The invention relates to a gas-steam circulation heating-electricity-cooling combined supply system and a gas-steam circulation heating-electricity-cooling combined supply method for a thermal power plant with zero energy loss rate and belongs to the technical field of gas-steam combined circulation heating-electricity-cooling combined supply. The gas-steam circulation heating-electricity-coolingcombined supply system comprises a heat-electricity combined circulation part, a large temperature difference adsorption waste steam recovery heat pump, a large temperature difference adsorption fluegas recovery heat pump, a flue gas condensation recovery acquisition device, an initial station steam-water heat exchanger, an adsorption heat pump/refrigeration all-in-one machine and the like, wherein the heat-electricity combined circulation part consists of a burning machine, a waste heat boiler, a steam turbine, a generator and the like. An operation regulating method for carrying out combination energy optimization on an integral thermal system, which is based on an adsorption heat-exchange waste heat recovery and large temperature difference heat supply technology and combines a climate compensation technology, is adopted, so that aiming at the characteristics of a gas-steam combined circulation system, the effect that the energy utilization efficiency for once of the thermal powerplant is close to, even exceeds 100 percent is realized. In the invention, energy resources at each energy grade are utilized to drive generating equipment, heating equipment and air-conditioning cold supply equipment, so that the energy-saving effect that compared with a flue gas low heating value, the effective energy output has no energy loss is achieved.