45 results about "Respiratory Mucosa" patented technology

The invention provides a polypeptide, and the sequence of the polypeptide is AEDVGDVAFVKNDT. The polypeptide provided by the invention can inhibit the human respiratory syncytial virus surface protein F so as to inhibit the fusion of the human respiratory syncytial virus surface protein F and a host cell membrane. The invention also provides the sheep colostrum. The sheep colostrum comprises the polypeptide with the antiviral function, so that the sheep colostrum is helpful for old people with relatively weak resistance to resist infection of human respiratory syncytial viruses and promotes repair of respiratory mucosa. The invention also provides a preparation method of the sheep colostrum. The preparation method is simple and can be used for industrial production. The invention also provides a preparation method of the polypeptide.

The invention belongs to the technical field of medical equipment, and particularly relates to pneumology department foreign matter forceps which comprise forceps handles, the upper ends of the forceps handles are fixedly connected with connecting blocks, forceps clips are rotationally arranged on the two sides of the upper end of a sleeve, and traction type rotating mechanisms used for adjusting the angle of foreign matter are further arranged on the forceps clips. The traction type rotating mechanism comprises a rotating block rotationally arranged on one side of the upper end of the forceps holder, and an anti-skid pad is arranged on one side of the rotating block; by means of the traction type rotating mechanism, when the foreign matter is a long-strip sharp foreign matter such as a fishbone and a pin, the foreign matter is clamped between the two rotating blocks, the rotating blocks are driven to rotate so that the foreign matter can rotate, when the foreign matter rotates, the two sharp ends of the foreign matter can be away from the inner wall of the respiratory tract till the foreign matter is parallel to the sleeve, and at the moment, the foreign matter is taken out; therefore, the condition that a patient feels uncomfortable due to the fact that the respiratory mucosa is punctured by the foreign matter in the taking-out process due to scraping between the foreign matter and the respiratory tract can be avoided.

The present application provides a low odor / low whitening structure instant adhesive and a preparation method thereof. The low odor / low whitening structure instant adhesive comprises 70-90 wt% of cyano acrylate, 3-20 wt% of acrylic acid copolymer, 1-13 wt% of fumed silica, 0.2-2 wt% of plasticizer, 0.1-1 wt% of carbon black and 0-0.05 wt% of additive in terms of mass fraction. The present application selects ultra-high purity monomers in the environment of low polymerization inhibitor, which can significantly shorten the polymerization induction period, so that the monomer can be instantaneously initiated and completely cured after contacting the surface of the substrate, thereby minimizing the release of volatile monomers into the environment, further reducing the gaseous monomer that causes respiratory tract / mucosa irritation from the source, and inhibiting the polymerization of volatile monomers in the air to form white powder.

According to the fixing and lubricating device for the bronchoscope catheter, an elastic sponge body is arranged in a first cylinder, a first through hole in interference fit with the bronchoscope catheter is formed in the elastic sponge body, the bronchoscope catheter penetrating through the first through hole is flexibly clamped, and clamping and fixing of the bronchoscope catheter are achieved; a doctor can loosen the bronchoscope catheter and emphatically operate the bronchoscope body with two hands, so that the operation convenience is improved, the bronchoscope catheter is subjected to additional resistance when just entering the body of a patient, the operation safety is improved, and lubricating oil is filled between the first barrel and the second barrel, so that the bronchoscope catheter is more convenient to use. The elastic sponge body absorbs lubricating oil through the sponge strips, so that the outer surface of the bronchoscope catheter is uniformly lubricated when the bronchoscope catheter penetrates through the first through hole, friction between the bronchoscope catheter and the respiratory mucosa of a patient is reduced, and the respiratory mucosa is not prone to being damaged.

The invention belongs to the technical field of biological medicine, and particularly relates to a respiratory tract allergic inflammation relieving agent based on environmental microorganism extracts and application of the respiratory tract allergic inflammation relieving agent. According to the invention, the application of the paracoccus iili in preparation of the product for preventing and treating the chronic respiratory disease is found for the first time, and the paracoccus iili as a purely natural and pollution-free environmental beneficial bacterium does not destroy the balance of microorganisms in an indoor environment, can generate beneficial metabolites, and is beneficial to reducing the risk of the respiratory disease. Cell and animal experiments find that the paracoccus Iili can reduce asthma-related inflammatory factors, directly acts on respiratory mucosa through inhalation exposure, can play a role in preventing and protecting respiratory diseases, and has a good development value. The asthma prevention and treatment product based on paracoccus Israei can be combined with balance maintenance of microbial communities, and a comprehensive and sustainable respiratory disease risk prevention effect is provided for the indoor environment.

The invention discloses an infrared glazing dryer for digital presswork, and belongs to the field of digital presswork processing. Comprising a bottom plate, the upper surface of the bottom plate is fixedly connected with a drying box, the left side of the interior of the drying box is provided with a through feeding port, the right side of the interior of the drying box is provided with a through discharging port, and two infrared lamps are symmetrically arranged on the upper portion of the interior of the drying box; solvent waste gas volatilized in the drying process is captured in real time through a negative pressure system composed of an air exhaust box and an air exhaust nozzle, harmful substances in the waste gas are effectively removed in cooperation with adsorption of an activated carbon net and filtration of a filter net, discomfort such as headache and nausea caused by suction of workers is avoided, and the risk of respiratory mucosa injury and liver and kidney dysfunction is reduced; meanwhile, the design that the drawing plate is matched with the handle is adopted, the activated carbon net can be rapidly replaced, the net body stability is ensured through the supporting plate, maintenance does not need tools, and time and labor are saved.

The present application provides a tuberculosis vaccine based on bovine beta defensin 5 and its application in preventing tuberculosis, which comprises a fusion protein of tuberculosis AH antigen and bovine beta defensin 5 or a coding sequence thereof. The present application fuses and expresses Ag85A and HspX, which are surface dominant antigens of Mycobacterium tuberculosis, and an optimized sequence of bovine beta defensin 5, and then purifies the protein to mix with poly I:C to prepare a fusion protein vaccine AHB-P. Or the coding sequence of the fusion gene is optimized and then connected to a vector pVAX1 to prepare a fusion DNA vaccine pVAX1-AHB. The respiratory mucosa of mice is immunized with the two fusion vaccines, and it is proved that the two fusion vaccines can enhance the body's resistance to tuberculosis infection.

This invention belongs to the technical field of functional foods or health foods, specifically relating to a composition for improving respiratory health, its preparation method, and its application. By weight, the composition comprises: 10-100 parts of boysenberry apple powder, 2-20 parts of yeast β-glucan, and 1-10 parts of inactive edible yeast Epicor. This invention, through the scientific ratio of boysenberry apple powder, yeast β-glucan, and inactive edible yeast Epicor, and a targeted enzymatic hydrolysis process, helps enhance the immune function of the respiratory mucosa, maintain respiratory comfort, and is gentle, safe, and suitable for long-term consumption.

The present invention provides a subglottic suction device, comprising: a sputum culture bottle, a connecting assembly, an air inlet cylinder, a mounting cylinder, an adjusting assembly, and a locking mechanism. By moving the adjusting assembly so that the adjusting assembly is clamped on the locking mechanism, the air inlet corresponding to the adjusting assembly is opened, and at this time, outside air will enter the sputum culture bottle through the opened air inlet, thereby reducing the negative pressure value in the sputum culture bottle. By changing the number of groups of adjusting assemblies clamped on the locking mechanism, the corresponding number of air inlet holes can be opened, thereby facilitating the adjustment of the negative pressure value in the sputum culture bottle to the negative pressure value required for subglottic suction according to demand. Then, the connecting tube is connected to the suction tube on the air bag to perform subglottic suction. By separating the adjusting assembly and the locking mechanism, the adjusting assembly can be again blocked by the air inlet, making it convenient to switch between sputum suction and subglottic suction operations without adjusting the negative pressure gauge. The adjustment is convenient, and the risk of causing respiratory mucosal damage and bleeding is reduced.

The utility model provides a controllable subglottic suction connector. The controllable subglottic suction connector comprises a connecting body, a first sealing piece and a second sealing piece. The connecting body is provided with a first connecting end, a second connecting end and a third connecting end which are communicated with one another. The first sealing piece is movably installed at the second connecting end so as to control the second connecting end to be opened or closed. The second sealing piece is movably installed at the third connecting end so as to control the third connecting end to be opened or closed. The controllable subglottic suction connector at least has the following advantages that operation is flexible and convenient, pressure relief is sufficient, and the injury risk of respiratory tract mucosa of a patient is reduced; 2, the sputum suction device and the subglottic suction tube do not need to be repeatedly pulled and inserted for many times, and cross infection caused by sputum secretions and generated aerosol can be effectively avoided; and 3, the design structure is simple, materials are convenient to take, the operation is convenient, and the manufacturing cost and the use cost are low. And 4, the thumb is not in direct contact with sputum in the connecting body, so that the risk of occupational exposure of nurses is greatly reduced.

Disclosed are compositions and methods for treating, amelioriating, reversing and / or preventing (acting as a prophylaxis): a respiratory condition involving an infection or an inflammation, or any lung condition involving inflammation or infection, e.g., of a respiratory mucosa, and / or an infection or an inflammation of an underlying muscle of the respiratory tract; or, an asthma; a bronchitis; a sinusitis or rhinosinusitis; an infection of a sinus; chronic obstructive airway disease; emphysema; chronic bronchitis; pneumonia; or, a bronchiectasis. In alternative embodiments, the therapeutic combination comprises an orally administered Amphotericin B or equivalent antifungal alone, or a combination of Amphotericin B and: one antibiotic; two antibiotics; three antibiotics; or, four or more antibiotics. In alternative embodiments, these compositions and methods are dosaged and administered to children in need thereof. In alternative embodiments, compositions and methods of the invention are dosaged, formulated and dosaged as tablet, capsule, liquid, powder or aerosol preparations or formulations, or preparations or formulations for oral delivery or inhalation.

The invention relates to a compound atomized liquid for pet respiratory mucosa and a preparation method thereof. Each 100 mL of the compound atomized liquid is prepared from 0.15 to 0.20 g of a liquorice root extract, 0.18 to 0.25 g of L-lysine hydrochloride, 0.20 to 0.25 g of chitosan oligosaccharide, 0.25 to 0.35 g of yeast-beta-glucan, 0.008 to 0.015 g of EDTA-2Na (Ethylene Diamine Tetraacetic Acid), 0.4 to 0.6 g of trehalose, 0.65 to 0.75 g of sodium chloride, 0.5 to 1.0 mg of micromolecular antimicrobial peptide and the balance of citric acid / phosphate buffer solution. Wherein the molecular weight of the chitosan oligosaccharide is less than or equal to 2000Da; the pH value of the compound atomized liquid is 6.0-7.0; and the osmotic pressure of the compound atomized liquid is 280-320 mOsm / kg. By compounding the natural anti-inflammatory component, the immunopotentiator, the mucosa protective agent and the micromolecular antimicrobial peptide, synergistic treatment is realized, and side effects are reduced.

The invention provides a pharmaceutical composition of a nintedanib solution for inhalation. The pharmaceutical composition comprises a first container and a second container, the first container is filled with a first solution, and the first solution contains nintedanib or pharmaceutically acceptable salt thereof and does not contain a nonionic osmotic pressure regulator; the second container is filled with a second solution, and the second solution contains an ionic osmotic pressure regulator and a nonionic osmotic pressure regulator. The medicinal composition disclosed by the invention is simple in component, stable in preparation, capable of avoiding generation of genotoxic impurities, high in safety, lower in irritation to respiratory mucosa and capable of improving the compliance of a patient.

The invention discloses a low-injury lung isolation ventilation catheter, belongs to the technical field of lung isolation equipment, and aims to solve the problems that although a product in split type insertion connection has certain flexibility, only pure insertion connection lacks an effective limiting structure, and the connection stability is insufficient. The three-way connector can rotate relative to the connecting pipe, connection stability and operation flexibility are both considered, surgical operation smoothness is improved, independent inflation cavities achieve independent control of multiple air bags, fixation is reliable, cross influence is avoided, the isolation effect is better, the drainage function of the affected side lung is achieved, and the structure design of the independent drainage cavities is adopted, so that the drainage effect is good. The device has the advantages that the device is simple in structure and convenient to operate, aspiration in the resuscitation period caused by pulmonary effusion on the affected side is prevented, clinical application is safer, the visual cavity is matched with the camera, accurate catheterization is achieved, respiratory mucosa injury is reduced, the stability problem of a split type plug-in product is solved, and the risks of displacement and unplanned catheter drawing in an operation are avoided through double limiting of the limiting ring, the clamping groove and the limiting plate.

The application discloses a kind of children respiratory tract secretion negative pressure cleaning equipment, comprising: cleaning device and medicament adding device.Cleaning device includes secretion suction pipe, secretion collection tank and negative pressure generator, one end of secretion suction pipe is equipped with suction head, a plurality of suction holes are opened in the lateral wall of suction head, a plurality of suction holes are spaced distribution along the circumference of suction head, the tail end of secretion suction pipe is connected with the inlet of secretion collection tank, the outlet of secretion collection tank is connected with the inlet of negative pressure generator;Medicament adding device includes medicament injection pipe and liquid storage tank, one end of medicament injection pipe is communicated with liquid storage tank.A plurality of suction holes effectively expand the coverage of single suction, significantly reduce the risk of a single suction hole being completely blocked, ensure the continuity of suction process, while avoiding potential damage to respiratory mucosa by pressure fluctuation.By the way of lubricating mucosa, diluting viscous secretion, thereby reducing suction resistance and improving the tolerance of sick children.

The invention provides a low-odor / low-whitening structure instant adhesive and a preparation method thereof. The low-odor / low-whitening structure instant adhesive is prepared from the following components in percentage by mass: 70 to 90 weight percent of cyanoacrylate, 3 to 20 weight percent of acrylic acid copolymer, 1 to 13 weight percent of fumed silica, 0.2 to 2 weight percent of plasticizer, 0.1 to 1 weight percent of carbon black and 0 to 0.05 weight percent of additive. The polymerization induction period can be remarkably shortened by selecting the ultra-high-purity monomers in the environment of a low polymerization inhibitor, so that the monomers can be instantaneously initiated and completely cured after being in contact with the surface of a base material, release of volatile monomers to the environment is reduced to the maximum extent, and then gaseous monomers causing respiratory tract / mucosa stimulation are reduced from the source; and the volatile monomer is inhibited from polymerizing in the air to form white powder.

The invention relates to a herbal preparation in the form of film-coated tablets for the supportive treatment of allergic rhinitis and sinusitis, and a process for preparing such a preparation. The preparation according to the invention contains herbal extracts obtained from a mixture of medicinal herbs including Bupleurum root (Radix Bupleurum), Platycodon grandiflorus root (Radix Platycodi grandiflori), Xanthium strumarium fruit (Fructus Xanthii strumarii), Magnolia officinalis flower (Flos Magnoliae), and Oroxylum indicum bark (Cortex Oroxyli indici), in which each herb is used in appropriate amounts to create synergistic anti-inflammatory, anti-allergic, decongestant, expectorant, and immune-enhancing effects on the respiratory mucosa. The preparation also includes a film-coating system containing a film-forming polymer, plasticizer, and coloring agent, along with tablet-forming excipients such as preservatives, fillers, stabilizers, and anti-caking agents in appropriate proportions to create a highly stable film-coated tablet.The preparation according to the invention has the advantages of preserving the active ingredients of the medicinal herbs, increasing stability, improving bioavailability, being convenient to use, and contributing to enhancing the effectiveness of supporting the treatment of symptoms of allergic rhinitis and sinusitis. It is also safe for long-term use because the preparation contains herbal extracts of natural origin that have been used for a long time in traditional medicine, and does not contain synthetic vasoconstrictors, corticosteroids, or antibiotics. In addition, the extraction and purification process helps remove impurities and reduce irritating components, thereby limiting the risk of unwanted side effects with prolonged use.

The utility model belongs to the field of medical equipment, and particularly relates to a sputum excretion device convenient to store, which comprises a mounting frame, a piston rod, a piston block, a shell, a conical cover and the like, the shell is fixedly connected onto the mounting frame, the piston rod is slidably connected onto the mounting frame, the front end of the piston rod penetrates through the shell and extends into the shell, and the piston block is fixedly connected to the most front end of the piston rod. The outer diameter of the conical cover is equal to the inner diameter of the shell, the conical cover is in sliding fit with the shell, the conical cover is fixedly connected to the inner front portion of the shell, and the diameter of the cross section of the conical cover is gradually decreased from the front end to the rear end to form a gradually-narrowed channel. Through a protection mechanism composed of the air bag, the air inlet valve, the exhaust assembly and the like, a soft sealing interface capable of adapting to the respiratory tract of a patient can be provided, friction or collision with the respiratory mucosa is reduced, more comfortable experience is provided, meanwhile, the exhaust assembly is designed to ensure that excessive air in the air bag is exhausted in time, and the safety of the patient is improved. And the proper size of the air bag is kept.

The invention is applicable to the technical field of biology, and provides a streptococcus suis type 2 multi-epitope inhalation type subunit vaccine and application thereof. According to the invention, 4 CTL epitopes, 7 HTL epitopes and 6 B cell epitopes are screened out aiming at conserved epitopes of SS2 virulence factors SSU05-1022 and SpaA, the epitopes are fused by AAY / GPGPG / EAAAK linkers, L7 / L12 ribosomal protein is introduced as an adjuvant, and the inhalation type subunit vaccine 1022-SpaA V3 is constructed; the vaccine can improve the levels of sIgA and serum IgG of respiratory mucosa and activate related immune cells by virtue of 60 micrograms of intranasal primary immunization-enhanced immunization, so that a mucosa and system dual immune mechanism is formed; the survival rate of mice after SS2 multi-strain challenge reaches up to 100%, and the bacterial load can be reduced; and the vaccine is safe and non-toxic, is inhaled, saves cost and is suitable for industrial large-scale production.

The invention discloses a novel coronal virus mucosal immune vaccine based on a non-replicating vesicular stomatitis virus vector. The vaccine is delivered through a mucosal immunization way; the vaccine can be used in new crown vaccines, and can also be used in combination with other respiratory tract infection viruses such as respiratory syncytial vaccines (RSV) and influenza. At present, preparation of respiratory mucosa vaccines, especially multivalent vaccines, from replication-deficient VSV is not reported yet. According to the invention, safety and immunogenicity evaluation is carried out on the constructed VSVMT-S2P non-replicating recombinant VSV new crown vaccine in healthy narrative golden hamster and CP immunosuppression hamster models, and the VSVMT-S2P vaccine is found to be very safe in healthy animals; and the protein is highly safe in CP immunosuppressed hamsters. The VSVMT-S2P vaccine is subjected to single inoculation in the body of the narrative golden hamster through intranasal and intramuscular injection respectively, and it is proved that the VSVMT-S2P vaccine can effectively stimulate comprehensive immune response.

The invention relates to the field of immunology, in particular to preparation of a mucous membrane adjuvant for recruiting pre-DC and application of the mucous membrane adjuvant in influenza vaccines. Tridecafluoroheptyl ethylene oxide and mannose are grafted on polyethyleneimine, the polyethyleneimine and structural protein hemagglutinin of influenza viruses are adsorbed to form a nano vaccine MF25PEI / HA, secretion of CCL2 is promoted by activating a TLR4 pathway of nasal cavity cDC, pre-DC is recruited and differentiated into cDC, and the network steady state of the nasal cavity cDC is maintained. HA uptake is increased by targeting cDC, cDC maturation is stimulated, and high-level immune response is induced. After intranasal immunization of MF25PEI / HA, secretion of high-level IgA and IgG is caused, activation of B cells, T cells and Tfh cells is promoted, and differentiation of memory B cells and memory T cells is induced. Effective protection can be provided for the influenza H1N1 virus, and a new thought is provided for research and development of respiratory mucosa vaccines.

This utility model discloses a respiratory spray device, relating to the field of respiratory medicine technology. It includes a nebulizer body with a limiting cap snapped onto its top. A limiting device is threaded onto one side of the limiting cap, and a mist outlet is fixedly connected to the side of the nebulizer body. Through the design of a filter and filtration components, this utility model achieves purification and safety during operation. The filtration components accurately intercept impurities mixed with the medication from the outside, such as airborne dust, fibers, and tiny foreign objects that may be introduced when the medicine bottle is opened, ensuring extremely high purity of the medication injected into the nebulizer body and preventing impurities from interfering with the nebulization effect. The organic cotton filter inside the filter deeply filters any remaining un-nebulized droplets and fine impurity particles in the mist after nebulization, effectively removing components that may irritate the respiratory mucosa and significantly reducing patient discomfort when inhaling the mist.

The invention discloses a bronchopneumonia sampling device suitable for children. The bronchopneumonia sampling device comprises a piston cylinder; a hole is formed in the center of the front end of the piston cylinder to be fixedly connected with the fixing block, the push handle is arranged outside the piston cylinder, and the piston head is slidably connected inside the rear end; the blowing cylinder is arranged at the front end of the push handle; a plurality of blowing openings are arranged outside the blowing cylinder in an array manner, and the front end is rotationally connected with the rotating cylinder; the front end of the piston head is provided with a spring which is fixedly connected with the bottom of the piston cylinder; when the piston is pulled, the negative pressure one-way valve is opened, so that negative pressure is formed in the sampling barrel, a sample can be stably and accurately sucked, and the situation that the sample is insufficiently collected due to insufficient negative pressure or the respiratory mucosa of a child is damaged due to excessive negative pressure is avoided; when the piston is pushed, the air blowing one-way valve is opened, and the air blowing port of the air blowing cylinder can blow air flow to dilute microorganisms in the oral cavity.

The invention discloses a spleen-tonifying and qi-tonifying tea atomized liquid based on a traditional Chinese medicine formula and a preparation method thereof. The atomized liquid consists of the following nine traditional Chinese medicinal materials: ginseng, astragalus membranaceus, black tea, liquorice, Chinese yam, pericarpium citri reticulatae, pinellia ternate, platycodon grandiflorum and poria cocos. Ginseng, astragalus membranaceus and black tea are combined as core components and cooperate with liquorice, Chinese yam and other adjuvants to form a compound system with remarkable spleen tonifying and qi tonifying effects. Ginseng and astragalus mongholicus have a synergistic effect to remarkably improve the qi tonifying effect, active ingredients contained in ginseng and astragalus mongholicus can enhance the immunity of the organism, improve the anti-fatigue ability, regulate blood glucose metabolism and improve exercise tolerance, and by adopting a modern atomization delivery technology, the active ingredients are rapidly absorbed through respiratory mucosa and directly enter human body circulation through lung circulation, so that the health care effect is achieved. According to the preparation method, the bioavailability is greatly improved, the defect that a traditional oral preparation possibly aggravates the metabolic burden of the liver is overcome, the atomization delivery mode avoids the first-pass effect, the spleen strengthening and qi tonifying effects can be achieved quickly, and a novel solution is provided for conditioning of the sub-health state.

The invention discloses a fatty acid modified influenza hemagglutinin antigen and application thereof, and belongs to the technical field of biological medicine, the fatty acid modified influenza hemagglutinin antigen comprises a receptor binding domain (RBD) of influenza hemagglutinin, and further comprises N-terminal fatty acid modified cysteine (Cys), the fatty acid modified N-terminal cysteine (Cys) is characterized in that the sulfydryl of the Cys is modified by diacylglycerol, or the sulfydryl of the Cys is modified by diacylglycerol and alpha-amino is modified by fatty acyl; the fatty acid modified influenza hemagglutinin antigen can be polymerized into nanoparticles, and the fatty acid modified influenza hemagglutinin antigen not only can induce antigen-specific humoral immunity through injection inoculation, but also can induce antigen-specific mucosal immunity and humoral immunity through respiratory mucosa inoculation. The invention also discloses a method for preparing the fatty acid modified influenza hemagglutinin antigen by using the escherichia coli, and application of the fatty acid modified influenza hemagglutinin antigen in preparation of products capable of causing animals to generate antigen-specific antibodies.

The application provides an atomized inhalation new crown vaccine and a preparation method thereof, the new crown vaccine is a recombinant protein, and a nucleotide sequence encoding the recombinant protein is obtained by connecting the following modules in series: a SP signal peptide nucleic acid artificial sequence, a S protein nucleic acid artificial sequence, a Tri T4 phage fibroin folding region nucleic acid artificial sequence, a Linker nucleic acid artificial sequence, a nucleic acid artificial sequence of a Fc antibody constant region, and a N nucleocapsid protein nucleic acid artificial sequence. In the selection process of the immunization antigen, in addition to the S protein, the relatively conservative nucleocapsid protein is also selected as the immunization antigen, so that the effective protection of the vaccine on the body can be maintained in the case of mutation of the new crown virus. The vaccine prepared by the application belongs to an inhalation new crown vaccine, can target the respiratory mucosa immunity through FcRn, and can enhance the immune protection efficiency of the vaccine.

The invention relates to breathing physiotherapy equipment, which is characterized in that an oxygen mixing module is detachably connected with a main machine, so that the oxygen mixing module can convey oxygen of oxygen supply equipment into the main machine at different concentrations and flows. Mixed gas from the first gas outlet of the main machine enters the water tank through the second gas inlet, so that water in the water tank forms water vapor and makes contact with the gas, gas humidification is achieved, respiratory mucosa is protected, and damage and inflammation caused by inhalation of dry gas are avoided. Respiratory tract smoothness is maintained, and the blocking risk is reduced; and the comfort level of a user can be improved. The titration module is used for monitoring breathing parameters of a patient, the optimal breathing support strength is accurately matched for the patient, airway smoothness can be ensured, apnea and other problems can be prevented, discomfort or injury caused by too high pressure to the patient can be avoided, the patient can be helped to find a good treatment pressure level, and the patient can be effectively controlled according to specific requirements of the patient. Different modules are flexibly selected and combined, and a personalized treatment scheme is achieved.

The present invention discloses a multi-functional atomizer, which includes a water mist generator and a liquid storage tank that are in threaded fit. The water mist generator includes a housing and a nano-spray assembly located inside the housing. One side of the nano-spray assembly is connected to the liquid storage tank. A spray port is correspondingly arranged on the housing. A connecting pipe fitting that can be communicated with the nano-spray assembly is arranged inside the spray port. One end of the connecting pipe fitting far away from the nano-spray assembly is externally connected to an atomization mask that is communicated with the human mouth and nose. An external oxygen supply interface that can be communicated with the connecting pipe fitting is arranged on the housing, and the external oxygen supply interface is connected to an oxygen supply device. The present invention has the following beneficial effects: The atomizer can spray nano-scale liquid particles and can be connected to an oxygen supply device. While serving as a humidifying device for medical oxygen inhalation, it enables the nano-particles to have a larger absorption area with the lungs, can improve the treatment effect and protect the respiratory mucosa.

The application discloses a kind of liposome polypeptide vaccine of pulmonary inhalation immunity and its preparation method and application, belong to biological medicine technical field.The vaccine includes the liposome of DSPC and DDAB, polypeptide antigen and molecular adjuvant loaded therein.The optimal preparation process condition is: the mass ratio of DSPC and DDAB 5:1, ultrasonic power 275 W, ultrasonic number 50 times, the liposome particle size obtained is about 100 nm, surface is positive charge, meet the physical property requirement of respiratory mucosa immunity.The vaccine can be widely distributed in lung and long time retention after pulmonary mucosa route immunity, promote the uptake and activation of dendritic cell in lung to antigen, further activate T, B cell, produce mucosal immune response, and be taken up after dendritic cell, transport to lymph node, stimulate systemic adaptive immune response.The application provides effective mucosal immune vaccine platform for the prevention and treatment of respiratory pathogenic microorganism infection.

The utility model relates to the technical field of medical rehabilitation instruments, in particular to equipment for cardiovascular rehabilitation training activities of children, which comprises an air blowing pipe and a rubber push rod, and a bent pipe is fixedly mounted at the right end of the air blowing pipe. The swing mechanism is driven to swing upwards and make a sound through cooperation of a movable disc, a rubber push rod and other structures, so that the breathing training device increases interestingness of children through the swing mechanism, meanwhile, after the children blow air, backflow air is effectively exhausted through the blocking mechanism, and the interestingness of the children is improved. The ability of the trainer to flexibly adjust the training intensity according to the progress degree of children is greatly enhanced, meanwhile, discomfort symptoms such as stimulation to the respiratory mucosa of the children and unsmooth breathing caused by backflow are avoided, and the diversity and depth of the training effect are remarkably improved through the improvement. Therefore, the comprehensive rehabilitation of the cardiopulmonary function of children is positively promoted.