11 results about "Mucosal inflammation" patented technology

The present invention relates to the field of probiotics, in particular to an Akkermansia muciniphila MG784 for alleviating constipation, promoting defecation, improving intestinal barrier function and intestinal immunity, and its uses. The Akkermansia muciniphila MG784 provided by the present invention has the deposition number DSM 35549. The Akkermansia muciniphila MG784 provided by the present invention can increase the levels of motilin (MTL), gastrin (GAS), and acetylcholine in the gastrointestinal tract, promote intestinal peristalsis, improve the small intestine propulsion rate, and ameliorate defecation time and fecal output. Furthermore, Akkermansia muciniphila MG784 can also alleviate colonic mucosal inflammation, improve the thickness of the digestive tract muscular layer, modulate the structure of the intestinal microbiota, significantly increase the abundance of beneficial bacteria, and decrease the abundance of harmful bacteria.

This invention discloses a traditional Chinese medicine composition for treating ulcerative colitis, its preparation method, combined drugs, and applications. The traditional Chinese medicine composition for treating ulcerative colitis of this invention is made from the following raw materials in parts by weight: Astragalus membranaceus 13-26 parts, Lonicera japonica 10-20 parts, Sargentodoxa cuneata 10-20 parts, Prunus mume 8-16 parts, Agrimonia pilosa 8-16 parts, Allium macrostemon 6-12 parts, Platycodon grandiflorus 6-12 parts, Coptis chinensis 3-6 parts, and Panax notoginseng powder 1-3 parts. An animal model of ulcerative colitis was constructed using DSS induction, and the results showed that the traditional Chinese medicine composition of this invention has a certain therapeutic effect on ulcerative colitis. Clinical studies showed that the traditional Chinese medicine composition of this invention, used in combination with mesalazine enteric-coated tablets, can reduce the modified Mayo score and serum inflammatory markers in patients with active ulcerative colitis, improve colonic mucosal inflammation and gastrointestinal symptoms, and effectively treat active ulcerative colitis of the damp-heat type.

Disclosed are compositions and methods for treating, amelioriating, reversing and / or preventing (acting as a prophylaxis): a respiratory condition involving an infection or an inflammation, or any lung condition involving inflammation or infection, e.g., of a respiratory mucosa, and / or an infection or an inflammation of an underlying muscle of the respiratory tract; or, an asthma; a bronchitis; a sinusitis or rhinosinusitis; an infection of a sinus; chronic obstructive airway disease; emphysema; chronic bronchitis; pneumonia; or, a bronchiectasis. In alternative embodiments, the therapeutic combination comprises an orally administered Amphotericin B or equivalent antifungal alone, or a combination of Amphotericin B and: one antibiotic; two antibiotics; three antibiotics; or, four or more antibiotics. In alternative embodiments, these compositions and methods are dosaged and administered to children in need thereof. In alternative embodiments, compositions and methods of the invention are dosaged, formulated and dosaged as tablet, capsule, liquid, powder or aerosol preparations or formulations, or preparations or formulations for oral delivery or inhalation.

The present application belongs to the field of biological medicine and food technology, and particularly relates to application of milk-derived extracellular vesicles in improving brain health and / or improving nerve-related discomfort conditions. Compared with the prior art, the present application constructs a chronic restraint stress (CRS) induced anxiety model in adolescent mice, and uses open field test, buried bead test, tail suspension test and other behavioral experiments for functional evaluation. The results show that the milk-derived extracellular vesicles significantly improve the anxiety-like behavior of mice, indicating that the milk-derived extracellular vesicles can significantly improve the anxiety-like behavior of adolescent mice induced by chronic restraint stress (CRS) by remodeling the gut-brain axis function, and that the supplementation of milk-derived extracellular vesicles in adolescents can significantly reduce the susceptibility to anxiety in adulthood. At the same time, the present application also constructs a D-gal induced cognitive impairment model in mice, and the results show that it can reduce the production of pro-inflammatory cytokines, inhibit mucosal inflammation, thereby maintaining intestinal homeostasis and alleviating cognitive impairment.

The invention discloses lactobacillus helveticus PP0208 and application thereof in prevention and treatment of allergic rhinitis, and belongs to the technical field of microorganisms. The technical problem to be solved is to provide the lactobacillus helveticus for treating the allergic rhinitis, and the key point of the technical scheme is that the lactobacillus helveticus PP0208 is provided, and the preservation number of the lactobacillus helveticus PP0208 is CGMCC (China General Microbiological Culture Collection Center) No.28753. The lactobacillus helveticus PP0208 viable bacteria, the thermally inactivated bacteria and the extracellular vesicles of the lactobacillus helveticus PP0208 disclosed by the invention all have the effect of remarkably inhibiting allergic rhinitis mucosal inflammation, can down-regulate the expression of inflammatory factors and regulate the proportion of Treg cells, and cooperatively promotes the development of diseases towards the healing direction by coordinating the intestinal flora structure and the change of metabolites of the intestinal flora structure. The compound has a wide application prospect in preparation of drugs for effectively preventing and treating allergic rhinitis.

The invention discloses an oral cavity cleaning device for neurosurgical nursing, and particularly relates to the technical field of clinical nursing, a patient arm-chair is fixedly connected to the upper end of a supporting base, a nursing support is fixedly connected to the patient arm-chair, and a fixing bottom plate fixedly connected to the upper end of the supporting base is arranged below the patient arm-chair; and a spray gun is arranged on the fixed bottom plate. According to the oral cavity cleaning device for neurosurgery nursing, through the synergistic effect of the switching assembly and the driving assembly, mechanical switching of three core functions of water spraying cleaning, air injection drying and air suction pollution discharge is achieved, in the water spraying mode, high-pressure clear water can be used for flushing residues in hidden areas such as tooth slits and tongue coating, and the cleaning effect is good. The air injection mode can quickly blow-dry oral effusion and reduce mucosa inflammation caused by a humid environment, the air suction mode can efficiently remove residual effusion and falling residues in the oral cavity through negative pressure adsorption of an air pump, and the problems that a traditional tool is not thorough in cleaning and needs to frequently replace equipment are solved.

A topical cream or ointment is provided that provides for the binding to CB1 and / or CB2 receptors for the soothing of pain, inflammation of smooth muscle, tendons, ligaments, skeletal muscle, endothelial cell, synovial cell, peripheral nerve fibers, reduction of endothelial bruising, promotion of healing of endothelial bruising, and dermatological itch sensation wherein the improvement comprises providing the effect of cannabinoid using plant extracts. A topically administered formulation is also provided for treating anal mucosal inflammation, soothing of pain, inflammation of anal mucosal inflammation; reducing keratinocyte apoptosis; treating viral-associated epithelial damage, treating radiation dermatitis; and treating chemotherapy-induced dermatitis.

The invention discloses sound power driven Janus hydrogel as well as a preparation method and application thereof. The hydrogel comprises silver peroxide and a hydrogel matrix, the hydrogel matrix is prepared from methacrylated silk fibroin, gamma-polyglutamic acid-N-hydroxysuccinimide ester and a photoinitiator. Through component synergy and structural innovation, the prepared hydrogel can release ROS according to ultrasonic drive, destroys bacterial biofilms, and cooperates with Ag < + > slowly released by Ag2O2 to achieve an efficient sterilization effect; after the hydrogel is cross-linked by ultraviolet light, a Janus structure of which one side is adhered and the other side is anti-adhesion can be formed. Pharmacodynamic experiment results show that the sonodynamic-driven Janus hydrogel prepared by the invention has an excellent antibacterial effect, can be used for promoting wound healing, repairing alveolar bone defects and the like, and also provides a new choice for repairing infections such as periodontitis, oral mucosa inflammation and the like or skin wounds.

The invention belongs to the technical field of biomedicine, and particularly relates to application of a cocklebur fruit plant exosome to treatment of allergic rhinitis, the cocklebur fruit plant exosome has a definite treatment effect on the allergic rhinitis, can improve allergic behaviors, relieve respiratory mucosa inflammation and down-regulate expression of allergy-related molecules (IgE, IL-4 and histamine), and can be used for treating allergic rhinitis. The anti-inflammatory and anti-allergic active ingredients of the fructus xanthii are naturally enriched, so that the bioavailability of the active ingredients is remarkably improved; the therapeutic effects of inhibiting histamine release, regulating immune balance and relieving nasal mucosa inflammation infiltration are achieved by relying on the carried natural active substances; meanwhile, by virtue of inherent low immunogenicity and high biocompatibility of the plant exosome, the safety concern of a traditional Chinese medicine preparation is avoided, and the medication safety is remarkably improved.

Hyperbranched dextrins, preferentially hyperbranched and hydrogenated dextrins, for topical use in the prevention or treatment of at least one symptom selected from redness, heat, swelling and pain, as well as in the prevention or treatment of the symptoms of skin inflammation and of mucosal inflammation. The invention also relates to the use of these hyperbranched, and preferably hyperbranched and hydrogenated, dextrins to prevent or reduce or eliminate the irritant effect induced by ingredients contained in cosmetic or dermatological compositions.

The present disclosure relates to 1,4:3,6-dianhydrohexitol, specifically isosorbide, and compositions comprising 1,4:3,6-dianhydrohexitol for treating oral inflammatory conditions. These conditions, which include both oral mucosal inflammation and periodontal diseases, are characterized by elevated levels of pro-inflammatory mediators, particularly IL-1 alpha and IL-8. Using the EpiOral™ model, isosorbide has demonstrated significant ability to reduce IL-1 alpha secretion and IL-8 gene expression in inflamed oral epithelial cells. These results support its therapeutic relevance in treating oral inflammatory conditions through modulation of key inflammatory mediators.