43 results about "Therapeutic Hormone" patented technology

The present disclosure provides industrially scalable methods of making (Z)-endoxifen or a salt thereof, crystalline forms of endoxifin, and compositions comprising them. The present disclosure also provides methods for treating hormone-dependent breast and hormone-dependent reproductive tract disorders.

The present invention relates to a pharmaceutical composition for oral administration, for example in the form of a tablet or a powder suitable to be filled into a capsule shell, comprising 2-(isoindolin-2-ylmethyl)-5-((1-(methylsulfonyl)- piperidin-4-yl)methoxy)-4H-pyran-4-one (I) or a pharmaceutically acceptable salt thereof as an active ingredient. Compound (I) or a pharmaceutically acceptable salt thereof is a selective inhibitor of CYP11A1 enzyme and is useful in the treatment of hormonally regulated diseases such as cancer including prostate cancer and breast cancer.

The present disclosure provides industrially scalable methods of making (Z)-endoxifen or a salt thereof, crystalline forms of endoxifen, and compositions comprising them. The present disclosure also provides methods for treating hormone-dependent breast and hormone-dependent reproductive tract disorders.

The invention relates to application of Sirt1 in preparation of products for diagnosis, prognosis or treatment of steroid-induced femoral head necrosis, and belongs to the technical field of biotechnology and medicine. It is found that Sirt1 participates in dexamethasone-induced osteoblast ferroptosis, differential expression of Sirt1 can significantly affect the degree of dexamethasone-induced osteoblast ferroptosis, and occurrence of the steroid-induced femoral head necrosis phenomenon is prompted. The invention provides application of Sirt1 as a marker molecule for diagnosing steroid-induced femoral head necrosis in preparation of a reagent for diagnosing or screening steroid-induced femoral head necrosis, and provides application of an expression promoter of Sirt1 in preparation of a medicine for treating steroid-induced femoral head necrosis.

The present disclosure provides industrially scalable methods of making (Z)-endoxifen or a salt thereof, crystalline forms of endoxifin, and compositions comprising them. The present disclosure also provides methods for treating hormone-dependent breast and hormone-dependent reproductive tract disorders.

Described herein are methods of treating a biochemical relapse patient of hormone-sensitive prostate cancer using a pharmaceutical product comprising an androgen receptor inhibitor, such as dalotamide.

A drug delivery system for oral administration of hydrophobic drugs with enhanced and extended absorption and improved pharmacokinetics is provided. In one embodiment, formulations comprising testosterone and testosterone esters, e.g., testosterone palmitate, are disclosed. Methods of treating a hormone deficiency or effecting male contraception with the inventive formulations are also provided.

The present disclosure provides industrially scalable methods of making (Z)-endoxifen or a salt thereof, crystalline forms of endoxifin, and compositions comprising them. The present disclosure also provides methods for treating hormone-dependent breast and hormone-dependent reproductive tract disorders.

The present application relates to a kind of SGLT2 inhibitor in the preparation for treating hormone receptor low reaction type reproductive system disease in the application of drug, in particular, SGLT2 inhibitor and hormone can improve or enhance the sensitivity and / or for reversing the drug resistance of endocrine therapy drug, such as hormone, can enhance the therapeutic effect of such drug, especially in drug-resistant reproductive system disease and tumor treatment has good application prospect.

Methods for treating hormonally driven disorders by administering the PI3K / mT0R inhibitor gedatolisib in combination with hormone therapy are provided. Hormonally driven disorders include, for example, prostate cancer and endometrial disorders. The treatment regimens can also include additional therapies, such as chemotherapy, surgery and / or administration of an immune checkpoint inhibitor(s), a receptor tyrosine kinase inhibitor, a CDK 4 / 6 inhibitor or an epigenetic-targeted therapy.

A composition contains β-glucan and is used for preventing and / or treating hormone-dependent dermatitis, skin mucositis or other skin inflammatory diseases.

The invention belongs to the technical field of medicinal chemistry, and particularly relates to a pharmaceutical composition for treating hormone-resistant severe asthma and application of the pharmaceutical composition. The invention relates to an application of pentagalloylglucose (PGG) in preparation of a medicine for treating or preventing hormone-resistant severe asthma. The traditional Chinese medicine composition has a better effect on emphysema caused by severe asthma. The invention reveals and verifies that intestinal injury is a key upstream factor causing severe asthma and hormone resistance for the first time. Through targeted repair of intestinal tracts, the PGG can fundamentally remodel the immune microenvironment of the lung, and creates conditions for hormone to play a role. The discovery breaks through the limitation that traditional asthma treatment only focuses on local targets of the respiratory tract, and a brand new theoretical basis and a feasible solution are provided for overcoming the worldwide problem of hormone resistance.

To provide: diarylhydantoin compounds, including diarylthiohydantoins; methods for synthesizing them; and methods for using them in the treatment of hormone refractory prostate cancer.SOLUTION: A method for treating a hyperproliferative disorder comprises administering a pharmaceutical composition of the present invention to a subject in need of such treatment, thereby treating the hyperproliferative disorder. The invention provides a series of compounds having strong antagonistic activities with minimal agonistic activities against AR.SELECTED DRAWING: None

To provide a combination therapy for use in treating hormone receptor positive and HER2 negative locally advanced unresectable or metastatic breast cancer.SOLUTION: Provided is a method comprising administering a combination therapy including ipatasertib, fulvestrant, and a CDK4 / 6 inhibitor over a 28-day cycle.SELECTED DRAWING: Figure 1A

The present disclosure relates to compositions and methods for treating hormone receptor positive (HR+) cancer with (Z)-endoxifen and a CDK4 / 6 inhibitor, such as abemaciclib. The disclosure is based on the discovery that (Z)-endoxifen and abemaciclib have synergistic effects on reducing tumor growth and proliferation in breast cancer models. The disclosure also provides fixed dose combinations of (Z)-endoxifen and abemaciclib, which offers advantages in terms of convenience and compliance. The compositions and methods are suitable for treating subjects with hormone receptor positive (HR+) and human epidermal growth factor receptor 2 negative (HER2-) breast cancer, especially those who are contraindicated for aromatase inhibitor therapy and / or ovarian suppression therapy.

The present disclosure provides industrially scalable methods of making (Z)-endoxifen or a salt thereof, crystalline forms of endoxifin, and compositions comprising them. The present disclosure also provides methods for treating hormone-dependent breast and hormone-dependent reproductive tract disorders.

The invention provides a cortex phellodendri composition for treating facial hormone-dependent dermatitis and a preparation method of the cortex phellodendri composition, and relates to the technical field of traditional Chinese medicines. The golden cypress composition is prepared from the following traditional Chinese medicines in parts by weight: 5-15 parts of golden cypress, 3-10 parts of fructus forsythiae, 2-7 parts of honeysuckle, 2-7 parts of oriental wormwood, 1-4 parts of dandelion and 0.5-2 parts of cassia twig. The cortex phellodendri composition disclosed by the invention can be used for treating hormone-dependent dermatitis after being coated or pasted on the face, and is quick in effect taking, good in effect and not easy to relapse.

The present invention discloses a system and method for preparing and delivering various precursor compositions as a replacement therapy for testosterone and other hormone deficiencies that naturally occur with aging in humans and other mammals. Precursor compositions are selected and designed for the purpose of formulating non-toxic therapeutic hormone supplement for oral consumption. The invention features low dose continuous supplementation to be incorporated with daily meals. The process of the present invention delivers an orally ingested substance, e.g., a food, supplement, etc., that contains an anti-aging formulation comprising a hormone precursor (prohormone) that is absorbed by the digestive system and secreted into the bloodstream with a second substance to facilitate its ingestion, absorption and delivery to the body's tissues.

The present application, in certain aspects, pertains to methods and compositions for the treatment of a hormone-dependent cancer (such as an endometrial cancer (e.g., endometrioid endometrial cancer) or hormone-receptor positive breast cancer), using a composition comprising nanoparticles comprising sirolimus and an albumin in combination with an estrogen suppressor (such as letrozole or fulvestrant).

The invention provides an application of angelica sinensis in promoting hair growth. Specifically, the invention provides application of a traditional Chinese medicine angelica sinensis or an extract thereof in preparation of a composition or a preparation capable of improving hair damage caused by external glucocorticoid. The invention also provides a composition containing the angelica sinensis or the extract thereof, application of the composition, and a method for improving hair damage by using the angelica sinensis or the extract thereof. Experiments show that the angelica sinensis or the extract thereof can effectively improve the hair damage degree, the hair growth cycle and the in-vivo hormone level, so that the newborn hair coverage area and the newborn hair length are increased, the hair rest period is shortened, the hair growth period is advanced, and the hair follicle growth state is improved. Wide application prospects are realized in the fields of treating hair injury, alopecia and the like caused by hormones.

The present invention relates to an improved process for the preparation of 4H-pyranone structured CYP11A1 inhibitors such as 2-(isoindolin-2-ylmethyl)-5-((1-(methylsulfonyl)piperidin-4-yl)methoxy)-4H-pyran-4-one (1A) and key intermediates thereof such as 2-(chloromethyl)-5-hydroxy-4H-pyran-4-one (II), 5-hydroxy-2-(isoindolin-2-ylmethyl)-4H-pyran-4-one (III), (1-(methylsulfonyl)piperidin-4-yl)methyl methane sulfonate (V′) and (1-(methyl-sulfonyl)piperidin-4-yl)methyl 4-methylbenzene sulfonate (V″). CYP11A1 inhibitors are useful in the treatment of hormonally regulated cancers, such as prostate cancer and breast cancer.

We disclose a pharmaceutical composition adapted for oral delivery comprising native testosterone; a treatment regimen comprising administration of the composition(s); and methods and uses for the treatment of hormone related conditions such as hypogonadism in human male, female and transgender subjects.

The present invention relates to diarylhydantoin compounds, including diarylthiohydantoins, and methods for synthesizing them and using them in the treatment of hormone refractory prostate cancer.

Methods for treating hormonally driven disorders by administering the PI3K / mTOR inhibitor gedatolisib in combination with hormone therapy are provided. Hormonally driven disorders include, for example, prostate cancer and endometrial disorders. The treatment regimens can also include additional therapies, such as chemotherapy, surgery and / or administration of an immune checkpoint inhibitor(s), a receptor tyrosine kinase inhibitor, a CDK 4 / 6 inhibitor or an epigenetic-targeted therapy.

A drug for preventing or treating steroid-induced osteonecrosis of the femoral head, comprising an active ingredient cycloastragenol. The drug can remarkably improve intraosseous blood supply in the steroid-induced osteonecrosis of the femoral head, reduce formation of necrotic areas and empty lacunae, decrease excessive bone resorption and reduce CTSK protein expression, and provide a potential prevention and treatment scheme for treatment of steroid-induced osteonecrosis of the femoral head.

The invention relates to endocrine therapy for use in a method of treating a hormone-receptor (HR)-positive breast cancer, that is typed as having a low risk of recurrence. The invention further relates to methods of treating an individual with HR-positive breast cancer with endocrine therapy according to the cancer's typed risk of recurrence.

The present disclosure provides industrially scalable methods of making (Z)-endoxifen or a salt thereof, crystalline forms of endoxifen, and compositions comprising them. The present disclosure also provides methods for treating hormone-dependent breast and hormone-dependent reproductive tract disorders.

The present invention relates to compounds capable of inhibiting TRIM24 activity and their use in combination with androgen deprivation therapy and / or androgen receptor signaling inhibitors and / or any type of AR inhibitor (e.g., pharmacological AR degrader) in a method of treatment of a hormone-sensitive metastatic prostate cancer, in particular in prostate cancer that are characterized by recurrent point mutations in SPOP. Moreover, the invention posits the use of inhibiting TRIM24 activity for the treatment of AR-V7-driven castration-resistant prostate cancer (CRPC).

The present invention discloses a system and method for improving the quality of life in canines and other domesticated animals. As animals age testosterone and other supportive hormones diminish causing reduced activity, a lack of mobility, decreased bone density, and general well-being. Precursor compositions are selected and designed for the purpose of formulating non-toxic therapeutic hormone supplements for oral consumption. The process and method of this invention is comprised of therapies produced from two or more selected non-toxic prohormones that combine during digestion and delivered through a chewable and edible gummy treat. As such there is no requirement for changing the subject's current diet. The present invention features a continuous low dose supplementation to be incorporated daily whereby dosages are correlated according to the subject's age, weight, sex, and breed. The beneficial results of the present invention are achieved through the absorption of the prohormones in the composition into the bloodstream effecting delivery to all cells including those specific cells where the conversion enzymes are activated by the organism's needs. The delivery and transport of inactive prohormones minimizes liver toxicity since the precursors are carried through the hepatic portal system to and through the liver and into general circulation in inactive forms.

The present invention relates to compounds capable of inhibiting TRIM24 activity and their use in combination with androgen deprivation therapy and / or androgen receptor signaling inhibitors and / or any type of AR inhibitor (e.g., pharmacological AR degrader) in a method of treatment of a hormone-sensitive metastatic prostate cancer, in particular in prostate cancer that are characterized by recurrent point mutations in SPOP. Moreover, the invention posits the use of inhibiting TRIM24 activity for the treatment of AR-V7-driven castration-resistant prostate cancer (CRPC).