45 results about "Ileum" patented technology

The invention discloses an application of DUOX2 in identification of ileum subtype and colon subtype Crohn's disease. A group of new DUOX2-epi is analyzed and identified based on single cell transcriptome sequencing, the proportion of the cells in the Crohn disease inflammation tissue is obviously increased, and the proportion of the DUOX2-epi in the colon type Crohn disease inflammation tissue is obviously higher than that in the ileum type Crohn disease inflammation tissue; in addition, in ileum type and colon type Crohn diseases, interaction with surrounding cells is carried out through different mechanisms, so that the occurrence and development of the diseases are promoted. Therefore, based on a DUOX2-epi mediated intercellular communication network, a gene prediction module for predicting different subtypes of Crohn diseases and evaluating the treatment effect of a biological agent is developed, and based on a DUOX2 molecular network, an experimental basis and a research direction are provided for subsequent in-depth research, and a new strategy is expected to be provided for diagnosis and treatment of different subtypes of Crohn diseases.

The invention discloses a pig intestine organoid and lymphocyte co-culture system as well as a construction method and application thereof, and belongs to the technical field of virus culture. The co-culture system is obtained by co-culturing porcine ileum organs and porcine small intestine epithelium lymphocytes. By using the co-culture system, the PEDV still can infect the organoid under the condition of not adding pancreatin, and by using the co-culture system to separate and culture the PEDV wild strain, the pathological change of the organoid can be observed during blind passage of the fourth generation, and at the moment, the pathological change does not appear on Vero cells. Reverse transcription-polymerase chain reaction (RT-PCR) identification finds that a stripe can be amplified after a PEDV wild strain is continuously passed for five generations on the co-culture system, and no stripe can be amplified after the PEDV is continuously and blindly passed for five generations on Vero cells no matter whether pancreatin is added or not. The proposal of the invention is of great significance to understanding the pathogenesis of PEDV and developing new drugs and therapies for preventing PEDV infection.

The invention discloses a Crohn disease identification system, which comprises a data acquisition module, which is used for obtaining a fungus ITS amplicon sequence variant data set based on the results of microorganism DNA extraction and fungus ITS sequencing on respectively acquired fungus sample data of ileum end mucous membranes of healthy personnel and target patients; the model construction module is used for carrying out first training on a constructed Crohn disease recognition model by using a fungus ITS amplicon sequence variant data set based on a random forest algorithm, and determining a model characteristic strain type based on an initial Crohn disease recognition model obtained by the first training; performing second training on the initial Crohn disease recognition model according to the model characteristic strain type to obtain a target Crohn disease recognition model; and inputting the ITS amplicon sequence variant of the model characteristic strain of the individual to be identified into the Crohn disease identification model to obtain an identification result. The recognition system provided by the invention is high in recognition accuracy, good in robustness and simple and efficient in operation.

A composition for use in a method of providing sustained energy release over time in a subject is described. The composition comprises or consists of microparticles comprising high glycaemic index (GI) carbohydrate contained within a gastric-resistant, ileal-sensitive, GLP-1 stimulative, non-porous carrier configured for release of the high GI carbohydrate in the ileum, wherein the composition is administered orally to the subject.

The utility model belongs to the technical field of colon lavage devices, and discloses a smooth colon lavage device which comprises an infusion bag, a liquid guide pipeline is arranged at the bottom end of the infusion bag, a first connecting assembly is arranged between the infusion bag and the liquid guide pipeline, and a valve is installed at the end, close to the infusion bag, of the liquid guide pipeline. A liquid guide tip is arranged at the end, away from the infusion bag, of the liquid guide pipeline, a second connecting assembly is arranged between the liquid guide pipeline and the liquid guide tip, and the first connecting assembly comprises a first connecting pipeline, a first threaded groove and a first external thread. Compared with a traditional enema bag which is poor in direct lavage effect and poor in comfort level, the device has the advantages that the lavage effect is improved, the use experience of a patient is remarkably improved, and risks and discomfort in the operation process are reduced.

The invention relates to the technical field of biological agriculture, in particular to a preparation method, device and application of basic ionic liquid for animals, and the basic ionic liquid comprises potassium bicarbonate, potassium carbonate, sodium bicarbonate, sodium carbonate, germanium dioxide, sodium selenite, chromic oxide, chitosan oligosaccharide and purified water. The preparation method and device of the basic ionic liquid for animals and the application have the beneficial effects that through scientific proportioning and careful preparation, the basic ionic liquid can remarkably improve the growth performance, the immunity and the intestinal health level of animals, improve the villus height and the crypt depth of jejunum and ileum, and improve the animal immunity. And a ratio of fluff length to recess depth; and by optimizing the equipment structure and the operation process, the preparation efficiency and quality are improved, and the labor cost and the error rate are reduced.

The application discloses a compound plant essential oil preparation for improving intestinal tract barrier function of laying hens and a preparation method thereof, relates to the technical field of livestock and poultry intestinal tract health regulation, and comprises microcapsule particles with a multilayer structure, which sequentially comprises a core layer, a first coating layer, an intermediate functional layer and a second coating layer; the compound plant essential oil preparation for improving intestinal tract barrier function of laying hens and the preparation method thereof are characterized in that the preparation is arranged as a multilayer microcapsule structure composed of the core layer, the first coating layer, the intermediate functional layer and the second coating layer in sequence, and the first coating layer and the second coating layer adopt enteric polymers with different pH dissolution ranges, so that the intermediate functional layer can be released first in the pH environment from the duodenum to the jejunum, and the core layer is released subsequently in the pH environment of the ileum, thereby realizing the graded and zoned release of active components of plant essential oils in the front and rear sections of the small intestine of laying hens, and matching different essential oil components with the barrier repair requirements of each section of the intestinal tract.

The invention discloses an application of fangchinoline in prevention and treatment of salmonella infection. The fangchinoline alkali is an isoquinoline alkaloid, and is a host-oriented treatment natural compound. The fangchinoline disclosed by the invention has a relatively strong effect of treating salmonella infection diseases in vivo and in vitro, and specifically, the fangchinoline can effectively reduce the quantity of intracellular infection bacteria. Administration of the fangchinoline can significantly reduce the load of pathogenic bacteria in the liver, spleen, colon, cecum and ileum of a mouse, and reduce the proinflammatory factor level of an organism. In-vivo and in-vitro safety shows that the fangchinoline has no toxic or side effect below the test dosage. Besides, the fangchinoline alkali and the fluoroquinolone medicine are combined for use, so that the remarkable synergistic antibacterial activity is achieved, and the remarkable synergistic antibacterial activity is shown in reducing the number of salmonella infection bacteria in cells and reducing the load of pathogenic bacteria in the liver, the spleen and the colon of a mouse. The invention provides a new perspective for the development of novel anti-infection drugs, and also provides a new idea for the prevention and control of increasingly serious salmonella infection.

The invention belongs to the technical field of livestock breeding, and particularly relates to application of borneol essential oil in relieving piglet diarrhea. The invention focuses on the application of the borneol essential oil in the field of piglet breeding, analyzes the effects of the borneol essential oil in the antibacterial and antioxidant capacities of piglet intestinal tracts, and reveals that the borneol essential oil improves the stress response capacity of piglets by regulating the activity of antioxidant enzymes of the piglets. Research finds that the borneol essential oil can significantly improve the resistance of piglets to stimulus by adjusting the activity of antioxidant enzymes in the piglets so as to further improve the form of the intestinal tracts of the piglets, which is represented by increasing the height and density of jejunum and rectum villus of the piglets and finally significantly improving the diarrhea rate of the piglets. The invention provides a systematic and reliable scientific basis and theoretical basis for the application of the borneol essential oil to prevention and alleviation of piglet diarrhea by using a nutrition regulation and control means in live pig breeding.

The invention discloses a feed pharmaceutical composition for treating ileitis of piglets, a preparation method and application, and belongs to the field of traditional Chinese medicine preparations, the feed pharmaceutical composition comprises a component A and a component B. The component A comprises, by weight, 10-20 parts of licorice roots, 10-20 parts of Chinese dates, 10-30 parts of baked ginger, 10-15 parts of pomegranate rind and 5-10 parts of Chinese yam; the component B is prepared from 6.5 to 10 parts of lactobacillus fermentum and 6.5 to 10 parts of bacillus subtilis, and the mass ratio of the lactobacillus fermentum to the bacillus subtilis is 1 to 1. According to the present invention, etiology and pathogenesis analysis is performed on pig ileitis through traditional Chinese medicine syndrome differentiation for the first time, the treatment rule and the traditional Chinese medicine prescription are obtained, and in addition, after the mixed probiotics enter the animal body, the colonization of pathogenic bacteria in the ileum can be significantly inhibited and reduced, the occurrence of the ileitis is prevented, the diarrhea rate is reduced, and the growth performance of the infected pig is improved; the content of proinflammatory factors can be reduced, so that the intestinal inflammation reaction is relieved, and on the basis of treating ileitis, the multiple advantages of increasing the lean meat percentage, improving the meat quality and flavor and enhancing the nutrition and health care value are achieved.

The invention discloses a drainage self-closing device for preventive ileum fistulization, relates to an ileum fistulization device, and aims to solve the problem that the conventional preventive ileum fistulization method needs a secondary operation. The device comprises a Y-shaped drainage tube, a water injection tube, an air injection tube, a purse string, a suture line, a knot pushing rod and a suture needle, wherein a bag receiving hole is formed in the side wall of the inlet end of the Y-shaped drainage tube, and the tube wall of the outlet end of the Y-shaped drainage tube is a T-shaped tube wall; the end part of the gas injection tube is a balloon; the knot pushing rod is a hollow pipe, a lower hole is formed in the lower end of the pipe, and a wire outlet hole is formed in the side wall of the pipe close to the lower hole; and an inclined plate plug is arranged at the upper part of the wire outlet hole in the hollow pipe. The device is used for fistulization, healing of the fistulization opening is accelerated, and the device can be used for clinical medicine, in particular to the field of gastrointestinal surgery.

The invention discloses a frog bradykinin and application thereof, and belongs to the technical field of biomedicine. The amino acid sequence of the frog bradykinin is RPARPPGFTP, the bradykinin is obtained through experimental screening, then the activity of the frog bradykinin is verified through experiments, experimental results show that the bradykinin can cause concentration-dependent contraction of the ileum of an in-vitro rat, the biological activity of the bradykinin is higher than that of BK reported in the past, and the bradykinin can be used for preparing the bradykinin. When the concentration reaches-8M, higher biological activity can be shown. The invention provides a new thought for efficiently screening bradykinin of amphibians and other species, and has very important significance.

The present invention relates to a stoma plug suitable for controlling the discharge of biological fluids from the colon, ileum and / or ureter (50) respectively through a stoma (45) formed by colostomy, ileostomy or urostomy. The stoma plug comprises a tube (10) having an opening (12) in its proximal part and at least one opening (14) in its distal part, and a two-way valve system (20) comprising a base element (22) and a plug (24), which is connected to the tube (10) via the base element (22) and is configured to control the flow of fluid through the opening (12) in the proximal part of the tube (10), a two-way valve system (20), and a cap (30) configured to cover the two-way valve system (20) and the stoma (45) and including an opening (32) for direct access to the two-way valve system (20) from the outside. The tube (10) is configured to be inserted into the colon, ileum and / or ureter (50) through its distal part, and the two-way valve system (20) is configured to remain passively closed and to open when the plug (24) is displaced from at least one opening (21).

The invention relates to the technical field of animal feed processing, and particularly discloses a pig feed and a processing method thereof.The pig feed comprises a cereal raw material, a protein raw material, an energy supplementing raw material, a mineral raw material, a vitamin and microelement premix and two-phase fermented corn particles, wherein the two-phase fermented corn granules are composed of a delayed release granule core containing fermented corn, lipid, a pH sensitive polymer coating layer and a quick release outer layer containing fermented corn, so that a part of a fermentation product is quickly released in the gastric segment, and the other part of the fermentation product is delayed to be released in the rear segment of the small intestine, especially in the ileum region, so as to realize targeted regulation and control on ileum flora. Compared with daily ration only adopting common fermented corn, the processing method has the advantages that the growth performance is kept, the ratio of ileum lactic acid bacteria to escherichia coli can be more effectively increased, the intestinal health is improved, the emission of ammonia gas and hydrogen sulfide in excrement is further reduced, and the processing method has remarkable nutrition regulation and control and environment-friendly effects.

The invention relates to the technical field of biology, and discloses a strain of lactobacillus reuteri, the preservation number of the lactobacillus reuteri is CCTCC NO: M20231546, the preservation date is August 31, 2023, the preservation unit is China Center for Type Culture Collection, the preservation address is Wuhan University, Wuhan, China, the classification name is Limobacillus reuteri XY227, the preservation number is CCTCC NO: M20231546, the preservation number is CCTCC NO: M20231546, the preservation number is CCTCC NO: M20231546, the preservation number is CCTCC NO: M20231546, and the preservation number is CCTCC NO: M20231546. The bacterial strain can increase the content of amino acid in serum of rats, and further experiments surprisingly find that the bacterial strain can also increase the content of amino acid in serum and ileum of pigs, and the capacity of increasing branched chain amino acid is particularly outstanding; the invention further discloses application of the lactobacillus reuteri and a feed.

The application belongs to the technical field of biological medicine, and particularly relates to application of a CLIC5 gene in preparation of a drug for preventing and / or treating intestinal inflammation. The application provides application of the CLIC5 gene in preparation of a drug for preventing and / or treating intestinal inflammation, wherein a nucleotide sequence of the CLIC5 gene is shown as SEQ ID NO:1. The application finds that intestinal epithelial cell-specific knockout of the CLIC5 can reduce a serum endotoxin level, improve intestinal epithelial barrier function, increase a content of butyric acid, reduce a serum inflammatory factor level, and also reduce a gene expression level of an inflammatory factor in an ileum and a colon. The application first discloses that intestinal epithelial cell-specific knockout of the CLIC5 can effectively prevent or treat intestinal inflammation and reduce a body inflammatory factor level, thereby providing a new target and method for treating human intestinal inflammation.

A stoma plug suitable for controlling the output of biological fluids from a colon, ileum and / or ureter through a stoma created by a colostomy, ileostomy or urostomy, respectively. The stoma plug includes a tube comprising an opening in a proximal portion and at least one opening in a distal portion, a two-way valve system including a base element and a plug, the two-way valve system connected to the tube through the base element, the two-way valve system configured to control the fluid flow through the opening of the proximal portion of the tube, and a cap configured to cover the two-way valve system and the stoma, the cap including an opening to directly access the two-way valve system from the outside. The tube is configured to be inserted into the colon, ileum and / or ureter through its distal portion, and the two-way valve system is configured to passively remain closed and to be opened when the plug is displaced from the at least one opening

The utility model relates to a leather bridge loop type ileum stoma drainage device, which belongs to the technical field of ileum stoma and comprises a collecting box, an air supply box and an abdominal wall, a connecting pipe is inserted in the right side of the collecting box, a connecting assembly is arranged on the outer side of the connecting pipe, and an observation box is fixedly communicated with the right side of the connecting pipe. The right side of the observation box fixedly communicates with a hose, the bottom of the air supply box communicates with an air outlet pipe, the right side of the air outlet pipe communicates with an air bag, and a locking assembly is arranged on the inner side of the air bag. According to the leather bridge loop type ileum stoma drainage device, through the arrangement of the connecting assembly, the collecting box and the connecting pipe can be disassembled easily, the device can be cleaned easily after being used, the use convenience of the device can be improved easily, through the arrangement of the locking assembly, adjustment between the air bag and the hose is achieved, and therefore the drainage requirements of different intestinal tracts are met; the use flexibility of the device is improved, and the whole device is convenient to clean, high in flexibility and convenient to use.

This invention provides a process for preparing ileal-targeted empty capsules, relating to the field of pharmaceutical excipients technology. The process includes the following steps: preparing the following raw materials: gelatin, titanium dioxide, and sodium stearate; dissolving the gelatin in water at 60-70°C, heating and stirring, adding titanium dioxide and sodium stearate, mixing well, and allowing to stand to obtain a film-forming gel. This invention utilizes a preparation mechanism involving the mixing of water-soluble polyacrylic acid resin IV, polyacrylic acid resin III, and polyvinyl alcohol, with the remaining materials added in steps, to achieve the predetermined goal of ileal disintegration. Furthermore, based on the synergistic effect of polyacrylic acid resin III with water-soluble polyacrylic acid resin IV and polyvinyl alcohol, the drug release rate of the empty capsule is improved, allowing the drug to rapidly reach an effective concentration in the ileum and exert its therapeutic effect more effectively.

The invention belongs to the technical field of biological medicines, and particularly relates to application of a CLIC5 gene in preparation of a medicine for preventing and / or treating intestinal inflammation. The invention provides application of a CLIC5 gene in preparation of a medicine for preventing and / or treating intestinal inflammation. The nucleotide sequence of the CLIC5 gene is shown as SEQ ID NO: 1. Experiments find that the intestinal epithelial cell specific knockout CLIC5 can reduce the serum endotoxin level, improve the intestinal epithelial barrier function, increase the content of butyric acid, reduce the serum inflammatory factor level and reduce the gene expression level of inflammatory factors in ileum and colon. The invention reveals for the first time that intestinal epithelial cell specific knockout CLIC5 can effectively prevent or treat intestinal inflammation and reduce the level of body inflammatory factors, and provides a new target and a new method for treating human intestinal inflammation.

The present invention relates to a pH responsive polymer composition for the enteric coating of hard shell capsules, which composition is suitable for the delivery of pharmaceutical dosage forms, in particular microbiota, to the ileum and colon. The pH responsive polymer composition comprises at least one anionic poly (meth) acrylate copolymer, at least one glidant, at least one plasticizer, and 1 to < 6% of at least one nonionic emulsifier based on the total weight of the pH responsive polymer composition.

A slow-release microencapsulate comprises a FODMAP encapsulated within a denatured protein matrix. The microencapsulate is gastric-resistant and ileal-sensitive, and configured to release the FODMAP slowly in the ileum of the subject to inhibit or prevent gas formation and bloating. A method of preventing or inhibiting gastrointestinal gas formation or bloating associated with consumption of FODMAP in a subject is also described.

The present disclosure discloses Lactobacillus reuteri CCFM1132 capable of relieving hyperuricemia and application thereof, which belongs to the technical field of microorganisms. The L. reuteri CCFM1132 can reduce serum uric acid levels of mice with hyperuricemia, inhibit the activity of serum and liver xanthine oxidase (XOD), and reduce the occurrence of hyperuricemia and gout; reduce serum creatinine levels, reduce serum total triglyceride (TG) levels, and inhibit the activity of serum alkaline phosphatase (ALP); and promote the expression of ileum uric acid transporter ABCG2. The L. reuteri CCFM1132 of the present disclosure can be used for preparing functional bacterial agents, food and medicines for relieving hyperuricemia and gout, and has a wide application prospect.

The invention provides an ileum stoma auxiliary device. The ileum stoma auxiliary device is characterized by comprising a hollow tube body, an ostomy bag is mounted at the top of the tube body; a bottom disc extending outwards is arranged at the bottom end of the tube body, and a sewing ring is arranged on the upper surface of the bottom disc; a middle disc extending outwards is arranged in the middle of the tube body, and a sewing ring is arranged on the upper surface of the middle disc. Related complications after ileum stoma operation are reduced, and ileum stoma reduction operation is facilitated.

A gastrointestinal implant adapted to be implanted in a gastrointestinal structure such as a duodenum, a jejunum, and / or an ileum comprises a plurality of adjacent layers bonded to one another. One of more of the layers comprises at least one of a selected pore size and interpore distance, and at least one medicament is coupled to at least one medial surface of one or more layers to achieve one or more treatment goals selected from minimizing or alleviating trauma associated with implantation of the gastrointestinal sleeve, preventing or treating infection, treating eating disorders or conditions of the patient, treating one or more gastrointestinal tract structures exterior to or distal to at least a portion of the sleeve, or treating the patient's microbiome.

The present invention belongs to the field of traditional Chinese medicine and discloses a new use of a Dengyinnaotong composition. The Dengyinnaotong composition includes Dengzhan Xixin, Ginkgo Biloba, Panax Notoginseng, and Rhizoma Cimicifugae. The application of the Dengyinnaotong composition in the preparation of a medicament for preventing and / or treating atherosclerosis has the effect of significantly inhibiting atherosclerotic plaques and regulating blood lipids. At the same time, the Dengyinnaotong composition has a protective effect on ileal tissue and / or colon tissue, can significantly increase the average number of goblet cells per villus of the ileum, the length of the villi, and the thickness of the muscular layer, and can increase the number of goblet cells per crypt of the colon tissue. The application of the Dengyinnaotong composition in the preparation of a medicament for regulating intestinal flora can significantly increase the abundance of Alloprevotella_Bacteroides, Ruminococcus, Prevotellaceae_NK3B31_group, and Parabacteroides at the genus level, and significantly reduce the abundance of Blautia and Desulfovibrio. The new use of the Dengyinnaotong composition found in the present invention has expanded the scope of clinical application of the Dengyinnaotong composition and has broad application prospects.

The invention discloses an ileum bladder expansion supporting drainage device which comprises an ileum supporting balloon, two ureter supporting balloons in one-to-one correspondence with two ureters, two ureter supports in one-to-one correspondence with the two ureters and a four-cavity catheter. According to the ileum bladder dilatation supporting drainage device, through cooperation of the four-cavity catheter, the ureter support, the ileum supporting balloon and the ureter supporting balloon, the ileum supporting balloon and the ureter supporting balloon are subjected to water filling expansion, so that the ileum supporting balloon supports the ileum, the ureter supporting balloon supports the ureter, the ureter is dilated, and the drainage effect is improved. Meanwhile, an anastomotic stoma between the ileum and the ureter is expanded, and the problem that the anastomotic stoma is narrow is solved; meanwhile, the ureter supporting balloon and the ileum supporting balloon have certain hardness after being inflated with water, the ureter supporting balloon plays a role in supporting the ureter stent after being inflated with water, and the ureter stent is prevented from moving and falling off.

The invention relates to the technical field of fistulization devices, in particular to an ileum fistulization device with a stoma monitoring function, which comprises a fixed chassis, a covering assembly and a monitoring assembly. The monitoring assembly comprises a fixing ring; an electrode plate and a photoelectric sensor are arranged at the bottom of the fixing ring; an electric control assembly is arranged on the fixing ring and electrically connected with the electrode plates and the photoelectric sensor through wires. According to the invention, leakage monitoring and ischemia early warning functions are integrated, tissue impedance can be measured through the electrode slice, and leakage can be accurately identified. Meanwhile, the photoelectric sensor is used for monitoring the blood oxygen saturation degree, the oppression ischemia condition can be found in time, and stoma tissue necrosis is prevented. According to the invention, seepage and ischemia states can be monitored in advance according to monitoring data, and the problem that detection and alarm can only be carried out after certain serious consequences are generated by a transmission monitoring device is avoided. The skin injury and infection risk caused by leakage or ischemia of a patient can be remarkably reduced, and the use comfort and life quality of the patient are improved.

The application discloses a pig breed disease resistance breeding screening method based on taurine cholate metabolic markers, and belongs to the technical field of animal breeding. The application effectively screens the breeding pigs with stronger intestinal barrier function by establishing a breeding standard based on the intestinal barrier function difference, especially taking the taurine cholate level as a key index, and improves the health level and production benefit of pigs. Compared with the prior art, the ileum villus height to crypt depth ratio of the breeding pig is increased by 25.3%, the mRNA relative expression amount of ZO-1 and other tight junction proteins is increased by 32.7%, the SIgA and IgG levels are increased by 38.5%, the health level of the pig is significantly improved, and the production benefit is increased by 15.6%.

This invention relates to the field of poultry feed technology, and more particularly to a diet for determining the loss of endogenous amino acids in poultry and its application. The diet provided by this invention, by mass percentage, comprises 12-14% total amino acids, 17-22% hydrolyzed casein, 16-20% glucose, 18-21.6% amylose, and 30-37.4% amylopectin, wherein the ratio of glucose to starch is 0.30-0.40, and the ratio of amylose to amylopectin is 0.55-0.65. This invention can effectively detect the loss of endogenous amino acids in the ileum of broilers while ensuring normal weight gain and digestive physiological status, thereby improving the accuracy of calculating standard ileal amino acid digestibility, helping to reduce the waste of protein feed resources in broilers, and achieving precision nutrition.