully disinfected skin wound surface and dried, a solid barrier is formed on the part, the wound surface can be covered, damaged tissues below the wound surface can be protected against external stimulation, and the sucralfate wet gel dressing is used for treating non-infectious wound surfaces and ulcers, especially vascular ulcers, diabetic ulcers, bedsores and radiodermatitis, and has a good application prospect. A layer of protective barrier is formed on the broken or damaged surface, so that physiological healing is promoted.

This invention belongs to the field of biomedical nanomaterials and radiation damage drugs, specifically relating to a magnesium-ethylene glycol tetraacetic acid (EGTA) nanomedicine, its preparation method, and its applications. This study proposes using magnesium-EGTA nanomedicine to treat radiation dermatitis. EGTA's chelating ability for calcium ions is significantly higher than that of magnesium ions and other metal ions. Its unique ion selectivity provides an important theoretical basis and application potential for targeting and inhibiting mitochondrial calcium overload in the pathological process of radiation dermatitis. Magnesium ions are cofactors of many enzymes and have anti-inflammatory, collagen synthesis-promoting, and angiogenesis-enhancing effects. This study constructs a Mg-EGTA-based nanomedicine system, utilizing EGTA's stronger chelating ability for calcium ions, thereby achieving targeted regulation of mitochondrial calcium homeostasis through a calcium-magnesium ion intelligent replacement mechanism in response to calcium overload, providing new ideas and methods for the prevention and treatment of radiation dermatitis.

The invention discloses a gel for preventing radiodermatitis. According to the invention, firstly, iNOS-DNA enzyme is designed, and the nucleotide sequence of the iNOS-DNA enzyme is shown as SEQ ID NO.1; the preparation method comprises the following steps: dissolving iNOS-DNA enzyme and cobalt nitrate in methanol to obtain a solution A, and dissolving dimethylimidazole in methanol to obtain a solution B; the solution A and the solution B are mixed and stirred, and iNOS-DZ-ZIF-67 is obtained; the preparation method comprises the following steps: dissolving hyaluronic acid in a sodium acetate solution to obtain a hyaluronic acid (HA) solution, adding iNOS-DZ-ZIF-67 / HA into the hyaluronic acid (HA) solution, stirring in a dark place, freeze-drying and precipitating, and adding water and mixing when in use to obtain the gel for preventing radiodermatitis. The prepared gel has good stability, slow release property and angiogenesis effect, the delivery rate and antibacterial property can be improved, and radiodermatitis can be prevented and treated in a targeted mode.

This invention discloses a method for preparing and applying a dual-network sprayable hydrogel for the repair of radiation-induced skin damage. The hydrogel introduces aldehyde groups into Polygonatum odoratum polysaccharide via sodium periodate oxidation, causing it to chemically crosslink with the amino groups of quaternized chitosan to form a first-layer network. Simultaneously, sodium alginate is introduced into the system, and calcium ions are used to crosslink and construct a second-layer physical crosslinking network. This invention achieves instant gelation upon injection under physiological conditions, effectively avoiding the operational complexity caused by pre-mixed crosslinking agents and optimizing gel performance. The resulting hydrogel exhibits significantly improved mechanical and adhesive properties. In vitro cell experiments and in vivo animal experiments show that this sprayable hydrogel can effectively promote cell proliferation and migration, effectively maintain macrophage mitochondrial dysfunction caused by ionizing radiation, and possesses good antioxidant and anti-inflammatory activities, demonstrating broad application prospects in the repair and treatment of radiation dermatitis.

This invention belongs to the field of animal model construction technology, specifically providing a method for constructing and using a mouse radiation dermatitis model. The method involves irradiating localized areas of healthy mice with X-rays at a dose rate of 5.128 Gy / min in fractionated doses every other day, with a total dose of 30-49 Gy, to establish a mouse radiation dermatitis model. This invention uses a fractionated X-ray irradiation mode commonly used in clinical radiotherapy, which can stably induce radiation dermatitis of varying degrees. Skin damage is significantly dependent on the irradiation dose. A total dose of 30 Gy is optimal, and after 35 days of development, a standardized model closely resembling clinical grade II radiation dermatitis can be constructed. This method is simple to operate, has good reproducibility, and a low animal mortality rate. It can realistically simulate the skin damage process of clinical radiotherapy, providing a reliable basis for research on the mechanism of radiation dermatitis and is suitable for the screening and identification of related preventive and therapeutic drugs.

A topical formulation is provided for treating systems of radiation treatments that includes a moisturizer base, and a plurality of active ingredients that include a corticosteroid, silymarin, and epigallocatechin-3-gallate (EGCG).

The invention belongs to the technical field of new application of a periplaneta americana extract, and provides application of the periplaneta americana extract in preparation of a medicine for treating radiodermatitis. Skin wound healing promoting drug effect research tests find that the American cockroach extract provided by the invention has a remarkable repair promoting effect on a full-thickness skin defect rat model established by an operation, and the effect is remarkably superior to that of Kangfuxin liquid; a pharmacological research test on prevention and treatment of X-ray-induced rat radiodermatitis shows that the American cockroach extract provided by the invention can significantly improve clinical symptoms of a Wistar rat radiodermatitis model induced by X-ray irradiation, and the pharmacological effect is significantly superior to that of a positive drug triethanolamine emulsifiable paste; research tests on efficacy of electron ray induced rat back dermatitis in external use find that the American cockroach extract provided by the invention can significantly improve clinical symptoms of an SD rat radiodermatitis model induced by electron ray irradiation, and shows a significant skin injury repair effect.

A topical cream or ointment is provided that provides for the binding to CB1 and / or CB2 receptors for the soothing of pain, inflammation of smooth muscle, tendons, ligaments, skeletal muscle, endothelial cell, synovial cell, peripheral nerve fibers, reduction of endothelial bruising, promotion of healing of endothelial bruising, and dermatological itch sensation wherein the improvement comprises providing the effect of cannabinoid using plant extracts. A topically administered formulation is also provided for treating anal mucosal inflammation, soothing of pain, inflammation of anal mucosal inflammation; reducing keratinocyte apoptosis; treating viral-associated epithelial damage, treating radiation dermatitis; and treating chemotherapy-induced dermatitis.

The utility model provides a device for after tumor radiotherapy chest shielding and protection. The main frame whole of device is U shape structure, and the four arounds of main frame are fixed with edge board, soft pad, and the inside of main frame is fixed with top support, bottom support, edge support respectively, and left, right chest guard seat is fixed with top support, bottom support, edge support respectively with connecting rod, and chest guard is connected with left, right chest guard seat respectively, and rectangular frame is connected with main frame, and the edge board on both sides of main frame is fixed with braces, magic tape, and connecting band is fixed on neck fixed band, and main frame is connected with neck fixed band through hanging ear, hook and connecting band. The device is combined with the chest guard of main frame and rectangular frame, which forms a gap of 3-5cm between the device and the skin, protects the external preparation applied on the skin, prevents radioactive dermatitis infection and protects the privacy of the patient, has a reasonable structure design, is simple and practical to operate, and can be widely applied in clinical treatment.

The invention provides a silk fibroin skin protective agent and application, relates to the technical field of medical cosmetology, and provides a compound external composition aiming at radiodermatitis caused by radiotherapy. According to the preparation, silk fibroin is taken as a core active component, coated titanium dioxide core-shell particles, an antioxidant component and a moisturizing and repairing aid are combined, the components are proportioned according to the mass percent defined in the specification, and the pH value is kept within the range of 5.0-8.0. According to the composite inorganic particles, the photocatalytic activity is reduced through coating and surface modification, and silk fibroin endows good film forming and healing promoting characteristics in a nano-particle form, so that the synergistic effect of physical protection, oxidation resistance and barrier repair is achieved. The formulations are suitable for skin protection, wet healing and long-term barrier maintenance during and after radiotherapy. Specific preparation process parameters, various dosage form embodiments and a functional and safety assessment method are provided in the specification.

The invention relates to a medical ray protection preparation for relieving radiodermatitis, and belongs to the technical field of biomedical skin treatment. The preparation is composed of a preparation A and a preparation B. The preparation A is composed of the following components in percentage by weight: 0.01-0.03% of superoxide dismutase, 0.005-0.05% of trehalose and the balance of ultrapure water. The preparation B is prepared from the following components in percentage by weight: 0.01 to 0.04 percent of chlorogenic acid, 2.5 percent of potassium sorbate, 15 percent of sorbitol, 1 percent of hyaluronic acid, 2.5 percent of carboxymethyl chitosan and the balance of purified water. The superoxide dismutase, the trehalose, the chlorogenic acid and other active ingredients are utilized to relieve radiodermatitis from multiple aspects of removing active oxygen at a wound part, resisting inflammation, inhibiting bacteria and promoting skin barrier repair, and by utilizing the moisturizing and antibacterial effects of carboxymethyl chitosan and the functions of promoting collagen production and tissue repair of hyaluronic acid, the wound healing effect is improved, and the wound healing effect is improved. The radiodermatitis is comprehensively treated.

The utility model relates to the technical field of medical instruments, and particularly discloses a radiodermatitis auxiliary detecting instrument which comprises a detecting instrument body and a detecting pen, a display screen and operation buttons are arranged on the top of the detecting instrument body, an interface groove is formed in the side edge of the detecting instrument body, a wire is fixedly connected in the interface groove, and the wire is fixedly connected with the detecting pen. A handle clamping groove used for containing a detection pen is formed in the top of the detecting instrument body, a winding groove is formed in the side edge of the detecting instrument body, a winding wheel set used for winding a wire is arranged in the winding groove, and a positioning device used for limiting rotation of the winding wheel set is arranged at the top of the detecting instrument body. When the detecting instrument is carried, the detecting pen can be stored in the handle clamping groove in the top of the detecting instrument body, the wire can be stored in the winding groove in the side edge of the detecting instrument body, the redundant wire is wound in order through the winding wheel set, the wire is prevented from being dragged while unwinding of the wire is not affected, and the using and carrying safety of the detecting instrument is improved.

The present application relates to a kind of biological active microneedle patch for repairing radiation dermatitis and its preparation method and application, belong to biomedical material technical field.The microneedle patch of the present application includes backing layer and needle tip layer, wherein the material of backing layer is methacrylated hyaluronic acid with photo-crosslinking characteristics, the material of needle tip layer is silk fibroin and hyaluronic acid, and loaded with chlorogenic acid and adipose stem cell exosome as core bioactive component.The microneedle patch of the present application has excellent mechanical properties and biological activity, can minimally invasive penetration skin keratin layer barrier, realize the accurate delivery and sustained release of active ingredient to damaged tissue deep layer.Microneedle patch improves the problem of insufficient mechanical strength of natural polymer microneedle through the composite structure of "methacrylated hyaluronic acid backing + silk fibroin needle tip", realizes the synergistic effect of antioxidant, anti-inflammatory and extracellular matrix homeostasis reconstruction through "chlorogenic acid + adipose stem cell exosome", and can be used for repairing radiation dermatitis.

The invention relates to a medicine prescription for treating radiodermatitis and application thereof. The medicine comprises the following components in percentage by weight: 0.01%-2% of acetate of a peptide compound, 2%-5% of a first solvent, 0.05%-1.75% of a bacteriostatic agent, 0.5%-3% of a gel matrix, 0.05%-3% of a metal ion complexing agent, a pH regulator for regulating the pH value to 3-7, and a second solvent supplemented to 100%. The prescription of the medicine for treating radiodermatitis is especially suitable for symptomatic treatment of chronic pruritus such as atopic dermatitis, and the local action mechanism of the medicine gives consideration to both curative effect and safety. The medicine can be directly administered to an affected part, so that the uncertainty of in-vivo circulation is reduced; the use by patients is convenient and the compliance is improved.