Enteric sodium butyrate microcapsules as well as preparation method and application thereof

An enteric-coated sodium butyrate and sodium butyrate technology, applied in the application, additional food elements, animal feed and other directions, can solve the problems of low fluidity, limited, easy moisture absorption, etc., to reduce the content and reduce the diarrhea rate , The effect of not easy to absorb moisture

Inactive Publication Date: 2020-03-24
GUANGZHOU GREAT BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] But in the prior art, there are still very limited strategies on how to better overcome the shortcomings of sodium butyrate, such as esophageal irritation, hygroscopicity, and low fluidity. Therefore, it is necessary to develop a novel enteric sodium butyrate preparation. very necessary

Method used

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  • Enteric sodium butyrate microcapsules as well as preparation method and application thereof
  • Enteric sodium butyrate microcapsules as well as preparation method and application thereof
  • Enteric sodium butyrate microcapsules as well as preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0042] This embodiment provides an enteric-coated sodium butyrate microcapsule, the enteric-coated sodium butyrate microcapsule comprises an inner core layer and a coating material layer coated on the surface of the inner core layer; the inner core layer comprises a sodium butyrate core and a wrapped Excipient layer of sodium butyrate core. The auxiliary material is a mixture of hardened oil, glucose and fat powder, which respectively account for 40%, 15% and 20% of the total mass of the microcapsules. The coating material is hydroxypropylmethylcellulose acetate succinate, accounting for 10% of the total mass of the microcapsules.

[0043] Its preparation method is:

[0044] (1) mixing the raw material of sodium butyrate and the auxiliary material in molten state for 40 minutes at 85° C., and coating it to obtain the inner core layer;

[0045] (2) Spray coating material on the surface of the inner core layer prepared in step (1) at 85° C. for 4 hours, and dry at 85° C. to ob...

Embodiment 2

[0047] This embodiment provides an enteric-coated sodium butyrate microcapsule, the enteric-coated sodium butyrate microcapsule comprises an inner core layer and a coating material layer coated on the surface of the inner core layer; the inner core layer comprises a sodium butyrate core and a wrapped Excipient layer of sodium butyrate core. The auxiliary material is a mixture of glyceryl monostearate, stearyl alcohol and glucose, which account for 40%, 30% and 10% of the total mass of the microcapsules respectively. The coating material is a mixture of hypromellose phthalate and polyvinyl acetate phthalate, accounting for 2% and 3% of the total mass of the microcapsules respectively.

[0048] Its preparation method is:

[0049] (1) mixing the sodium butyrate raw material and the auxiliary material in the molten state at 80° C. for 50 minutes, and coating to obtain the inner core layer;

[0050] (2) spray coating material on the surface of the inner core layer prepared in ste...

Embodiment 3

[0052] This embodiment provides an enteric-coated sodium butyrate microcapsule, the enteric-coated sodium butyrate microcapsule comprises an inner core layer and a coating material layer coated on the surface of the inner core layer; the inner core layer comprises a sodium butyrate core and a wrapped Excipient layer of sodium butyrate core. The auxiliary material is a mixture of fat powder and auxiliary powder, accounting for 50% and 25% of the total mass of the microcapsules respectively. The coating material is a mixture of cellulose acetate and hypromellose acetate succinate, accounting for 5% and 5% of the total mass of the microcapsules respectively.

[0053] Its preparation method is:

[0054] (1) mixing the sodium butyrate raw material and the auxiliary material in the molten state at 90° C. for 30 minutes, and coating to obtain the inner core layer;

[0055] (2) spray coating material on the surface of the inner core layer prepared in step (1) at 90° C. for 3 hours, ...

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Abstract

The invention relates to an enteric sodium butyrate microcapsule as well as a preparation method and an application thereof. The enteric sodium butyrate microcapsule comprises an inner core layer anda coating material layer coating the surface of the inner core layer, the inner core layer comprises a sodium butyrate core and an auxiliary material layer wrapping the sodium butyrate core. The enteric sodium butyrate microcapsule preparation provided by the invention does not have rancidity-like smell, is not easy to absorb moisture, has good fluidity and dispersibility, can be slowly dissolvedin intestinal tracts, achieves targeted release of the intestinal tracts, and significantly improves the absorption effect. Compared with common sodium butyrate powder, when the sodium butyrate powderis used as a feed additive for feeding animals, the average daily feed intake and daily gain of the animals can be remarkably improved, the feed-to-weight ratio is reduced, and the diarrhea rate is reduced; the content of harmful bacteria such as escherichia coli in ileum and colons of animals can be remarkably reduced, and meanwhile beneficial bacteria such as lactic acid bacteria and bifidobacteria in the colons and cecum are remarkably increased.

Description

technical field [0001] The invention belongs to the technical field of feed additives, and in particular relates to an enteric-coated sodium butyrate microcapsule and a preparation method and application thereof. Background technique [0002] Butyric acid, as the most important representative of short-chain volatile fatty acids, is the main anion in the colon lumen and the nutrient substance of the colon cells. can. It plays an important role in regulating the microecological balance of the gastrointestinal tract, electrolyte balance and food attraction. Butyric acid has the physiological effect of feed acidifier and can improve animal production performance, so it is widely used in the breeding process. However, due to its freeness and volatility, it is made into a relatively stable sodium salt, namely sodium butyrate, in production. [0003] Sodium butyrate is an important nutrient for intestinal epithelial cells. As a source of energy for intestinal epithelial cells, i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23K50/30A23K50/60A23K40/30A23K20/105
CPCA23K50/30A23K50/60A23K40/30A23K20/105
Inventor 魏平华程怀灵张抒赵子君
Owner GUANGZHOU GREAT BIOLOGICAL TECH
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