The invention discloses a hyper-gravity device for enhancing a reaction by gas-liquid efficient premixing and an application method thereof. The hyper-gravity device comprises a motor, a main shaft, arotor, a shell, a liquid distributor, a secondary shaft, a speed-increasing gear, a speed-increasing gear output shaft and a charging cavity, wherein the main shaft at an output end of the motor passes through the bottom of the shell and extends into the shell; the rotor is fixed on an upper part of the main shaft; the charging cavity is arranged on an upper part of the shell; a lower part of thecharging cavity is connected with the liquid distributor; the main shaft is fixedly connected with the speed-increasing gear through the secondary shaft; the output shaft of the speed-increasing gearpasses through the bottom of the charging cavity and extends into the charging cavity; stirring wings are arranged on a part of the output shaft of the speed-increasing gear in the charging cavity. By adopting the hyper-gravity device, gas is distributed in a liquid phase in a nano-micron size, long gas retention period and high gas-liquid mass transfer efficiency are achieved, and the macro-reaction rate is increased effectively.