Empty targeting capsule and preparation method thereof

A hollow capsule, functional technology, applied in the field of medicine and food, can solve the problem of dependence on gelatin, achieve high curative effect, good drug release effect, and small dose effect

Active Publication Date: 2014-09-24
王荣辉 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to aim at the defects of traditional hollow capsules such as excessive reliance on gelatin, while emphasizing the health care effect of the prepared capsule itself on the human body, and fully considering the health care function of the selected raw materials themselves, to provide a targeted function Hollow capsules and preparation method thereof

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1: The hollow capsule with duodenum targeting function is composed of the following components in parts by weight:

[0024] Chitosan 1~2 parts, pectin 20~25 parts, carrageenan 5~10 parts, resistant starch 1~5 parts, glycerin 1~5 parts, polyvinyl alcohol 1~3 parts, water 50~100 parts;

[0025] The preparation method of the hollow capsule with duodenum targeting function, comprises the steps:

[0026] a. Preparation of pectin-chitosan polymer

[0027] a.1 Dissolve chitosan in 0.3% acetic acid (V / V) solution to make a chitosan acetic acid solution with a mass percentage of 0.5%,

[0028] a.2 Dissolve 3 times of chitosan weight pectin in distilled water to make a 5% pectin solution by mass percentage,

[0029] a.3 Slowly add the chitosan solution into the pectin solution, and homogenize it with a beater for 2 minutes at a speed of 20000r / min, so that the polymerization becomes emulsified,

[0030] a.4 Place the polymerized pectin-chitosan solution at room temp...

Embodiment 2

[0041] Embodiment 2: The hollow capsule with ileum targeting function is composed of the following components in parts by weight:

[0042] 2~3 parts of chitosan, 15~25 parts of pectin, 5~10 parts of carrageenan, 1~5 parts of resistant starch, 1~2 parts of sorbitol, 1~3 parts of glycerin, 1~3 parts of silicon dioxide, 50~100 parts of water;

[0043] The preparation method of the hollow capsule with ileum targeting function comprises the following steps:

[0044] a. Preparation of pectin-chitosan polymer

[0045] a.1 Dissolve chitosan in 0.3% acetic acid (V / V) solution to make a chitosan acetic acid solution with a mass percentage of 1%,

[0046] a.2 Dissolve pectin with 3 times the weight of chitosan in distilled water to make a pectin solution with a mass percentage of 2%,

[0047] a.3 Slowly add the chitosan solution into the pectin solution, and homogenize it with a beater for 3 minutes at a speed of 15000r / min, so that the polymerization becomes emulsified,

[0048] a.4 ...

Embodiment 3

[0057] Embodiment 3: The hollow capsule with colon targeting function is composed of the following components by weight:

[0058] Chitosan 3~5 parts, pectin 12~25, carrageenan 5~10, resistant starch 5~10, propylene glycol 1~5, polyvinyl alcohol 1~1.5, silicon dioxide 1~1.5, water 50~100 ;

[0059] The preparation method of the hollow capsule with colon targeting function, comprises the steps:

[0060] a. Preparation of pectin-chitosan polymer

[0061] a.1 Dissolve chitosan in 0.3% acetic acid (V / V) solution to make a chitosan acetic acid solution with a mass percentage of 1%,

[0062] a.2 Dissolve pectin with 3 times the weight of chitosan in distilled water to make a pectin solution with a mass percentage of 3%,

[0063] a.3 Slowly add the chitosan solution into the pectin solution, and homogenize it with a beater for 3 minutes at a speed of 18000r / min, so that the polymerization becomes emulsified,

[0064] a.4 Place the polymerized pectin-chitosan solution at room tempe...

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Abstract

The invention discloses an empty targeting capsule. The empty targeting capsule comprises chitosan, pectin, carrageenan, resistant starch, plasticizer and water repellent agents, wherein sorbitol, glycerol, propylene glycol, mannitol and polyethylene glycol are selected and used as the plasticizer, and polyvinyl alcohol and silicon dioxide are selected and used as the water repellent agents. A preparation method includes the first step of preparing pectin-chitosan polymers, the second step of mixing and dissolving raw materials, and the third step of forming the empty targeting capsule through the conventional mold dipping method. The duodenal targeting capsule, the ileum targeting capsule and the colon targeting capsule can be prepared according to different components and different methods as required; protonated amidogen in the chitosan and ionized carboxyl in the pectin are combined into secondary valence bonds through electrostatic attraction, and polyelectrolyte coordination complexes are formed; the prepared duodenal targeting capsule, the prepared ileum targeting capsule and the prepared colon targeting capsule are accurate in positioning and good in drug release effect and have the advantages of being small in dosage, high in curative effect and low in toxic and side effect.

Description

technical field [0001] The invention relates to a hollow capsule and a preparation method, in particular to a hollow capsule with a targeting function and a preparation method, belonging to the field of medicine and food. Background technique [0002] Capsules, as the most common dosage form in health food pharmaceutical dosage forms, have become the main packaging materials for oral solid preparations due to their good taste masking effect, good bioavailability, beautiful appearance and easy swallowing. With the improvement of the level and people's consumption ability, as well as the medical and health services and consumers' increasing attention to their own health, the consumption of medicines will increase year by year. The pharmaceutical industry provides a broad development space for the hard capsule industry with an average annual growth rate of nearly 20%. . [0003] In recent years, with the rapid development of the pharmaceutical industry at home and abroad, the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K47/36A23P1/04A23P10/35
Inventor 杨公明吴丽王荣辉朱小花王皓
Owner 王荣辉
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