15 results about "Gastrointestinal system" patented technology

The invention relates to a plant lactobacillus with effects of dispelling effects of alcohol, protecting the liver and restoring consciousness and application of the plant lactobacillus. The plant lactobacillus is a plant lactobacillus BGI-J9 strain, and the preservation number of the plant lactobacillus is CCTCC NO: M 20242630. The invention further discloses a preparation method of the plant lactobacillus with the effects of dispelling effects of alcohol, protecting the liver and restoring consciousness and application of the plant lactobacillus with the effects of dispelling effects of alcohol, protecting the liver and restoring consciousness. The strain has excellent tolerance to gastric acid, intestinal juice and cholate in a gastrointestinal tract system, can survive in the gastrointestinal tract, and provides a basis for continuously playing a probiotic effect; the compound has excellent inhibition capability on common intestinal pathogens; free radicals can be removed, and oxidative damage to the body is reduced; good alcohol metabolism enzyme synthesis capability and alcohol metabolism promoting potential are realized; the strain also has an excellent improvement effect on alcohol-damaged mice, specifically, the metabolism of ethanol and acetaldehyde in a body is accelerated, the occurrence time of drunkenness is obviously delayed, and the sobering time is shortened; intestinal injury and systemic inflammation caused by alcohol are improved; liver oxidative stress caused by alcohol is improved, and the occurrence and development process of alcoholic fatty liver is delayed; and cognitive function impairment caused by alcohol is improved.

The invention relates to a gastrointestinal tract peristalsis space-time simulation method based on digital twinning, which comprises the following steps: abstracting a neuromuscular activation process of a gastrointestinal tract into a physiological excitation field, constructing a variable topology strain network of a gastrointestinal wall, and forming a functional contraction path; introducing a control equation set to enable the excitation field to reflect fluctuation evolution in time, reflect tension distribution in space and cause geometric deformation in structure; analyzing the behavior difference between the twinborn body and the real gastrointestinal system by using the error field; error feedback is conducted to excitation field parameters, and closed-loop adjustment is achieved; historical state data and current feedback are fused, and a time sequence diagram network is adopted for modeling a creeping trend; the process from real fitting to future behavioral ability evolution prediction is realized; mapping the continuous creeping process into a space-time activity density map; extracting activity mutation, wriggling stagnation and reverse propagation characteristics of the key area by using topological convolution; the semantic indexes easy to understand are output, a predictable peristalsis behavior model is constructed, and clinical visibility and auxiliary diagnosis value are improved.

Systems and methods for treating Inflammatory Bowel Disease (IBD) using neuromodulation are described herein. For example, IBD can be treated by delivering an electrical signal to one or more sacral nerves of a patient via a signal delivery device positioned proximate one or more of the patient's sacral nerves. In some embodiments, the electrical signal can modulate neural activity in the patient, which may in turn reduce inflammation in the patient by altering an imbalance between the patient's sympathetic nervous system and parasympathetic nervous system, and / or modifying a threshold for an inflammatory response in the gastrointestinal system.

The present invention provides an injectable depot composition comprising linagliptin and low-dose liraglutide. The combination therapy of linagliptin and low-dose liraglutide provides a synergistic effect in the treatment of obesity compared to the administration of each drug alone. In addition, the administration dose of liraglutide can be reduced compared to the administration of liraglutide alone, and thus the direct cause of side effects related to the gastrointestinal system and the cardiovascular system of liraglutide can be reduced. Furthermore, by the combination of linagliptin, it has the advantage of additionally providing an improvement effect on metabolic diseases and cardiovascular diseases related to blood sugar, blood lipids, blood pressure, fatty liver, etc. In addition, compared to the conventional liraglutide dosage form of once-daily subcutaneous injection, the depot composition of linagliptin and liraglutide of the present invention can significantly improve patient convenience and patient compliance by unifying the administration route and improving the administration cycle.

There is an innovative cockroach killer consisting of two active chemical substances (one in salt form composed of sodium ions and bicarbonate ions, and the other in powdered sugar form). Their chemical formulas are NaHCO3 ( fig.2) and C12H22O11 ( fig.1), respectively and are available in powder form or in specific plastic trapping containers. The product in question is placed in indoor and outdoor areas. The sweet taste of the first chemical substance C12H22O11 attracts the cockroach to taste it; taking a small dose, the above substance passes through the salivary glands and liquefies; after liquefaction, the second chemical substance NaHCO3 starts to act and expand internally in the cockroach's gastrointestinal system, causing swelling and immediate extermination of said insect.

Generally, the inventive technology relates to systems, methods, and compositions to formulate short-chain fatty acid phenolic compounds, such as cannabinoids, terpenes and other volatile compounds found in cannabinoid-producing plants such as Cannabis. In one embodiment, a natural or treated aloe vera extract may act as a cannabinoid-carrier and / or solubilizing agent forming one or more cannabinoid-infused aloe vera extract compositions, generally referred to herein as a composition or formulation of the invention. In one preferred aspect, the formulations and compositions of the invention may include safer and more palatable cannabinoid-delivery methods for both medicine and recreation. The formulations and compositions of the invention may further exhibit enhanced pharmacokinetic properties, such as enhanced bioavailability and increase adsorption in the gastrointestinal system.

The application belongs to the technical field of food manufacturing, and specifically discloses a preparation method of fermented flower and fruit juice drink, which uses solid-liquid secondary fermentation as a technical means, and performs solid fermentation on dehydrated, kneaded and sterilized fresh flowers by connecting the fermentation bacteria, grinds the flower petals after fermentation, and obtains the leaching liquor through water extraction, mixes the leaching liquor with fruit juice, and then performs liquid fermentation, and obtains the fermented flower and fruit juice through sterilization, compounding, homogenization and clarification. The application uses different types of probiotics in combination with the preparation method of solid-liquid fermentation, effectively improves the free radical removal rate, total phenol content and polyphenol bioavailability in the flower and fruit juice, and thus improves the antioxidant activity and nutritional value of the flower and fruit juice; meanwhile, a large amount of flavor substances and nutritional substances are produced in the fermentation process, and the substances interact with each other to produce rich metabolic products, and the nutritional quality and flavor diversity of the flower and fruit juice are improved; the secondary fermentation also brings a large amount of active probiotics, and has the effects of helping digestion and adjusting the gastrointestinal system.

The present invention provides an obesity treatment regimen for reducing side effects by low-dose combination administration of linagliptin and liraglutide. The combination therapy of linagliptin and low-dose liraglutide provides a synergistic effect in obesity treatment compared to administration of each drug alone. Furthermore, the administration dose of liraglutide can be reduced compared to administration of liraglutide alone, and thus the direct cause of side effects related to the gastrointestinal system and the cardiovascular system of liraglutide can be reduced. Furthermore, by the combination of linagliptin, it has the advantage of additionally providing an improvement effect on metabolic diseases and cardiovascular diseases related to blood sugar, blood lipids, blood pressure, fatty liver, etc.

Methods of treating cancer of the digestive system, preferably of the gastrointestinal system, in a patient using an anti-GUCY2CxCD3 antibody are disclosed.

To provide therapeutic agents that can increase protection or mitigate of the effects of exposure to ionizing radiation useful for increasing the survival of normal cellular, tissue, organ and system and restoration of these functions after accidental exposure to ionizing radiation or in a radiation therapy setting.SOLUTION: Provided is a pharmaceutical composition for protecting a subject after exposure to radiation, the subject being undergoing radiation therapy for head and neck cancer, and the pharmaceutical composition comprising a therapeutically effective amount of substantially isolated rIL-12, thereby reducing radiation-induced damage to one or more of the subject's immune system, gastrointestinal system, and mucosal tissue.SELECTED DRAWING: Figure 2

The invention belongs to the technical field of preparation of foot bath bags, and particularly relates to a foot bath bag made of hotpot materials and a preparation method of the foot bath bag. The foot bath bag is prepared from one or more of bran-fried rhizoma atractylodis, pericarpium citri reticulatae, rhizoma pinellinae praeparata, poria cocos, bran-fried semen coicis, fructus amomi, bran-fried rhizoma atractylodis macrocephalae, ligusticum wallichii, radix cyathulae, radix salviae miltiorrhizae, radix paeoniae rubra, flos carthami, herba lycopi, herba leonuri, salted cortex eucommiae, salted radix morindae officinalis, ginger-processed cortex magnoliae officinalis, poria with hostwood, moutan bark, cortex albiziae, fructus citri sarcodactylis, pericarpium zanthoxyli, chili, anise, red wine, fresh ginger and wormwood. According to the foot bath bag, the problems that oral traditional Chinese medicine is large in stimulation to the gastrointestinal system, poor in patient compliance and the like are solved, the multiple effects of dispelling cold and removing dampness, promoting blood circulation to remove blood stasis, clearing liver and improving vision, tonifying qi and deficiency, clearing dampness and restraining prescription, strengthening yang and dispelling evil and the like can be achieved in a foot bath mode, and the foot bath bag has the advantages of being safe to use and efficient.

A method for treating the gastrointestinal or a urogenital system of a subject with prebiotic nutrients and probiotic bacteria is provided. Multi-chamber products are described which include at least two chambers wherein probiotic bacteria or human microbiome transplants are contained in one or more inner chambers and wherein prebiotic nutrients are contained in an outer chamber, the outer chamber completely enclosing the inner chamber(s). One or both chambers may contain a pharmaceutically acceptable material that is solid outside the human body when in a dry environment, but that melts at internal body temperature. The products may be administered by oral, rectal, vaginal, or urethral routes.

The invention discloses a gastrointestinal stimulation system and method based on olfactory, tactile and magnetic current stimulation, the system comprises a multi-mode stimulation system, the multi-mode stimulation system specifically comprises an olfactory stimulation module, a warm touch stimulation module and a magnetic current stimulation module, the multi-mode stimulation subsystem can output a stimulation signal with adjustable and controllable parameters, and the stimulation signal is used for outputting a stimulation signal with adjustable and controllable parameters. The control signal coordination system acts on the enteric nervous system and the peripheral gastrointestinal system of a subject, and the olfactory stimulation module, the warm touch stimulation module and the magnetic current stimulation module receive instructions of the control signal coordination system and respectively generate gas pulses to the subject, generate slow wave signals or warm thorns to be applied to the subject and generate a controlled magnetic field to act on the subject. Probiotics are activated through magnetic current, pathogenic bacteria are inhibited, intestinal nerve regulation and control are enhanced through smell and touch, the problem that gastrointestinal motility is difficult to synchronize through single stimulation is solved, an exclusive treatment scheme is generated by configuring a file manager, stimulation parameters are dynamically adjusted, physiological differences of different subjects can be adapted, and treatment limitation is avoided.

The invention relates to a preoperative simulation and evaluation method for gastrointestinal system reconstruction, which comprises the following steps of: acquiring multi-source preoperative clinical data, identifying stress and strain response trajectories formed in a lesion process of gastrointestinal tissues, and calibrating a structural response lag region in the gastrointestinal tissues so as to determine an adjustable tissue boundary range; synthesizing tissue deformation adaptability, anatomical continuity and adjacent organ space constraint conditions, and screening a plurality of anatomical pathways as reconstruction candidate paths; evaluating the stress concentration trend of the anastomotic stoma and the peripheral area in the postoperative stage based on the candidate paths in combination with the operation parameters of a traction angle, suture displacement and tension transfer generated in the operation, identifying the area with potential structural fatigue or deformation accumulation risk, and establishing strain adaptability indexes corresponding to the paths; by analyzing the pressure distribution pattern and the peristalsis direction of the gastrointestinal system of a patient, a pressure migration intersection point caused by structural adjustment is identified, and in combination with a path change trend, a potential fluid backflow, pressure accumulation or negative pressure interference risk area existing after anastomosis is judged.