30 results about "Radiodermatitis" patented technology

The invention discloses a tumor radiotherapy prognosis prediction simulation method and system based on big data and a medium, and relates to the technical field of tumor radiotherapy prognosis, and the method comprises the following steps: collecting basic physiological information of a tumor patient, and collecting a color image and a temperature image of skin of a radiotherapy part of the tumor patient; skin color feature extraction and skin temperature feature extraction are carried out to obtain skin color feature data and skin temperature feature data; a radiodermatitis prediction model is constructed; performing prediction simulation on the skin of the radiotherapy part of the tumor patient based on the radiodermatitis prediction model, and performing prediction simulation correction to obtain a radiodermatitis prediction result of the tumor patient; the method is used for solving the problem that when an existing tumor radiotherapy prognosis technology is used for predicting and simulating disease development, the risk and time of radiodermatitis of a tumor patient cannot be objectively and accurately predicted and simulated according to physiological characteristics of skin of the tumor patient after radiotherapy.

The invention discloses a spirulina extracellular vesicle-loaded astaxanthin hydrogel as well as a preparation method and application thereof, and astaxanthin is loaded into spirulina extracellular vesicles to form spirulina extracellular vesicle-loaded astaxanthin nanoparticles. And then, the nano-particles are contained in self-assembled hydrogel composed of aldehyde hyaluronic acid and carboxymethyl chitosan, and the spirulina extracellular vesicle astaxanthin-loaded hydrogel is prepared and obtained. The preparation method comprises the following steps: firstly, preparing the spirulina extracellular vesicle astaxanthin-loaded hydrogel, and preparing the spirulina extracellular vesicle astaxanthin-loaded hydrogel. The hydrogel prepared by the invention can realize synergistic and complementary effects of spirulina extracellular vesicles and astaxanthin, realizes a protective effect on radiodermatitis by relieving oxidative stress, recovering mitochondrial functions and reducing inflammatory response, and shows long-term biological safety.

The invention relates to cream for repairing radiodermatitis and a preparation method of the cream, and belongs to the technical field of biomedical skin treatment. The cream consists of the following components in percentage by weight: 8% of glycerin monostearate, 6% of stearic acid, 5% of white vaseline, 4% of liquid wax, 1-2% of tea tree oil, 1-2% of eugenol, 1-2% of vitamin E, 3% of trehalose, 8% of polyethylene glycol (PEG-400), 10% of glycerol, 0.5% of methylparaben, 1% of triethanolamine and the balance of purified water. According to the cream disclosed by the invention, the natural traditional Chinese medicine component eugenol and the natural substance vitamin E are utilized to synergistically enhance the anti-oxidation and bacteriostatic effects, and the tea tree oil, the trehalose and other effective components are utilized to repair radiodermatitis from multiple aspects of anti-inflammation, bacteriostasis, antioxidation, promotion of skin barrier repair and the like. The cream is simple in component, good in treatment effect, high in safety and convenient to produce and process, and can be popularized and applied to treatment of radiodermatitis.

The invention discloses a core-shell nano-enzyme composite spray gel dressing and a preparation method and application thereof.The dressing comprises a component A prepared from sodium alginate, N-isopropylacrylamide PNIPAM, core-shell nano-enzyme and curcumin and a component B of a divalent metal salt solution, and the component A and the component B are sprayed at the same time to form the core-shell nano-enzyme composite spray gel dressing. The preparation method of the core-shell nano enzyme comprises the following steps: mixing potassium ferrocyanide, ferric trichloride and polyvinylpyrrolidone to obtain a Prussian blue nano particle precursor solution; carrying out ultrasonic emulsification treatment and replacement on the curcumin core solution and the Prussian blue nanoparticle precursor solution; and freeze-drying to obtain the core-shell nano-enzyme. Through rapid ionic crosslinking of sodium alginate and divalent metal ions and the temperature-sensitive phase change characteristic of the temperature-sensitive polymer poly (N-isopropylacrylamide), the gel dressing is rapidly formed, the damaged skin is effectively covered and protected, the excellent antioxidant, anti-inflammatory and antibacterial capabilities are achieved, and the healing cycle of the radiodermatitis wound can be remarkably shortened.

The invention provides a marker for diagnosing and treating radiodermatitis and application of the marker. The relation between SENP5 and radiodermatitis is researched for the first time, it is found that SENP5 is in positive correlation with occurrence and development of radiodermatitis, an SENP5 overexpression group shows better radiation resistance, skin cells are protected, and damage caused by radiation is relieved. The SENP5 is mainly used for promoting DNA damage repair by mediating an HR repair pathway. Besides, the SENP5 knocked-down cell line is successfully constructed by designing shRNA for specifically knocking down the SENP5 expression level, and it is proved that after SENP5 knocked-down skin cells are irradiated by 60Co rays, the cell survival level is lowered, the homologous recombination repair pathway is obviously inhibited, the NF-kappa B pathway is obviously activated, and the inflammation level is improved. Therefore, SENP5 is represented as an anti-radiation gene in skin cells, and SENP5 can be used as a biomarker of radiodermatitis for early diagnosis of radiodermatitis and targeted preparation of drugs for radiodermatitis.

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a composition for topical application containing sucralfate wet gel. The invention relates to a local application composition containing sucralfate wet gel, which is prepared from the following components in percentage by mass: 15 to 25 percent of sucralfate wet gel, 10 to 18 percent of polyethylene glycol, 0.2 to 0.5 percent of polyethylene glycol stearate, 0.1 to 0.21 percent of sodium methyl p-hydroxybenzoate, 0.01 to 0.023 percent of sodium propyl p-hydroxybenzoate and the balance of purified water. The sucralfate wet gel dressing is smeared on a non-infected and carefully disinfected skin wound surface and dried, a solid barrier is formed on the part, the wound surface can be covered, damaged tissues below the wound surface can be protected against external stimulation, and the sucralfate wet gel dressing is used for treating non-infectious wound surfaces and ulcers, especially vascular ulcers, diabetic ulcers, bedsores and radiodermatitis, and has a good application prospect. A layer of protective barrier is formed on the broken or damaged surface, so that physiological healing is promoted.

This invention belongs to the field of biomedical nanomaterials and radiation damage drugs, specifically relating to a magnesium-ethylene glycol tetraacetic acid (EGTA) nanomedicine, its preparation method, and its applications. This study proposes using magnesium-EGTA nanomedicine to treat radiation dermatitis. EGTA's chelating ability for calcium ions is significantly higher than that of magnesium ions and other metal ions. Its unique ion selectivity provides an important theoretical basis and application potential for targeting and inhibiting mitochondrial calcium overload in the pathological process of radiation dermatitis. Magnesium ions are cofactors of many enzymes and have anti-inflammatory, collagen synthesis-promoting, and angiogenesis-enhancing effects. This study constructs a Mg-EGTA-based nanomedicine system, utilizing EGTA's stronger chelating ability for calcium ions, thereby achieving targeted regulation of mitochondrial calcium homeostasis through a calcium-magnesium ion intelligent replacement mechanism in response to calcium overload, providing new ideas and methods for the prevention and treatment of radiation dermatitis.

Compositions and methods for treating cutaneous radiation injury (CRI), including radiation dermatitis, radiation proctopathy, or oral mucositis, employing one or more functional inhibitor of acid sphingomyelinase (FIASMA).

Compositions and methods for treating cutaneous radiation injury (CRI), including radiation dermatitis, radiation proctopathy, or oral mucositis, utilizing one or more functional inhibitors of acid sphingomyelinase (FIASMA).

The invention discloses a gel for preventing radiodermatitis. According to the invention, firstly, iNOS-DNA enzyme is designed, and the nucleotide sequence of the iNOS-DNA enzyme is shown as SEQ ID NO.1; the preparation method comprises the following steps: dissolving iNOS-DNA enzyme and cobalt nitrate in methanol to obtain a solution A, and dissolving dimethylimidazole in methanol to obtain a solution B; the solution A and the solution B are mixed and stirred, and iNOS-DZ-ZIF-67 is obtained; the preparation method comprises the following steps: dissolving hyaluronic acid in a sodium acetate solution to obtain a hyaluronic acid (HA) solution, adding iNOS-DZ-ZIF-67 / HA into the hyaluronic acid (HA) solution, stirring in a dark place, freeze-drying and precipitating, and adding water and mixing when in use to obtain the gel for preventing radiodermatitis. The prepared gel has good stability, slow release property and angiogenesis effect, the delivery rate and antibacterial property can be improved, and radiodermatitis can be prevented and treated in a targeted mode.

This invention discloses a method for preparing and applying a dual-network sprayable hydrogel for the repair of radiation-induced skin damage. The hydrogel introduces aldehyde groups into Polygonatum odoratum polysaccharide via sodium periodate oxidation, causing it to chemically crosslink with the amino groups of quaternized chitosan to form a first-layer network. Simultaneously, sodium alginate is introduced into the system, and calcium ions are used to crosslink and construct a second-layer physical crosslinking network. This invention achieves instant gelation upon injection under physiological conditions, effectively avoiding the operational complexity caused by pre-mixed crosslinking agents and optimizing gel performance. The resulting hydrogel exhibits significantly improved mechanical and adhesive properties. In vitro cell experiments and in vivo animal experiments show that this sprayable hydrogel can effectively promote cell proliferation and migration, effectively maintain macrophage mitochondrial dysfunction caused by ionizing radiation, and possesses good antioxidant and anti-inflammatory activities, demonstrating broad application prospects in the repair and treatment of radiation dermatitis.

The utility model relates to an oxygen therapy device for neck radiodermatitis, which comprises an oxygen tube externally connected with an oxygen therapy device, and is characterized by further comprising a neck oxygen therapy ring for fixing the oxygen tube, the neck oxygen conveying ring comprises an oxygen conveying section, two telescopic sections and two wet compressing sections, one sides of the two telescopic sections are correspondingly connected to the two sides of the oxygen conveying section respectively, one sides of the two wet compressing sections are correspondingly connected to the other sides of the two telescopic sections respectively, and the other sides of the two wet compressing sections are detachably connected correspondingly; the oxygen conveying section is provided with a connector connected with the oxygen pipe, and a plurality of air outlet holes are further formed in the inner side face of the oxygen conveying section. According to the oxygen therapy device for the neck radiodermatitis, a high-oxygen environment can be formed in a dermatitis area, and the rehabilitation speed of the neck radiodermatitis is increased.

Skin radioactive injury (CRI) is injury to the skin or subterranean tissue of animals, including mammals and humans, induced or caused by exposure to radiation of industrially or military related sources, such as radioactive substances used in nuclear power plants or nuclear weapons. Light skin lesions (e.g., sunburn due to overexposure to sunlight) are generally not considered to fall within the definition of CRI; however, the term CRI may include a dermatological condition (such as radiodermatitis) or other condition (such as radiorectal disease, oral mucositis, or severe oral mucositis), each of which may be observed following administration of medical radiation therapy to the body region for the treatment of cancer or other condition treatable with radiation. Disclosed are compositions and methods for treating skin radiation injury (CRI), including radiodermatitis, radiation rectal disease, or oral mucositis, with one or more acid sphingomyelinase function inhibitors (FIASMA).

The present invention discloses a spreadable graphene oxide hybrid soybean protein hydrogel and a preparation method and application thereof. The present invention extracts SPI from soybean protein isolate by means of gallic acid under alkaline conditions; simultaneously grafts SPI-GA with phenol and thiol (SH) to form SPI-GA-SH; dissolves dopamine in a graphene oxide solution to react and obtain a PGO stock solution; finally, SPI-SH-GA and PGO are self-assembled into a spreadable biogel in a glycerol / water binary solvent system. Cytological studies have shown that SPI-SH-GA@PGO is non-toxic to HaCaT cells and has antibacterial properties. It also promotes cell migration, angiogenesis and inhibits cell apoptosis. The spreadable biogel prepared by the present invention forms a protective film against radiation dermatitis during radiotherapy, and can be used as a skin radiation protector to improve radiation protection performance.

The present invention discloses an external traditional Chinese medicine compound ointment for treating radioactive dermatitis and a preparation method thereof. The ointment is composed of the following components in parts by weight: 1-40 parts of the extract of the stem and leaf of Gynura Root, 1-10 parts of the extract of Poria cocos, 1-15 parts of the extract of Coix lacryma-jobi, 1-10 parts of the extract of Forsythia suspensa, 1-15 parts of the extract of Atractylodes macrocephala, 0.1-0.5 part of paraben, 1-500 parts of petrolatum, 1-2 parts of β-sitosterol, 1-5 parts of zinc oxide powder, 1-2 parts of talcum powder, 1-2 parts of sodium stearate, and 1-20 parts of ethanol. The traditional Chinese medicine of the present invention adopts traditional Chinese medicine extracts, which maximally reduces the residues of pesticides and heavy metals, improves the solubility, and makes the medicine more easily absorbed by the skin. The external traditional Chinese medicine compound ointment of the present invention can effectively treat radioactive dermatitis, with good effect, quick onset, and low cost. After the patients use it, the related adverse manifestations of radioactive dermatitis significantly subside.

Provided herein are topical formulations containing copper ions and methods of treating radiation dermatitis, damage caused by radiation therapy, or other radiation-induced damage conditions in various areas of the body using such formulations. Methods of treating radiation dermatitis using topical copper ion treatments are provided. A topical treatment in its basic form comprises a biocompatible copper ion solution or suspension obtained by leaching of the copper ions from copper metal. The copper ion solution or suspension is combined with various carriers to form the copper ion treatment including creams, gels, lotions, foams, pastes, tampons, solutions, suppositories, body wipes, wound dressings, skin patches, and suture material. Methods of making the copper ion solution or suspension from solid copper metal in a biocompatible solution are also provided.

This invention belongs to the field of animal model construction technology, specifically providing a method for constructing and using a mouse radiation dermatitis model. The method involves irradiating localized areas of healthy mice with X-rays at a dose rate of 5.128 Gy / min in fractionated doses every other day, with a total dose of 30-49 Gy, to establish a mouse radiation dermatitis model. This invention uses a fractionated X-ray irradiation mode commonly used in clinical radiotherapy, which can stably induce radiation dermatitis of varying degrees. Skin damage is significantly dependent on the irradiation dose. A total dose of 30 Gy is optimal, and after 35 days of development, a standardized model closely resembling clinical grade II radiation dermatitis can be constructed. This method is simple to operate, has good reproducibility, and a low animal mortality rate. It can realistically simulate the skin damage process of clinical radiotherapy, providing a reliable basis for research on the mechanism of radiation dermatitis and is suitable for the screening and identification of related preventive and therapeutic drugs.

A topical formulation is provided for treating systems of radiation treatments that includes a moisturizer base, and a plurality of active ingredients that include a corticosteroid, silymarin, and epigallocatechin-3-gallate (EGCG).

The invention belongs to the technical field of new application of a periplaneta americana extract, and provides application of the periplaneta americana extract in preparation of a medicine for treating radiodermatitis. Skin wound healing promoting drug effect research tests find that the American cockroach extract provided by the invention has a remarkable repair promoting effect on a full-thickness skin defect rat model established by an operation, and the effect is remarkably superior to that of Kangfuxin liquid; a pharmacological research test on prevention and treatment of X-ray-induced rat radiodermatitis shows that the American cockroach extract provided by the invention can significantly improve clinical symptoms of a Wistar rat radiodermatitis model induced by X-ray irradiation, and the pharmacological effect is significantly superior to that of a positive drug triethanolamine emulsifiable paste; research tests on efficacy of electron ray induced rat back dermatitis in external use find that the American cockroach extract provided by the invention can significantly improve clinical symptoms of an SD rat radiodermatitis model induced by electron ray irradiation, and shows a significant skin injury repair effect.

The invention discloses a method for establishing a rat radiodermatitis model. The method comprises the following steps: S1, setting a control group, a low-dose group, a medium-dose group, a high-dose group and a false irradiation group; the control group is not irradiated, and the skin state of the rats under the condition that the rats are not damaged by radiation is observed; the total irradiation dose of the low-dose group is 35Gy; the total irradiation dose of the medium dose group is 40Gy; the total irradiation dose of the high-dose group is 45Gy; s2, selecting rats, shaving and cleaning radiation parts of the rats, and performing anesthesia treatment on the rats; s3, a 6MeV electron accelerator is adopted for radiation irradiation, the irradiation time of a low-dose group is 5.83 minutes, the irradiation time of a medium-dose group is 6.67 minutes, and the irradiation time of a high-dose group is 7.5 minutes; s4, after irradiation is completed, the rats are removed and transferred into a clean cage, the reaction of the rats after irradiation is observed, and the initial conditions of skin injuries including erythema and swelling are recorded; experiments should regularly record the health condition of the rat.

1. The name of this design product: Postoperative Breast Radiotherapy Bracket. 2. Purpose of this product design: Used to support the patient's breasts during radiotherapy to prevent sagging of the breasts and the obstruction of the skin under the breasts, which may cause radiation dermatitis. It also plays a role in preventing and protecting the skin damage in the radiotherapy area of ​​breast patients. 3. The key design point of this design product lies in the combination of shape and pattern. 4. The picture or photo that best illustrates the design points: use the status reference diagram.

A topical cream or ointment is provided that provides for the binding to CB1 and / or CB2 receptors for the soothing of pain, inflammation of smooth muscle, tendons, ligaments, skeletal muscle, endothelial cell, synovial cell, peripheral nerve fibers, reduction of endothelial bruising, promotion of healing of endothelial bruising, and dermatological itch sensation wherein the improvement comprises providing the effect of cannabinoid using plant extracts. A topically administered formulation is also provided for treating anal mucosal inflammation, soothing of pain, inflammation of anal mucosal inflammation; reducing keratinocyte apoptosis; treating viral-associated epithelial damage, treating radiation dermatitis; and treating chemotherapy-induced dermatitis.

The utility model provides a device for after tumor radiotherapy chest shielding and protection. The main frame whole of device is U shape structure, and the four arounds of main frame are fixed with edge board, soft pad, and the inside of main frame is fixed with top support, bottom support, edge support respectively, and left, right chest guard seat is fixed with top support, bottom support, edge support respectively with connecting rod, and chest guard is connected with left, right chest guard seat respectively, and rectangular frame is connected with main frame, and the edge board on both sides of main frame is fixed with braces, magic tape, and connecting band is fixed on neck fixed band, and main frame is connected with neck fixed band through hanging ear, hook and connecting band. The device is combined with the chest guard of main frame and rectangular frame, which forms a gap of 3-5cm between the device and the skin, protects the external preparation applied on the skin, prevents radioactive dermatitis infection and protects the privacy of the patient, has a reasonable structure design, is simple and practical to operate, and can be widely applied in clinical treatment.

The invention provides a silk fibroin skin protective agent and application, relates to the technical field of medical cosmetology, and provides a compound external composition aiming at radiodermatitis caused by radiotherapy. According to the preparation, silk fibroin is taken as a core active component, coated titanium dioxide core-shell particles, an antioxidant component and a moisturizing and repairing aid are combined, the components are proportioned according to the mass percent defined in the specification, and the pH value is kept within the range of 5.0-8.0. According to the composite inorganic particles, the photocatalytic activity is reduced through coating and surface modification, and silk fibroin endows good film forming and healing promoting characteristics in a nano-particle form, so that the synergistic effect of physical protection, oxidation resistance and barrier repair is achieved. The formulations are suitable for skin protection, wet healing and long-term barrier maintenance during and after radiotherapy. Specific preparation process parameters, various dosage form embodiments and a functional and safety assessment method are provided in the specification.

The invention relates to a medical ray protection preparation for relieving radiodermatitis, and belongs to the technical field of biomedical skin treatment. The preparation is composed of a preparation A and a preparation B. The preparation A is composed of the following components in percentage by weight: 0.01-0.03% of superoxide dismutase, 0.005-0.05% of trehalose and the balance of ultrapure water. The preparation B is prepared from the following components in percentage by weight: 0.01 to 0.04 percent of chlorogenic acid, 2.5 percent of potassium sorbate, 15 percent of sorbitol, 1 percent of hyaluronic acid, 2.5 percent of carboxymethyl chitosan and the balance of purified water. The superoxide dismutase, the trehalose, the chlorogenic acid and other active ingredients are utilized to relieve radiodermatitis from multiple aspects of removing active oxygen at a wound part, resisting inflammation, inhibiting bacteria and promoting skin barrier repair, and by utilizing the moisturizing and antibacterial effects of carboxymethyl chitosan and the functions of promoting collagen production and tissue repair of hyaluronic acid, the wound healing effect is improved, and the wound healing effect is improved. The radiodermatitis is comprehensively treated.

The utility model relates to the technical field of medical instruments, and particularly discloses a radiodermatitis auxiliary detecting instrument which comprises a detecting instrument body and a detecting pen, a display screen and operation buttons are arranged on the top of the detecting instrument body, an interface groove is formed in the side edge of the detecting instrument body, a wire is fixedly connected in the interface groove, and the wire is fixedly connected with the detecting pen. A handle clamping groove used for containing a detection pen is formed in the top of the detecting instrument body, a winding groove is formed in the side edge of the detecting instrument body, a winding wheel set used for winding a wire is arranged in the winding groove, and a positioning device used for limiting rotation of the winding wheel set is arranged at the top of the detecting instrument body. When the detecting instrument is carried, the detecting pen can be stored in the handle clamping groove in the top of the detecting instrument body, the wire can be stored in the winding groove in the side edge of the detecting instrument body, the redundant wire is wound in order through the winding wheel set, the wire is prevented from being dragged while unwinding of the wire is not affected, and the using and carrying safety of the detecting instrument is improved.

The present application relates to a kind of biological active microneedle patch for repairing radiation dermatitis and its preparation method and application, belong to biomedical material technical field.The microneedle patch of the present application includes backing layer and needle tip layer, wherein the material of backing layer is methacrylated hyaluronic acid with photo-crosslinking characteristics, the material of needle tip layer is silk fibroin and hyaluronic acid, and loaded with chlorogenic acid and adipose stem cell exosome as core bioactive component.The microneedle patch of the present application has excellent mechanical properties and biological activity, can minimally invasive penetration skin keratin layer barrier, realize the accurate delivery and sustained release of active ingredient to damaged tissue deep layer.Microneedle patch improves the problem of insufficient mechanical strength of natural polymer microneedle through the composite structure of "methacrylated hyaluronic acid backing + silk fibroin needle tip", realizes the synergistic effect of antioxidant, anti-inflammatory and extracellular matrix homeostasis reconstruction through "chlorogenic acid + adipose stem cell exosome", and can be used for repairing radiation dermatitis.

A method for alleviating radiation-induced skin damage (e.g., radiation dermatitis), comprising administering to a subject in need thereof a pharmaceutical composition comprising an effective amount of salvigenin and optionally silymarin, rosmarinic acid, carvacrol, or a combination thereof.

The invention relates to a medicine prescription for treating radiodermatitis and application thereof. The medicine comprises the following components in percentage by weight: 0.01%-2% of acetate of a peptide compound, 2%-5% of a first solvent, 0.05%-1.75% of a bacteriostatic agent, 0.5%-3% of a gel matrix, 0.05%-3% of a metal ion complexing agent, a pH regulator for regulating the pH value to 3-7, and a second solvent supplemented to 100%. The prescription of the medicine for treating radiodermatitis is especially suitable for symptomatic treatment of chronic pruritus such as atopic dermatitis, and the local action mechanism of the medicine gives consideration to both curative effect and safety. The medicine can be directly administered to an affected part, so that the uncertainty of in-vivo circulation is reduced; the use by patients is convenient and the compliance is improved.

The invention discloses an ointment for radiodermatitis, a preparation method and an external medicine, and the ointment for radiodermatitis comprises the following components: 15 g of dried periplaneta americana polypide, 20 g of rhizoma bletillae, 15 g of scutellaria baicalensis, 10 g of lithospermum, 15 g of radix angelicae, 50 g of angelica sinensis, 0.5 g of dragon's blood, 30 g of liquorice and 50 g of beewax. The preparation method of the ointment for radiodermatitis is characterized by comprising the following steps: S1, cutting dry American cockroach bodies, rhizoma bletillae, radix scutellariae, radix arnebiae seu lithospermi, radix angelicae, radix angelicae sinensis and liquorice into pieces, adding sesame oil, and stirring and infiltrating; s2, carrying out ultrasonic extraction at 55 DEG C, and filtering after extraction, and S3, concentrating an extracting solution to a proper concentration to prepare an initial ointment; s4, taking natural beewax, heating to 60 DEG C, fully melting, filtering, pouring the ointment in the stirring process, fully and uniformly mixing, and continuously stirring; and S5, taking the mixed solution, adding the dragon's blood powder into the mixed solution, stirring at 60 DEG C, and naturally cooling to obtain the finished ointment.