Method for preparing micro-capsule by taking xanthan gum and gelatine as wall materials through complex coacervation method

A technique of complex coacervation and xanthan gum, which is applied in the direction of microcapsules, capsule delivery, and pharmaceutical formulations, can solve the problems of large particle size and low encapsulation rate of microcapsules, and achieve narrow particle size distribution, cheap excipients, good slow release effect

Inactive Publication Date: 2013-06-12
HEILONGJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] The present invention aims to solve the problems of low encapsulation efficiency and large particle size of the microcapsules prepared by the existing method, and provides a method for preparing microcapsules by using xanthan gum and gelatin as wall materials by complex coacervation

Method used

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  • Method for preparing micro-capsule by taking xanthan gum and gelatine as wall materials through complex coacervation method
  • Method for preparing micro-capsule by taking xanthan gum and gelatine as wall materials through complex coacervation method

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specific Embodiment approach 1

[0017] Specific embodiment one: In this embodiment, a method for preparing microcapsules by using xanthan gum and gelatin as the wall material complex coacervation method comprises the following steps:

[0018] 1. Add gelatin to water, soak for 20-30 minutes, heat to dissolve, and obtain a gelatin solution with a concentration of 0.05g / mL-0.45g / mL, and let it stand for 6h-8h;

[0019] 2. Add xanthan gum into water, soak for 20min-30min, heat to dissolve, and obtain a xanthan gum solution with a concentration of 0.001g / mL-0.05g / mL, and let it stand for 6h-8h;

[0020] 3. Add the core material to the gelatin solution prepared in step 1, high shear 20s ~ 40s to obtain a stable O / W emulsion, then add the xanthan gum solution prepared in step 2 dropwise therein, at a temperature of 50 Under the condition of ~60°C, stir at constant temperature for 15min ~ 25min to obtain a mixed solution; wherein the ratio of the quality of gelatin in the gelatin solution described in step 3 to the ...

specific Embodiment approach 2

[0024] Embodiment 2: The difference between this embodiment and Embodiment 1 is that a gelatin solution with a concentration of 0.25 g / mL is obtained in Step 1, and other steps and parameters are the same as Embodiment 1.

specific Embodiment approach 3

[0025] Embodiment 3: This embodiment is different from Embodiment 1 or 2 in that: in step 2, a xanthan gum solution with a concentration of 0.01 g / mL is obtained, and other steps and parameters are the same as Embodiment 1 or 2.

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Abstract

The invention relates to the technical field of preparation of micro-capsules, in particular to a method for preparing a micro-capsule by taking xanthan gum and gelatine as wall materials through a complex coacervation method. The invention aims to solve the problems of being low in micro-capsule encapsulation efficiency and large in grain diameter prepared by the current method. The preparation method comprises the following steps of: 1, preparing gelatine solution; 2, preparing xanthan gum solution; 3, preparing steady O / W type emulsion, and then adding the xanthan gum solution to obtain mixed solution; 4, adding a curing agent after adjusting pH of the mixed solution; and 5, drying to obtain the micro-capsule. The method disclosed by the invention has the advantages that the encapsulation efficiency can be above 90%; the drug loading capacity can be up to 70% maximally; if being placed below 60 DEG C for 10 days, the micro-capsule is only oxidized by 3-8%; the antioxidant ability is strong; in the event of carrying out an in-vitro drug release test, the whole drug releasing time is 12 hours; the accumulated release rate can be above 90%; the slow-release effect is good; and the method disclosed by the invention is mainly used for preparing the micro-capsule by taking xanthan gum and gelatine as the wall materials through the complex coacervation method.

Description

technical field [0001] The invention relates to the technical field of microcapsule preparation, in particular to a method for preparing microcapsules by using xanthan gum and gelatin as wall materials through complex coacervation. Background technique [0002] Microcapsule technology began in the 1930s, and Wurster in the United States prepared microcapsules by physical methods. By the 1970s, the process of microcapsule technology became more and more mature, and the scope of application gradually expanded. Today, it has expanded from the initial drug coating and carbon-free copying to many fields such as medicine, food, daily chemicals, fertilizers, and chemicals. At present, microcapsule technology is developing rapidly abroad, and the United States has always been in the leading position in its research. About 60% of food in the United States uses this technology. The global research institutes on microencapsulation technology increased from 2% in 2002 to 22% in 2006 a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K47/42A61K47/36
Inventor 李强赵学玲龚显峰王伟张华
Owner HEILONGJIANG UNIV
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