Hollow silicon dioxide sub-micron sphere with inner core and its preparation method and use

A technology of silica and spherical silica, applied in the field of nanomaterials, can solve the problems of cumbersome process, difficult to achieve uniformity, high cost, etc., and achieve broad application prospects and good monodispersity

Inactive Publication Date: 2012-03-28
TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method is simple and intuitive in theory, but has great limitations in operation.
For example, it is difficult to control the thickness and uniformity of the shell, and the removal of the template may lead to structural damage of the shell, and the process is cumbersome and time-consuming
[F Caruso, R A Caruso, H Mohwald.Science, 1998, 282, 1111] The process of hollow nanomaterials prepared by nozzle reactor method is simple and universal, but it needs a specially designed high-temperature furnace containing nozzle atomizer. device, its cost is very expensive, and it is difficult to achieve uniform [G L Messing, S C Zhang, G V Jayanthi.J.Am.Chem.Soc., 1993, 76, 2707]

Method used

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  • Hollow silicon dioxide sub-micron sphere with inner core and its preparation method and use
  • Hollow silicon dioxide sub-micron sphere with inner core and its preparation method and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Step 1: Prepare hybrid silica submicron spheres by sol-gel method.

[0026] Prepare respectively 100 parts by volume, 20 parts by volume and 5 parts by volume of aqueous ammonia, ethyl tetrasilicate and trimethoxysilylpropylethylenediamine ethanol solution; The molar concentrations are 0.05mol / L, 0.5mol / L and 7×10 -4 mol / L.

[0027] Add 5 parts by volume of ethyl orthosilicate ethanol solution dropwise to the mixed solution of ammonia water and ethanol stirred by magnetic force, carry out hydrolysis reaction for 10 minutes, after obtaining the spherical silica inner core, add the above-mentioned trimethoxysilylpropyl ethylenediamine ethanol Solution and ethyl tetrasilicate ethanol solution are added to the above reaction mixture solution by double injection, and the reaction is continued on the spherical silica inner core to form an organic-inorganic hybrid silica intermediate layer until all the silicate alcohol solution is added dropwise to the reaction mixture. In ...

Embodiment 2

[0033] Step 1: Prepare hybrid silica submicron spheres by sol-gel method.

[0034] Prepare 160 parts by volume of aqueous ammonia mixed solution with the mixed solvent of methanol and acetonitrile, prepare respectively 30 parts by volume and 10 parts by volume of methanol solution of methyl orthosilicate and trimethoxysilylpropylethylenediamine; ammoniacal liquor, methyl orthosilicate and The molar concentrations of trimethoxysilylpropylethylenediamine are 1.5mol / L, 0.02mol / L and 1×10 -3 mol / L.

[0035] Add 15 parts by volume of methyl orthosilicate methanol solution dropwise to a magnetically stirred mixed solution of ammonia, methanol and acetonitrile, and perform a hydrolysis reaction for 5 minutes to obtain a spherical silica core; subsequently, the above-mentioned trimethoxysilane Propylethylenediamine methanol solution and methyl orthosilicate methanol solution are added to the above reaction mixture solution by double injection, and the reaction is continued on the sph...

Embodiment 3

[0041] Step 1: Prepare hybrid silica submicron spheres by sol-gel method.

[0042] Prepare 200 parts by volume of ammonia water mixed solution with a mixed solution of acetone and propanol, prepare 40 parts by volume of propanol mixed solution of ethyl orthosilicate and propyl orthosilicate and 20 parts by volume of propanol solution of γ-aminopropyltrimethoxysilane Parts by volume; the molar concentrations of ammonia, ethyl orthosilicate and propyl orthosilicate, and γ-aminopropyltrimethoxysilane are respectively 6.5mol / L, 1.5mol / L and 1.5×10 -3 mol / L.

[0043] Add 18 parts by volume of a propanol mixed solution of ethyl orthosilicate and propyl orthosilicate dropwise to a magnetically stirred mixed solution of ammonia, acetone and propanol, and perform a hydrolysis reaction for 25 minutes to obtain spherical silica After the inner core, double-inject the above-mentioned γ-aminopropyltrimethoxysilane propanol solution and the propanol mixed solution of ethyl orthosilicate an...

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Abstract

The present invention belongs to the technical field of the nano material, especially relating to a hollow silica submicron ball with a kernel and the preparation method and the use. In an alcohol system, a silicon ester and a silane coupling agent hydrolyze together under an ammonia catalysis, which produces the hybrid silica submicron ball. The hydrofluoric acid liquor processes a sol of the hybrid silica submicron ball, which produces the hollow silica submicron ball with the kernel. The particle size of the round submicron ball is between 100nm and 1000nm and the thickness of a shell is between 20nm and 200 nm. A movable round silica kernel with the particle size between 50nm and 600nm is in a hollow cavity. The submicron ball has a mesopore structure, of which the average pore diameter is between 3nm and 10nm and the specific surface area is between 140m2/g and 500 m<2>/g. the present invention can serve as a release carrier for a therapeutic medicine and can be used to build a photonic crystal, serving as a micro reactor, a energy storage material and a catalyst carrier of the chemical reaction. The present invention has the simple method and process and short production period.

Description

technical field [0001] The invention belongs to the technical field of nanometer materials, in particular to a hollow silicon dioxide submicron sphere with an inner core, a preparation method and application thereof. Background technique [0002] In recent years, hollow nano-microspheres with a size of 1-1000 nm have received extensive attention. This kind of hollow material has properties that ordinary nano-micron materials do not have, such as high specific surface area, low density, hollow structure, etc., so it has many new uses and can be widely used in the fields of catalysis, optical devices, biomedicine and medicine. Among them, hollow silica has been successfully used as a carrier for sustained release of drugs, a microreactor for chemical reactions, energy storage carrier materials, catalyst carrier materials, lightweight composite carrier materials for electronic paper, etc. [0003] Compared with the preparation of general nano-microspheres, the preparation of h...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C01B33/113C01B33/18C01B33/12A61K47/04B82B3/00A61K31/7076A61K31/337A61K31/19
Inventor 唐芳琼陈东李琳琳
Owner TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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