Method for preparing magnetic mesoporous apatite microsphere material by utilizing hydrothermal method

A technology of mesoporous apatite and hydrothermal method, which is applied in chemical instruments and methods, phosphorus compounds, inorganic chemistry, etc., can solve the problem of affecting drug sustained release performance and biodegradability, and the difficulty of magnetic hydroxyapatite surface morphology Control and other issues to achieve excellent drug sustained release performance, excellent biocompatibility and biological activity, and uniform particle size distribution

Inactive Publication Date: 2013-05-29
SHANGHAI NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The surface morphology of magnetic hydroxyapatite prepared by the above methods is not easy to control, which will affect its drug sustained release performance and biodegradation performance

Method used

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  • Method for preparing magnetic mesoporous apatite microsphere material by utilizing hydrothermal method
  • Method for preparing magnetic mesoporous apatite microsphere material by utilizing hydrothermal method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] (1) Preparation of calcium chloride solution containing shell organic matter: Soak shell nacre in 1.0 mol / L HCl solution for 1 day. Filter with a Buchner funnel to filter out the shell organic matter that is insoluble in hydrochloric acid. Add 1.0 mol / L NaOH solution dropwise until the pH of the filtrate is 7.0, then dilute with deionized water until the concentration of calcium ions in the solution is 0.25 mol / L, to obtain the CaCl containing shell organic matter 2 solution.

[0024] (2) Preparation of magnetic calcium carbonate microspheres: 0.55 g Fe 3 o 4 Magnetic nanoparticles (specific saturation magnetization 62.4emu / g, particle size 10-15nm) dispersed in 200 mL of 0.25 mol / L CaCl containing shell organic matter 2 solution, and then quickly poured 200 mL of 0.25 mol / L sodium carbonate solution to form a brown precipitate, and continued to stir for 1.5 h. After filtering, washing with deionized water several times, and drying in an oven at 80°C, magnetic calci...

Embodiment 2

[0032] Four kinds of magnetic mesoporous hydroxyapatite microspheres prepared in Example 1 were selected to carry out drug sustained-release experiments.

[0033] (1) Prepare PBS solution: weigh 8.00 g sodium chloride, 0.20 g potassium chloride, 2.98 g NaCl 2 HPO 4 12H 2 O, 0.52 g NaH 2 PO 4 2H 2 O was dissolved in distilled water and the volume was adjusted to 1000ml.

[0034] (2) Drug loading: 0.40 g vancomycin was weighed and dissolved in 20 ml phosphate buffer solution (PBS), and 0.40 g magnetic mesoporous hydroxyapatite microspheres were added to the above solution. Stir at 37 °C for 12 h at 150 r / min, centrifuge, and vacuum-dry the obtained precipitate at 50 °C to obtain drug-loaded magnetic mesoporous hydroxyapatite microspheres.

[0035] (3) Drug release from drug-loaded magnetic mesoporous hydroxyapatite microspheres: Weigh 0.04 g of drug-loaded magnetic mesoporous hydroxyapatite microspheres and wrap them in a semipermeable membrane dialysis bag with a dialysis...

Embodiment 3

[0038] (1) Preparation of calcium chloride solution containing shell organic matter: Soak shell nacre in 1.0 mol / L HCl solution for 1 day. Filter with a Buchner funnel to filter out the shell organic matter that is insoluble in inorganic acids. Add 1.0 mol / L NaOH solution dropwise until the pH of the filtrate is 7.0, then dilute with deionized water until the concentration of calcium ions in the solution is 0.10 mol / L, and finally obtain CaCl containing shell organic matter 2 solution.

[0039] (2) Preparation of magnetic calcium carbonate microspheres: 0.55 g Fe 3 o 4 Magnetic nanoparticles, (specific saturation magnetization 62.4emu / g, particle size 10-15nm) dispersed in 200 mL of 0.10 mol / L CaCl containing shell organic matter 2 solution, and then quickly poured 200 mL of sodium carbonate solution with a concentration of 0.10 mol / L to form a brown precipitate, and continued to stir for 1.5 h. After filtering, washing with deionized water several times, and drying in an ...

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Abstract

The invention relates to the fields of inorganic non-metal materials and medical materials, and discloses a method for preparing a magnetic mesoporous apatite microsphere material by utilizing a hydrothermal method. The method comprises the following steps: based on conch used as a raw material, preparing magnetic calcium carbonate microspheres by using an in-situ composite technology; placing the magnetic calcium carbonate microspheres in a phosphate solution for hydrothermal treatment; and then converting the magnetic calcium carbonate microspheres into the magnetic mesoporous apatite microspheres. The magnetic mesoporous apatite microsphere material has the advantages of good medicament controlled-release property, good magnetic property, good biocompatibility and good bioactivity and has a wide application prospect in biomedicine fields of magnetic targeted medicine carriers, ferromagnetic seeds, bone repair materials and the like. In the method, as the conch is used as the raw material, the cost is low, the process is simple, the reaction speed is rapid, and the method is environment-friendly.

Description

technical field [0001] The invention relates to the field of inorganic non-metallic materials and medical materials, in particular to a preparation method of a magnetic mesoporous hydroxyapatite microsphere material, especially a mesoporous hydroxyapatite microsphere material prepared by a hydrothermal method. Background technique [0002] Hydroxyapatite [Ca 10 (PO 4 ) 6 (OH) 2 HA for short] is the main inorganic component of hard tissues such as human bones and teeth. It has good biocompatibility, biological activity, no toxic side effects, and no immune response. It can promote the growth of new bone after implantation in the body. It has been widely used in human hard tissue replacement materials and repair materials. The structure of HA in organisms is complex, and in most cases the composition of minerals is impure, and calcium ions are often lacking, and are easily replaced by sodium and magnesium ions. Hydroxide ions and phosphate ions are easily replaced by carb...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C01B25/32
Inventor 郭亚平姚勇波郭亚军褚联峰
Owner SHANGHAI NORMAL UNIVERSITY
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